{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T23:40:19Z","timestamp":1736034019562,"version":"3.32.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:00:00Z","timestamp":1735948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T00:00:00Z","timestamp":1735948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-85295-6","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T22:14:35Z","timestamp":1736028875000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of hypertension on changes in peripapillary retinal nerve fiber layer thickness in type 2 diabetes patients"],"prefix":"10.1038","volume":"15","author":[{"given":"Jae-Yun","family":"Sung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Seen","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka-Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"issue":"10027","key":"85295_CR1","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/S0140-6736(16)00618-8","volume":"387","author":"B Zhou","year":"2016","unstructured":"Zhou, B. et al. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4\u00b7 4 million participants. Lancet 387(10027), 1513\u20131530 (2016).","journal-title":"Lancet"},{"key":"85295_CR2","doi-asserted-by":"crossref","unstructured":"Sohn, E. H. et al. Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc. Natl. Acad. Sci.  113(19), 2655-E2664 (2016).","DOI":"10.1073\/pnas.1522014113"},{"issue":"12","key":"85295_CR3","doi-asserted-by":"publisher","first-page":"5074","DOI":"10.1167\/iovs.18-24891","volume":"59","author":"S Vujosevic","year":"2018","unstructured":"Vujosevic, S. et al. Peripapillary microvascular and neural changes in diabetes mellitus: an OCT-angiography study. Investig Ophthalmol. Visual Sci. 59(12), 5074\u20135081 (2018).","journal-title":"Investig Ophthalmol. Visual Sci."},{"issue":"5","key":"85295_CR4","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s00592-017-0970-5","volume":"54","author":"R Sim\u00f3","year":"2017","unstructured":"Sim\u00f3, R., Ciudin, A., Sim\u00f3-Servat, O. & Hern\u00e1ndez, C. Cognitive impairment and dementia: a new emerging complication of type 2 diabetes\u2014the diabetologist\u2019s perspective. Acta Diabetol. 54(5), 417\u2013424 (2017).","journal-title":"Acta Diabetol."},{"key":"85295_CR5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1161\/01.HYP.23.2.145","volume":"23","author":"NHBPEPW Group","year":"1994","unstructured":"Group, N. H. B. P. E. P. W. National high blood pressure education program working group report on hypertension in diabetes. Hypertension 23, 145\u2013158 (1994).","journal-title":"Hypertension"},{"issue":"7258","key":"85295_CR6","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1136\/bmj.321.7258.412","volume":"321","author":"AI Adler","year":"2000","unstructured":"Adler, A. I. et al. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. Bmj 321(7258), 412\u2013419 (2000).","journal-title":"Bmj"},{"issue":"3","key":"85295_CR7","doi-asserted-by":"publisher","first-page":"e0229665","DOI":"10.1371\/journal.pone.0229665","volume":"15","author":"L Liu","year":"2020","unstructured":"Liu, L. et al. Hypertension, blood pressure control and diabetic retinopathy in a large population-based study. PLoS One. 15(3), e0229665 (2020).","journal-title":"PLoS One"},{"key":"85295_CR8","doi-asserted-by":"crossref","unstructured":"Zhang, M. et al. Associations between blood pressure levels and diabetic retinopathy in patients with diabetes mellitus: a population-based study. Heliyon 9, 6 (2023).","DOI":"10.1016\/j.heliyon.2023.e16830"},{"issue":"11","key":"85295_CR9","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.2337\/db21-0491","volume":"70","author":"M-W Lee","year":"2021","unstructured":"Lee, M-W. et al. Effect of systemic hypertension on peripapillary RNFL thickness in patients with diabetes without diabetic retinopathy. Diabetes 70(11), 2663\u20132667 (2021).","journal-title":"Diabetes"},{"issue":"12","key":"85295_CR10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1167\/iovs.62.12.21","volume":"62","author":"M-W Lee","year":"2021","unstructured":"Lee, M-W. et al. Impacts of systemic hypertension on the macular microvasculature in diabetic patients without clinical diabetic retinopathy. Investig Ophthalmol. Visual Sci. 62(12), 21\u201321 (2021).","journal-title":"Investig Ophthalmol. Visual Sci."},{"issue":"Supplement_1","key":"85295_CR11","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.2337\/dc18-S002","volume":"41","author":"AD Association","year":"2018","unstructured":"Association, A. D. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes\u20142018. Diabetes care. 41(Supplement_1), S13\u2013S27 (2018).","journal-title":"Diabetes care"},{"issue":"1","key":"85295_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1159\/000381994","volume":"3","author":"H-Y Lee","year":"2015","unstructured":"Lee, H-Y. & Park, J. B. The Korean Society of Hypertension guidelines for the management of hypertension in 2013: its essentials and key points. Pulse 3(1), 21\u201328 (2015).","journal-title":"Pulse"},{"issue":"19","key":"85295_CR13","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","volume":"289","author":"AV Chobanian","year":"2003","unstructured":"Chobanian, A. V. et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. Jama 289(19), 2560\u20132571 (2003).","journal-title":"Jama"},{"issue":"7","key":"85295_CR14","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1097\/IJG.0b013e31824d1e12","volume":"22","author":"A Harris","year":"2013","unstructured":"Harris, A. et al. Association of the optic disc structure with the use of antihypertensive medications: the Thessaloniki eye study. J. Glaucoma  22(7), 526\u2013531 (2013).","journal-title":"J. Glaucoma"},{"issue":"12","key":"85295_CR15","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1167\/iovs.19-27652","volume":"60","author":"M-W Lee","year":"2019","unstructured":"Lee, M-W., Lee, W-H., Park, G-S., Lim, H-B. & Kim, J-Y. Longitudinal changes in the peripapillary retinal nerve fiber layer thickness in hypertension: 4-year prospective observational study. Investig Ophthalmol. Visual Sci. 60(12), 3914\u20133919 (2019).","journal-title":"Investig Ophthalmol. Visual Sci."},{"issue":"4","key":"85295_CR16","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/hr.2010.263","volume":"34","author":"JB Lopes de Faria","year":"2011","unstructured":"Lopes de Faria, J. B., Silva, K. C. & Lopes de Faria, J. M. The contribution of hypertension to diabetic nephropathy and retinopathy: the role of inflammation and oxidative stress. Hypertens. Res. 34(4), 413\u2013422 (2011).","journal-title":"Hypertens. Res."},{"key":"85295_CR17","doi-asserted-by":"crossref","unstructured":"Cantor, E., M\u00e9ndez, F., Rivera, C., Castillo, A. & Mart\u00ednez-Blanco, A. Blood pressure, ocular perfusion pressure and open-angle glaucoma in patients with systemic hypertension. Clin. Ophthalmol. 2018, 1511\u20131517 (2018).","DOI":"10.2147\/OPTH.S165747"},{"issue":"10","key":"85295_CR18","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1001\/jamaophthalmol.2019.2537","volume":"137","author":"HB Lim","year":"2019","unstructured":"Lim, H. B., Shin, Y. I., Lee, M. W., Park, G. S. & Kim, J. Y. Longitudinal changes in the peripapillary retinal nerve fiber layer thickness of patients with type 2 diabetes. JAMA Ophthalmol. 137(10), 1125\u20131132 (2019).","journal-title":"JAMA Ophthalmol."},{"issue":"2","key":"85295_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/iovs.62.2.9","volume":"62","author":"M-W Lee","year":"2021","unstructured":"Lee, M-W. et al. Peripapillary retinal nerve fiber layer and microvasculature in prolonged type 2 diabetes patients without clinical diabetic retinopathy. Investig Ophthalmol. Visual Sci. 62(2), 9\u20139 (2021).","journal-title":"Investig Ophthalmol. Visual Sci."},{"issue":"1","key":"85295_CR20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.tem.2013.09.005","volume":"25","author":"R Simo","year":"2014","unstructured":"Simo, R. & Hern\u00e1ndez, C. Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives. Trends Endocrinol. Metabol. 25(1), 23\u201333 (2014).","journal-title":"Trends Endocrinol. Metabol"},{"issue":"9131","key":"85295_CR21","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/S0140-6736(98)07019-6","volume":"352","author":"UPDS Group","year":"1998","unstructured":"Group, U. P. D. S. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352(9131), 837\u2013853 (1998).","journal-title":"Lancet"},{"issue":"14","key":"85295_CR22","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1056\/NEJM199309303291401","volume":"329","author":"D Control","year":"1993","unstructured":"Control, D. & Group, C. T. R. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New. Engl. J. Med. 329(14), 977\u2013986 (1993).","journal-title":"New. Engl. J. Med."},{"issue":"16","key":"85295_CR23","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1001\/jama.290.16.2159","volume":"290","author":"TWT for the Diabetes","year":"2003","unstructured":"for the Diabetes, T. W. T., Control, Interventions, C. T. E. D. & Group, C. R. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the epidemiology of diabetes interventions and complications (EDIC) study. JAMA 290(16), 2159 (2003).","journal-title":"JAMA"},{"issue":"3","key":"85295_CR24","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.ophtha.2020.07.051","volume":"128","author":"RS Chong","year":"2021","unstructured":"Chong, R. S. et al. Association of antihypertensive medication with retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness. Ophthalmology 128(3), 393\u2013400 (2021).","journal-title":"Ophthalmology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85295-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85295-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85295-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T23:07:42Z","timestamp":1736032062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85295-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,4]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["85295"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-85295-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,1,4]]},"assertion":[{"value":"2 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"792"}}