{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:54:42Z","timestamp":1793314482782,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-34815-5","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T20:17:32Z","timestamp":1767557852000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimization of Hymenopellis radicata extracts using RSM and ANN-GA and evaluation of biological activities"],"prefix":"10.1038","volume":"16","author":[{"given":"Ay\u015fenur","family":"G\u00fcrgen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Sevindik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana","family":"Krupodorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aras Fahrettin","family":"Korkmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre Cem","family":"Eraslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilgaz","family":"Akata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"34815_CR1","doi-asserted-by":"publisher","first-page":"925387","DOI":"10.3389\/fphar.2022.925387","volume":"13","author":"RM Chugh","year":"2022","unstructured":"Chugh, R. M. et al. Fungal mushrooms: a natural compound with therapeutic applications. Front. Pharmacol. 13, 925387 (2022).","journal-title":"Front. Pharmacol."},{"key":"34815_CR2","doi-asserted-by":"publisher","first-page":"741","DOI":"10.3390\/foods14050741","volume":"14","author":"A Singh","year":"2025","unstructured":"Singh, A., Saini, R. K., Kumar, A., Chawla, P. & Kaushik, R. Mushrooms as nutritional powerhouses: A review of their bioactive compounds, health benefits, and value-added products. Foods 14, 741 (2025).","journal-title":"Foods"},{"key":"34815_CR3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.56782\/pps.141","volume":"21","author":"M Sevindik","year":"2023","unstructured":"Sevindik, M., Bal, C., Eraslan, E. C., Uysal, I. & Mohammed, F. S. Medicinal mushrooms: a comprehensive study on their antiviral potential. Prospects Pharm. Sci. 21, 42\u201356 (2023).","journal-title":"Prospects Pharm. Sci."},{"key":"34815_CR4","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3390\/ijms26020827","volume":"26","author":"Z N\u00e9meth","year":"2025","unstructured":"N\u00e9meth, Z. et al. The importance of edible medicinal mushrooms and their potential use as therapeutic agents against insulin resistance. Int. J. Mol. Sci. 26, 827 (2025).","journal-title":"Int. J. Mol. Sci."},{"key":"34815_CR5","doi-asserted-by":"publisher","first-page":"837266","DOI":"10.3389\/fmicb.2022.837266","volume":"13","author":"A Bhambri","year":"2022","unstructured":"Bhambri, A., Srivastava, M., Mahale, V. G., Mahale, S. & Karn, S. K. Mushrooms as potential sources of active metabolites and medicines. Front. Microbiol. 13, 837266 (2022).","journal-title":"Front. Microbiol."},{"key":"34815_CR6","doi-asserted-by":"publisher","first-page":"5393","DOI":"10.3390\/molecules28145393","volume":"28","author":"P \u0141ysakowska","year":"2023","unstructured":"\u0141ysakowska, P., Sobota, A. & Wirkijowska, A. Medicinal mushrooms: their bioactive components, nutritional value and application in functional food production\u2014A review. Molecules 28, 5393 (2023).","journal-title":"Molecules"},{"key":"34815_CR7","doi-asserted-by":"publisher","first-page":"e0244749","DOI":"10.1371\/journal.pone.0244749","volume":"15","author":"S Zheng","year":"2020","unstructured":"Zheng, S., Zhang, W. & Liu, S. Optimization of ultrasonic-assisted extraction of polysaccharides and triterpenoids from the medicinal mushroom Ganoderma lucidum and evaluation of their in vitro antioxidant capacities. PloS One. 15, e0244749 (2020).","journal-title":"PloS One"},{"key":"34815_CR8","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.3390\/agronomy12081812","volume":"12","author":"MJ Alia\u00f1o-Gonz\u00e1lez","year":"2022","unstructured":"Alia\u00f1o-Gonz\u00e1lez, M. J. et al. Ultrasound-assisted extraction of total phenolic compounds and antioxidant activity in mushrooms. Agronomy 12, 1812 (2022).","journal-title":"Agronomy"},{"key":"34815_CR9","doi-asserted-by":"publisher","first-page":"e16949","DOI":"10.1111\/jfpp.16949","volume":"46","author":"A G\u00fcrgen","year":"2022","unstructured":"G\u00fcrgen, A. & Sevindik, M. Application of artificial neural network coupling multiobjective particle swarm optimization algorithm to optimize pleurotus ostreatus extraction parameters. J. Food Process. Preserv. 46, e16949 (2022).","journal-title":"J. Food Process. Preserv."},{"key":"34815_CR10","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3390\/jof10030225","volume":"10","author":"V Lazi\u0107","year":"2024","unstructured":"Lazi\u0107, V. et al. The effect of green extraction technologies on the chemical composition of medicinal Chaga mushroom extracts. J. Fungi. 10, 225 (2024).","journal-title":"J. Fungi"},{"key":"34815_CR11","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1007\/S10267-006-0312-X","volume":"47","author":"Y Mizuta","year":"2006","unstructured":"Mizuta, Y. Two new species and one new variety of Oudemansiella (Agaricales) from Japan. Mycoscience 47, 380\u2013384 (2006).","journal-title":"Mycoscience"},{"key":"34815_CR12","doi-asserted-by":"publisher","first-page":"248","DOI":"10.5943\/cream\/11\/1\/18","volume":"11","author":"W NA","year":"2021","unstructured":"NA, W., Saini, M. & Malik, N. Xerula radicata var. Setosa var. nov. and three new records of the family Physalacriaceae, agaricales from the Indian subcontinent. Curr. Res. Environ. Appl. Mycol. (Journal Fungal Biology). 11, 248\u2013262 (2021).","journal-title":"Curr. Res. Environ. Appl. Mycol. (Journal Fungal Biology)"},{"key":"34815_CR13","first-page":"24","volume":"1","author":"R Kumar","year":"2015","unstructured":"Kumar, R., Bisht, N., Mishra, G., Kalita, K. & Bezbaroa, N. Micro and macrofungal diversity in Langol herbal garden Manipur, India. Int. J. Curr. Life Sci. 1, 24\u201334 (2015).","journal-title":"Int. J. Curr. Life Sci."},{"key":"34815_CR14","first-page":"1","volume":"6","author":"GT Opande","year":"2017","unstructured":"Opande, G. T., Musyimi, D. M. & Sarah, T. C. A rich mushroom diversity at Maseno University, Siriba campus, Maseno (Kenya). Int. J. Microbiol. Mycol. 6, 1\u20138 (2017).","journal-title":"Int. J. Microbiol. Mycol."},{"key":"34815_CR15","first-page":"144","volume":"32","author":"LKP Zou","year":"2011","unstructured":"Zou, L. K. P. et al. Cultivation, identification and amino acid composition of Xerula radicata. FOOD Sci. 32, 144\u2013147 (2011).","journal-title":"FOOD Sci."},{"key":"34815_CR16","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.3390\/molecules28031123","volume":"28","author":"EH Erbiai","year":"2023","unstructured":"Erbiai, E. H. et al. Antioxidant properties, bioactive compounds contents, and chemical characterization of two wild edible mushroom species from Morocco: Paralepista flaccida (Sowerby) Vizzini and Lepista nuda (Bull.) Cooke. Molecules 28, 1123 (2023).","journal-title":"Molecules"},{"key":"34815_CR17","doi-asserted-by":"publisher","first-page":"101955","DOI":"10.1016\/j.fbio.2022.101955","volume":"49","author":"J Garcia","year":"2022","unstructured":"Garcia, J., Rodrigues, F., Saavedra, M. J., Nunes, F. M. & Marques, G. Bioactive polysaccharides from medicinal mushrooms: A review on their isolation, structural characteristics and antitumor activity. Food Bioscience. 49, 101955 (2022).","journal-title":"Food Bioscience"},{"key":"34815_CR18","doi-asserted-by":"publisher","first-page":"e0140355","DOI":"10.1371\/journal.pone.0140355","volume":"10","author":"N Nowacka","year":"2015","unstructured":"Nowacka, N. et al. Antibacterial, antiradical potential and phenolic compounds of thirty-one polish mushrooms. PloS One. 10, e0140355 (2015).","journal-title":"PloS One"},{"key":"34815_CR19","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.lwt.2019.03.017","volume":"107","author":"F Bach","year":"2019","unstructured":"Bach, F. et al. Bio compounds of edible mushrooms: in vitro antioxidant and antimicrobial activities. Lwt 107, 214\u2013220 (2019).","journal-title":"Lwt"},{"key":"34815_CR20","doi-asserted-by":"publisher","first-page":"41206","DOI":"10.1038\/s41598-025-25130-0","volume":"15","author":"AF Korkmaz","year":"2025","unstructured":"Korkmaz, A. F., G\u00fcrgen, A., Krupodorova, T., Sevindik, M. & Akata, I. Artificial intelligence-assisted optimization of extraction enhances the biological activity of Phylloporia ribis. Sci. Rep. 15, 41206 (2025).","journal-title":"Sci. Rep."},{"key":"34815_CR21","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.3390\/molecules30163317","volume":"30","author":"M Sevindik","year":"2025","unstructured":"Sevindik, M., G\u00fcrgen, A., Korkmaz, A. F. & Akata, I. Optimizing ultrasonic-assisted extraction process of Paralepista flaccida: A comparative study of antioxidant, anticholinesterase, and antiproliferative activities via response surface methodology and artificial neural network modeling. Molecules 30, 3317 (2025).","journal-title":"Molecules"},{"key":"34815_CR22","doi-asserted-by":"publisher","first-page":"23147","DOI":"10.1038\/s41598-025-08118-8","volume":"15","author":"A G\u00fcrgen","year":"2025","unstructured":"G\u00fcrgen, A. & Sevindik, M. Optimization of biological activities of Agaricus species: an artificial intelligence-assisted approach. Sci. Rep. 15, 23147 (2025).","journal-title":"Sci. Rep."},{"key":"34815_CR23","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1615\/IntJMedMushrooms.2024057054","volume":"27","author":"A G\u00fcrgen","year":"2025","unstructured":"G\u00fcrgen, A. & Sevindik, M. Single and multi-objective optimization of the red pine mushroom lactarius deliciosus (Agaricomycetes) extraction conditions using artificial intelligence methods and biological activities of optimized extracts. Int. J. Med. Mushrooms. 27, 59\u201373 (2025).","journal-title":"Int. J. Med. Mushrooms"},{"key":"34815_CR24","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","volume":"37","author":"O Erel","year":"2004","unstructured":"Erel, O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin. Biochem. 37, 277\u2013285 (2004).","journal-title":"Clin. Biochem."},{"key":"34815_CR25","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","volume":"38","author":"O Erel","year":"2005","unstructured":"Erel, O. A new automated colorimetric method for measuring total oxidant status. Clin. Biochem. 38, 1103\u20131111 (2005).","journal-title":"Clin. Biochem."},{"key":"34815_CR26","first-page":"310","volume":"59","author":"M Sevindik","year":"2021","unstructured":"Sevindik, M. Anticancer, antimicrobial, antioxidant and DNA protective potential of mushroom Leucopaxillus gentianeus (Qu\u00e9l.) Kotl. Indian J. Experimental Biology (IJEB). 59, 310\u2013315 (2021).","journal-title":"Indian J. Experimental Biology (IJEB)"},{"key":"34815_CR27","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12906-025-04851-9","volume":"25","author":"O \u00dcnal","year":"2025","unstructured":"\u00dcnal, O. et al. Optimization of Phellinus hartigii extracts: biological activities, and phenolic content analysis. BMC Complement. Med. Ther. 25, 113 (2025).","journal-title":"BMC Complement. Med. Ther."},{"key":"34815_CR28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GL Ellman","year":"1961","unstructured":"Ellman, G. L., Courtney, K. D., Andres Jr, V. & Featherstone, R. M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7, 88\u201395 (1961).","journal-title":"Biochem. Pharmacol."},{"key":"34815_CR29","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.3390\/antiox10121899","volume":"10","author":"S Chun","year":"2021","unstructured":"Chun, S., Gopal, J. & Muthu, M. Antioxidant activity of mushroom extracts\/polysaccharides\u2014Their antiviral properties and plausible antiCOVID-19 properties. Antioxidants 10, 1899 (2021).","journal-title":"Antioxidants"},{"key":"34815_CR30","doi-asserted-by":"publisher","first-page":"112621","DOI":"10.1016\/j.biopha.2022.112621","volume":"147","author":"RW Mwangi","year":"2022","unstructured":"Mwangi, R. W., Macharia, J. M., Wagara, I. N. & Bence, R. L. The antioxidant potential of different edible and medicinal mushrooms. Biomed. Pharmacother. 147, 112621 (2022).","journal-title":"Biomed. Pharmacother."},{"key":"34815_CR31","doi-asserted-by":"crossref","unstructured":"Din\u00e7er, E., I\u015f\u0131k, H., Hepokur, C., Tutar, U. & \u00c7elik, C. Cytotoxic, antioxidant, antibiofilm, and antimicrobial activities of mushroom species from Turkey. Int. J. Med. Mushrooms 25, 75\u201386 (2023).","DOI":"10.1615\/IntJMedMushrooms.2023047802"},{"key":"34815_CR32","doi-asserted-by":"crossref","unstructured":"Bal, C., Sevindik, M., Krupodorova, T. & Eraslan, E. Total carbohydrate and protein contents and some biological activities of edible macrolepiota mastoidea mushroom. Acta Aliment 54, 337\u2013346 (2025).","DOI":"10.1556\/066.2025.00027"},{"key":"34815_CR33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1615\/IntJMedMushrooms.2024055569","volume":"26","author":"A G\u00fcrgen","year":"2024","unstructured":"G\u00fcrgen, A., Unal, O. & Sevindik, M. Biological activities of the golden chantarelle mushroom Cantharellus cibarius (Agaricomycetes) extracts obtained as a result of single and multi-objective optimization studies. Int. J. Med. Mushrooms. 26, 63\u201374 (2024).","journal-title":"Int. J. Med. Mushrooms"},{"key":"34815_CR34","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.3390\/foods13101560","volume":"13","author":"M Sevindik","year":"2024","unstructured":"Sevindik, M., G\u00fcrgen, A., Khassanov, V. T. & Bal, C. Biological activities of ethanol extracts of Hericium erinaceus obtained as a result of optimization analysis. Foods 13, 1560 (2024).","journal-title":"Foods"},{"key":"34815_CR35","doi-asserted-by":"crossref","unstructured":"Nguyen, M. H. et al. Unveiling the potential of medicinal herbs as the source for in vitro screening toward the inhibition of Nrf2. Heliyon. 10, e38411 (2024).","DOI":"10.1016\/j.heliyon.2024.e38411"},{"key":"34815_CR36","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.sajb.2019.05.033","volume":"124","author":"M Garrab","year":"2019","unstructured":"Garrab, M. et al. Phenolic composition, antioxidant and anticholinesterase properties of the three mushrooms Agaricus silvaticus Schaeff., Hydnum rufescens Pers. and Meripilus giganteus (Pers.) Karst. in Tunisia. South. Afr. J. Bot. 124, 359\u2013363 (2019).","journal-title":"South. Afr. J. Bot."},{"key":"34815_CR37","doi-asserted-by":"publisher","first-page":"6631","DOI":"10.1038\/s41598-022-10669-z","volume":"12","author":"P Wongsa","year":"2022","unstructured":"Wongsa, P., Phatikulrungsun, P. & Prathumthong, S. FT-IR characteristics, phenolic profiles and inhibitory potential against digestive enzymes of 25 herbal infusions. Sci. Rep. 12, 6631 (2022).","journal-title":"Sci. Rep."},{"key":"34815_CR38","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3390\/antibiotics9080513","volume":"9","author":"P Angelini","year":"2020","unstructured":"Angelini, P. et al. Evaluation of antioxidant, antimicrobial and tyrosinase inhibitory activities of extracts from tricholosporum goniospermum, an edible wild mushroom. Antibiotics 9, 513 (2020).","journal-title":"Antibiotics"},{"key":"34815_CR39","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3390\/molecules29010213","volume":"29","author":"K Felegyi","year":"2023","unstructured":"Felegyi, K. et al. Anticholinesterase and antityrosinase secondary metabolites from the fungus Xylobolus subpileatus. Molecules 29, 213 (2023).","journal-title":"Molecules"},{"key":"34815_CR40","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1615\/IntJMedMushrooms.2025059728","volume":"27","author":"S Kabaktepe","year":"2025","unstructured":"Kabaktepe, S. et al. Evaluation of bioactive potential of hortiboletus rubellus: Antioxidant, enzyme inhibition and antiproliferative effects. Int. J. Med. Mushrooms. 27, 21\u201331 (2025).","journal-title":"Int. J. Med. Mushrooms"},{"key":"34815_CR41","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jiec.2024.01.024","volume":"135","author":"GS Park","year":"2024","unstructured":"Park, G. S., Shin, J., Hong, S., Gopal, J. & Oh, J. W. Anticarcinogenic potential of the mushroom polysaccharide lentinan on gastric and colon cancer cells: Antiproliferative, antitumorigenic, Mu-2-related death-inducing gene, MUDENG ramifications. J. Ind. Eng. Chem. 135, 122\u2013130 (2024).","journal-title":"J. Ind. Eng. Chem."},{"key":"34815_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1615\/IntJMedMushrooms.2025060581","volume":"27","author":"M Sevindik","year":"2025","unstructured":"Sevindik, M. et al. The role of medicinal mushrooms in cancer treatment: bioactive compounds and therapeutic potential. Int. J. Med. Mushrooms. 27, 1\u201324 (2025).","journal-title":"Int. J. Med. Mushrooms"},{"key":"34815_CR43","doi-asserted-by":"crossref","unstructured":"Wasser, S. P. Medicinal mushrooms in human clinical studies. Part I. Anticancer, oncoimmunological, and Immunomodulatory activities: a review. Int. J. Med. Mushrooms 19, 279\u2013317 (2017).","DOI":"10.1615\/IntJMedMushrooms.v19.i4.10"},{"key":"34815_CR44","first-page":"442","volume":"19","author":"MM Kosanic","year":"2020","unstructured":"Kosanic, M. M., \u0160eklic, D. S., Jovanovic, M. M., Petrovic, N. N. & Markovic, S. D. Hygrophorus eburneus, edible mushroom, a promising natural bioactive agent. EXCLI J. 19, 442 (2020).","journal-title":"EXCLI J."},{"key":"34815_CR45","first-page":"643","volume":"72","author":"AK Khan","year":"2015","unstructured":"Khan, A. K. et al. Pharmacological activities of protocatechuic acid. Acta Pol. Pharm. 72, 643\u2013650 (2015).","journal-title":"Acta Pol. Pharm."},{"key":"34815_CR46","first-page":"18","volume":"81","author":"AE \u015eabik","year":"2024","unstructured":"\u015eabik, A. E., Mohammed, F. S., Sevindik, M., Uysal, I. & Bal, C. Gallic acid: derivatives and biosynthesis, pharmacological and therapeutic effect, biological activity. Bull. Univ. Agricultural Sci. Veterinary Med. Cluj-Napoca Food Sci. Technol. 81, 18\u201327 (2024).","journal-title":"Bull. Univ. Agricultural Sci. Veterinary Med. Cluj-Napoca Food Sci. Technol."},{"key":"34815_CR47","doi-asserted-by":"crossref","unstructured":"Isemura, M. Catechin in human health and disease. Molecules 24, 528 (2019).","DOI":"10.3390\/molecules24030528"},{"key":"34815_CR48","doi-asserted-by":"publisher","first-page":"49","DOI":"10.56782\/pps.147","volume":"21","author":"FS Mohammed","year":"2023","unstructured":"Mohammed, F. S., Sevindik, M., Uysal, \u0130. & Sabik, A. E. Quercetin: derivatives, biosynthesis, biological activity, pharmacological and therapeutic effects. Prospects Pharm. Sci. 21, 49\u201356 (2023).","journal-title":"Prospects Pharm. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34815-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34815-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34815-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T22:02:16Z","timestamp":1770156136000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-34815-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,4]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["34815"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-34815-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,4]]},"assertion":[{"value":"21 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4696"}}