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This work aimed to assess the therapeutic anti-inflammatory immune potentials of the seaweeds <jats:italic>Padina pavonia<\/jats:italic> and <jats:italic>Jania rubens<\/jats:italic> extracts on carbon tetrachloride (CCL<jats:sub>4<\/jats:sub>)-caused liver damage in mice. Our experimentation included two testing regimens: pre-treatment and post-treatment of <jats:italic>P. pavonia<\/jats:italic> and <jats:italic>J. rubens<\/jats:italic> extracts in CCL<jats:sub>4<\/jats:sub>\/mice. Pre-treatment and post-treatment of <jats:italic>P. pavonia<\/jats:italic> and <jats:italic>J. rubens<\/jats:italic> extracts in CCL<jats:sub>4<\/jats:sub>\/mice increased WBCs count and lymphocytes relative numbers and reduced the neutrophils and monocytes relative numbers. Pre-treatment and post-treatment of <jats:sub>CCL4<\/jats:sub>\/mice with <jats:italic>P. pavonia<\/jats:italic> and <jats:italic>J. rubens<\/jats:italic> extracts significantly reduced the release amounts of pro-inflammatory cytokines TNF-\u03b1 and IL-6 and significantly inhibited the increased CRP level. Furthermore, pre-treatment and post-treatment of CCL<jats:sub>4<\/jats:sub>\/mice with <jats:italic>P. pavonia<\/jats:italic> and <jats:italic>J. rubens<\/jats:italic> extracts recovered the activities of GSH, and significantly decreased MDA level. CCL4\/mice pre-treated and post-treated with <jats:italic>P. pavonia<\/jats:italic> and <jats:italic>J. rubens<\/jats:italic> extracts decreased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Pre- and post-treatment of CCL<jats:sub>4<\/jats:sub>\/mice with the <jats:italic>P. pavonia<\/jats:italic> and <jats:italic>J. rubens<\/jats:italic> extracts ameliorated the liver damages caused by CCl<jats:sub>4<\/jats:sub> and significantly inhibited the necrotic area, indicating hepatic cell death and decreased periportal hepatic degeneration, fibrosis, and inflammation.<\/jats:p>","DOI":"10.1038\/s41598-025-87379-9","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T12:56:25Z","timestamp":1738760185000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Therapeutic anti-inflammatory immune potentials of some seaweeds extracts on chemically induced liver injury in mice"],"prefix":"10.1038","volume":"15","author":[{"given":"Eman","family":"Bases","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa M.","family":"El-Sheekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimaa M.","family":"El Shafay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"El-shenody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Nassef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"87379_CR1","doi-asserted-by":"crossref","unstructured":"Bataller, R. & Brenner, D. 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