{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:35:37Z","timestamp":1794270937099,"version":"4.9.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM008433"],"award-info":[{"award-number":["T32 GM008433"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regenerative Engineering and Medicine Center"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-85670-3","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T05:36:18Z","timestamp":1738042578000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lymphatic vessel network injury reduces local tumor control despite preservation of the tumor-draining lymph node"],"prefix":"10.1038","volume":"15","author":[{"given":"Lauren N.","family":"Liebman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary S.","family":"Buchwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanna","family":"Nepiyushchikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s J.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Brandon","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"85670_CR1","doi-asserted-by":"crossref","unstructured":"Petrova, T. V. & Koh, G. Y. Biological functions of lymphatic vessels. Sci. (80-) 369, (2020).","DOI":"10.1126\/science.aax4063"},{"key":"85670_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nrc3677","volume":"2014 143 14","author":"SA Stacker","year":"2014","unstructured":"Stacker, S. A. et al. Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat. Rev. Cancer. 143(14), 159\u2013172 (2014).","journal-title":"Nat. Rev. Cancer"},{"key":"85670_CR3","doi-asserted-by":"crossref","unstructured":"Gillot, L., Baudin, L., \u00b7, Rouaud, L. & Kridelka, F. & Agn\u00e8s No\u00ebl, \u00b7. The pre-metastatic niche in lymph nodes: Formation and characteristics. 78, 5987\u20136002 (2021).","DOI":"10.1007\/s00018-021-03873-z"},{"key":"85670_CR4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1080\/2162402X.2019.1667742","volume":"8","author":"RLG Maus","year":"2019","unstructured":"Maus, R. L. G. et al. Identification of novel, immune-mediating extracellular vesicles in human lymphatic effluent draining primary cutaneous melanoma. Oncoimmunology 8, 12 (2019).","journal-title":"Oncoimmunology"},{"key":"85670_CR5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.celrep.2012.01.005","volume":"1","author":"AW Lund","year":"2012","unstructured":"Lund, A. W. et al. VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics. Cell. Rep. 1, 191\u2013199 (2012).","journal-title":"Cell. Rep."},{"key":"85670_CR6","doi-asserted-by":"publisher","first-page":"444183","DOI":"10.3389\/fimmu.2019.00720","volume":"10","author":"L Garnier","year":"2019","unstructured":"Garnier, L., Gkountidi, A. O. & Hugues, S. Tumor-associated lymphatic vessel features and immunomodulatory functions. Front. Immunol. 10, 444183 (2019).","journal-title":"Front. Immunol."},{"key":"85670_CR7","doi-asserted-by":"crossref","unstructured":"Steele, M. M. et al. T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control. Nat. Immunol. 24, 664\u2013675 (2023).","DOI":"10.1038\/s41590-023-01443-y"},{"key":"85670_CR8","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1172\/JCI79434","volume":"126","author":"AW Lund","year":"2016","unstructured":"Lund, A. W. et al. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. J. Clin. Invest. 126, 3389\u20133402 (2016).","journal-title":"J. Clin. Invest."},{"key":"85670_CR9","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ccell.2016.06.003","volume":"30","author":"EW Roberts","year":"2016","unstructured":"Roberts, E. W. et al. Critical role for CD103+\/CD141\u2009+\u2009dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in Melanoma. Cancer Cell. 30, 324\u2013336 (2016).","journal-title":"Cancer Cell."},{"key":"85670_CR10","doi-asserted-by":"crossref","unstructured":"Buchwald, Z. S. et al. Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy. J. Immunother Cancer 8, (2020).","DOI":"10.1136\/jitc-2020-000867"},{"key":"85670_CR11","doi-asserted-by":"publisher","first-page":"5058","DOI":"10.1158\/1078-0432.CCR-17-3427","volume":"24","author":"AE Marciscano","year":"2018","unstructured":"Marciscano, A. E. et al. Elective nodal irradiation attenuates the combinatorial efficacy of stereotactic radiation therapy and immunotherapy. Clin. Cancer Res. 24, 5058\u20135071 (2018).","journal-title":"Clin. Cancer Res."},{"key":"85670_CR12","doi-asserted-by":"crossref","unstructured":"Fankhauser, M. et al. Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma. Sci. Transl. Med. 9, (2017).","DOI":"10.1126\/scitranslmed.aal4712"},{"key":"85670_CR13","doi-asserted-by":"publisher","first-page":"4512","DOI":"10.1096\/fj.15-274761","volume":"29","author":"NA Rohner","year":"2015","unstructured":"Rohner, N. A. et al. Lymph node biophysical remodeling is associated with melanoma lymphatic drainage. FASEB J. 29, 4512\u20134522 (2015).","journal-title":"FASEB J."},{"key":"85670_CR14","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jconrel.2015.12.027","volume":"223","author":"NA Rohner","year":"2016","unstructured":"Rohner, N. A. & Thomas, S. N. Melanoma growth effects on molecular clearance from tumors and biodistribution into systemic tissues versus draining lymph nodes. J. Control Release. 223, 99\u2013108 (2016).","journal-title":"J. Control Release"},{"key":"85670_CR15","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1089\/ten.tea.2022.0020","volume":"28","author":"MJ O\u2019Melia","year":"2022","unstructured":"O\u2019Melia, M. J., Rohner, N. A. & Thomas, S. N. Tumor vascular remodeling affects molecular dissemination to Lymph Node and systemic leukocytes. Tissue Eng. Part. A. 28, 781\u2013794 (2022).","journal-title":"Tissue Eng. Part. A"},{"key":"85670_CR16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.sopen.2022.02.001","volume":"8","author":"T Chen","year":"2022","unstructured":"Chen, T., Lin, Y. & Tan, Q. Risk factors for lower extremity lymphedema after inguinal lymphadenectomy in melanoma patients: A retrospective cohort study. Surg. Open. Sci. 8, 33\u201339 (2022).","journal-title":"Surg. Open. Sci."},{"key":"85670_CR17","doi-asserted-by":"publisher","first-page":"1152314","DOI":"10.3389\/fphar.2023.1152314","volume":"14","author":"V Pillay","year":"2023","unstructured":"Pillay, V. et al. Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling. Front. Pharmacol. 14, 1152314 (2023).","journal-title":"Front. Pharmacol."},{"key":"85670_CR18","doi-asserted-by":"publisher","first-page":"5128","DOI":"10.1016\/j.biomaterials.2013.03.034","volume":"34","author":"ST Proulx","year":"2013","unstructured":"Proulx, S. T. et al. Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis. Biomaterials 34, 5128 (2013).","journal-title":"Biomaterials"},{"key":"85670_CR19","doi-asserted-by":"publisher","first-page":"7053","DOI":"10.1158\/0008-5472.CAN-10-0271","volume":"70","author":"ST Proulx","year":"2010","unstructured":"Proulx, S. T. et al. Quantitative imaging of lymphatic function with liposomal indocyanine green. Cancer Res. 70, 7053\u20137062 (2010).","journal-title":"Cancer Res."},{"key":"85670_CR20","doi-asserted-by":"publisher","first-page":"5128","DOI":"10.1016\/j.biomaterials.2013.03.034","volume":"34","author":"ST Proulx","year":"2013","unstructured":"Proulx, S. T. et al. Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis. Biomaterials 34, 5128\u20135137 (2013).","journal-title":"Biomaterials"},{"key":"85670_CR21","doi-asserted-by":"crossref","unstructured":"Sestito, L. F. et al. Lymphatic-draining nanoparticles deliver Bay K8644 payload to lymphatic vessels and enhance their pumping function. Sci. Adv. 9, (2023).","DOI":"10.1126\/sciadv.abq0435"},{"key":"85670_CR22","doi-asserted-by":"crossref","unstructured":"Chong, C. et al. In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging. Sci. Rep. 6, (2016).","DOI":"10.1038\/srep22930"},{"issue":"4","key":"85670_CR23","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1364\/BOE.7.001100","volume":"7","author":"S Kwon","year":"2016","unstructured":"Kwon, S. et al. Characterization of internodal collecting lymphatic vessel function after surgical removal of an axillary lymph node in mice. Biomed. Opt. Express. 7 (4), 1100\u20131115 (2016). 7, 1100-1115.","journal-title":"Biomed. Opt. Express"},{"key":"85670_CR24","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s10456-013-9332-2","volume":"16","author":"ST Proulx","year":"2013","unstructured":"Proulx, S. T. et al. Non-invasive dynamic near-infrared imaging and quantification of vascular leakage in vivo. Angiogenesis 16, 525\u2013540 (2013).","journal-title":"Angiogenesis"},{"key":"85670_CR25","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","volume":"41","author":"KE de Visser","year":"2023","unstructured":"de Visser, K. E. & Joyce, J. A. The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Cancer Cell. 41, 374\u2013403 (2023).","journal-title":"Cancer Cell."},{"key":"85670_CR26","doi-asserted-by":"crossref","unstructured":"Jones, D. Parallels of resistance between angiogenesis and lymphangiogenesis inhibition in cancer therapy. Cells 9, (2020).","DOI":"10.3390\/cells9030762"},{"key":"85670_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2012.00283","volume":"3","author":"JL Astarita","year":"2012","unstructured":"Astarita, J. L., Acton, S. E., Turley, S. J. & Podoplanin emerging functions in development, the immune system, and cancer. Front. Immunol. 3, 1\u201311 (2012).","journal-title":"Front. Immunol."},{"key":"85670_CR28","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/imr.12520","volume":"276","author":"M Das","year":"2017","unstructured":"Das, M., Zhu, C. & Kuchroo, V. K. Tim-3 and its role in regulating anti-tumor immunity. Immunol. Rev. 276, 97\u2013111 (2017).","journal-title":"Immunol. Rev."},{"key":"85670_CR29","doi-asserted-by":"crossref","unstructured":"Escobar, G., Mangani, D. & Anderson, A. C. T cell factor 1: A master regulator of the T cell response in disease. Sci. Immunol. 5 (2020).","DOI":"10.1126\/sciimmunol.abb9726"},{"key":"85670_CR30","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","volume":"8","author":"K Murali-Krishna","year":"1998","unstructured":"Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: A reevaluation of Bystander activation during viral infection. Immunity 8, 177\u2013187 (1998).","journal-title":"Immunity"},{"key":"85670_CR31","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1158\/0008-5472.CAN-09-2982","volume":"70","author":"T Takeshima","year":"2010","unstructured":"Takeshima, T. et al. Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL: Its potentiation by combination with TH1 cell therapy. Cancer Res. 70, 2697\u20132706 (2010).","journal-title":"Cancer Res."},{"key":"85670_CR32","doi-asserted-by":"crossref","unstructured":"Fransen, M. F. et al. Tumor-draining lymph nodes are pivotal in PD-1\/PD-L1 checkpoint therapy. JCI Insight 3, (2018).","DOI":"10.1172\/jci.insight.124507"},{"key":"85670_CR33","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1016\/j.cell.2022.09.020","volume":"185","author":"Q Huang","year":"2022","unstructured":"Huang, Q. et al. The primordial differentiation of tumor-specific memory CD8\u2009+\u2009T cells as bona fide responders to PD-1\/PD-L1 blockade in draining lymph nodes. Cell 185, 4049\u20134066e25 (2022).","journal-title":"Cell"},{"key":"85670_CR34","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.avsg.2017.01.023","volume":"43","author":"H Jun","year":"2017","unstructured":"Jun, H. et al. Modified mouse models of chronic secondary Lymphedema: Tail and Hind limb models. Ann. Vasc Surg. 43, 288\u2013295 (2017).","journal-title":"Ann. Vasc Surg."},{"key":"85670_CR35","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1089\/wound.2021.0033","volume":"11","author":"JF Hsu","year":"2022","unstructured":"Hsu, J. F., Yu, R. P., Stanton, E. W., Wang, J. & Wong, A. K. Current advancements in animal models of Postsurgical Lymphedema: A systematic review. Adv. Wound Care. 11, 399\u2013418 (2022).","journal-title":"Adv. Wound Care"},{"issue":"9","key":"85670_CR36","first-page":"1","volume":"91","author":"MJ Weiler","year":"2019","unstructured":"Weiler, M. J., Cribb, M. T., Nepiyushchikh, Z., Nelson, T. S. & Dixon, J. B. A novel mouse tail lymphedema model for observing lymphatic pump failure during lymphedema development. Sci. Rep.. 91 (9), 1\u201315 (2019).","journal-title":"Sci. Rep. 2019"},{"key":"85670_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/15330338211036304","volume":"20","author":"Y Li","year":"2021","unstructured":"Li, Y., Zhao, L. & Li, X. F. Hypoxia and the tumor microenvironment. Technol. Cancer Res. Treat. 20, 1\u20139 (2021).","journal-title":"Technol. Cancer Res. Treat."},{"key":"85670_CR38","doi-asserted-by":"crossref","unstructured":"Huang, A. C. & Zappasodi, R. A decade of checkpoint blockade immunotherapy in melanoma: Understanding the molecular basis for immune sensitivity and resistance. Nat. Immunol. 23, 660\u2013670 (2022).","DOI":"10.1038\/s41590-022-01141-1"},{"key":"85670_CR39","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1200\/JCO.21.02229","volume":"40","author":"JD Wolchok","year":"2022","unstructured":"Wolchok, J. D. et al. Long-term outcomes with Nivolumab Plus Ipilimumab or Nivolumab alone Versus Ipilimumab in patients with Advanced Melanoma. J. Clin. Oncol. 40, 127\u2013137 (2022).","journal-title":"J. Clin. Oncol."},{"key":"85670_CR40","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3390\/diagnostics10090660","volume":"10","author":"A Onaciu","year":"2020","unstructured":"Onaciu, A. et al. Spontaneous and induced animal models for cancer research. Diagnostics 10, 660 (2020).","journal-title":"Diagnostics"},{"key":"85670_CR41","doi-asserted-by":"crossref","unstructured":"Ireson, C. R., Alavijeh, M. S., Palmer, A. M., Fowler, E. R. & Jones, H. J. The role of mouse tumour models in the discovery and development of anticancer drugs. Br. J. Cancer 121, 101\u2013108 (2019).","DOI":"10.1038\/s41416-019-0495-5"},{"key":"85670_CR42","doi-asserted-by":"publisher","unstructured":"Patton, E. E. et al. Melanoma models for the next generation of therapies. https:\/\/doi.org\/10.1016\/j.ccell.2021.01.011","DOI":"10.1016\/j.ccell.2021.01.011"},{"key":"85670_CR43","doi-asserted-by":"publisher","first-page":"R281","DOI":"10.1152\/ajpregu.00369.2013","volume":"306","author":"TS Nelson","year":"2014","unstructured":"Nelson, T. S. et al. Minimally invasive method for determining the effective lymphatic pumping pressure in rats using near-infrared imaging. Am. J. Physiol. - Regul. Integr. Comp. Physiol. 306, R281 (2014).","journal-title":"Am. J. Physiol. - Regul. Integr. Comp. Physiol."},{"key":"85670_CR44","doi-asserted-by":"crossref","unstructured":"Bernard, F. C. et al. Multichromatic near-infrared imaging to assess interstitial lymphatic and venous uptake in vivo. J. Biomed. Opt. 26, (2021).","DOI":"10.1117\/1.JBO.26.12.126001"},{"key":"85670_CR45","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.mvr.2014.07.013","volume":"96","author":"JW Breslin","year":"2014","unstructured":"Breslin, J. W. Mechanical forces and lymphatic transport. Microvasc. Res. 96, 46\u201354 (2014).","journal-title":"Microvasc Res."},{"key":"85670_CR46","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1089\/lrb.2015.0028","volume":"13","author":"M Jafarnejad","year":"2015","unstructured":"Jafarnejad, M., Woodruff, M. C., Zawieja, D. C., Carroll, M. C. & Moore, J. E. Modeling lymph flow and fluid exchange with blood vessels in lymph nodes. Lymphat Res. Biol. 13, 234\u2013247 (2015).","journal-title":"Lymphat Res. Biol."},{"key":"85670_CR47","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1080\/09553002.2019.1562253","volume":"95","author":"SA Narayanan","year":"2019","unstructured":"Narayanan, S. A., Ford, J. & Zawieja, D. C. Impairment of lymphatic endothelial barrier function by X-ray irradiation. Int. J. Radiat. Biol. 95, 562\u2013570 (2019).","journal-title":"Int. J. Radiat. Biol."},{"key":"85670_CR48","doi-asserted-by":"publisher","first-page":"H155","DOI":"10.1152\/ajpheart.00387.2022","volume":"324","author":"R Singh","year":"2023","unstructured":"Singh, R. et al. Dichotomous effects of in vivo and in vitro ionizing radiation exposure on lymphatic function. Am. J. Physiol. Hear. Circ. Physiol. 324, H155\u2013H171 (2023).","journal-title":"Am. J. Physiol. - Hear. Circ. Physiol."},{"key":"85670_CR49","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s40471-019-00192-7","volume":"6","author":"MR Schwartz","year":"2019","unstructured":"Schwartz, M. R., Luo, L. & Berwick, M. Sex differences in Melanoma. Curr. Epidemiol. Rep. 6, 112 (2019).","journal-title":"Curr. Epidemiol. Rep."},{"key":"85670_CR50","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1001\/jamadermatol.2019.3353","volume":"156","author":"KG Paulson","year":"2020","unstructured":"Paulson, K. G. et al. Age-specific incidence of Melanoma in the United States. JAMA Dermatol. 156, 57\u201364 (2020).","journal-title":"JAMA Dermatology"},{"key":"85670_CR51","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1126\/sciimmunol.aao3125","volume":"3","author":"A Wieland","year":"2018","unstructured":"Wieland, A. et al. Enhancing FcR-mediated antibody effector function during persistent viral infection. Sci. Immunol. 3, 3125 (2018).","journal-title":"Sci. Immunol."},{"key":"85670_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-33592-8","volume":"8","author":"W Stauffer","year":"2018","unstructured":"Stauffer, W., Sheng, H., Lim, H. N. & EzColocalization An ImageJ plugin for visualizing and measuring colocalization in cells and organisms. Sci. Rep. 8, 1\u201313 (2018).","journal-title":"Sci. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85670-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85670-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85670-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T05:36:32Z","timestamp":1738042592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85670-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["85670"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-85670-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,28]]},"assertion":[{"value":"16 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3485"}}