{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T07:09:35Z","timestamp":1794553775232,"version":"4.9.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-86858-3","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T14:24:07Z","timestamp":1737987847000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Gut\u2013brain axis and neuropsychiatric health: recent advances"],"prefix":"10.1038","volume":"15","author":[{"given":"Ceymi","family":"Doenyas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e1ta","family":"Cserj\u00e9si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"86858_CR1","doi-asserted-by":"crossref","unstructured":"Collins, J. M., Cryan, J. F. & OMahony, S. M. Importance of the microbiota in early life and influence on future health. In The Gut-Brain Axis (2nd edition) 37\u201376 (Academic Press, 2024).","DOI":"10.1016\/B978-0-323-99971-7.00017-5"},{"key":"86858_CR2","first-page":"101857","volume":"85","author":"Y Cheng","year":"2023","unstructured":"Cheng, Y., Chen, C. & Zhang, F. Immunity orchestrates a bridge in gut\u2013brain axis of neurodegenerative diseases. ARR 85, 101857 (2023).","journal-title":"ARR"},{"key":"86858_CR3","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/jamapsychiatry.2022.4974","volume":"80","author":"W Gong","year":"2023","unstructured":"Gong, W. et al. Role of the gut\u2013brain axis in the shared genetic etiology between gastrointestinal tract diseases and psychiatric disorders: A genome-wide pleiotropic analysis. JAMA Psychiatry. 80, 360\u2013370 (2023).","journal-title":"JAMA Psychiatry."},{"key":"86858_CR4","doi-asserted-by":"publisher","first-page":"4968","DOI":"10.1038\/s41380-023-02161-5","volume":"28","author":"K Hashimoto","year":"2023","unstructured":"Hashimoto, K. Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: the role of Epstein\u2013Barr virus and the gut\u2013brain axis. Mol. Psychiatry 28, 4968\u20134976 (2023).","journal-title":"Mol. Psychiatry"},{"key":"86858_CR5","doi-asserted-by":"publisher","first-page":"403","DOI":"10.5607\/en20047","volume":"29","author":"TY Choi","year":"2020","unstructured":"Choi, T. Y., Choi, Y. P. & Koo, J. W. Mental disorders linked to crosstalk between the gut microbiome and the brain. Exp. Neurobiol. 29, 403\u2013416 (2020).","journal-title":"Exp. Neurobiol."},{"key":"86858_CR6","doi-asserted-by":"crossref","unstructured":"D\u00e9carie-Spain, L., Hayes, A. M., Lauer, L. T. & Kanoski, S. E. The gut\u2013brain axis and cognitive control: A role for the vagus nerve. In Seminars in Cell & Developmental Biology, Vol. 156, 201\u2013209 (Academic Press, 2024).","DOI":"10.1016\/j.semcdb.2023.02.004"},{"key":"86858_CR7","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.neuron.2019.02.008","volume":"101","author":"C F\u00fclling","year":"2019","unstructured":"F\u00fclling, C., Dinan, T. G. & Cryan, J. F. Gut microbe to brain signaling: What happens in vagus\u2026. Neuron 101, 998\u20131002 (2019).","journal-title":"Neuron"},{"key":"86858_CR8","doi-asserted-by":"publisher","first-page":"104442","DOI":"10.1016\/j.ebiom.2023.104442","volume":"89","author":"C Carbia","year":"2023","unstructured":"Carbia, C. et al. The Microbiome-Gut-Brain axis regulates social cognition & craving in young binge drinkers. EbioMedicine. 89, 104442 (2023).","journal-title":"EbioMedicine."},{"key":"86858_CR9","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1021\/acschemneuro.9b00607","volume":"11","author":"P Fu","year":"2020","unstructured":"Fu, P., Gao, M. & Yung, K. K. L. Association of intestinal disorders with Parkinson\u2019s disease and Alzheimer\u2019s disease: A systematic review and meta-analysis. ACS Chem. Neurosci. 11, 395\u2013405 (2020).","journal-title":"ACS Chem. Neurosci."},{"key":"86858_CR10","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1002\/mds.27794","volume":"34","author":"K Tsukita","year":"2019","unstructured":"Tsukita, K., Sakamaki-Tsukita, H., Tanaka, K., Suenaga, T. & Takahashi, R. Value of in vivo \u03b1-synuclein deposits in Parkinson\u2019s disease: A systematic review and meta-analysis. Mov. Disord. 34, 1452\u20131463 (2019).","journal-title":"Mov. Disord."},{"key":"86858_CR11","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.actbio.2021.03.071","volume":"132","author":"AJ Bindas","year":"2021","unstructured":"Bindas, A. J., Kulkarni, S., Koppes, R. A. & Koppes, A. N. Parkinson\u2019s disease and the gut: Models of an emerging relationship. Acta Biomater. 132, 325\u2013344 (2021).","journal-title":"Acta Biomater."},{"key":"86858_CR12","doi-asserted-by":"publisher","first-page":"22211","DOI":"10.1038\/s41598-022-26543-x","volume":"12","author":"AJ Bindas","year":"2022","unstructured":"Bindas, A. J. et al. Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro. Sci. Rep. 12, 22211 (2022).","journal-title":"Sci. Rep."},{"key":"86858_CR13","doi-asserted-by":"publisher","first-page":"5488","DOI":"10.1038\/s41598-023-32713-2","volume":"13","author":"V Osadchiy","year":"2023","unstructured":"Osadchiy, V. et al. Machine learning model to predict obesity using gut metabolite and brain microstructure data. Sci. Rep. 13, 5488 (2023).","journal-title":"Sci. Rep."},{"key":"86858_CR14","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.csbj.2020.12.012","volume":"19","author":"M Wang","year":"2021","unstructured":"Wang, M. et al. Virulence factor-related gut microbiota genes and immunoglobulin A levels as novel markers for machine learning-based classification of autism spectrum disorder. CSBJ 19, 545\u2013554 (2021).","journal-title":"CSBJ"},{"key":"86858_CR15","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/jcpp.13650","volume":"64","author":"M Schulte-R\u00fcther","year":"2023","unstructured":"Schulte-R\u00fcther, M. et al. Using machine learning to improve diagnostic assessment of ASD in the light of specific differential and co-occurring diagnoses. J Child Psychol Psychiatry 64, 16\u201326 (2023).","journal-title":"J Child Psychol Psychiatry"},{"key":"86858_CR16","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1001\/jamapsychiatry.2021.2573","volume":"78","author":"VL Nikolova","year":"2021","unstructured":"Nikolova, V. L. et al. Perturbations in gut microbiota composition in psychiatric disorders: A review and meta-analysis. JAMA Psychiatry 78, 1343\u20131354 (2021).","journal-title":"JAMA Psychiatry"},{"key":"86858_CR17","doi-asserted-by":"publisher","first-page":"3626","DOI":"10.1038\/s41598-024-53929-w","volume":"14","author":"J Delanote","year":"2024","unstructured":"Delanote, J., Correa Rojo, A., Wells, P. M., Steves, C. J. & Ertaylan, G. Systematic identification of the role of gut microbiota in mental disorders: A TwinsUK cohort study. Sci. Rep. 14, 3626 (2024).","journal-title":"Sci. Rep."},{"key":"86858_CR18","doi-asserted-by":"publisher","first-page":"4491","DOI":"10.1113\/JP281951","volume":"601","author":"SJ Leigh","year":"2023","unstructured":"Leigh, S. J. et al. The impact of acute and chronic stress on gastrointestinal physiology and function: A microbiota\u2013gut\u2013brain axis perspective. J. Physiol. 601, 4491\u20134538 (2023).","journal-title":"J. Physiol."},{"key":"86858_CR19","doi-asserted-by":"publisher","first-page":"10695","DOI":"10.1038\/s41598-024-61418-3","volume":"14","author":"KA Howard","year":"2024","unstructured":"Howard, K. A., Ahmad, S. S., Chavez, J. V., Hoogerwoerd, H. & McIntosh, R. C. The central executive network moderates the relationship between posttraumatic stress symptom severity and gastrointestinal related issues. Sci. Rep. 14, 10695 (2024).","journal-title":"Sci. Rep."},{"issue":"24","key":"86858_CR20","first-page":"00399","volume":"S1550\u20134131","author":"GS Tofani","year":"2024","unstructured":"Tofani, G. S. et al. Gut microbiota regulates stress responsivity via the circadian system. Cell Metab. S1550\u20134131(24), 00399\u201300401 (2024).","journal-title":"Cell Metab."},{"key":"86858_CR21","doi-asserted-by":"publisher","first-page":"114079","DOI":"10.1016\/j.celrep.2024.114079","volume":"43","author":"CE Gheorghe","year":"2024","unstructured":"Gheorghe, C. E. et al. The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut. Cell Rep. 43, 114079 (2024).","journal-title":"Cell Rep."},{"key":"86858_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101340","volume":"53","author":"BA Matenchuk","year":"2020","unstructured":"Matenchuk, B. A., Mandhane, P. J. & Kozyrskyj, A. L. Sleep, circadian rhythm, and gut microbiota. Sleep Med. Rev. 53, 101340 (2020).","journal-title":"Sleep Med. Rev."},{"key":"86858_CR23","volume":"10","author":"GM Moloney","year":"2021","unstructured":"Moloney, G. M. et al. Improvements in sleep indices during exam stress due to consumption of a Bifidobacterium longum. BBI-Health 10, 100174 (2021).","journal-title":"BBI-Health"},{"key":"86858_CR24","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.1038\/s41598-024-53810-w","volume":"14","author":"E Patterson","year":"2024","unstructured":"Patterson, E. et al. Bifidobacterium longum 1714 improves sleep quality and aspects of well-being in healthy adults: A randomized, double-blind, placebo-controlled clinical trial. Sci. Rep. 14, 3725 (2024).","journal-title":"Sci. Rep."},{"key":"86858_CR25","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/s41575-023-00890-0","volume":"21","author":"MR Aburto","year":"2024","unstructured":"Aburto, M. R. & Cryan, J. F. Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota\u2013gut\u2013brain axis. Nat. Rev. Gastroenterol. Hepatol. 21, 222\u2013247 (2024).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"86858_CR26","doi-asserted-by":"publisher","first-page":"13982","DOI":"10.1038\/s41598-023-40497-8","volume":"13","author":"E Coletto","year":"2023","unstructured":"Coletto, E. et al. Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice. Sci. Rep. 13, 13982 (2023).","journal-title":"Sci. Rep."},{"key":"86858_CR27","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1038\/s41380-023-01972-w","volume":"28","author":"EA Mayer","year":"2023","unstructured":"Mayer, E. A., Ryu, H. J. & Bhatt, R. R. The neurobiology of irritable bowel syndrome. Mol. Psychiatry 28, 1451\u20131465 (2023).","journal-title":"Mol. Psychiatry"},{"key":"86858_CR28","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14095","volume":"33","author":"L Wilmes","year":"2021","unstructured":"Wilmes, L. et al. Of bowels, brain and behavior: A role for the gut microbiota in psychiatric comorbidities in irritable bowel syndrome. Neurogastroenterol. Motil. 33, e14095 (2021).","journal-title":"Neurogastroenterol. Motil."},{"key":"86858_CR29","doi-asserted-by":"publisher","first-page":"8769","DOI":"10.1038\/s41598-023-35774-5","volume":"13","author":"H Purssell","year":"2023","unstructured":"Purssell, H. et al. The prevalence and burden of Rome IV bowel disorders of gut brain interaction in patients with non-alcoholic fatty liver disease: a cross-sectional study. Sci. Rep. 13, 8769 (2023).","journal-title":"Sci. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-86858-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-86858-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-86858-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T14:24:10Z","timestamp":1737987850000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-86858-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["86858"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-86858-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,27]]},"assertion":[{"value":"27 January 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3415"}}