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The project strictly abides by ethical norms, and the legal guardians of all subjects have signed written informed consent. The main contents are as follows: 1. Voluntary participation: The guardians have fully understood the purpose, process and potential risks of the research. The guardians voluntarily agreed to the child\u2019s participation, and know that they could quit at any time. 2. Risks and benefits: We have known the possible risks (such as slight discomfort in blood collection and adverse reactions related to hydrogels) and potential benefits (which may improve immunity). There may be no direct personal benefits from understanding the research results. 3. Privacy protection: Personal information of the subjects has been de-identified, and only the research team can access it with authorization. 4. Protection of children\u2019s rights and interests: In addition to the guardian\u2019s consent, children over 8\u00a0years old also signed the informed consent form. 5. 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