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The non-linearity and regional heterogeneity inherent in the climate-dengue relationship and the lack of consistent data makes it difficult to make useful predictions for effective disease prevention. The current study investigates these non-linear climate-dengue links in Pune, a dengue hotspot region in India with a monsoonal climate and presents a model framework for predicting both the near-term and future dengue mortalities. Dengue mortality and meteorological conditions over a twelve-year period (2004\u20132015) are analyzed using statistical tools and machine learning methods. Our findings point to a significant influence of temperature, rainfall, and relative humidity on dengue mortality in Pune, at a time-lag of 2\u20135\u00a0months, providing sufficient lead time for an early warning targeted at curbing dengue outbreaks. We find that moderate rains spread over the summer monsoon season lead to an increase in dengue mortality, whereas heavy rains reduce it through the flushing effect, indicating the links between dengue and monsoon intraseasonal variability. Additionally,\u00a0warm temperatures above 27\u00b0C and humidity levels between 60% and 78% elevate the risk of dengue.\u00a0Based on these weather-dengue associations, we developed a machine-learning model utilizing the random forest regression algorithm. The dengue model yields a skillful forecast, achieving a statistically significant correlation coefficient of\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.77 and a relatively low Normalized Root Mean Squared Error score of 0.52 between actual and predicted dengue mortalities, at a lead time of two months. The model finds that the relative contributions of temperature, rainfall, and relative humidity to dengue mortality in Pune are 41%, 39%, and 20%, respectively. We use the dengue model in conjunction with the climate change simulations from the Coupled Model Intercomparison Project phase 6 for the future dengue mortality projections under a global warming scenario. In a changing climate, dengue-related mortality in Pune is projected to rise by 13% in the near future (2021\u20132040), 23\u201340% in the mid-century (2041\u20132060), and 30\u2013112% in the late century (2081\u20132100) under low-to-high emission pathways in response to the associated increase in temperature and changes in monsoon rainfall patterns.\n                  <\/jats:p>","DOI":"10.1038\/s41598-025-85437-w","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:03:52Z","timestamp":1737435832000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Dengue dynamics, predictions, and future increase under changing monsoon climate in India"],"prefix":"10.1038","volume":"15","author":[{"given":"Yacob","family":"Sophia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9311-5162","authenticated-orcid":false,"given":"Mathew Koll","family":"Roxy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu","family":"Murtugudde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Karipot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Sapkota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panini","family":"Dasgupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana","family":"Baliwant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Saunik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhiyant","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajib","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revati K.","family":"Phalkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"85437_CR1","unstructured":"WHO. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengur. 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