{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T00:30:31Z","timestamp":1794357031706,"version":"4.9.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-86917-9","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:33:15Z","timestamp":1737628395000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical utility of hematological parameters in aplastic anemia"],"prefix":"10.1038","volume":"15","author":[{"given":"Lizhong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"issue":"2","key":"86917_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/bjh.13853","volume":"172","author":"SB Killick","year":"2016","unstructured":"Killick, S. B. et al. Guidelines for the diagnosis and management of adult aplastic anaemia. Br. J. Haematol. 172 (2), 187\u2013207. https:\/\/doi.org\/10.1111\/bjh.13853 (2016).","journal-title":"Br. J. Haematol."},{"issue":"10","key":"86917_CR2","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1515\/CCLM.2010.292","volume":"48","author":"E Piva","year":"2010","unstructured":"Piva, E., Brugnara, C., Chiandetti, L. & Plebani, M. Automated reticulocyte counting: state of the art and clinical applications in the evaluation of erythropoiesis. Clin. Chem. Lab. Med. 48 (10), 1369\u20131380. https:\/\/doi.org\/10.1515\/CCLM.2010.292 (2010).","journal-title":"Clin. Chem. Lab. Med."},{"issue":"5","key":"86917_CR3","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/ijlh.12374","volume":"37","author":"C Teixeira","year":"2015","unstructured":"Teixeira, C., Barbot, J. & Freitas, M. I. Reference values for reticulocyte parameters and hypochromic RBC in healthy children. Int. J. Lab. Hematol. 37 (5), 626\u2013630. https:\/\/doi.org\/10.1111\/ijlh.12374 (2015).","journal-title":"Int. J. Lab. Hematol."},{"issue":"18","key":"86917_CR4","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.3390\/jcm10184250","volume":"10","author":"C Hoenemann","year":"2021","unstructured":"Hoenemann, C. et al. Reticulocyte and erythrocyte hemoglobin parameters for iron deficiency and anemia diagnostics in Patient blood management. Narrative Rev. J. Clin. Med. 10 (18), 4250. https:\/\/doi.org\/10.3390\/jcm10184250 (2021).","journal-title":"Narrative Rev. J. Clin. Med."},{"issue":"6","key":"86917_CR5","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1182\/blood.V70.6.1718.1718","volume":"70","author":"Incidence of aplastic","year":"1987","unstructured":"Incidence of aplastic. anemia: the relevance of diagnostic criteria. By the international agranulocytosis and aplastic anemia study. Blood 70 (6), 1718\u20131721 (1987).","journal-title":"Blood"},{"issue":"3","key":"86917_CR6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1182\/blood.V45.3.355.355","volume":"45","author":"BM Camitta","year":"1975","unstructured":"Camitta, B. M., Rappeport, J. M., Parkman, R. & Nathan, D. G. Selection of patients for bone marrow transplantation in severe aplastic anemia. Blood 45 (3), 355\u2013363 (1975).","journal-title":"Blood"},{"issue":"2","key":"86917_CR7","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1365-2141.1988.tb02460.x","volume":"70","author":"A Bacigalupo","year":"1988","unstructured":"Bacigalupo, A. et al. Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party. Br. J. Haematol. 70 (2), 177\u2013182. https:\/\/doi.org\/10.1111\/j.1365-2141.1988.tb02460.x (1988).","journal-title":"Br. J. Haematol."},{"issue":"17","key":"86917_CR8","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1056\/NEJMra1413485","volume":"379","author":"NS Young","year":"2018","unstructured":"Young, N. S. Aplastic Anemia. N. Engl. J. Med. 379 (17), 1643\u20131656. https:\/\/doi.org\/10.1056\/NEJMra1413485 (2018).","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"86917_CR9","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1007\/s12185-010-0601-1","volume":"91","author":"JH Kwon","year":"2010","unstructured":"Kwon, J. H. et al. Clinical course of non-severe aplastic anemia in adults. Int. J. Hematol. 91 (5), 770\u2013775. https:\/\/doi.org\/10.1007\/s12185-010-0601-1 (2010).","journal-title":"Int. J. Hematol."},{"issue":"7987","key":"86917_CR10","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/s0140-6736(76)92462-4","volume":"2","author":"HP Lohrmann","year":"1976","unstructured":"Lohrmann, H. P., Kern, P., Niethammer, D. & Heimpel, H. Identification of high-risk patients with aplastic anaemia in selection for allogeneic 0one-marrow transplantation. Lancet (London England)  2 (7987), 647\u2013650. https:\/\/doi.org\/10.1016\/s0140-6736(76)92462-4 (1976).","journal-title":"Lancet (London England)"},{"issue":"4","key":"86917_CR11","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/bjh.12661","volume":"164","author":"A Kulagin","year":"2014","unstructured":"Kulagin, A. et al. Prognostic value of paroxysmal nocturnal haemoglobinuria clone presence in aplastic anaemia patients treated with combined immunosuppression: results of two-centre prospective study. Br. J. Haematol. 164 (4), 546\u2013554. https:\/\/doi.org\/10.1111\/bjh.12661 (2014).","journal-title":"Br. J. Haematol."},{"issue":"Suppl 1","key":"86917_CR12","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/ijlh.12500","volume":"38","author":"M Buttarello","year":"2016","unstructured":"Buttarello, M. Laboratory diagnosis of anemia: are the old and new red cell parameters useful in classification and treatment,  how?. Int. J. Lab. Hematol. 38 (Suppl 1), 123\u2013132. https:\/\/doi.org\/10.1111\/ijlh.12500 (2016).","journal-title":"how? Int. J. Lab. Hematol."},{"issue":"2","key":"86917_CR13","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3390\/ani14020349","volume":"14","author":"A Perez-Ecija","year":"2024","unstructured":"Perez-Ecija, A., Martinez, C., Fernandez-Casta\u00f1er, J. & Mendoza, F. J. The immature reticulocyte fraction (IRF) in the Sysmex XN-1000V Analyzer can differentiate between causes of regenerative and non-regenerative Anemia in Dogs and cats. Anim. Open Access J. MDPI 14 (2), 349. https:\/\/doi.org\/10.3390\/ani14020349 (2024).","journal-title":"Animals: Open. Access. J. MDPI"},{"issue":"9","key":"86917_CR14","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.3324\/haematol.2011.042622","volume":"96","author":"MG Afable","year":"2011","unstructured":"Afable, M. G. 2 et al. Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia. Haematologica 96 (9), 1269\u20131275. https:\/\/doi.org\/10.3324\/haematol.2011.042622 (2011).","journal-title":"Haematologica"},{"key":"86917_CR15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.lfs.2017.09.020","volume":"189","author":"HF Zhang","year":"2017","unstructured":"Zhang, H. F., Huang, Z. D., Wu, X. R., Li, Q. & Yu, Z. F. Comparison of T lymphocyte subsets in aplastic anemia and hypoplastic myelodysplastic syndromes. Life Sci. 189, 71\u201375. https:\/\/doi.org\/10.1016\/j.lfs.2017.09.020 (2017).","journal-title":"Life Sci."},{"issue":"8","key":"86917_CR16","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s00277-011-1177-4","volume":"90","author":"B H\u00f6chsmann","year":"2011","unstructured":"H\u00f6chsmann, B., Rojewski, M. & Schrezenmeier, H. Paroxysmal nocturnal hemoglobinuria (PNH): higher sensitivity and validity in diagnosis and serial monitoring by flow cytometric analysis of reticulocytes. Ann. Hematol. 90 (8), 887\u2013899. https:\/\/doi.org\/10.1007\/s00277-011-1177-4 (2011).","journal-title":"Ann. Hematol."},{"issue":"6","key":"86917_CR17","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/jcla.21712","volume":"28","author":"SA Yahng","year":"2014","unstructured":"Yahng, S. A. et al. New proposed guidelines for early identification of successful myeloid and erythroid engraftment in hematopoietic stem cell transplantation. J. Clin. Lab. Anal. 28 (6), 469\u2013477. https:\/\/doi.org\/10.1002\/jcla.21712 (2014).","journal-title":"J. Clin. Lab. Anal."},{"issue":"2","key":"86917_CR18","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/ped.13478","volume":"60","author":"F Stripeli","year":"2018","unstructured":"Stripeli, F. et al. Post-transfusion changes in serum hepcidin and iron parameters in preterm infants. Pediatr. Int. 60 (2), 148\u2013152. https:\/\/doi.org\/10.1111\/ped.13478 (2018).","journal-title":"Pediatr. Int."},{"issue":"1","key":"86917_CR19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.cll.2014.10.004","volume":"35","author":"E Piva","year":"2015","unstructured":"Piva, E., Brugnara, C., Spolaore, F. & Plebani, M. Clinical utility of reticulocyte parameters. Clin. Lab. Med. 35 (1), 133\u2013163. https:\/\/doi.org\/10.1016\/j.cll.2014.10.004 (2015).","journal-title":"Clin. Lab. Med."},{"issue":"6","key":"86917_CR20","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1111\/bjh.17403","volume":"194","author":"P Scheinberg","year":"2021","unstructured":"Scheinberg, P. Acquired severe aplastic anaemia: how medical therapy evolved in the 20th and 21st centuries. Br. J. Haematol. 194 (6), 954\u2013969. https:\/\/doi.org\/10.1111\/bjh.17403 (2021).","journal-title":"Br. J. Haematol."},{"issue":"3","key":"86917_CR21","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1001\/jama.282.3.271","volume":"282","author":"NS Young","year":"1999","unstructured":"Young, N. S. Acquired aplastic anemia. JAMA 282 (3), 271\u2013278. https:\/\/doi.org\/10.1001\/jama.282.3.271 (1999).","journal-title":"JAMA"},{"issue":"1","key":"86917_CR22","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3324\/haematol.2021.278413","volume":"107","author":"Y 17 Zaimoku","year":"2022","unstructured":"Zaimoku, Y. et al. Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag. Haematologica 107 (1), 126\u2013133. https:\/\/doi.org\/10.3324\/haematol.2021.278413 (2022).","journal-title":"Haematologica"},{"key":"86917_CR23","doi-asserted-by":"publisher","first-page":"884312","DOI":"10.3389\/fimmu.2022.884312","volume":"13","author":"R Li","year":"2022","unstructured":"Li, R. et al. Predicting response of severe aplastic Anemia to rabbit-antithymocyte immunoglobulin based immunosuppressive therapy combined with Eltrombopag. Front. Immunol. 13, 884312. https:\/\/doi.org\/10.3389\/fimmu.2022.884312 (2022).","journal-title":"Front. Immunol."},{"key":"86917_CR24","doi-asserted-by":"crossref","unstructured":"Scheinberg, P. et al. Predicting response to immunosuppressive therapy and survival in severe aplastic anaemia. Br. J.  Haematol. 144 (2), 206\u2013216. (2005).","DOI":"10.1111\/j.1365-2141.2008.07450.x"},{"key":"86917_CR25","doi-asserted-by":"crossref","unstructured":"Brodsky, R. A., & Jones, R. J. Aplastic anaemia. Lancet (London, England)  365 (9471), 1647\u20131656. (2005).","DOI":"10.1016\/S0140-6736(05)66515-4"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-86917-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-86917-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-86917-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T22:10:11Z","timestamp":1737670211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-86917-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["86917"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-86917-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,23]]},"assertion":[{"value":"5 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All procedures performed in studies involving human participants were following the ethical standards of the institutional research committee and with the Helsinki Declaration of 1975, as revised in 2008. Approval was obtained from the Ethics Committee of Shanxi Bethune Hospital. The Ethics Committee of Shanxi Bethune Hospital allowed the researchers to collect pseudonymized sociodemographic and morbidity relevant data from patients who gave Broad Consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"This retrospective study was approved by the institutional review board of Shanxi Bethune Hospital, and informed consent was waived.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"2946"}}