{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:59:30Z","timestamp":1782932370487,"version":"3.54.5"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-87252-9","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T12:31:06Z","timestamp":1737981066000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cross-sectional study of proteomic differences between moderate and severe psoriasis"],"prefix":"10.1038","volume":"15","author":[{"given":"Lingling","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibo","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"87252_CR1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jaad.2016.07.064","volume":"76","author":"J Takeshita","year":"2017","unstructured":"Takeshita, J. et al. Psoriasis and comorbid diseases. J. Am. Acad. Dermatol. 76, 377\u2013390. https:\/\/doi.org\/10.1016\/j.jaad.2016.07.064 (2017).","journal-title":"J. Am. Acad. Dermatol."},{"key":"87252_CR2","doi-asserted-by":"publisher","unstructured":"Kimball, A. B. et al. Risks of developing psychiatric disorders in pediatric patients with psoriasis. J. Am. Acad. Dermatol. 67, 651\u2013657.e651-652, (2012). https:\/\/doi.org\/10.1016\/j.jaad.2011.11.948","DOI":"10.1016\/j.jaad.2011.11.948"},{"key":"87252_CR3","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1016\/s0140-6736(18)30949-8","volume":"391","author":"F Van den Bosch","year":"2018","unstructured":"Van den Bosch, F. & Coates, L. Clinical management of psoriatic arthritis. Lancet 391, 2285\u20132294. https:\/\/doi.org\/10.1016\/s0140-6736(18)30949-8 (2018).","journal-title":"Lancet"},{"key":"87252_CR4","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/s0140-6736(20)32549-6","volume":"397","author":"CEM Griffiths","year":"2021","unstructured":"Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E. & Barker J. Psoriasis Lancet 397, 1301\u20131315, doi:https:\/\/doi.org\/10.1016\/s0140-6736(20)32549-6 (2021).","journal-title":"J. Psoriasis Lancet"},{"key":"87252_CR5","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1080\/09546634.2019.1688756","volume":"32","author":"N Sutaria","year":"2021","unstructured":"Sutaria, N. & Au, S. C. Failure rates and survival times of systemic and biologic therapies in treating psoriasis: A retrospective study. J. Dermatolog Treat. 32, 617\u2013620. https:\/\/doi.org\/10.1080\/09546634.2019.1688756 (2021).","journal-title":"J. Dermatolog Treat."},{"key":"87252_CR6","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.jaad.2020.10.094","volume":"84","author":"YA Elnabawi","year":"2021","unstructured":"Elnabawi, Y. A. et al. CCL20 in psoriasis: A potential biomarker of disease severity, inflammation, and impaired vascular health. J. Am. Acad. Dermatol. 84, 913\u2013920. https:\/\/doi.org\/10.1016\/j.jaad.2020.10.094 (2021).","journal-title":"J. Am. Acad. Dermatol."},{"key":"87252_CR7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.jaad.2020.04.138","volume":"84","author":"JW Glickman","year":"2021","unstructured":"Glickman, J. W. et al. Cross-sectional study of blood biomarkers of patients with moderate to severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation. J. Am. Acad. Dermatol. 84, 370\u2013380. https:\/\/doi.org\/10.1016\/j.jaad.2020.04.138 (2021).","journal-title":"J. Am. Acad. Dermatol."},{"key":"87252_CR8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jdermsci.2023.07.005","volume":"111","author":"J Deng","year":"2023","unstructured":"Deng, J. et al. Multi-omics approach identifies PI3 as a biomarker for disease severity and hyper-keratinization in psoriasis. J. Dermatol. Sci. 111, 101\u2013108. https:\/\/doi.org\/10.1016\/j.jdermsci.2023.07.005 (2023).","journal-title":"J. Dermatol. Sci."},{"key":"87252_CR9","doi-asserted-by":"publisher","unstructured":"Wang, X. et al. IL-17 pathway members as potential biomarkers of effective systemic treatment and Cardiovascular Disease in patients with moderate-to-severe psoriasis. Int. J. Mol. Sci. 23 https:\/\/doi.org\/10.3390\/ijms23010555 (2022).","DOI":"10.3390\/ijms23010555"},{"key":"87252_CR10","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1093\/rheumatology\/keaa405","volume":"60","author":"E Leijten","year":"2021","unstructured":"Leijten, E. et al. Broad proteomic screen reveals shared serum proteomic signature in patients with psoriatic arthritis and psoriasis without arthritis. Rheumatol. (Oxford). 60, 751\u2013761. https:\/\/doi.org\/10.1093\/rheumatology\/keaa405 (2021).","journal-title":"Rheumatol. (Oxford)"},{"key":"87252_CR11","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.jaad.2021.07.035","volume":"86","author":"K Navrazhina","year":"2022","unstructured":"Navrazhina, K. et al. The inflammatory proteome of hidradenitis suppurativa skin is more expansive than that of psoriasis vulgaris. J. Am. Acad. Dermatol. 86, 322\u2013330. https:\/\/doi.org\/10.1016\/j.jaad.2021.07.035 (2022).","journal-title":"J. Am. Acad. Dermatol."},{"key":"87252_CR12","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1111\/bjd.20642","volume":"186","author":"K Navrazhina","year":"2022","unstructured":"Navrazhina, K. et al. Large-scale serum analysis identifies unique systemic biomarkers in psoriasis and hidradenitis suppurativa. Br. J. Dermatol. 186, 684\u2013693. https:\/\/doi.org\/10.1111\/bjd.20642 (2022).","journal-title":"Br. J. Dermatol."},{"key":"87252_CR13","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1111\/bjd.18807","volume":"182","author":"M Maurelli","year":"2020","unstructured":"Maurelli, M. et al. Psoriasin (S100A7) is increased in the serum of patients with moderate-to-severe psoriasis. Br. J. Dermatol. 182, 1502\u20131503. https:\/\/doi.org\/10.1111\/bjd.18807 (2020).","journal-title":"Br. J. Dermatol."},{"key":"87252_CR14","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1111\/1346-8138.16032","volume":"48","author":"Y Matsunaga","year":"2021","unstructured":"Matsunaga, Y., Hashimoto, Y. & Ishiko, A. Stratum corneum levels of calprotectin proteins S100A8\/A9 correlate with disease activity in psoriasis patients. J. Dermatol. 48, 1518\u20131525. https:\/\/doi.org\/10.1111\/1346-8138.16032 (2021).","journal-title":"J. Dermatol."},{"key":"87252_CR15","doi-asserted-by":"publisher","first-page":"11382","DOI":"10.1038\/s41598-019-47774-5","volume":"9","author":"E Sz\u00e9l","year":"2019","unstructured":"Sz\u00e9l, E. et al. Comprehensive proteomic analysis reveals intermediate stage of non-lesional psoriatic skin and points out the importance of proteins outside this trend. Sci. Rep. 9, 11382. https:\/\/doi.org\/10.1038\/s41598-019-47774-5 (2019).","journal-title":"Sci. Rep."},{"key":"87252_CR16","doi-asserted-by":"publisher","first-page":"e0240956","DOI":"10.1371\/journal.pone.0240956","volume":"16","author":"VV Sobolev","year":"2021","unstructured":"Sobolev, V. V. et al. LC-MS\/MS analysis of lesional and normally looking psoriatic skin reveals significant changes in protein metabolism and RNA processing. PLoS One. 16, e0240956. https:\/\/doi.org\/10.1371\/journal.pone.0240956 (2021).","journal-title":"PLoS One"},{"key":"87252_CR17","doi-asserted-by":"publisher","first-page":"104207","DOI":"10.1016\/j.jprot.2021.104207","volume":"240","author":"W Wang","year":"2021","unstructured":"Wang, W. et al. Proteomic analysis of psoriatic skin lesions in a Chinese population. J. Proteom. 240, 104207. https:\/\/doi.org\/10.1016\/j.jprot.2021.104207 (2021).","journal-title":"J. Proteom."},{"key":"87252_CR18","doi-asserted-by":"publisher","first-page":"141","DOI":"10.6026\/97320630018141","volume":"18","author":"SR Shah","year":"2022","unstructured":"Shah, S. R., Mohanty, V., Chaudhury, D., Prasad, T. S. K. & Shenoy, M. M. Evaluation of serum proteome from Indian psoriasis patients. Bioinformation 18, 141\u2013146. https:\/\/doi.org\/10.6026\/97320630018141 (2022).","journal-title":"Bioinformation"},{"key":"87252_CR19","doi-asserted-by":"publisher","unstructured":"Tanca, A. et al. A straightforward and efficient analytical pipeline for metaproteome characterization. Microbiome 2 https:\/\/doi.org\/10.1186\/s40168-014-0049-2 (2014).","DOI":"10.1186\/s40168-014-0049-2"},{"key":"87252_CR20","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1021\/pr101060v","volume":"10","author":"A Michalski","year":"2011","unstructured":"Michalski, A., Cox, J. & Mann, M. More than 100,000 detectable peptide species elute in single shotgun proteomics runs but the majority is inaccessible to data-dependent LC-MS\/MS. J. Proteome Res. 10, 1785\u20131793. https:\/\/doi.org\/10.1021\/pr101060v (2011).","journal-title":"J. Proteome Res."},{"key":"87252_CR21","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1080\/14789450.2016.1209418","volume":"13","author":"T Muth","year":"2016","unstructured":"Muth, T., Renard, B. Y. & Martens, L. Metaproteomic data analysis at a glance: Advances in computational microbial community proteomics. Expert Rev. Proteom. 13, 757\u2013769. https:\/\/doi.org\/10.1080\/14789450.2016.1209418 (2016).","journal-title":"Expert Rev. Proteom."},{"key":"87252_CR22","doi-asserted-by":"publisher","first-page":"e8126","DOI":"10.15252\/msb.20178126","volume":"14","author":"C Ludwig","year":"2018","unstructured":"Ludwig, C. et al. Data-independent acquisition-based SWATH-MS for quantitative proteomics: a tutorial. Mol. Syst. Biol. 14, e8126. https:\/\/doi.org\/10.15252\/msb.20178126 (2018).","journal-title":"Mol. Syst. Biol."},{"key":"87252_CR23","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.7150\/thno.31144","volume":"9","author":"M Xu","year":"2019","unstructured":"Xu, M. et al. In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine. Theranostics 9, 2475\u20132488. https:\/\/doi.org\/10.7150\/thno.31144 (2019).","journal-title":"Theranostics"},{"key":"87252_CR24","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jid.2018.04.041","volume":"139","author":"AC Foulkes","year":"2019","unstructured":"Foulkes, A. C. et al. A framework for multi-omic prediction of treatment response to biologic therapy for psoriasis. J. Invest. Dermatol. 139, 100\u2013107. https:\/\/doi.org\/10.1016\/j.jid.2018.04.041 (2019).","journal-title":"J. Invest. Dermatol."},{"key":"87252_CR25","doi-asserted-by":"publisher","first-page":"2248318","DOI":"10.1080\/09546634.2023.2248318","volume":"34","author":"J Cui","year":"2023","unstructured":"Cui, J. et al. Potential biomarkers for psoriasis topical treatment by in-depth serum proteomics. J. Dermatolog Treat. 34, 2248318. https:\/\/doi.org\/10.1080\/09546634.2023.2248318 (2023).","journal-title":"J. Dermatolog Treat."},{"key":"87252_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02044-z","author":"X Zheng","year":"2024","unstructured":"Zheng, X. et al. Mass spectrometry-based proteomics analysis unveils PTPRS inhibits proliferation and inflammatory response of keratinocytes in Psoriasis. Inflammation https:\/\/doi.org\/10.1007\/s10753-024-02044-z (2024).","journal-title":"Inflammation"},{"key":"87252_CR27","doi-asserted-by":"publisher","first-page":"1015182","DOI":"10.3389\/fimmu.2022.1015182","volume":"13","author":"Q Dong","year":"2022","unstructured":"Dong, Q. et al. IL-17A and TNF-\u03b1 inhibitors induce multiple molecular changes in psoriasis. Front. Immunol. 13, 1015182. https:\/\/doi.org\/10.3389\/fimmu.2022.1015182 (2022).","journal-title":"Front. Immunol."},{"key":"87252_CR28","doi-asserted-by":"publisher","first-page":"116112","DOI":"10.1016\/j.jep.2022.116112","volume":"305","author":"H Zhou","year":"2023","unstructured":"Zhou, H. et al. Analysis of the mechanism of Buyang Huanwu decoction against cerebral ischemia-reperfusion by multi-omics. J. Ethnopharmacol. 305, 116112. https:\/\/doi.org\/10.1016\/j.jep.2022.116112 (2023).","journal-title":"J. Ethnopharmacol."},{"key":"87252_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"87252_CR30","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"key":"87252_CR31","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013d592. https:\/\/doi.org\/10.1093\/nar\/gkac963 (2023).","journal-title":"Nucleic Acids Res."},{"key":"87252_CR32","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13073-015-0208-5","volume":"7","author":"WR Swindell","year":"2015","unstructured":"Swindell, W. R. et al. Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance. Genome Med. 7, 86. https:\/\/doi.org\/10.1186\/s13073-015-0208-5 (2015).","journal-title":"Genome Med."},{"key":"87252_CR33","doi-asserted-by":"publisher","first-page":"e15079","DOI":"10.1111\/exd.15079","volume":"33","author":"T Traks","year":"2024","unstructured":"Traks, T. et al. High-throughput proteomic analysis of chronic inflammatory skin diseases: Psoriasis and atopic dermatitis. Exp. Dermatol. 33, e15079. https:\/\/doi.org\/10.1111\/exd.15079 (2024).","journal-title":"Exp. Dermatol."},{"key":"87252_CR34","doi-asserted-by":"publisher","unstructured":"Li, Y. et al. Quantitative analysis of differentially expressed proteins in psoriasis vulgaris using tandem mass tags and parallel reaction monitoring. Clin. Proteom. 17 https:\/\/doi.org\/10.1186\/s12014-020-09293-8 (2020).","DOI":"10.1186\/s12014-020-09293-8"},{"key":"87252_CR35","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1159\/000533981","volume":"240","author":"B Kromann","year":"2024","unstructured":"Kromann, B. et al. Proteins in the skin and blood in patients with psoriasis: A systematic review of Proteomic studies. Dermatology 240, 317\u2013328. https:\/\/doi.org\/10.1159\/000533981 (2024).","journal-title":"Dermatology"},{"key":"87252_CR36","doi-asserted-by":"publisher","first-page":"5601","DOI":"10.1158\/1078-0432.Ccr-14-3308","volume":"21","author":"CY Chiang","year":"2015","unstructured":"Chiang, C. Y. et al. SH3BGRL3 protein as a potential prognostic biomarker for Urothelial Carcinoma: A novel binding partner of epidermal growth factor receptor. Clin. Cancer Res. 21, 5601\u20135611. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-14-3308 (2015).","journal-title":"Clin. Cancer Res."},{"key":"87252_CR37","doi-asserted-by":"publisher","first-page":"14048","DOI":"10.1039\/c8ra00744f","volume":"8","author":"S Zhang","year":"2018","unstructured":"Zhang, S. et al. Differential CRABP-II and FABP5 expression patterns and implications for medulloblastoma retinoic acid sensitivity. RSC Adv. 8, 14048\u201314055. https:\/\/doi.org\/10.1039\/c8ra00744f (2018).","journal-title":"RSC Adv."},{"key":"87252_CR38","doi-asserted-by":"publisher","first-page":"108805","DOI":"10.1016\/j.isci.2024.108805","volume":"27","author":"E Cohen","year":"2024","unstructured":"Cohen, E. et al. Significance of stress keratin expression in normal and diseased epithelia. iScience 27, 108805. https:\/\/doi.org\/10.1016\/j.isci.2024.108805 (2024).","journal-title":"iScience"},{"key":"87252_CR39","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1016\/j.jid.2017.06.005","volume":"137","author":"M Jiang","year":"2017","unstructured":"Jiang, M. et al. TGF\u03b2\/SMAD\/microRNA-486-3p signaling Axis mediates keratin 17 expression and keratinocyte hyperproliferation in Psoriasis. J. Invest. Dermatol. 137, 2177\u20132186. https:\/\/doi.org\/10.1016\/j.jid.2017.06.005 (2017).","journal-title":"J. Invest. Dermatol."},{"key":"87252_CR40","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/1523-1747.ep12274844","volume":"84","author":"RE Schopf","year":"1985","unstructured":"Schopf, R. E. & Straussfeld, E. Stimulus-dependent increased generation of oxygen intermediates in monocytes and polymorphonuclear leukocytes in psoriasis. J. Invest. Dermatol. 84, 73\u201376. https:\/\/doi.org\/10.1111\/1523-1747.ep12274844 (1985).","journal-title":"J. Invest. Dermatol."},{"key":"87252_CR41","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1111\/bjd.15682","volume":"177","author":"J Dou","year":"2017","unstructured":"Dou, J. et al. Integrative analyses reveal biological pathways and key genes in psoriasis. Br. J. Dermatol. 177, 1349\u20131357. https:\/\/doi.org\/10.1111\/bjd.15682 (2017).","journal-title":"Br. J. Dermatol."},{"key":"87252_CR42","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1111\/jdv.18292","volume":"36","author":"KX Yan","year":"2022","unstructured":"Yan, K. X. et al. iTRAQ-based quantitative proteomics reveals biomarkers\/pathways in psoriasis that can predict the efficacy of methotrexate. J. Eur. Acad. Dermatol. Venereol. 36, 1784\u20131795. https:\/\/doi.org\/10.1111\/jdv.18292 (2022).","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"87252_CR43","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1111\/bjd.14718","volume":"175","author":"J Vegfors","year":"2016","unstructured":"Vegfors, J., Ekman, A. K., Stoll, S. W., Bivik Eding, C. & Enerb\u00e4ck, C. Psoriasin (S100A7) promotes stress-induced angiogenesis. Br. J. Dermatol. 175, 1263\u20131273. https:\/\/doi.org\/10.1111\/bjd.14718 (2016).","journal-title":"Br. J. Dermatol."},{"key":"87252_CR44","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/86342","volume":"2","author":"K Triantafilou","year":"2001","unstructured":"Triantafilou, K., Triantafilou, M. & Dedrick, R. L. A CD14-independent LPS receptor cluster. Nat. Immunol. 2, 338\u2013345. https:\/\/doi.org\/10.1038\/86342 (2001).","journal-title":"Nat. Immunol."},{"key":"87252_CR45","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.jaad.2013.12.002","volume":"70","author":"M Kakeda","year":"2014","unstructured":"Kakeda, M., Arock, M., Schlapbach, C. & Yawalkar, N. Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis. J. Am. Acad. Dermatol. 70, 683\u2013690e681. https:\/\/doi.org\/10.1016\/j.jaad.2013.12.002 (2014).","journal-title":"J. Am. Acad. Dermatol."},{"key":"87252_CR46","doi-asserted-by":"publisher","first-page":"e1800119","DOI":"10.1002\/prca.201800119","volume":"13","author":"A G\u0119gotek","year":"2019","unstructured":"G\u0119gotek, A., Domingues, P., Wro\u0144ski, A., Ambro\u017cewicz, E. & Skrzydlewska, E. The proteomic profile of keratinocytes and lymphocytes in psoriatic patients. Proteom. Clin. Appl. 13, e1800119. https:\/\/doi.org\/10.1002\/prca.201800119 (2019).","journal-title":"Proteom. Clin. Appl."},{"key":"87252_CR47","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/imm.13634","volume":"169","author":"D Sharygin","year":"2023","unstructured":"Sharygin, D., Koniaris, L. G., Wells, C., Zimmers, T. A. & Hamidi, T. Role of CD14 in human disease. Immunology 169, 260\u2013270. https:\/\/doi.org\/10.1111\/imm.13634 (2023).","journal-title":"Immunology"},{"key":"87252_CR48","doi-asserted-by":"publisher","unstructured":"Nakamizo, S. et al. Single-cell analysis of human skin identifies CD14\u2009+\u2009type 3 dendritic cells co-producing IL1B and IL23A in psoriasis. J. Exp. Med. 218 https:\/\/doi.org\/10.1084\/jem.20202345 (2021).","DOI":"10.1084\/jem.20202345"},{"key":"87252_CR49","doi-asserted-by":"publisher","first-page":"1250504","DOI":"10.3389\/fimmu.2023.1250504","volume":"14","author":"J Kim","year":"2023","unstructured":"Kim, J. et al. Multi-omics segregate different transcriptomic impacts of anti-IL-17A blockade on type 17 T-cells and regulatory immune cells in psoriasis skin. Front. Immunol. 14, 1250504. https:\/\/doi.org\/10.3389\/fimmu.2023.1250504 (2023).","journal-title":"Front. Immunol."},{"key":"87252_CR50","doi-asserted-by":"publisher","first-page":"914","DOI":"10.15252\/embr.201642109","volume":"17","author":"IS Afonina","year":"2016","unstructured":"Afonina, I. S. et al. The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes. EMBO Rep. 17, 914\u2013927. https:\/\/doi.org\/10.15252\/embr.201642109 (2016).","journal-title":"EMBO Rep."},{"key":"87252_CR51","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.jid.2015.12.027","volume":"136","author":"A Schmitt","year":"2016","unstructured":"Schmitt, A. et al. MALT1 protease activity controls the expression of inflammatory genes in Keratinocytes upon Zymosan Stimulation. J. Invest. Dermatol. 136, 788\u2013797. https:\/\/doi.org\/10.1016\/j.jid.2015.12.027 (2016).","journal-title":"J. Invest. Dermatol."},{"key":"87252_CR52","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jid.2016.09.031","volume":"137","author":"E Van Nuffel","year":"2017","unstructured":"Van Nuffel, E. et al. CARD14-Mediated activation of paracaspase MALT1 in keratinocytes: Implications for Psoriasis. J. Invest. Dermatol. 137, 569\u2013575. https:\/\/doi.org\/10.1016\/j.jid.2016.09.031 (2017).","journal-title":"J. Invest. Dermatol."},{"key":"87252_CR53","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","volume":"23","author":"J Schmitz","year":"2005","unstructured":"Schmitz, J. et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23, 479\u2013490. https:\/\/doi.org\/10.1016\/j.immuni.2005.09.015 (2005).","journal-title":"Immunity"},{"key":"87252_CR54","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1111\/exd.12027","volume":"21","author":"A Balato","year":"2012","unstructured":"Balato, A. et al. IL-33 is secreted by psoriatic keratinocytes and induces pro-inflammatory cytokines via keratinocyte and mast cell activation. Exp. Dermatol. 21, 892\u2013894. https:\/\/doi.org\/10.1111\/exd.12027 (2012).","journal-title":"Exp. Dermatol."},{"key":"87252_CR55","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3389\/fimmu.2017.00475","volume":"8","author":"B Griesenauer","year":"2017","unstructured":"Griesenauer, B. & Paczesny, S. The ST2\/IL-33 Axis in Immune cells during inflammatory diseases. Front. Immunol. 8, 475. https:\/\/doi.org\/10.3389\/fimmu.2017.00475 (2017).","journal-title":"Front. Immunol."},{"key":"87252_CR56","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.jid.2020.07.027","volume":"141","author":"F Zeng","year":"2021","unstructured":"Zeng, F. et al. An Autocrine Circuit of IL-33 in Keratinocytes is involved in the progression of Psoriasis. J. Invest. Dermatol. 141, 596\u2013606e597. https:\/\/doi.org\/10.1016\/j.jid.2020.07.027 (2021).","journal-title":"J. Invest. Dermatol."},{"key":"87252_CR57","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/imm.13203","volume":"160","author":"Z Chen","year":"2020","unstructured":"Chen, Z. et al. Interleukin-33 alleviates psoriatic inflammation by suppressing the T helper type 17 immune response. Immunology 160, 382\u2013392. https:\/\/doi.org\/10.1111\/imm.13203 (2020).","journal-title":"Immunology"},{"key":"87252_CR58","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.jid.2021.08.397","volume":"142","author":"M Dragan","year":"2022","unstructured":"Dragan, M. et al. Epidermis-intrinsic transcription factor Ovol1 coordinately regulates barrier maintenance and neutrophil accumulation in psoriasis-like inflammation. J. Invest. Dermatol. 142, 583\u2013593e585. https:\/\/doi.org\/10.1016\/j.jid.2021.08.397 (2022).","journal-title":"J. Invest. Dermatol."},{"key":"87252_CR59","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.jpha.2022.12.003","volume":"13","author":"W Zeng","year":"2023","unstructured":"Zeng, W., Song, Y., Wang, R., He, R. & Wang, T. Neutrophil elastase: From mechanisms to therapeutic potential. J. Pharm. Anal. 13, 355\u2013366. https:\/\/doi.org\/10.1016\/j.jpha.2022.12.003 (2023).","journal-title":"J. Pharm. Anal."},{"key":"87252_CR60","doi-asserted-by":"publisher","unstructured":"Voynow, J. A. & Shinbashi, M. Neutrophil elastase and chronic lung disease. Biomolecules 11, (2021). https:\/\/doi.org\/10.3390\/biom11081065","DOI":"10.3390\/biom11081065"},{"key":"87252_CR61","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.jid.2019.12.015","volume":"140","author":"J Skrzeczynska-Moncznik","year":"2020","unstructured":"Skrzeczynska-Moncznik, J. et al. Differences in staining for neutrophil elastase and its controlling inhibitor SLPI reveal heterogeneity among neutrophils in Psoriasis. J. Invest. Dermatol. 140, 1371\u20131378e1373. https:\/\/doi.org\/10.1016\/j.jid.2019.12.015 (2020).","journal-title":"J. Invest. Dermatol."},{"key":"87252_CR62","doi-asserted-by":"publisher","first-page":"e14849","DOI":"10.1111\/dth.14849","volume":"34","author":"M Kojanova","year":"2021","unstructured":"Kojanova, M. et al. Demographic data, comorbidities, quality of life, and survival probability of biologic therapy associated with sex-specific differences in psoriasis in the Czech Republic. Dermatol. Ther. 34, e14849. https:\/\/doi.org\/10.1111\/dth.14849 (2021).","journal-title":"Dermatol. Ther."},{"key":"87252_CR63","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s40257-017-0274-0","volume":"18","author":"D H\u00e4gg","year":"2017","unstructured":"H\u00e4gg, D., Sundstr\u00f6m, A., Eriksson, M. & Schmitt-Egenolf, M. Severity of Psoriasis differs between men and women: a study of the clinical outcome measure Psoriasis Area and Severity Index (PASI) in 5438 Swedish Register patients. Am. J. Clin. Dermatol. 18, 583\u2013590. https:\/\/doi.org\/10.1007\/s40257-017-0274-0 (2017).","journal-title":"Am. J. Clin. Dermatol."},{"key":"87252_CR64","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.jaci.2022.03.028","volume":"150","author":"A Adachi","year":"2022","unstructured":"Adachi, A. et al. Estradiol suppresses psoriatic inflammation in mice by regulating neutrophil and macrophage functions. J. Allergy Clin. Immunol. 150, 909\u2013919e908. https:\/\/doi.org\/10.1016\/j.jaci.2022.03.028 (2022).","journal-title":"J. Allergy Clin. Immunol."},{"key":"87252_CR65","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/jid.2012.339","volume":"133","author":"R Parisi","year":"2013","unstructured":"Parisi, R., Symmons, D. P., Griffiths, C. E. & Ashcroft, D. M. Global epidemiology of psoriasis: A systematic review of incidence and prevalence. J. Invest. Dermatol. 133, 377\u2013385. https:\/\/doi.org\/10.1038\/jid.2012.339 (2013).","journal-title":"J. Invest. Dermatol."},{"key":"87252_CR66","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1101\/gr.092759.109","volume":"19","author":"M Krzywinski","year":"2009","unstructured":"Krzywinski, M. et al. Circos: An information aesthetic for comparative genomics. Genome Res. 19, 1639\u20131645. https:\/\/doi.org\/10.1101\/gr.092759.109 (2009).","journal-title":"Genome Res."},{"key":"87252_CR67","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","volume":"30","author":"A Kr\u00e4mer","year":"2014","unstructured":"Kr\u00e4mer, A., Green, J., Pollard, J. Jr. & Tugendreich, S. Causal analysis approaches in ingenuity pathway analysis. Bioinformatics 30, 523\u2013530. https:\/\/doi.org\/10.1093\/bioinformatics\/btt703 (2014).","journal-title":"Bioinformatics"},{"key":"87252_CR68","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2021.01.004","volume":"184","author":"X Nie","year":"2021","unstructured":"Nie, X. et al. Multi-organ proteomic landscape of COVID-19 autopsies. Cell 184, 775\u2013791e714. https:\/\/doi.org\/10.1016\/j.cell.2021.01.004 (2021).","journal-title":"Cell"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87252-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87252-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87252-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T12:31:09Z","timestamp":1737981069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87252-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["87252"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-87252-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4710909\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,27]]},"assertion":[{"value":"9 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3387"}}