{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:49:49Z","timestamp":1778107789305,"version":"3.51.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"THE SCIENTIFIC AND TECHNOLOGICAL RESEARCH COUNCIL OF T\u00dcRK\u0130YE (TUBITAK).","award":["122O688"],"award-info":[{"award-number":["122O688"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-85238-1","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:21:07Z","timestamp":1740378067000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Regenerative effect of lyophilized dental follicle mesenchymal stem cells and platelet-rich fibrin in skin wounds in geriatric and young rats"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2773-8243","authenticated-orcid":false,"given":"Osman","family":"Bulut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0351-2805","authenticated-orcid":false,"given":"Deniz","family":"Genc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3081-0691","authenticated-orcid":false,"given":"\u00c7i\u011fdem Elif","family":"Demirci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1172-5536","authenticated-orcid":false,"given":"Leyla","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-3491","authenticated-orcid":false,"given":"Tolga Meri\u00e7","family":"D\u00fcmbek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-3986","authenticated-orcid":false,"given":"Aziz","family":"B\u00fclb\u00fcl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"85238_CR1","first-page":"15","volume":"215","author":"J K\u00f6ssi","year":"2001","unstructured":"K\u00f6ssi, J., Elenius, K., Niinikoski, J., Peltonen, J. & Laato, M. Overview of wound healing. Ann. Chir. Gynaecol. 215, 15\u201318 (2001).","journal-title":"Ann. Chir. Gynaecol."},{"key":"85238_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fcvm.2019.00109","volume":"6","author":"J Le Blanc","year":"2019","unstructured":"Le Blanc, J. & Lordkipanidz\u00e9, M. Platelet function in aging. Front. Cardiovasc. Med. 6, 109 (2019).","journal-title":"Front. Cardiovasc. Med."},{"key":"85238_CR3","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1089\/scd.2012.0176","volume":"21","author":"CS Lin","year":"2012","unstructured":"Lin, C. S., Lin, G. & Lue, T. F. Allogeneic and xenogeneic transplantation of adipose-derived stem cells in immunocompetent recipients without immunosuppressants. Stem Cells Dev. 21, 2770\u20132778 (2012).","journal-title":"Stem Cells Dev."},{"key":"85238_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116364","volume":"241","author":"MF Graca","year":"2020","unstructured":"Graca, M. F., Miguel, S. P., Cabral, C. S. & Correia, I. J. Hyaluronic acid-based wound dressings: A review. Carbohydr. Polym. 241, 116364 (2020).","journal-title":"Carbohydr. Polym."},{"key":"85238_CR5","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1615\/CritRevBiomedEng.2018027342","volume":"46","author":"JR Dave","year":"2018","unstructured":"Dave, J. R. & Tomar, G. B. Dental tissue-derived mesenchymal stem cells: Applications in tissue engineering. Crit. Rev. Biomed. Eng. 46, 429\u201368 (2018).","journal-title":"Crit. Rev. Biomed. Eng."},{"key":"85238_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4103\/jisp.jisp_182_16","volume":"21","author":"R Khurana","year":"2017","unstructured":"Khurana, R., Kudva, P. B. & Husain, S. Y. Comparative evaluation of the isolation and quantification of stem cells derived from dental pulp and periodontal ligament of a permanent tooth and to assess their viability and proliferation on a platelet-rich fibrin scaffold. J. Indian Soc. Periodontol. 21, 16\u201320 (2017).","journal-title":"J. Indian Soc. Periodontol."},{"key":"85238_CR7","doi-asserted-by":"publisher","first-page":"7131","DOI":"10.3390\/molecules26237131","volume":"26","author":"NA Ngah","year":"2021","unstructured":"Ngah, N. A. et al. Lyophilised platelet-rich fibrin: Physical and biological characterisation. Molecules 26, 7131 (2021).","journal-title":"Molecules"},{"key":"85238_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/bioengineering10010058","volume":"10","author":"R Narayanaswamy","year":"2023","unstructured":"Narayanaswamy, R. et al. Evolution and clinical advances of platelet-rich fibrin in musculoskeletal regeneration. Bioengineering (Basel) 10, 58 (2023).","journal-title":"Bioengineering (Basel)"},{"key":"85238_CR9","doi-asserted-by":"publisher","first-page":"142","DOI":"10.5966\/sctm.2011-0018","volume":"1","author":"S Maxson","year":"2012","unstructured":"Maxson, S., Lopez, E. A., Yoo, D., Danilkovitch-Miagkova, A. & Leroux, M. A. Concise review: Role of mesenchymal stem cells in wound repair. Stem Cells Transl. Med. 1, 142\u2013149 (2012).","journal-title":"Stem Cells Transl. Med."},{"key":"85238_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jot.2017.03.002","volume":"29","author":"W Lin","year":"2017","unstructured":"Lin, W. et al. Mesenchymal stem cells homing to improve bone healing. J. Orthop. Translat. 29, 19\u201327 (2017).","journal-title":"J. Orthop. Translat."},{"key":"85238_CR11","doi-asserted-by":"publisher","first-page":"8509","DOI":"10.3390\/ijms15058509","volume":"15","author":"Q Li","year":"2014","unstructured":"Li, Q. et al. Lyophilized platelet-rich fibrin (PRF) promotes craniofacial bone regeneration through Runx2. Int. J. Mol. Sci. 15, 8509\u20138525 (2014).","journal-title":"Int. J. Mol. Sci."},{"key":"85238_CR12","doi-asserted-by":"publisher","first-page":"102861","DOI":"10.1016\/j.amsu.2021.102861","volume":"70","author":"F Nilay Tutak","year":"2021","unstructured":"Nilay Tutak, F. & Anna\u00e7, E. The effect of mesenchymal stem cells lyophilisate femoral artery of rat anastomosis: A histopathological and histomorphometric study. Ann. Med. Surg. (Lond.) 70, 102861 (2021).","journal-title":"Ann. Med. Surg. (Lond.)"},{"key":"85238_CR13","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s00784-023-05447-8","volume":"28","author":"G Torumtay Cin","year":"2024","unstructured":"Torumtay Cin, G., Lektemur Alpan, A. & \u00c7evik, \u00d6. Efficacy of injectable platelet-rich fibrin on clinical and biochemical parameters in non-surgical periodontal treatment: A split-mouth randomized controlled trial. Clin. Oral. Invest. 28, 46 (2024).","journal-title":"Clin. Oral. Invest."},{"key":"85238_CR14","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1631\/jzus.B1000184","volume":"11","author":"SZ Zhang","year":"2010","unstructured":"Zhang, S. Z. et al. Preliminary study on the freeze-drying of human bone marrow-derived mesenchymal stem cells. J. Zhejiang Univ. Sci. B. 11, 889\u2013894 (2010).","journal-title":"J. Zhejiang Univ. Sci. B."},{"key":"85238_CR15","doi-asserted-by":"publisher","first-page":"972028","DOI":"10.1155\/2013\/972028","volume":"2013","author":"S Murthy","year":"2013","unstructured":"Murthy, S. et al. Evaluation of in vivo wound healing activity of Bacopa monniera on different wound model in rats. Biomed. Res. Int. 2013, 972028 (2013).","journal-title":"Biomed. Res. Int."},{"key":"85238_CR16","doi-asserted-by":"publisher","first-page":"77","DOI":"10.17221\/5253-VETMED","volume":"57","author":"F Sabol","year":"2012","unstructured":"Sabol, F. et al. Immunohistological changes in skin wounds during the early periods of healing in a rat model. Vet. Med. Czech. 57, 77\u201382 (2012).","journal-title":"Vet. Med. Czech."},{"key":"85238_CR17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cytogfr.2018.06.002","volume":"43","author":"V De Ara\u00fajo Farias","year":"2018","unstructured":"De Ara\u00fajo Farias, V., Carrillo-G\u00e1lvez, A. B., Mart\u00edn, F. & Anderson, P. TGF-\u03b2 and mesenchymal stromal cells in regenerative medicine, autoimmunity and cancer. Cytokine Growth Factor Rev. 43, 25\u201337 (2018).","journal-title":"Cytokine Growth Factor Rev."},{"key":"85238_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4062\/biomolther.2017.260","volume":"27","author":"AP Ayala-Cuellar","year":"2019","unstructured":"Ayala-Cuellar, A. P., Kang, J. H., Jeung, E. B. & Choi, K. C. Roles of mesenchymal stem cells in tissue regeneration and immunomodulation. Biomol. Ther. (Seoul) 27, 25\u201333 (2019).","journal-title":"Biomol. Ther. (Seoul)"},{"key":"85238_CR19","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.3390\/cells11172691","volume":"11","author":"DD Linkova","year":"2022","unstructured":"Linkova, D. D., Rubtsova, Y. P. & Egorikhina, M. N. Cryostorage of mesenchymal stem cells and biomedical cell-based products. Cells 11, 2691 (2022).","journal-title":"Cells"},{"key":"85238_CR20","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.jtv.2021.04.009","volume":"30","author":"F Bilgen","year":"2021","unstructured":"Bilgen, F., Ural, A. & Bekerecioglu, M. Platelet-rich fibrin: An effective chronic wound healing accelerator. J. Tissue Viability. 30, 616\u2013620 (2021).","journal-title":"J. Tissue Viability."},{"key":"85238_CR21","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1002\/jcb.25235","volume":"116","author":"V D'esposito","year":"2015","unstructured":"D\u2019esposito, V. et al. Platelet-rich plasma increases growth and motility of adipose tissue-derived mesenchymal stem cells and controls adipocyte secretory function. J. Cell Biochem. 116, 2408\u201324018 (2015).","journal-title":"J. Cell Biochem."},{"key":"85238_CR22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1159\/000129129","volume":"35","author":"C Quinn","year":"2008","unstructured":"Quinn, C. & Flake, A. W. In vivo differentiation potential of mesenchymal stem cells: Prenatal and postnatal model systems. Transfus. Med. Hemother. 35, 239\u2013247 (2008).","journal-title":"Transfus. Med. Hemother."},{"key":"85238_CR23","doi-asserted-by":"publisher","first-page":"e0266137","DOI":"10.1371\/journal.pone.0266137","volume":"17","author":"D Gen\u00e7","year":"2022","unstructured":"Gen\u00e7, D. et al. Dental follicle mesenchymal stem cells ameliorated glandular dysfunction in Sj\u00f6gren\u2019s syndrome murine model. PLoS One 17, e0266137 (2022).","journal-title":"PLoS One"},{"key":"85238_CR24","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13287-016-0303-6","volume":"9","author":"DE Lee","year":"2016","unstructured":"Lee, D. E., Ayoub, N. & Agrawal, D. K. Mesenchymal stem cells and cutaneous wound healing: Novel methods to increase cell delivery and therapeutic efficacy. Stem Cell Res. Ther. 9, 37 (2016).","journal-title":"Stem Cell Res. Ther."},{"key":"85238_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.681171","volume":"9","author":"D Lu","year":"2021","unstructured":"Lu, D., Xu, Y., Liu, Q. & Zhang, Q. Mesenchymal stem cell-macrophage crosstalk and maintenance of inflammatory microenvironment homeostasis. Front. Cell Dev. Biol. 9, 681171 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"85238_CR26","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1002\/stem.720","volume":"29","author":"FA Fierro","year":"2011","unstructured":"Fierro, F. A., Kalomoiris, S., Sondergaard, C. S. & Nolta, J. A. Effects on proliferation and differentiation of multipotent bone marrow stromal cells engineered to express growth factors for combined cell and gene therapy. Stem Cells. 29, 1727\u20131737 (2011).","journal-title":"Stem Cells."},{"key":"85238_CR27","first-page":"7390","volume":"10","author":"Y Xia","year":"2017","unstructured":"Xia, Y. et al. Epidermal growth factor promotes mesenchymal stem cell-mediated wound healing and hair follicle regeneration. Int. J. Clin. Exp. Pathol. 10, 7390\u20137400 (2017).","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"85238_CR28","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1097\/01.ASW.0000418541.31366.a3","volume":"25","author":"TN Demidova-Rice","year":"2012","unstructured":"Demidova-Rice, T. N., Hamblin, M. R. & Herman, I. M. Acute and impaired wound healing: Pathophysiology and current methods for drug delivery, part 2: Role of growth factors in normal and pathological wound healing: Therapeutic potential and methods of delivery. Adv. Skin. Wound Care. 25, 349\u2013370 (2012).","journal-title":"Adv. Skin. Wound Care."},{"key":"85238_CR29","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","volume":"4","author":"H Sies","year":"2015","unstructured":"Sies, H. Oxidative stress: A concept in redox biology and medicine. Redox Biol. 4, 180\u2013183 (2015).","journal-title":"Redox Biol."},{"key":"85238_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.700729","volume":"15","author":"Z Varga-Medveczky","year":"2021","unstructured":"Varga-Medveczky, Z. et al. Age-related inflammatory balance shift, nasal barrier function, and cerebro-morphological status in healthy and diseased rodents. Front. Neurosci. 15, 700729 (2021).","journal-title":"Front. Neurosci."},{"key":"85238_CR31","first-page":"72","volume":"1","author":"K Jin","year":"2010","unstructured":"Jin, K. Modern biological theories of aging. Aging Dis. 1, 72\u201374 (2010).","journal-title":"Aging Dis."},{"key":"85238_CR32","doi-asserted-by":"publisher","first-page":"4472","DOI":"10.3390\/ijms20184472","volume":"20","author":"L Zuo","year":"2019","unstructured":"Zuo, L. et al. Inflammaging and oxidative stress in human diseases: From molecular mechanisms to novel treatments. Int. J. Mol. Sci. 20, 4472 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"85238_CR33","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.3390\/biomedicines11092526","volume":"11","author":"M Fern\u00e1ndez-Guarino","year":"2023","unstructured":"Fern\u00e1ndez-Guarino, M., Hern\u00e1ndez-Bule, M. L. & Bacci, S. Cellular and molecular processes in wound healing. Biomedicines 11, 2526 (2023).","journal-title":"Biomedicines"},{"key":"85238_CR34","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1126\/science.aam7928","volume":"356","author":"SA Eming","year":"2017","unstructured":"Eming, S. A., Wynn, T. A. & Martin, P. Inflammation and metabolism in tissue repair and regeneration. Science 356, 1026\u20131030 (2017).","journal-title":"Science"},{"key":"85238_CR35","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3390\/biomedicines8050101","volume":"8","author":"BZ Johnson","year":"2020","unstructured":"Johnson, B. Z., Stevenson, A. W., Pr\u00eale, C. M., Fear, M. W. & Wood, F. M. The role of IL-6 in skin fibrosis and cutaneous wound healing. Biomedicines 8, 101 (2020).","journal-title":"Biomedicines"},{"key":"85238_CR36","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3390\/cells12040634","volume":"12","author":"Z Kargarpour","year":"2023","unstructured":"Kargarpour, Z., Panahipour, L., Mildner, M., Miron, R. J. & Gruber, R. Lipids of platelet-rich fibrin reduce the inflammatory response in mesenchymal cells and macrophages. Cells 12, 634 (2023).","journal-title":"Cells"},{"key":"85238_CR37","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1007\/s10753-014-9888-z","volume":"37","author":"BKAH Abdel-Salam","year":"2014","unstructured":"Abdel-Salam, B. K. A. H. Modulatory effect of whey proteins in some cytokines involved in wound healing in male diabetic albino rats. Inflammation 37, 1616\u20131622 (2014).","journal-title":"Inflammation"},{"key":"85238_CR38","doi-asserted-by":"publisher","first-page":"284","DOI":"10.4103\/0972-0707.114344","volume":"16","author":"B Naik","year":"2013","unstructured":"Naik, B., Karunakar, P., Jayadev, M. & Marshal, V. R. Role of platelet rich fibrin in wound healing: A critical review. J. Conserv. Dent. 16, 284\u2013293 (2013).","journal-title":"J. Conserv. Dent."},{"key":"85238_CR39","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3390\/biomimetics7030087","volume":"7","author":"RB Diller","year":"2022","unstructured":"Diller, R. B. & Tabor, A. J. The role of the extracellular matrix (ECM) in wound healing: A review. Biomimetics (Basel) 7, 87 (2022).","journal-title":"Biomimetics (Basel)"},{"key":"85238_CR40","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.jid.2020.11.014","volume":"141","author":"X Ding","year":"2021","unstructured":"Ding, X., Kakanj, P., Leptin, M. & Eming, S. A. Regulation of the wound healing response during aging. J. Invest. Dermatol. 141, 1063\u20131070 (2021).","journal-title":"J. Invest. Dermatol."},{"key":"85238_CR41","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.actbio.2010.07.037","volume":"7","author":"C Vater","year":"2011","unstructured":"Vater, C., Kasten, P. & Stiehler, M. Culture media for the differentiation of mesenchymal stromal cells. Acta Biomaterialia 7, 463\u2013477 (2011).","journal-title":"Acta Biomaterialia"},{"key":"85238_CR42","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1089\/ten.tec.2017.0018","volume":"23","author":"DD Cissell","year":"2017","unstructured":"Cissell, D. D., Link, J. M., Hu, J. C. & Athanasiou, K. A. A modified hydroxyproline assay based on hydrochloric acid in ehrlich\u2019s solution accurately measures tissue collagen content. Tissue Eng. Part C Methods 23, 243\u2013250 (2017).","journal-title":"Tissue Eng. Part C Methods"},{"key":"85238_CR43","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.3390\/ijms18081675","volume":"18","author":"S Jimi","year":"2017","unstructured":"Jimi, S. et al. Acceleration mechanisms of skin wound healing by autologous micrograft in mice. Int. J. Mol. Sci. 18, 1675 (2017).","journal-title":"Int. J. Mol. Sci."},{"key":"85238_CR44","doi-asserted-by":"publisher","first-page":"14041","DOI":"10.3390\/ijms241814041","volume":"24","author":"MS Gatto","year":"2023","unstructured":"Gatto, M. S. & Najahi-Missaoui, W. Lyophilization of nanoparticles, does it really work? Overview of the current status and challenges. Int. J. Mol. Sci. 24, 14041 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"85238_CR45","doi-asserted-by":"crossref","unstructured":"Goftman, V.V. et al. Freeze-dried polymer-coated quantum dots for perspective biomedical application. In Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics. Vol. 9448. SPIE, (2015).","DOI":"10.1117\/12.2178368"},{"key":"85238_CR46","doi-asserted-by":"publisher","first-page":"2300155","DOI":"10.1002\/adbi.202300155","volume":"8","author":"T Paresishvili","year":"2024","unstructured":"Paresishvili, T. & Kakabadze, Z. Freeze-dried mesenchymal stem cells: From bench to bedside. Rev. Adv. Biol. 8, 2300155 (2024).","journal-title":"Rev. Adv. Biol."},{"key":"85238_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102861","volume":"70","author":"FN Tutak","year":"2021","unstructured":"Tutak, F. N. & Anna\u00e7, E. The effect of mesenchymal stem cells lyophilisate on femoral artery of rat anastomosis: A histopathological and histomorphometric study. Ann. Med. Sur. 70, 102861 (2021).","journal-title":"Ann. Med. Sur."},{"key":"85238_CR48","doi-asserted-by":"publisher","first-page":"142","DOI":"10.5966\/sctm.2011-0018","volume":"1","author":"S Maxson","year":"2012","unstructured":"Maxson, S., Lopez, E. A., Yoo, D., Danilkovitch-Miagkova, A. & Leroux, M. A. Concise review: Role of mesenchymal stem cells in wound repair. Stem Cells Transl. Med. 1, 142\u2013149 (2012).","journal-title":"Stem Cells Transl. Med."},{"key":"85238_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.789274","volume":"13","author":"Z Wang","year":"2022","unstructured":"Wang, Z., Qi, F., Luo, H., Xu, G. & Wang, D. Inflammatory microenvironment of skin wounds. Front. Immunol. 13, 789274 (2022).","journal-title":"Front. Immunol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85238-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85238-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85238-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:09:33Z","timestamp":1740380973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85238-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["85238"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-85238-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4522929\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"3 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6623"}}