{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:52:11Z","timestamp":1775487131637,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82071133"],"award-info":[{"award-number":["82071133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-85535-9","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:35:14Z","timestamp":1736487314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Systematic identification of pathological mechanisms, prognostic biomarkers and therapeutic targets by integrating lncRNA expression variation in salivary gland mucoepidermoid carcinoma"],"prefix":"10.1038","volume":"15","author":[{"given":"Yan-ping","family":"Zou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-feng","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-xuan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruo-lan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-gang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"85535_CR1","doi-asserted-by":"publisher","first-page":"3928","DOI":"10.1002\/cncr.26697","volume":"118","author":"CH McHugh","year":"2012","unstructured":"McHugh, C. H. et al. Prognostic factors in mucoepidermoid carcinoma of the salivary glands. Cancer 118, 3928\u20133936. https:\/\/doi.org\/10.1002\/cncr.26697 (2012).","journal-title":"Cancer"},{"key":"85535_CR2","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/s12885-019-5564-x","volume":"19","author":"JY Fu","year":"2019","unstructured":"Fu, J. Y. et al. Salivary gland carcinoma in Shanghai (2003\u20132012): an epidemiological study of incidence, site and pathology. BMC Cancer. 19, 350. https:\/\/doi.org\/10.1186\/s12885-019-5564-x (2019).","journal-title":"BMC Cancer"},{"key":"85535_CR3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s12105-022-01420-1","volume":"16","author":"A Skalova","year":"2022","unstructured":"Skalova, A., Hyrcza, M. D. & Leivo, I. Update from the 5th Edition of the World Health Organization Classification of Head and Neck tumors: salivary glands. Head Neck Pathol. 16, 40\u201353. https:\/\/doi.org\/10.1007\/s12105-022-01420-1 (2022).","journal-title":"Head Neck Pathol."},{"key":"85535_CR4","doi-asserted-by":"publisher","first-page":"12956","DOI":"10.1073\/pnas.0906005106","volume":"106","author":"L Li","year":"2009","unstructured":"Li, L. et al. Role of human noncoding RNAs in the control of tumorigenesis. Proc. Natl. Acad. Sci. U S A. 106, 12956\u201312961. https:\/\/doi.org\/10.1073\/pnas.0906005106 (2009).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"85535_CR5","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.26355\/eurrev_201902_16988","volume":"23","author":"HL Cao","year":"2019","unstructured":"Cao, H. L., Liu, Z. J., Huang, P. L., Yue, Y. L. & Xi, J. N. lncRNA-RMRP promotes proliferation, migration and invasion of bladder cancer via miR-206. Eur. Rev. Med. Pharmacol. Sci. 23, 1012\u20131021. https:\/\/doi.org\/10.26355\/eurrev_201902_16988 (2019).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"85535_CR6","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1038\/s41388-017-0104-0","volume":"37","author":"Z Chen","year":"2018","unstructured":"Chen, Z. et al. CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells. Oncogene 37, 1885\u20131895. https:\/\/doi.org\/10.1038\/s41388-017-0104-0 (2018).","journal-title":"Oncogene"},{"key":"85535_CR7","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1016\/j.ymthe.2018.08.018","volume":"26","author":"S Xie","year":"2018","unstructured":"Xie, S. et al. Upregulation of lncRNA ADAMTS9-AS2 promotes salivary adenoid cystic Carcinoma Metastasis via PI3K\/Akt and MEK\/Erk Signaling. Mol. Ther. 26, 2766\u20132778. https:\/\/doi.org\/10.1016\/j.ymthe.2018.08.018 (2018).","journal-title":"Mol. Ther."},{"key":"85535_CR8","doi-asserted-by":"publisher","first-page":"811269","DOI":"10.3389\/fmolb.2022.811269","volume":"9","author":"L Liu","year":"2022","unstructured":"Liu, L. et al. Comprehensive analysis of necroptosis-related long noncoding RNA Immune Infiltration and Prediction of Prognosis in patients with Colon cancer. Front. Mol. Biosci. 9, 811269. https:\/\/doi.org\/10.3389\/fmolb.2022.811269 (2022).","journal-title":"Front. Mol. Biosci."},{"key":"85535_CR9","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bbrc.2018.11.102","volume":"508","author":"H Lu","year":"2019","unstructured":"Lu, H. et al. Screening and bioinformatics analysis of mRNA, long non-coding RNA and circular RNA expression profiles in mucoepidermoid carcinoma of salivary gland. Biochem. Biophys. Res. Commun. 508, 66\u201371. https:\/\/doi.org\/10.1016\/j.bbrc.2018.11.102 (2019).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"85535_CR10","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.canlet.2019.11.009","volume":"470","author":"X Lei","year":"2020","unstructured":"Lei, X. et al. Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy. Cancer Lett. 470, 126\u2013133. https:\/\/doi.org\/10.1016\/j.canlet.2019.11.009 (2020).","journal-title":"Cancer Lett."},{"key":"85535_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.oraloncology.2018.11.028","volume":"88","author":"C Mosconi","year":"2019","unstructured":"Mosconi, C. et al. Immune microenvironment and evasion mechanisms in adenoid cystic carcinomas of salivary glands. Oral Oncol. 88, 95\u2013101. https:\/\/doi.org\/10.1016\/j.oraloncology.2018.11.028 (2019).","journal-title":"Oral Oncol."},{"key":"85535_CR12","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1158\/1078-0432.CCR-19-3758","volume":"26","author":"M Linxweiler","year":"2020","unstructured":"Linxweiler, M. et al. The Immune Microenvironment and Neoantigen Landscape of Aggressive Salivary Gland carcinomas Differ by Subtype. Clin. Cancer Res. 26, 2859\u20132870. https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-3758 (2020).","journal-title":"Clin. Cancer Res."},{"key":"85535_CR13","doi-asserted-by":"publisher","first-page":"105777","DOI":"10.1016\/j.oraloncology.2022.105777","volume":"127","author":"ESA Egal","year":"2022","unstructured":"Egal, E. S. A. et al. Tumor microenvironment in salivary gland carcinomas: an orchestrated state of chaos. Oral Oncol. 127, 105777. https:\/\/doi.org\/10.1016\/j.oraloncology.2022.105777 (2022).","journal-title":"Oral Oncol."},{"key":"85535_CR14","doi-asserted-by":"publisher","first-page":"103605","DOI":"10.1016\/j.critrevonc.2022.103605","volume":"171","author":"L Lavareze","year":"2022","unstructured":"Lavareze, L. et al. Salivary gland cancer in the setting of tumor microenvironment: translational routes for therapy. Crit. Rev. Oncol. Hematol. 171, 103605. https:\/\/doi.org\/10.1016\/j.critrevonc.2022.103605 (2022).","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"85535_CR15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/01.pap.0000213058.74509.d3","volume":"13","author":"MA Luna","year":"2006","unstructured":"Luna, M. A. Salivary mucoepidermoid carcinoma: revisited. Adv. Anat. Pathol. 13, 293\u2013307. https:\/\/doi.org\/10.1097\/01.pap.0000213058.74509.d3 (2006).","journal-title":"Adv. Anat. Pathol."},{"key":"85535_CR16","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00018-014-1772-3","volume":"72","author":"FT Unger","year":"2015","unstructured":"Unger, F. T., Witte, I. & David, K. A. Prediction of individual response to anticancer therapy: historical and future perspectives. Cell. Mol. Life Sci. 72, 729\u2013757. https:\/\/doi.org\/10.1007\/s00018-014-1772-3 (2015).","journal-title":"Cell. Mol. Life Sci."},{"key":"85535_CR17","doi-asserted-by":"publisher","unstructured":"Supplitt, S., Karpinski, P., Sasiadek, M. & Laczmanska, I. Current achievements and applications of Transcriptomics in Personalized Cancer Medicine. Int. J. Mol. Sci. 22 https:\/\/doi.org\/10.3390\/ijms22031422 (2021).","DOI":"10.3390\/ijms22031422"},{"key":"85535_CR18","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","volume":"21","author":"J Yang","year":"2020","unstructured":"Yang, J. et al. Guidelines and definitions for research on epithelial-mesenchymal transition. Nat. Rev. Mol. Cell. Biol. 21, 341\u2013352. https:\/\/doi.org\/10.1038\/s41580-020-0237-9 (2020).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"85535_CR19","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/cr.2009.5","volume":"19","author":"J Xu","year":"2009","unstructured":"Xu, J., Lamouille, S. & Derynck, R. TGF-beta-induced epithelial to mesenchymal transition. Cell. Res. 19, 156\u2013172. https:\/\/doi.org\/10.1038\/cr.2009.5 (2009).","journal-title":"Cell. Res."},{"key":"85535_CR20","doi-asserted-by":"publisher","first-page":"eabn7571","DOI":"10.1126\/scitranslmed.abn7571","volume":"14","author":"EM Grasset","year":"2022","unstructured":"Grasset, E. M. et al. Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin. Sci. Transl Med. 14, eabn7571. https:\/\/doi.org\/10.1126\/scitranslmed.abn7571 (2022).","journal-title":"Sci. Transl Med."},{"key":"85535_CR21","doi-asserted-by":"publisher","first-page":"873871","DOI":"10.3389\/fimmu.2022.873871","volume":"13","author":"S Weng","year":"2022","unstructured":"Weng, S. et al. SCG2: a prognostic marker that pinpoints chemotherapy and immunotherapy in Colorectal Cancer. Front. Immunol. 13, 873871. https:\/\/doi.org\/10.3389\/fimmu.2022.873871 (2022).","journal-title":"Front. Immunol."},{"key":"85535_CR22","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10495-023-01898-2","volume":"29","author":"J Zhou","year":"2024","unstructured":"Zhou, J. et al. Promoting effect and immunologic role of secretogranin II on bladder cancer progression via regulating MAPK and NF-kappaB pathways. Apoptosis 29, 121\u2013141. https:\/\/doi.org\/10.1007\/s10495-023-01898-2 (2024).","journal-title":"Apoptosis"},{"key":"85535_CR23","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1038\/s41590-023-01605-y","volume":"24","author":"L Pang","year":"2023","unstructured":"Pang, L. et al. Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma. Nat. Immunol. 24, 1654\u20131670. https:\/\/doi.org\/10.1038\/s41590-023-01605-y (2023).","journal-title":"Nat. Immunol."},{"key":"85535_CR24","doi-asserted-by":"publisher","first-page":"11428","DOI":"10.7150\/thno.47432","volume":"10","author":"G Deng","year":"2020","unstructured":"Deng, G. et al. BET inhibitor suppresses melanoma progression via the noncanonical NF-kappaB\/SPP1 pathway. Theranostics 10, 11428\u201311443. https:\/\/doi.org\/10.7150\/thno.47432 (2020).","journal-title":"Theranostics"},{"key":"85535_CR25","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.7150\/jca.51253","volume":"12","author":"YY Jia","year":"2021","unstructured":"Jia, Y. Y., Yu, Y. & Li, H. J. POSTN promotes proliferation and epithelial-mesenchymal transition in renal cell carcinoma through ILK\/AKT\/mTOR pathway. J. Cancer. 12, 4183\u20134195. https:\/\/doi.org\/10.7150\/jca.51253 (2021).","journal-title":"J. Cancer"},{"key":"85535_CR26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s40478-023-01557-2","volume":"11","author":"H Kunhiraman","year":"2023","unstructured":"Kunhiraman, H. et al. IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic Hedgehog medulloblastoma. Acta Neuropathol. Commun. 11, 62. https:\/\/doi.org\/10.1186\/s40478-023-01557-2 (2023).","journal-title":"Acta Neuropathol. Commun."},{"key":"85535_CR27","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s10120-012-0210-1","volume":"16","author":"H Saito","year":"2013","unstructured":"Saito, H., Takaya, S., Osaki, T. & Ikeguchi, M. Increased apoptosis and elevated Fas expression in circulating natural killer cells in gastric cancer patients. Gastric Cancer. 16, 473\u2013479. https:\/\/doi.org\/10.1007\/s10120-012-0210-1 (2013).","journal-title":"Gastric Cancer"},{"key":"85535_CR28","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1038\/ncb3647","volume":"19","author":"S Grelet","year":"2017","unstructured":"Grelet, S. et al. Addendum: a regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression. Nat. Cell. Biol. 19, 1443. https:\/\/doi.org\/10.1038\/ncb3647 (2017).","journal-title":"Nat. Cell. Biol."},{"key":"85535_CR29","doi-asserted-by":"publisher","unstructured":"Lv, C. et al. ENO2 promotes Colorectal Cancer Metastasis by interacting with the LncRNA CYTOR and Activating YAP1-Induced EMT. Cells 11 https:\/\/doi.org\/10.3390\/cells11152363 (2022).","DOI":"10.3390\/cells11152363"},{"key":"85535_CR30","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1002\/1878-0261.12666","volume":"14","author":"R Shang","year":"2020","unstructured":"Shang, R. et al. Long noncoding RNA SLC2A1-AS1 regulates aerobic glycolysis and progression in hepatocellular carcinoma via inhibiting the STAT3\/FOXM1\/GLUT1 pathway. Mol. Oncol. 14, 1381\u20131396. https:\/\/doi.org\/10.1002\/1878-0261.12666 (2020).","journal-title":"Mol. Oncol."},{"key":"85535_CR31","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1515\/hsz-2020-0290","volume":"402","author":"Y Cui","year":"2021","unstructured":"Cui, Y., Zhang, C., Ma, S. & Guan, F. TFAP2A-induced SLC2A1-AS1 promotes cancer cell proliferation. Biol. Chem. 402, 717\u2013727. https:\/\/doi.org\/10.1515\/hsz-2020-0290 (2021).","journal-title":"Biol. Chem."},{"key":"85535_CR32","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/s1368-8375(00)00062-2","volume":"37","author":"H Ishibashi","year":"2001","unstructured":"Ishibashi, H. et al. Hypoxia-induced angiogenesis of cultured human salivary gland carcinoma cells enhances vascular endothelial growth factor production and basic fibroblast growth factor release. Oral Oncol. 37, 77\u201383. https:\/\/doi.org\/10.1016\/s1368-8375(00)00062-2 (2001).","journal-title":"Oral Oncol."},{"key":"85535_CR33","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.1016\/j.oooo.2018.09.013","volume":"127","author":"DC Branco","year":"2019","unstructured":"Branco, D. C. et al. HIF-1alpha, NOTCH1, ADAM12, and HB-EGF are overexpressed in mucoepidermoid carcinoma. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 127, e8\u2013e17. https:\/\/doi.org\/10.1016\/j.oooo.2018.09.013 (2019).","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"85535_CR34","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/s41419-021-03921-3","volume":"12","author":"J Xu","year":"2021","unstructured":"Xu, J. et al. LncRNA CERS6-AS1 promotes proliferation and metastasis through the upregulation of YWHAG and activation of ERK signaling in pancreatic cancer. Cell. Death Dis. 12, 648. https:\/\/doi.org\/10.1038\/s41419-021-03921-3 (2021).","journal-title":"Cell. Death Dis."},{"key":"85535_CR35","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41420-022-01150-x","volume":"8","author":"B Xu","year":"2022","unstructured":"Xu, B. et al. Long noncoding RNA CERS6-AS1 modulates glucose metabolism and tumor progression in hepatocellular carcinoma by promoting the MDM2\/p53 signaling pathway. Cell. Death Discov. 8, 348. https:\/\/doi.org\/10.1038\/s41420-022-01150-x (2022).","journal-title":"Cell. Death Discov"},{"key":"85535_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.5MIR0917-351R","author":"HF Aqbi","year":"2018","unstructured":"Aqbi, H. F., Wallace, M., Sappal, S., Payne, K. K. & Manjili, M. H. IFN-gamma orchestrates tumor elimination, tumor dormancy, tumor escape, and progression. J. Leukoc. Biol. https:\/\/doi.org\/10.1002\/JLB.5MIR0917-351R (2018).","journal-title":"J. Leukoc. Biol."},{"key":"85535_CR37","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41525-021-00249-x","volume":"6","author":"Y Lin","year":"2021","unstructured":"Lin, Y. et al. Immune cell infiltration signatures identified molecular subtypes and underlying mechanisms in gastric cancer. NPJ Genom Med. 6, 83. https:\/\/doi.org\/10.1038\/s41525-021-00249-x (2021).","journal-title":"NPJ Genom Med."},{"key":"85535_CR38","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1172\/JCI91190","volume":"127","author":"M Ayers","year":"2017","unstructured":"Ayers, M. et al. IFN-gamma-related mRNA profile predicts clinical response to PD-1 blockade. J. Clin. Invest. 127, 2930\u20132940. https:\/\/doi.org\/10.1172\/JCI91190 (2017).","journal-title":"J. Clin. Invest."},{"key":"85535_CR39","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nature07672","volume":"458","author":"M Guttman","year":"2009","unstructured":"Guttman, M. et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458, 223\u2013227. https:\/\/doi.org\/10.1038\/nature07672 (2009).","journal-title":"Nature"},{"key":"85535_CR40","doi-asserted-by":"publisher","first-page":"4669","DOI":"10.1158\/1078-0432.CCR-20-4459","volume":"27","author":"M Taki","year":"2021","unstructured":"Taki, M. et al. Tumor Immune Microenvironment during epithelial-mesenchymal transition. Clin. Cancer Res. 27, 4669\u20134679. https:\/\/doi.org\/10.1158\/1078-0432.CCR-20-4459 (2021).","journal-title":"Clin. Cancer Res."},{"key":"85535_CR41","doi-asserted-by":"publisher","unstructured":"Park, E. G., Pyo, S. J., Cui, Y., Yoon, S. H. & Nam, J. W. Tumor immune microenvironment lncRNAs. Brief. Bioinform. 23 https:\/\/doi.org\/10.1093\/bib\/bbab504 (2022).","DOI":"10.1093\/bib\/bbab504"},{"key":"85535_CR42","doi-asserted-by":"publisher","first-page":"786150","DOI":"10.3389\/fonc.2021.786150","volume":"11","author":"E Naakka","year":"2021","unstructured":"Naakka, E. et al. miR-22 and miR-205 Drive Tumor aggressiveness of Mucoepidermoid carcinomas of salivary glands. Front. Oncol. 11, 786150. https:\/\/doi.org\/10.3389\/fonc.2021.786150 (2021).","journal-title":"Front. Oncol."},{"key":"85535_CR43","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47. https:\/\/doi.org\/10.1093\/nar\/gkv007 (2015).","journal-title":"Nucleic Acids Res."},{"key":"85535_CR44","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U S A. 102, 15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102 (2005).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"85535_CR45","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon, A. et al. The Molecular signatures database (MSigDB) hallmark gene set collection. Cell. Syst. 1, 417\u2013425. https:\/\/doi.org\/10.1016\/j.cels.2015.12.004 (2015).","journal-title":"Cell. Syst."},{"key":"85535_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S Hanzelmann","year":"2013","unstructured":"Hanzelmann, S., Castelo, R. & Guinney, J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinform. 14, 7. https:\/\/doi.org\/10.1186\/1471-2105-14-7 (2013).","journal-title":"BMC Bioinform."},{"key":"85535_CR47","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","volume":"18","author":"P Charoentong","year":"2017","unstructured":"Charoentong, P. et al. Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell. Rep. 18, 248\u2013262. https:\/\/doi.org\/10.1016\/j.celrep.2016.12.019 (2017).","journal-title":"Cell. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85535-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85535-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85535-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T06:03:46Z","timestamp":1736489026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85535-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["85535"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-85535-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,10]]},"assertion":[{"value":"8 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1573"}}