{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T23:06:48Z","timestamp":1770160008531,"version":"3.49.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-34760-3","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:46:39Z","timestamp":1769741199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The arginine\/gallic acid-based deep eutectic solvent as a capable catalyst for the green synthesis of pyrano[2,3-d]pyrimidines"],"prefix":"10.1038","volume":"16","author":[{"given":"Elnaz","family":"Chegeni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davood","family":"Habibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arezo","family":"Monem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"34760_CR1","doi-asserted-by":"publisher","first-page":"9142","DOI":"10.1021\/ja048266j","volume":"126","author":"AP Abbott","year":"2004","unstructured":"Abbott, A. P., Boothby, D., Capper, G., Davies, D. L. & Rasheed, R. K. Deep eutectic solvents formed between choline chloride and carboxylic acids: versatile alternatives to ionic liquids. J. Am. Chem. Soc. 126, 9142\u20139147 (2004).","journal-title":"J. Am. Chem. Soc."},{"key":"34760_CR2","doi-asserted-by":"publisher","first-page":"116108","DOI":"10.1016\/j.trac.2020.116108","volume":"134","author":"\u00c1 Santana-Mayor","year":"2021","unstructured":"Santana-Mayor, \u00c1., Rodr\u00edguez-Ramos, R., Herrera-Herrera, A. V., Socas-Rodr\u00edguez, B. & Rodr\u00edguez-Delgado, M. \u00c1. Deep eutectic solvents. The new generation of green solvents in analytical chemistry. TrAC Trends Anal. Chem. 134, 116108 (2021).","journal-title":"TrAC Trends Anal. Chem."},{"key":"34760_CR3","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1021\/acs.jnatprod.7b00945","volume":"81","author":"Y Liu","year":"2018","unstructured":"Liu, Y. et al. Natural deep eutectic solvents: properties, applications, and perspectives. J. Nat. Prod. 81, 679\u2013690 (2018).","journal-title":"J. Nat. Prod."},{"key":"34760_CR4","doi-asserted-by":"publisher","first-page":"e202301597","DOI":"10.1002\/cctc.202301597","volume":"13","author":"AR Buzatu","year":"2024","unstructured":"Buzatu, A. R., Todea, A., Peter, F. & Boeriu, C. G. The role of reactive natural deep eutectic solvents in sustainable biocatalysis. ChemCatChem 13, e202301597 (2024).","journal-title":"ChemCatChem"},{"key":"34760_CR5","doi-asserted-by":"publisher","first-page":"18009","DOI":"10.1038\/s41598-023-45352-4","volume":"13","author":"A Monem","year":"2023","unstructured":"Monem, A., Habibi, D. & Goudarzi, H. An acid-based DES as a novel catalyst for the synthesis of pyranopyrimidines. Sci. Rep. 13, 18009 (2023).","journal-title":"Sci. Rep."},{"key":"34760_CR6","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1021\/acs.chemrev.0c00385","volume":"121","author":"BB Hansen","year":"2021","unstructured":"Hansen, B. B. et al. Deep eutectic solvents: a review of fundamentals and applications. Chem. Rev. 121, 1232\u20131285 (2021).","journal-title":"Chem. Rev."},{"key":"34760_CR7","doi-asserted-by":"publisher","first-page":"11060","DOI":"10.1021\/cr300162p","volume":"114","author":"EL Smith","year":"2014","unstructured":"Smith, E. L., Abbott, A. P. & Ryder, K. S. Deep eutectic solvents (DESs) and their applications. Chem. Rev. 114, 11060\u201311082 (2014).","journal-title":"Chem. Rev."},{"key":"34760_CR8","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.1039\/b917644f","volume":"39","author":"V Estevez","year":"2010","unstructured":"Estevez, V., Villacampa, M. & Menendez, J. C. Multicomponent reactions for the synthesis of pyrroles. Chem. Soc. Rev. 39, 4402\u20134421 (2010).","journal-title":"Chem. Soc. Rev."},{"key":"34760_CR9","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1134\/S1070363210120297","volume":"80","author":"MA Mironov","year":"2010","unstructured":"Mironov, M. A. Multicomponent reactions and combinatorial chemistry. Russ J. Gen. Chem. 80, 2628\u20132646 (2010).","journal-title":"Russ J. Gen. Chem."},{"key":"34760_CR10","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1039\/C4GC00013G","volume":"16","author":"RC Cioc","year":"2014","unstructured":"Cioc, R. C., Ruijter, E. & Orru, R. V. Multicomponent reactions: advanced tools for sustainable organic synthesis. Green. Chem. 16, 2958\u20132975 (2014).","journal-title":"Green. Chem."},{"key":"34760_CR11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jiec.2015.03.035","volume":"29","author":"M Zakeri","year":"2015","unstructured":"Zakeri, M., Nasef, M. M., Abouzari-Lotf, E., Moharami, A. & Heravi, M. M. Sustainable alternative protocols for the multicomponent synthesis of spiro-4H-pyrans catalyzed by 4-dimethylaminopyridine. J. Ind. Eng. Chem. 29, 273\u2013281 (2015).","journal-title":"J. Ind. Eng. Chem."},{"key":"34760_CR12","doi-asserted-by":"publisher","first-page":"106913","DOI":"10.1016\/j.catcom.2024.106913","volume":"187","author":"A Monem","year":"2024","unstructured":"Monem, A. et al. The choline chloride-based DES as a capable and new catalyst for the synthesis of benzopyranophenazinecarbonitriles. Catal. Commun. 187, 106913 (2024).","journal-title":"Catal. Commun."},{"key":"34760_CR13","doi-asserted-by":"publisher","first-page":"38148","DOI":"10.1039\/C9RA08074K","volume":"9","author":"TT Nguyen","year":"2019","unstructured":"Nguyen, T. T., Le, N. P. & Tran, P. H. An efficient multicomponent synthesis of 2,4,5-tri-substituted and 1,2,4,5-tetrasubstituted imidazoles catalyzed by a magnetic nano-particle supported Lewis acidic deep eutectic solvent. RSC Adv. 9, 38148\u201338153 (2019).","journal-title":"RSC Adv."},{"key":"34760_CR14","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1021\/ef5028873","volume":"29","author":"G Garc\u00eda","year":"2015","unstructured":"Garc\u00eda, G., Aparicio, S., Ullah, R. & Atilhan, M. Deep eutectic solvents: physico-chemical properties and gas separation applications. Energy Fuels. 29, 2616\u20132644 (2015).","journal-title":"Energy Fuels"},{"key":"34760_CR15","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1021\/acs.jafc.7b01588","volume":"65","author":"MN Clifford","year":"2017","unstructured":"Clifford, M. N. & Madala, N. E. Surrogate standards: a cost-effective strategy for identification of phytochemicals. J. Agric. Food Chem. 65, 3589\u20133590 (2017).","journal-title":"J. Agric. Food Chem."},{"key":"34760_CR16","first-page":"815","volume":"10","author":"FG Calvo-Flores","year":"2021","unstructured":"Calvo-Flores, F. G. & Mingorance-S\u00e1nchez, C. Deep eutectic solvents and multi-component reactions: two convergent items to green chemistry strategies. Chem. Open. 10, 815\u2013829 (2021).","journal-title":"Chem. Open."},{"key":"34760_CR17","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1021\/acs.inorgchem.1c03042","volume":"61","author":"S Rezayati","year":"2021","unstructured":"Rezayati, S. et al. Magnetic silica-coated picolylamine copper complex [Fe\u2083O\u2084@SiO\u2082@gp\/picolyl-amine-Cu(II)]-catalyzed Biginelli annulation reaction. Inorg. Chem. 61, 992\u20131010 (2021).","journal-title":"Inorg. Chem."},{"key":"34760_CR18","doi-asserted-by":"publisher","first-page":"25608","DOI":"10.1021\/acsomega.1c03672","volume":"6","author":"S Rezayati","year":"2021","unstructured":"Rezayati, S., Ramazani, A., Sajjadifar, S., Aghahosseini, H. & Rezaei, A. Design of a schiff base complex of copper coated on epoxy-modified core\u2013shell MNPs as an environmentally friendly and novel catalyst for the one-pot synthesis of various chromene-annulated heterocycles. ACS Omega. 6, 25608\u201325622 (2021).","journal-title":"ACS Omega"},{"key":"34760_CR19","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.3390\/molecules26123567","volume":"26","author":"Z Wang","year":"2021","unstructured":"Wang, Z. & Sun, J. Recent advances in the synthesis of benzo[b]furan derivatives and their biological activities. Molecules 26, 3567 (2021).","journal-title":"Molecules"},{"key":"34760_CR20","first-page":"2067","volume":"7","author":"X Zhang","year":"2020","unstructured":"Zhang, X., Li, X. & Wang, J. Recent advances in the synthesis of N-heterocycles via multicomponent reactions. Org. Chem. Front. 7, 2067\u20132090 (2020).","journal-title":"Org. Chem. Front."},{"key":"34760_CR21","doi-asserted-by":"publisher","first-page":"e7064","DOI":"10.1002\/aoc.7064","volume":"37","author":"F Kalantari","year":"2023","unstructured":"Kalantari, F., Rezayati, S., Ramazani, A. & Poor Heravi, M. Syntheses and structures of magnetic nanodendrimers and their catalytic application in organic synthesis. Appl. Organomet. Chem. 37, e7064 (2023).","journal-title":"Appl. Organomet. Chem."},{"key":"34760_CR22","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1021\/acs.orglett.8b03388","volume":"21","author":"H Aghahosseini","year":"2018","unstructured":"Aghahosseini, H. et al. Vinylphosphonium salt-mediated reactions: a one-pot condensation approach for the highly cis-selective synthesis of N-benzoylaziridines and the green synthesis of 1,4,2-dioxazoles as two important classes of heterocyclic compounds. Org. Lett. 21, 22\u201326 (2018).","journal-title":"Org. Lett."},{"key":"34760_CR23","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ultsonch.2013.06.009","volume":"21","author":"M Rouhani","year":"2014","unstructured":"Rouhani, M., Ramazani, A. & Joo, S. W. Novel, fast and efficient one-pot sono-chemical synthesis of 2-aryl-1,3,4-oxadiazoles. Ultrason. Sonochem. 21, 262\u2013267 (2014).","journal-title":"Ultrason. Sonochem"},{"key":"34760_CR24","first-page":"6123","volume":"65","author":"Y Li","year":"2022","unstructured":"Li, Y. & Zhang, Q. Recent advances in the synthesis of dihydropyrones and their medicinal applications. J. Med. Chem. 65, 6123\u20136145 (2022).","journal-title":"J. Med. Chem."},{"key":"34760_CR25","doi-asserted-by":"crossref","first-page":"28223","DOI":"10.1039\/D1RA05180F","volume":"11","author":"S Mishra","year":"2021","unstructured":"Mishra, S. & Pandey, A. Recent advances in the synthesis of thiazole derivatives and their biological applications. RSC Adv. 11, 28223\u201328247 (2021).","journal-title":"RSC Adv."},{"key":"34760_CR26","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.2174\/1385272822666181008142138","volume":"22","author":"Z Hosseinzadeh","year":"2018","unstructured":"Hosseinzadeh, Z., Ramazani, A. & Razzaghi-Asl, N. Anti-cancer nitrogen-containing heterocyclic compounds. Curr. Org. Chem. 22, 2256\u20132279 (2018).","journal-title":"Curr. Org. Chem."},{"key":"34760_CR27","doi-asserted-by":"crossref","first-page":"113487","DOI":"10.1016\/j.ejmech.2021.113487","volume":"220","author":"L Chen","year":"2021","unstructured":"Chen, L. & Zhang, H. Design and synthesis of novel heterocyclic compounds for angiogenesis inhibition: a review. Eur. J. Med. Chem. 220, 113487 (2021).","journal-title":"Eur. J. Med. Chem."},{"key":"34760_CR28","doi-asserted-by":"publisher","first-page":"e3813","DOI":"10.1002\/aoc.3813","volume":"31","author":"AQ Ali","year":"2017","unstructured":"Ali, A. Q. et al. Synthesis, structure and in vitro anticancer, DNA binding and cleavage activity of palladium(II) complexes based on Isatin thiosemicarbazone derivatives. Appl. Organomet. Chem. 31, e3813 (2017).","journal-title":"Appl. Organomet. Chem."},{"key":"34760_CR29","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.2174\/0929867329666220607160559","volume":"29","author":"A Sharma","year":"2022","unstructured":"Sharma, A. & Gupta, V. Recent advances in the development of anticancer heterocyclic compounds. Curr. Med. Chem. 29, 2639\u20132665 (2022).","journal-title":"Curr. Med. Chem."},{"key":"34760_CR30","first-page":"789","volume":"21","author":"Y Wang","year":"2022","unstructured":"Wang, Y. & Liu, X. Flavonoid-based heterocycles: synthesis, biological activities, and medicinal applications. Phytochem Rev. 21, 789\u2013817 (2022).","journal-title":"Phytochem Rev."},{"key":"34760_CR31","doi-asserted-by":"crossref","first-page":"112427","DOI":"10.1016\/j.ejmech.2020.112427","volume":"200","author":"S Kumar","year":"2020","unstructured":"Kumar, S. & Bawa, S. Coumarin-based heterocycles: recent advances in synthesis and biological activities. Eur. J. Med. Chem. 200, 112427 (2020).","journal-title":"Eur. J. Med. Chem."},{"key":"34760_CR32","doi-asserted-by":"crossref","first-page":"116190","DOI":"10.1016\/j.bmc.2021.116190","volume":"40","author":"R Patel","year":"2021","unstructured":"Patel, R. & Singh, J. Natural product-inspired synthesis of anti-inflammatory compounds: recent advances and future perspectives. Bioorg. Med. Chem. 40, 116190 (2021).","journal-title":"Bioorg. Med. Chem."},{"key":"34760_CR33","doi-asserted-by":"crossref","first-page":"104914","DOI":"10.1016\/j.bioorg.2021.104914","volume":"112","author":"R Kumar","year":"2021","unstructured":"Kumar, R. & Singh, P. Anti-inflammatory heterocyclic compounds: recent advances in synthesis and biological evaluation. Bioorg. Chem. 112, 104914 (2021).","journal-title":"Bioorg. Chem."},{"key":"34760_CR34","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/ardp.200200754","volume":"337","author":"MD Aytemir","year":"2004","unstructured":"Aytemir, M. D., \u00c7ali\u015f, \u00dc. & \u00d6zalp, M. Synthesis and evaluation of anticonvulsant and antimicrobial activities of 3-hydroxy-6-methyl-2-substituted 4H-pyran-4-ones. Arch. Pharm. Chem. Life Sci. 337, 281\u2013288 (2004).","journal-title":"Arch. Pharm. Chem. Life Sci."},{"key":"34760_CR35","doi-asserted-by":"publisher","first-page":"6329","DOI":"10.1002\/chem.200800836","volume":"14","author":"M Rueping","year":"2008","unstructured":"Rueping, M., Sugiono, E. & Merino, E. Asymmetric organocatalysis: an efficient enantioselective access to benzopyranes and Chromenes. Chem. Eur. J. 14, 6329\u20136332 (2008).","journal-title":"Chem. Eur. J."},{"key":"34760_CR36","doi-asserted-by":"publisher","first-page":"4531","DOI":"10.1080\/10406638.2023.2254900","volume":"44","author":"A Monem","year":"2024","unstructured":"Monem, A., Habibi, D. & Goudarzi, H. The novel catalyst (pypogallic acid-based deep eutectic solvent) for Preparation of the new compounds (pyrano[2,3-d]pyrimidines). Polycycl. Aromat. Compd. 44, 4531\u20134544 (2024).","journal-title":"Polycycl. Aromat. Compd."},{"key":"34760_CR37","first-page":"64448","volume":"5","author":"D Kumar","year":"2015","unstructured":"Kumar, D. et al. Multi-component reactions: a sustainable tool to 1,4-dihydropyridines and Pyrano [2,3-d]pyrimidines. RSC Adv. 5, 64448\u201364465 (2015).","journal-title":"RSC Adv."},{"key":"34760_CR38","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1021\/sc400312n","volume":"2","author":"G Brahmachari","year":"2014","unstructured":"Brahmachari, G. & Banerjee, B. Facile and one-pot access to diverse and densely functionalized 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocyclic scaffolds via an eco-friendly multicomponent reaction at room temperature using Urea as a novel organocatalyst. ACS Sustain. Chem. Eng. 2, 411\u2013422 (2014).","journal-title":"ACS Sustain. Chem. Eng."},{"key":"34760_CR39","doi-asserted-by":"publisher","first-page":"41048","DOI":"10.1039\/C8RA09038F","volume":"8","author":"G Mohammadi Ziarani","year":"2018","unstructured":"Mohammadi Ziarani, G., Moradi, R., Lashgari, N. & Badiei, A. Recent advances in the application of heterogeneous catalysts in the synthesis of pyrano[2,3-d]pyrimidines. RSC Adv. 8, 41048\u201341061 (2018).","journal-title":"RSC Adv."},{"key":"34760_CR40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.tetlet.2015.11.073","volume":"57","author":"AA Esmaeili","year":"2016","unstructured":"Esmaeili, A. A., Salehan, F., Habibi, A. & Fakhari, A. R. Efficient synthesis of novel pyrano[2,3-d]pyrido[1,2-a]pyrimidine derivatives via isocyanide-based three-component reactions. Tetrahedron Lett. 57, 100\u2013102 (2016).","journal-title":"Tetrahedron Lett."},{"key":"34760_CR41","doi-asserted-by":"publisher","first-page":"4668","DOI":"10.1039\/C5OB00380F","volume":"13","author":"N Rajesh","year":"2015","unstructured":"Rajesh, N. & Prajapati, D. A copper-catalyzed one-pot, three-component tandem conjugative alkynylation\/6-endo cyclization sequence: access to pyrano[2,3-d] pyrimidines. Org. Biomol. Chem. 13, 4668\u20134672 (2015).","journal-title":"Org. Biomol. Chem."},{"key":"34760_CR42","doi-asserted-by":"publisher","first-page":"74336","DOI":"10.1039\/C5RA16646B","volume":"5","author":"R Ghorbani-Vaghei","year":"2015","unstructured":"Ghorbani-Vaghei, R., Maghbooli, Y., Mahmoodi, J., Shahriari, A. & Poly (N-bromo-N-ethyl-benzene-1,3-disulfonamide) and N,N,N\u2019N\u2019-tetrabromobenzene-1,3-disulfon-amide as new efficient reagents for one-pot synthesis of Furano and pyranopyrimidin-ones (thiones). RSC Adv. 5, 74336\u201374342 (2015).","journal-title":"RSC Adv."},{"key":"34760_CR43","first-page":"2184","volume":"21","author":"R Kaur","year":"2017","unstructured":"Kaur, R. & Kumar, K. Recent advances in the synthesis of pyrano[2,3-d]pyrimidines: a review. Curr. Org. Chem. 21, 2184\u20132201 (2017).","journal-title":"Curr. Org. Chem."},{"key":"34760_CR44","doi-asserted-by":"publisher","first-page":"6984","DOI":"10.1021\/cr2000459","volume":"111","author":"S Fustero","year":"2011","unstructured":"Fustero, S., S\u00e1nchez-Rosell\u00f3, M., Barrio, P. & Simon-Fuentes, A. From 2000 to mid-2010: a fruitful decade for the synthesis of pyrazoles. Chem. Rev. 111, 6984\u20137034 (2011).","journal-title":"Chem. Rev."},{"key":"34760_CR45","doi-asserted-by":"publisher","first-page":"5756","DOI":"10.1021\/jo400523v","volume":"78","author":"X Pan","year":"2013","unstructured":"Pan, X., Luo, Y. & Wu, J. Route to pyrazolo[5,1-a]isoquinolines via a copper-catalyzed tandem reaction of 2-alkynylbromobenzene with pyrazole. J. Org. Chem. 78, 5756\u20135760 (2013).","journal-title":"J. Org. Chem."},{"key":"34760_CR46","doi-asserted-by":"publisher","first-page":"5056","DOI":"10.1016\/j.ejmech.2010.08.014","volume":"45","author":"NR Kamdar","year":"2010","unstructured":"Kamdar, N. R., Haveliwala, D. D., Mistry, P. T. & Patel, S. K. Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyrano-pyrimidines. Eur. J. Med. Chem. 45, 5056\u20135063 (2010).","journal-title":"Eur. J. Med. Chem."},{"key":"34760_CR47","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/hlca.201400276","volume":"98","author":"A Alizadeh","year":"2015","unstructured":"Alizadeh, A., Ghanbaripour, R. & Ng, S. W. An efficient synthesis of chromeno[2,3-d]pyrimidine-2,4-diones with a nitroketene-aminal moiety at C(5) by a one-pot four-component reaction. Helv. Chim. Acta. 98, 663\u2013667 (2015).","journal-title":"Helv. Chim. Acta"},{"key":"34760_CR48","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1021\/jo102131y","volume":"76","author":"X Fan","year":"2011","unstructured":"Fan, X. et al. Tandem reactions leading to bicyclic pyrimidine nucleosides and benzopyran-4-ones. J. Org. Chem. 76, 982\u2013985 (2011).","journal-title":"J. Org. Chem."},{"key":"34760_CR49","doi-asserted-by":"publisher","first-page":"4910","DOI":"10.1021\/jp0671998","volume":"111","author":"AP Abbott","year":"2007","unstructured":"Abbott, A. P., Harris, R. C. & Ryder, K. S. Application of hole theory to define ionic liquids by their transport properties. J. Phys. Chem. B. 111, 4910\u20134913 (2007).","journal-title":"J. Phys. Chem. B"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34760-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34760-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34760-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T11:03:16Z","timestamp":1770116596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34760-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["34760"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-34760-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"11 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of competing interest"}}],"article-number":"4627"}}