{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T01:36:35Z","timestamp":1794360995024,"version":"4.9.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"NHC Key Laboratory of Nuclear Technology Medical Transformation","award":["Grant no.2023HYX032"],"award-info":[{"award-number":["Grant no.2023HYX032"]}]},{"name":"Incubation Project of Mianyang Central Hospital","award":["Grant no.2022FH010"],"award-info":[{"award-number":["Grant no.2022FH010"]}]},{"name":"Health Commission of Sichuan Province Medical Science and Technology Program","award":["Grant no.24QNMP028"],"award-info":[{"award-number":["Grant no.24QNMP028"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant no.82400758"],"award-info":[{"award-number":["Grant no.82400758"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-85773-x","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T11:51:56Z","timestamp":1736337116000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective"],"prefix":"10.1038","volume":"15","author":[{"given":"Jianjun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"issue":"1","key":"85773_CR1","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/s12876-021-01906-2","volume":"21","author":"CL Li","year":"2021","unstructured":"Li, C. L., Jiang, M., Pan, C. Q., Li, J. & Xu, L. G. The global, regional, and national burden of acute pancreatitis in 204 countries and territories, 1990\u20132019. BMC Gastroenterol. 21 (1), 332 (2021).","journal-title":"BMC Gastroenterol."},{"issue":"6","key":"85773_CR2","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1136\/gutjnl-2017-314657","volume":"68","author":"NJ Schepers","year":"2019","unstructured":"Schepers, N. J. et al. Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis. Gut 68 (6), 1044\u20131051 (2019).","journal-title":"Gut"},{"issue":"3","key":"85773_CR3","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/den.13470","volume":"32","author":"JY Bang","year":"2020","unstructured":"Bang, J. Y., Wilcox, C. M., Arnoletti, J. P. & Varadarajulu, S. Superiority of endoscopic interventions over minimally invasive surgery for infected necrotizing pancreatitis: meta-analysis of randomized trials. Dig. Endosc. 32 (3), 298\u2013308 (2020).","journal-title":"Dig. Endosc"},{"key":"85773_CR4","doi-asserted-by":"publisher","first-page":"927","DOI":"10.2147\/PPA.S235430","volume":"14","author":"EM Janssen","year":"2020","unstructured":"Janssen, E. M. et al. F. P. Analysis of Patient preferences in Lung Cancer - estimating acceptable tradeoffs between Treatment Benefit and Side effects. Patient Prefer Adherence. 14, 927\u2013937 (2020).","journal-title":"Patient Prefer Adherence"},{"issue":"4","key":"85773_CR5","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.12669\/pjms.35.4.1286","volume":"35","author":"A Arif","year":"2019","unstructured":"Arif, A., Jaleel, F. & Rashid, K. Accuracy of BISAP score in prediction of severe acute pancreatitis. Pak J. Med. Sci. 35 (4), 1008\u20131012 (2019).","journal-title":"Pak J. Med. Sci."},{"issue":"2","key":"85773_CR6","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1053\/j.ajkd.2023.01.441","volume":"82","author":"R Chowdhury","year":"2023","unstructured":"Chowdhury, R., Turcotte, A. E., Rondon-Berrios, H. & Workeneh, B. T. Spurious Electrolyte and Acid-Base disorders in the patient with Cancer: a review. Am. J. Kidney Dis. 82 (2), 237\u2013242 (2023).","journal-title":"Am. J. Kidney Dis."},{"key":"85773_CR7","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.cca.2019.10.012","volume":"500","author":"B Pratumvinit","year":"2020","unstructured":"Pratumvinit, B. et al. Anion gap reference intervals show instrument dependence and weak correlation with albumin levels. Clin. Chim. Acta. 500, 172\u2013179 (2020).","journal-title":"Clin. Chim. Acta"},{"issue":"6","key":"85773_CR8","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1136\/adc.87.6.526","volume":"87","author":"M Hatherill","year":"2002","unstructured":"Hatherill, M., Waggie, Z., Purves, L., Reynolds, L. & Argent, A. Correction of the anion gap for albumin in order to detect occult tissue anions in shock. Arch. Dis. Child. 87 (6), 526\u2013529 (2002).","journal-title":"Arch. Dis. Child."},{"issue":"2","key":"85773_CR9","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/ehf2.14639","volume":"11","author":"H Sheng","year":"2024","unstructured":"Sheng, H. et al. The correlation between albumin-corrected anion gap and prognosis in patients with acute myocardial infarction. ESC Heart Fail. 11 (2), 826\u2013836 (2024).","journal-title":"ESC Heart Fail."},{"issue":"2","key":"85773_CR10","doi-asserted-by":"publisher","first-page":"2282708","DOI":"10.1080\/0886022X.2023.2282708","volume":"45","author":"P Gao","year":"2023","unstructured":"Gao, P., Min, J., Zhong, L. & Shao, M. Association between albumin corrected anion gap and all-cause mortality in critically ill patients with acute kidney injury: a retrospective study based on MIMIC-IV database. Ren. Fail. 45 (2), 2282708 (2023).","journal-title":"Ren. Fail."},{"issue":"1","key":"85773_CR11","doi-asserted-by":"publisher","first-page":"16903","DOI":"10.1038\/s41598-023-44182-8","volume":"13","author":"S Wang","year":"2023","unstructured":"Wang, S., Teng, H., Han, H. & Xu, Y. The relationship between albumin corrected anion gap levels and mortality in patients with asthma in the ICU. Sci. Rep. 13 (1), 16903 (2023).","journal-title":"Sci. Rep."},{"key":"85773_CR12","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.cca.2021.07.021","volume":"521","author":"T Hu","year":"2021","unstructured":"Hu, T., Zhang, Z. & Jiang, Y. Albumin corrected anion gap for predicting in-hospital mortality among intensive care patients with sepsis: a retrospective propensity score matching analysis. Clin. Chim. Acta. 521, 272\u2013277 (2021).","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"85773_CR13","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12944-023-01968-z","volume":"22","author":"J Wang","year":"2023","unstructured":"Wang, J. et al. Evaluating the efficacy and timing of blood purification modalities in early-stage hyperlipidemic acute pancreatitis treatment. Lipids Health Dis. 22 (1), 208 (2023).","journal-title":"Lipids Health Dis."},{"issue":"2","key":"85773_CR14","doi-asserted-by":"publisher","first-page":"ITC17","DOI":"10.7326\/AITC202102160","volume":"174","author":"TB Gardner","year":"2021","unstructured":"Gardner, T. B. Acute Pancreatitis. Ann. Intern. Med. 174 (2), ITC17\u2013ITC32 (2021).","journal-title":"Ann. Intern. Med."},{"issue":"10252","key":"85773_CR15","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","volume":"396","author":"L Boxhoorn","year":"2020","unstructured":"Boxhoorn, L. et al. Acute pancreatitis. Lancet 396 (10252), 726\u2013734 (2020).","journal-title":"Lancet"},{"issue":"5","key":"85773_CR16","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.jhep.2017.06.023","volume":"67","author":"B Scheiner","year":"2017","unstructured":"Scheiner, B. et al. Acid-base disorders in liver disease. J. Hepatol. 67 (5), 1062\u20131073 (2017).","journal-title":"J. Hepatol."},{"issue":"11","key":"85773_CR17","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1056\/NEJMoa2202884","volume":"387","author":"E de-Madaria","year":"2022","unstructured":"de-Madaria, E. et al. Aggressive or moderate fluid resuscitation in Acute Pancreatitis. N Engl. J. Med. 387 (11), 989\u20131000 (2022).","journal-title":"N Engl. J. Med."},{"key":"85773_CR18","doi-asserted-by":"crossref","unstructured":"Lu, Y., Guo, H., Chen, X. & Zhang, Q. Association between lactate\/albumin ratio and all-cause mortality in patients with acute respiratory failure: A retrospective analysis.PloS One 16(8), e0255744 (2021).","DOI":"10.1371\/journal.pone.0255744"},{"issue":"1","key":"85773_CR19","doi-asserted-by":"publisher","first-page":"16670","DOI":"10.1038\/s41598-023-43928-8","volume":"13","author":"H Xu","year":"2023","unstructured":"Xu, H. et al. Serum anion gap is associated with mortality in intensive care unit patients with diastolic heart failure. Sci. Rep. 13 (1), 16670 (2023).","journal-title":"Sci. Rep."},{"issue":"1","key":"85773_CR20","doi-asserted-by":"publisher","first-page":"7405","DOI":"10.1038\/s41598-022-11081-3","volume":"12","author":"J Chen","year":"2022","unstructured":"Chen, J. et al. The association between anion gap and in-hospital mortality of post-cardiac arrest patients: a retrospective study. Sci. Rep. 12 (1), 7405 (2022).","journal-title":"Sci. Rep."},{"issue":"24","key":"85773_CR21","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.21037\/atm-22-5916","volume":"10","author":"L Jiang","year":"2022","unstructured":"Jiang, L. et al. Predictive value of the serum anion gap for 28-day in-hospital all-cause mortality in sepsis patients with acute kidney injury: a retrospective analysis of the MIMIC-IV database. Ann. Transl Med. 10 (24), 1373 (2022).","journal-title":"Ann. Transl Med."},{"key":"85773_CR22","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2147\/IJGM.S293340","volume":"14","author":"F Gong","year":"2021","unstructured":"Gong, F., Zhou, Q., Gui, C., Huang, S. & Qin, Z. The Relationship between the serum anion gap and all-cause mortality in Acute Pancreatitis: an analysis of the MIMIC-III database. Int. J. Gen. Med. 14, 531\u2013538 (2021).","journal-title":"Int. J. Gen. Med."},{"issue":"4","key":"85773_CR23","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/bja\/85.4.599","volume":"85","author":"JP Nicholson","year":"2000","unstructured":"Nicholson, J. P., Wolmarans, M. R. & Park, G. R.The role of albumin in critical illness. Br. J. Anaesth. 85 (4), 599\u2013610 (2000).","journal-title":"Br. J. Anaesth."},{"issue":"1","key":"85773_CR24","doi-asserted-by":"publisher","first-page":"162","DOI":"10.2215\/CJN.03020906","volume":"2","author":"JA Kraut","year":"2007","unstructured":"Kraut, J. A. & Madias, N. E. Serum anion gap: its uses and limitations in clinical medicine. Clin. J. Am. Soc. Nephrol. 2 (1), 162\u2013174 (2007).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"1","key":"85773_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s12872-023-03200-3","volume":"23","author":"L Jian","year":"2023","unstructured":"Jian, L. et al. Association between albumin corrected anion gap and 30-day all-cause mortality of critically ill patients with acute myocardial infarction: a retrospective analysis based on the MIMIC-IV database. BMC Cardiovasc. Disord. 23 (1), 211 (2023).","journal-title":"BMC Cardiovasc. Disord"},{"issue":"6","key":"85773_CR26","doi-asserted-by":"publisher","first-page":"430","DOI":"10.4274\/balkanmedj.galenos.2023.2023-7-87","volume":"40","author":"B G\u00fcndo\u011fan Uzunay","year":"2023","unstructured":"G\u00fcndo\u011fan Uzunay, B., K\u00f6ker, A., \u00dclgen Tekerek, N., D\u00f6nmez, L. & Dursun, O. Role of albumin-corrected Anion Gap and Lactate Clearance in Predicting Mortality in Pediatric Intensive Care patients. Balkan Med. J. 40 (6), 430\u2013434 (2023).","journal-title":"Balkan Med. J."},{"issue":"12","key":"85773_CR27","doi-asserted-by":"publisher","first-page":"4894","DOI":"10.21037\/jtd-22-1633","volume":"14","author":"R Wang","year":"2022","unstructured":"Wang, R. et al. Preoperative albumin corrected anion gap is associated with in-hospital and long-term mortality in patients undergoing coronary artery bypass grafting in a retrospective cohort study. J. Thorac. Dis. 14 (12), 4894\u20134903 (2022).","journal-title":"J. Thorac. Dis."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85773-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85773-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85773-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T12:09:58Z","timestamp":1736338198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-85773-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["85773"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-85773-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]},"assertion":[{"value":"19 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"In order to safeguard patient confidentiality, all personal data underwent de-identification, with random numerical identifiers assigned in place of individual identification. Consequently, the Beth Israel Deaconess Medical Center ethics committee exempted the necessity for informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethic Statement"}}],"article-number":"1318"}}