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Neurology 61(8 Suppl 4), S2\u20138 (2003).","journal-title":"Neurology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85205-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85205-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85205-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T19:05:46Z","timestamp":1736276746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85205-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["85205"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-85205-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4810764\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"assertion":[{"value":"27 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethics committee of Dalian Municipal Central Hospital (approval number: 2022-039-60). All methods were carried out in accordance with relevant guidelines and regulations. All of the human subjects in this study provided written informed consent for their participation in our research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"To analyze the relationships among the degree of migraine with RLS, white matter lesions and brain structural volume, 102 migraineurs with RLS were selected. The RLS flow and HIT-6 score were recorded to reflect the degree of headache. The brain structural volumes were calculated with artificial intelligence. The WMLs of migraineurs with RLS were concentrated mainly in the white matter of the lateral ventricular margin and deep white matter. There were significant differences in WML variables among migraineurs with RLS with different HIT-6 grades and MIDAS grades. There was a significant difference in the volume of brain structures, and there was a significant difference among migraineurs with different RLS flows, HIT-6 grades and peripheral cerebrospinal fluid volumes. There was a positive correlation between frontal pole volume and RLS flow. The volume of specific brain structures was negatively correlated with RLS flow but positively correlated with HIT-6 grade. The volume of specific brain structures was negatively correlated with the HIT-6 grade. There was no correlation between WML severity and RLS flow or migraine severity. Volume changes occurred in parts of the brain structures of migraineurs with RLS. Shunt flow and the degree of migraine in migraineurs with RLS were correlated with structural volume changes in some brain regions.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1145"}}