{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:58:39Z","timestamp":1771469919675,"version":"3.50.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260157"],"award-info":[{"award-number":["82260157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-87205-2","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T02:24:36Z","timestamp":1737512676000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comprehensive RNA-seq analysis of benign prostatic hyperplasia (BPH) in rats exposed to testosterone and estradiol"],"prefix":"10.1038","volume":"15","author":[{"given":"Xiao-Hu","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Wen","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Xin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Heng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"87205_CR1","doi-asserted-by":"publisher","first-page":"658","DOI":"10.3389\/fphar.2020.00658","volume":"11","author":"ZJ Yu","year":"2020","unstructured":"Yu, Z. J. et al. Efficacy and side effects of drugs commonly used for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia. Front. Pharmacol. 11, 658. https:\/\/doi.org\/10.3389\/fphar.2020.00658 (2020).","journal-title":"Front. Pharmacol."},{"key":"87205_CR2","doi-asserted-by":"publisher","first-page":"13181","DOI":"10.1111\/jcmm.15926","volume":"24","author":"W He","year":"2020","unstructured":"He, W. et al. Changes in the expression and function of the PDE5 pathway in the obstructed urinary bladder. J. Cell. Mol. Med. 24, 13181\u201313195. https:\/\/doi.org\/10.1111\/jcmm.15926 (2020).","journal-title":"J. Cell. Mol. Med."},{"key":"87205_CR3","doi-asserted-by":"publisher","unstructured":"Russo, G. I. et al. The Investigative Role of statins in ameliorating lower urinary tract symptoms (LUTS): a systematic review. J. Clin. Med. 10, 859. https:\/\/doi.org\/10.3390\/jcm10030416 (2021).","DOI":"10.3390\/jcm10030416"},{"key":"87205_CR4","doi-asserted-by":"publisher","unstructured":"Jin, B. R. et al. 6'-Sialyllactose ameliorates in vivo and in vitro benign prostatic hyperplasia by regulating the E2F1\/pRb-AR pathway. Nutrients 2019, 11. https:\/\/doi.org\/10.3390\/nu11092203  (2019).","DOI":"10.3390\/nu11092203"},{"key":"87205_CR5","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.eururo.2009.04.033","volume":"56","author":"H Porst","year":"2009","unstructured":"Porst, H. et al. Effects of once-daily tadalafil on erectile function in men with erectile dysfunction and signs and symptoms of benign prostatic hyperplasia. Eur. Urol. 56, 727\u2013735. https:\/\/doi.org\/10.1016\/j.eururo.2009.04.033 (2009).","journal-title":"Eur. Urol."},{"key":"87205_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.eururo.2008.02.017","volume":"54","author":"M Oelke","year":"2008","unstructured":"Oelke, M. et al. Age and bladder outlet obstruction are independently associated with detrusor overactivity in patients with benign prostatic hyperplasia. Eur. Urol. 54, 419\u2013426. https:\/\/doi.org\/10.1016\/j.eururo.2008.02.017 (2008).","journal-title":"Eur. Urol."},{"key":"87205_CR7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1146\/annurev-med-063014-123902","volume":"67","author":"EH Kim","year":"2016","unstructured":"Kim, E. H., Larson, J. A. & Andriole, G. L. Management of benign prostatic hyperplasia. Annu. Rev. Med. 67, 137\u2013151. https:\/\/doi.org\/10.1146\/annurev-med-063014-123902 (2016).","journal-title":"Annu. Rev. Med."},{"key":"87205_CR8","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.eururo.2005.11.027","volume":"50","author":"A Tavani","year":"2006","unstructured":"Tavani, A. et al. Intake of selected micronutrients and the risk of surgically treated benign prostatic hyperplasia: a case-control study from Italy. Eur. Urol. 50, 549\u2013554. https:\/\/doi.org\/10.1016\/j.eururo.2005.11.027 (2006).","journal-title":"Eur. Urol."},{"key":"87205_CR9","doi-asserted-by":"publisher","unstructured":"Kim, N. H. et al. The effects of aronia melanocarpa extract on testosterone-induced benign prostatic hyperplasia in rats, and quantitative analysis of major constituents depending on extract conditions. Nutrients 12, 859. https:\/\/doi.org\/10.3390\/nu12061575 (2020).","DOI":"10.3390\/nu12061575"},{"key":"87205_CR10","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3389\/fendo.2019.00225","volume":"10","author":"A Aversa","year":"2019","unstructured":"Aversa, A., Duca, Y., Condorelli, R. A., Calogero, A. E. & La Vignera, S. Androgen deficiency and phosphodiesterase type 5 expression changes in aging male: therapeutic implications. Front. Endocrinol. 10, 225. https:\/\/doi.org\/10.3389\/fendo.2019.00225 (2019).","journal-title":"Front. Endocrinol."},{"key":"87205_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2174\/156720507779939878","volume":"4","author":"I Driscoll","year":"2007","unstructured":"Driscoll, I. & Resnick, S. M. Testosterone and cognition in normal aging and Alzheimer\u2019s disease: an update. Curr. Alzheimer Res. 4, 33\u201345. https:\/\/doi.org\/10.2174\/156720507779939878 (2007).","journal-title":"Curr. Alzheimer Res."},{"key":"87205_CR12","doi-asserted-by":"publisher","first-page":"322","DOI":"10.21037\/tau.2020.02.08","volume":"9","author":"B Chen","year":"2020","unstructured":"Chen, B. et al. Estrogen regulates the proliferation and inflammatory expression of primary stromal cell in benign prostatic hyperplasia. Translational Androl. Urol. 9, 322\u2013331. https:\/\/doi.org\/10.21037\/tau.2020.02.08 (2020).","journal-title":"Translational Androl. Urol."},{"key":"87205_CR13","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/art.42281","volume":"75","author":"EDO Roberson","year":"2023","unstructured":"Roberson, E. D. O. et al. Alterations of the primary cilia gene SPAG17 and SOX9 locus noncoding RNAs identified by RNA-Sequencing analysis in patients with systemic sclerosis. Arthritis Rheumatol. 75, 108\u2013119. https:\/\/doi.org\/10.1002\/art.42281 (2023).","journal-title":"Arthritis Rheumatol."},{"key":"87205_CR14","doi-asserted-by":"publisher","first-page":"17958","DOI":"10.3390\/ijms140917958","volume":"14","author":"K Zins","year":"2013","unstructured":"Zins, K. et al. Inhibition of stromal PlGF suppresses the growth of prostate cancer xenografts. Int. J. Mol. Sci. 14, 17958\u201317971. https:\/\/doi.org\/10.3390\/ijms140917958 (2013).","journal-title":"Int. J. Mol. Sci."},{"key":"87205_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41391-020-00277-1","volume":"24","author":"J Zhang","year":"2021","unstructured":"Zhang, J. et al. Animal models of benign prostatic hyperplasia. Prostate Cancer Prostatic Dis. 24, 49\u201357. https:\/\/doi.org\/10.1038\/s41391-020-00277-1 (2021).","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"87205_CR16","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3389\/fphar.2020.00311","volume":"11","author":"XF Xu","year":"2020","unstructured":"Xu, X. F. et al. \u03b11-Blockers and 5\u03b1-Reductase inhibitors are the most recommended drugs in treating Benign Prostatic Hyperplasia: an evidence-based evaluation of clinical practice guidelines. Front. Pharmacol. 11, 311. https:\/\/doi.org\/10.3389\/fphar.2020.00311 (2020).","journal-title":"Front. Pharmacol."},{"key":"87205_CR17","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41419-018-0744-1","volume":"9","author":"J Sheng","year":"2018","unstructured":"Sheng, J. et al. M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia. Cell. Death Dis. 9, 755. https:\/\/doi.org\/10.1038\/s41419-018-0744-1 (2018).","journal-title":"Cell. Death Dis."},{"key":"87205_CR18","doi-asserted-by":"publisher","first-page":"e12590","DOI":"10.1111\/cpr.12590","volume":"52","author":"BY Yang","year":"2019","unstructured":"Yang, B. Y. et al. 5-ARI induces autophagy of prostate epithelial cells through suppressing IGF-1 expression in prostate fibroblasts. Cell. Prolif. 52, e12590. https:\/\/doi.org\/10.1111\/cpr.12590 (2019).","journal-title":"Cell. Prolif."},{"key":"87205_CR19","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/s41598-017-18869-8","volume":"8","author":"DY Huang","year":"2018","unstructured":"Huang, D. Y. et al. Oral exposure of low-dose bisphenol A promotes proliferation of dorsolateral prostate and induces epithelial-mesenchymal transition in aged rats. Sci. Rep. 8, 490. https:\/\/doi.org\/10.1038\/s41598-017-18869-8 (2018).","journal-title":"Sci. Rep."},{"key":"87205_CR20","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.1007\/s11010-023-04695-2","volume":"478","author":"X Tang","year":"2023","unstructured":"Tang, X. et al. Comparative RNA-sequencing analysis of the prostate in a mouse model of benign prostatic hyperplasia with bladder outlet obstruction. Mol. Cell. Biochem. 478, 2721\u20132737. https:\/\/doi.org\/10.1007\/s11010-023-04695-2 (2023).","journal-title":"Mol. Cell. Biochem."},{"key":"87205_CR21","doi-asserted-by":"publisher","unstructured":"Chen, X. et al. Regulation of microRNAs by rape bee pollen on benign prostate hyperplasia in rats. Andrologia 52, e13386. https:\/\/doi.org\/10.1111\/and.13386 (2020).","DOI":"10.1111\/and.13386"},{"key":"87205_CR22","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4103\/ua.Ua_118_18","volume":"12","author":"V Agrawal","year":"2020","unstructured":"Agrawal, V., Khullar, R. & Jha, A. K. Assessment of posterior urethra in benign prostatic hyperplasia and after its surgery. Urol. Ann. 12, 63\u201368. https:\/\/doi.org\/10.4103\/ua.Ua_118_18 (2020).","journal-title":"Urol. Ann."},{"key":"87205_CR23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40779-022-00373-4","volume":"9","author":"LY Li","year":"2022","unstructured":"Li, L. Y. et al. Alterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats. Mil Med. Res. 9, 12. https:\/\/doi.org\/10.1186\/s40779-022-00373-4 (2022).","journal-title":"Mil Med. Res."},{"key":"87205_CR24","doi-asserted-by":"publisher","first-page":"102816","DOI":"10.1016\/j.redox.2023.102816","volume":"65","author":"BR Jin","year":"2023","unstructured":"Jin, B. R., Lim, C. Y., Kim, H. J., Lee, M. & An, H. J. Antioxidant mitoquinone suppresses benign prostatic hyperplasia by regulating the AR-NLRP3 pathway. Redox Biol. 65, 102816. https:\/\/doi.org\/10.1016\/j.redox.2023.102816 (2023).","journal-title":"Redox Biol."},{"key":"87205_CR25","doi-asserted-by":"publisher","unstructured":"Kim, M., Tran, P., Yin, J., Song, J. & Kim, H. Cinnamomum cassia and Rosa laevigata mixture improves benign prostatic hyperplasia in rats by regulating androgen receptor signaling and apoptosis. Nutrients 15 https:\/\/doi.org\/10.3390\/nu15040818 (2023).","DOI":"10.3390\/nu15040818"},{"key":"87205_CR26","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1186\/s12864-021-08146-4","volume":"22","author":"D Li","year":"2021","unstructured":"Li, D. et al. Baiting out a full length sequence from unmapped RNA-seq data. BMC Genom. 22, 857. https:\/\/doi.org\/10.1186\/s12864-021-08146-4 (2021).","journal-title":"BMC Genom."},{"key":"87205_CR27","doi-asserted-by":"publisher","unstructured":"Verdes, A. et al. Expression patterns, and distribution of novel ribbon worm predatory and defensive toxins. Mol. Biol. Evol. 39, 589. https:\/\/doi.org\/10.1093\/molbev\/msac096 (2022).","DOI":"10.1093\/molbev\/msac096"},{"key":"87205_CR28","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/s41591-022-01789-0","volume":"28","author":"F Rivellese","year":"2022","unstructured":"Rivellese, F. et al. Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial. Nat. Med. 28, 1256\u20131268. https:\/\/doi.org\/10.1038\/s41591-022-01789-0 (2022).","journal-title":"Nat. Med."},{"key":"87205_CR29","doi-asserted-by":"publisher","unstructured":"Ramshekar, A., Bretz, C. A. & Hartnett, M. E. RNA-Seq provides insights into VEGF-Induced Signaling in Human Retinal Microvascular endothelial cells: implications in retinopathy of Prematurity. Int. J. Mol. Sci. 23, 896. https:\/\/doi.org\/10.3390\/ijms23137354 (2022).","DOI":"10.3390\/ijms23137354"},{"key":"87205_CR30","doi-asserted-by":"publisher","first-page":"135298","DOI":"10.1016\/j.chemosphere.2022.135298","volume":"304","author":"VC de Leeuw","year":"2022","unstructured":"de Leeuw, V. C. et al. Neuronal differentiation pathways and compound-induced developmental neurotoxicity in the human neural progenitor cell test (hNPT) revealed by RNA-seq. Chemosphere 304, 135298. https:\/\/doi.org\/10.1016\/j.chemosphere.2022.135298 (2022).","journal-title":"Chemosphere"},{"key":"87205_CR31","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13059-020-02222-w","volume":"22","author":"J Yang","year":"2021","unstructured":"Yang, J. et al. Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma. Genome Biol. 22, 4. https:\/\/doi.org\/10.1186\/s13059-020-02222-w (2021).","journal-title":"Genome Biol."},{"key":"87205_CR32","doi-asserted-by":"publisher","first-page":"782054","DOI":"10.3389\/fmolb.2021.782054","volume":"8","author":"F Liu","year":"2021","unstructured":"Liu, F., Dong, J., Zhang, P., Zhou, D. & Zhang, Q. Transcriptome sequencing reveals key genes in three early phases of osteogenic, adipogenic, and Chondrogenic differentiation of bone marrow mesenchymal stem cells in rats. Front. Mol. Biosci. 8, 782054. https:\/\/doi.org\/10.3389\/fmolb.2021.782054 (2021).","journal-title":"Front. Mol. Biosci."},{"key":"87205_CR33","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41421-022-00377-3","volume":"8","author":"W Tan","year":"2022","unstructured":"Tan, W.. et al. Distinct phases of adult microglia proliferation: a myc-mediated early phase and a Tnfaip3-mediated late phase. Cell. Discov 8, 34. https:\/\/doi.org\/10.1038\/s41421-022-00377-3 (2022).","journal-title":"Cell. Discov."},{"key":"87205_CR34","doi-asserted-by":"publisher","first-page":"e1011858","DOI":"10.1371\/journal.pcbi.1011858","volume":"20","author":"M Bougu\u00e9on","year":"2024","unstructured":"Bougu\u00e9on, M. et al. A rule-based multiscale model of hepatic stellate cell plasticity: critical role of the inactivation loop in fibrosis progression. PLoS Comput. Biol. 20, e1011858. https:\/\/doi.org\/10.1371\/journal.pcbi.1011858 (2024).","journal-title":"PLoS Comput. Biol."},{"key":"87205_CR35","doi-asserted-by":"publisher","unstructured":"Chu, F. et al. The genetic and immunologic landscape underlying the risk of malignant progression in laryngeal dysplasia. Cancers 15, 8963. https:\/\/doi.org\/10.3390\/cancers15041117 (2023).","DOI":"10.3390\/cancers15041117"},{"key":"87205_CR36","doi-asserted-by":"publisher","first-page":"7036","DOI":"10.1038\/s41467-022-34534-9","volume":"13","author":"D Guerrero","year":"2022","unstructured":"Guerrero, D. et al. Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites. Nat. Commun. 13, 7036. https:\/\/doi.org\/10.1038\/s41467-022-34534-9 (2022).","journal-title":"Nat. Commun."},{"key":"87205_CR37","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.7150\/thno.82995","volume":"13","author":"L Guo","year":"2023","unstructured":"Guo, L. et al. PER2 integrates circadian disruption and pituitary tumorigenesis. Theranostics 13, 2657\u20132672. https:\/\/doi.org\/10.7150\/thno.82995 (2023).","journal-title":"Theranostics"},{"key":"87205_CR38","doi-asserted-by":"publisher","first-page":"5878","DOI":"10.1038\/s41467-022-33165-4","volume":"13","author":"C Aguilar","year":"2022","unstructured":"Aguilar, C. et al. Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis. Nat. Commun. 13, 5878. https:\/\/doi.org\/10.1038\/s41467-022-33165-4 (2022).","journal-title":"Nat. Commun."},{"key":"87205_CR39","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3892\/mmr.2019.10241","volume":"20","author":"YJ Zhang","year":"2019","unstructured":"Zhang, Y. J., Sun, Y. Z., Gao, X. H. & Qi, R. Q. Integrated bioinformatic analysis of differentially expressed genes and signaling pathways in plaque psoriasis. Mol. Med. Rep. 20, 225\u2013235. https:\/\/doi.org\/10.3892\/mmr.2019.10241 (2019).","journal-title":"Mol. Med. Rep."},{"key":"87205_CR40","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.1038\/s41467-018-05429-5","volume":"9","author":"G de C\u00e1rcer","year":"2018","unstructured":"de C\u00e1rcer, G. et al. Plk1 overexpression induces chromosomal instability and suppresses tumor development. Nat. Commun. 9, 3012. https:\/\/doi.org\/10.1038\/s41467-018-05429-5 (2018).","journal-title":"Nat. Commun."},{"key":"87205_CR41","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1002\/hep.30109","volume":"69","author":"B Bhushan","year":"2019","unstructured":"Bhushan, B. et al. TCPOBOP-Induced hepatomegaly and hepatocyte proliferation are attenuated by combined disruption of MET and EGFR Signaling. Hepatol. (Baltimore Md). 69, 1702\u20131718. https:\/\/doi.org\/10.1002\/hep.30109 (2019).","journal-title":"Hepatol. (Baltimore Md)"},{"key":"87205_CR42","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/s41467-018-07863-x","volume":"10","author":"S Haworth","year":"2019","unstructured":"Haworth, S. et al. Low-frequency variation in TP53 has large effects on head circumference and intracranial volume. Nat. Commun. 10, 357. https:\/\/doi.org\/10.1038\/s41467-018-07863-x (2019).","journal-title":"Nat. Commun."},{"key":"87205_CR43","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/ni.2262","volume":"13","author":"D Malhotra","year":"2012","unstructured":"Malhotra, D. et al. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat. Immunol. 13, 499\u2013510. https:\/\/doi.org\/10.1038\/ni.2262 (2012).","journal-title":"Nat. Immunol."},{"key":"87205_CR44","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3389\/fgene.2018.00256","volume":"9","author":"P Li","year":"2018","unstructured":"Li, P. et al. Messenger RNA sequencing and pathway analysis provide novel insights into the susceptibility to Salmonella enteritidis  infection in chickens. Front. Genet. 9, 256. https:\/\/doi.org\/10.3389\/fgene.2018.00256 (2018).","journal-title":"Front. Genet."},{"key":"87205_CR45","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1038\/s41467-019-10448-x","volume":"10","author":"G Br\u00e4nd\u00e9n","year":"2019","unstructured":"Br\u00e4nd\u00e9n, G. et al. Coherent diffractive imaging of microtubules using an X-ray laser. Nat. Commun. 10, 2589. https:\/\/doi.org\/10.1038\/s41467-019-10448-x (2019).","journal-title":"Nat. Commun."},{"key":"87205_CR46","doi-asserted-by":"publisher","unstructured":"Feng, Q. et al. ID09, A newly-designed tubulin inhibitor, regulating the proliferation, migration, EMT process and apoptosis of oral squamous cell carcinoma. Int. J. Biol. Sci. 18, 473\u2013490. https:\/\/doi.org\/10.7150\/ijbs.65824  (2022).","DOI":"10.7150\/ijbs.65824"},{"key":"87205_CR47","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1038\/s41598-022-05549-5","volume":"12","author":"N Kazmi","year":"2022","unstructured":"Kazmi, N. et al. Rho GTPase gene expression and breast cancer risk: a mendelian randomization analysis. Sci. Rep. 12, 1463. https:\/\/doi.org\/10.1038\/s41598-022-05549-5 (2022).","journal-title":"Sci. Rep."},{"key":"87205_CR48","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/s41419-021-04198-2","volume":"12","author":"Y Yan","year":"2021","unstructured":"Yan, Y. et al. Sulforaphane downregulated fatty acid synthase and inhibited microtubule-mediated mitophagy leading to apoptosis. Cell. Death Dis. 12, 917. https:\/\/doi.org\/10.1038\/s41419-021-04198-2 (2021).","journal-title":"Cell. Death Dis."},{"key":"87205_CR49","doi-asserted-by":"publisher","first-page":"572708","DOI":"10.3389\/fonc.2020.572708","volume":"10","author":"Z Zhou","year":"2020","unstructured":"Zhou, Z. et al. Hematopoietic gene expression regulation through m(6)a methylation predicts prognosis in stage III colorectal cancer. Front. Oncol. 10, 572708. https:\/\/doi.org\/10.3389\/fonc.2020.572708 (2020).","journal-title":"Front. Oncol."},{"key":"87205_CR50","doi-asserted-by":"publisher","first-page":"8605","DOI":"10.18632\/aging.103175","volume":"12","author":"H Xiao","year":"2020","unstructured":"Xiao, H. et al. Identification and functional activity of matrix-remodeling associated 5 (MXRA5) in benign hyperplastic prostate. Aging 12, 8605\u20138621. https:\/\/doi.org\/10.18632\/aging.103175 (2020).","journal-title":"Aging"},{"key":"87205_CR51","doi-asserted-by":"publisher","first-page":"e105432","DOI":"10.15252\/embj.2020105432","volume":"39","author":"Y Steblyanko","year":"2020","unstructured":"Steblyanko, Y. et al. Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins. EMBO J. 39, e105432. https:\/\/doi.org\/10.15252\/embj.2020105432 (2020).","journal-title":"EMBO J."},{"key":"87205_CR52","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.devcel.2021.04.005","volume":"56","author":"K Vuku\u0161i\u0107","year":"2021","unstructured":"Vuku\u0161i\u0107, K., Ponjavi\u0107, I., Bu\u0111a, R., Risteski, P. & Toli\u0107, I. M. Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation. Dev. Cell. 56, 1253\u20131267e1210. https:\/\/doi.org\/10.1016\/j.devcel.2021.04.005 (2021).","journal-title":"Dev. Cell."},{"key":"87205_CR53","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.semcdb.2021.03.014","volume":"117","author":"JR Paulson","year":"2021","unstructured":"Paulson, J. R., Hudson, D. F., Cisneros-Soberanis, F. & Earnshaw, W. C. Mitotic chromosomes. Semin. Cell Dev. Biol. 117, 7\u201329. https:\/\/doi.org\/10.1016\/j.semcdb.2021.03.014 (2021).","journal-title":"Semin. Cell Dev. Biol."},{"key":"87205_CR54","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1182\/blood.2021012924","volume":"139","author":"D Kumar","year":"2022","unstructured":"Kumar, D. et al. T-follicular helper cell expansion and chronic T-cell activation are characteristic immune anomalies in Evans syndrome. Blood 139, 369\u2013383. https:\/\/doi.org\/10.1182\/blood.2021012924 (2022).","journal-title":"Blood"},{"key":"87205_CR55","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.placenta.2009.07.005","volume":"30","author":"L Sati","year":"2009","unstructured":"Sati, L., Seval-Celik, Y., Unek, G., Korgun, E. T. & Demir, R. The presence of kinesin superfamily motor proteins KIFC1 and KIF17 in normal and pathological human placenta. Placenta 30, 848\u2013854. https:\/\/doi.org\/10.1016\/j.placenta.2009.07.005 (2009).","journal-title":"Placenta"},{"key":"87205_CR56","doi-asserted-by":"publisher","first-page":"101227","DOI":"10.1016\/j.arr.2020.101227","volume":"65","author":"T Lan","year":"2021","unstructured":"Lan, T., Shiyu, H., Shen, Z., Yan, B. & Chen, J. New insights into the interplay between miRNAs and autophagy in the aging of intervertebral discs. Ageing Res. Rev. 65, 101227. https:\/\/doi.org\/10.1016\/j.arr.2020.101227 (2021).","journal-title":"Ageing Res. Rev."},{"key":"87205_CR57","doi-asserted-by":"publisher","unstructured":"Liu, L. et al. miRNA Regulation network analysis in qianliening capsule treatment of benign prostatic hyperplasia. Evid. Based Complement. Altern. Medicine: eCAM 2015, 365484. https:\/\/doi.org\/10.1155\/2015\/365484 (2015).","DOI":"10.1155\/2015\/365484"},{"key":"87205_CR58","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","volume":"38","author":"MJ Goldman","year":"2020","unstructured":"Goldman, M. J. et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat. Biotechnol. 38, 675\u2013678. https:\/\/doi.org\/10.1038\/s41587-020-0546-8 (2020).","journal-title":"Nat. Biotechnol."},{"key":"87205_CR59","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.cell.2019.12.023","volume":"180","author":"DP Nusinow","year":"2020","unstructured":"Nusinow, D. P. et al. Quantitative proteomics of the cancer cell line encyclopedia. Cell 180, 387\u2013402e316. https:\/\/doi.org\/10.1016\/j.cell.2019.12.023 (2020).","journal-title":"Cell"},{"key":"87205_CR60","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12935-021-02438-1","volume":"22","author":"Y Quan","year":"2022","unstructured":"Quan, Y., Zhang, X. & Ping, H. Construction of a risk prediction model using m6A RNA methylation regulators in prostate cancer: comprehensive bioinformatic analysis and histological validation. Cancer Cell. Int. 22, 33. https:\/\/doi.org\/10.1186\/s12935-021-02438-1 (2022).","journal-title":"Cancer Cell. Int."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87205-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87205-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87205-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T02:24:39Z","timestamp":1737512679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87205-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["87205"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-87205-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"16 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2750"}}