{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:08:38Z","timestamp":1789474118451,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-87518-2","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T17:18:46Z","timestamp":1740071926000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Knowledge attitude and practice of patients with allergic conjunctivitis towards their disease"],"prefix":"10.1038","volume":"15","author":[{"given":"Ke","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"87518_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/ojo.OJO_31_2019","volume":"13","author":"KA Alqurashi","year":"2020","unstructured":"Alqurashi, K. A., Bamahfouz, A. Y. & Almasoudi, B. M. Prevalence and causative agents of allergic conjunctivitis and its determinants in adult citizens of Western Saudi Arabia: A survey. Oman J. Ophthalmol. 13, 29\u201333 (2020).","journal-title":"Oman J. Ophthalmol."},{"key":"87518_CR2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/164_2021_491","volume":"268","author":"A Mueller","year":"2022","unstructured":"Mueller, A. Allergic conjunctivitis: An update. Handb. Exp. Pharmacol. 268, 95\u201399 (2022).","journal-title":"Handb. Exp. Pharmacol."},{"key":"87518_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.4274\/tjo.galenos.2020.11456","volume":"51","author":"BV Villegas","year":"2021","unstructured":"Villegas, B. V. & Benitez-Del-Castillo, J. M. Current knowledge in allergic conjunctivitis. Turk. J. Ophthalmol. 51, 45\u201354 (2021).","journal-title":"Turk. J. Ophthalmol."},{"key":"87518_CR4","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1097\/ACI.0000000000000471","volume":"18","author":"E Villani","year":"2018","unstructured":"Villani, E., Rabbiolo, G. & Nucci, P. Ocular allergy as a risk factor for dry eye in adults and children. Curr. Opin. Allergy Clin. Immunol. 18, 398\u2013403 (2018).","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"87518_CR5","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1111\/all.12009","volume":"67","author":"A Leonardi","year":"2012","unstructured":"Leonardi, A. et al. Ocular allergy: Recognizing and diagnosing hypersensitivity disorders of the ocular surface. Allergy 67, 1327\u20131337 (2012).","journal-title":"Allergy"},{"key":"87518_CR6","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/ACI.0b013e32834a9676","volume":"11","author":"N Rosario","year":"2011","unstructured":"Rosario, N. & Bielory, L. Epidemiology of allergic conjunctivitis. Curr. Opin. Allergy Clin. Immunol. 11, 471\u2013476 (2011).","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"87518_CR7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2500\/aap.2014.35.3750","volume":"35","author":"L Bielory","year":"2014","unstructured":"Bielory, L. et al. Ocular and nasal allergy symptom burden in America: The allergies, immunotherapy, and rhinoconjunctivitis (AIRS) surveys. Allergy Asthma Proc. 35, 211\u2013218 (2014).","journal-title":"Allergy Asthma Proc."},{"key":"87518_CR8","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.exer.2013.07.019","volume":"117","author":"A Leonardi","year":"2013","unstructured":"Leonardi, A. Allergy and allergic mediators in tears. Exp. Eye Res. 117, 106\u2013117 (2013).","journal-title":"Exp. Eye Res."},{"key":"87518_CR9","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3111\/13696998.2011.576039","volume":"14","author":"JC Virchow","year":"2011","unstructured":"Virchow, J. C. et al. Impact of ocular symptoms on quality of life (QoL), work productivity and resource utilisation in allergic rhinitis patients\u2014An observational, cross sectional study in four countries in Europe. J. Med. Econ. 14, 305\u2013314 (2011).","journal-title":"J. Med. Econ."},{"key":"87518_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.2500\/aap.2017.38.4003","volume":"38","author":"WE Berger","year":"2017","unstructured":"Berger, W. E., Granet, D. B. & Kabat, A. G. Diagnosis and management of allergic conjunctivitis in pediatric patients. Allergy Asthma Proc. 38, 16\u201327 (2017).","journal-title":"Allergy Asthma Proc."},{"key":"87518_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110924","volume":"135","author":"Y Ding","year":"2020","unstructured":"Ding, Y. et al. Quercetin as a Lyn kinase inhibitor inhibits IgE-mediated allergic conjunctivitis. Food Chem. Toxicol. 135, 110924 (2020).","journal-title":"Food Chem. Toxicol."},{"key":"87518_CR12","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.alit.2020.06.004","volume":"69","author":"D Miyazaki","year":"2020","unstructured":"Miyazaki, D. et al. Epidemiological aspects of allergic conjunctivitis. Allergol. Int. 69, 487\u2013495 (2020).","journal-title":"Allergol. Int."},{"key":"87518_CR13","doi-asserted-by":"publisher","first-page":"349","DOI":"10.18176\/jiaci.0320","volume":"29","author":"M Kuruvilla","year":"2019","unstructured":"Kuruvilla, M., Kalangara, J. & Lee, F. E. E. Neuropathic pain and itch mechanisms underlying allergic conjunctivitis. J. Investig. Allergol. Clin. Immunol. 29, 349\u2013356 (2019).","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"87518_CR14","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1111\/all.13334","volume":"73","author":"D Elieh Ali Komi","year":"2018","unstructured":"Elieh Ali Komi, D., Rambasek, T. & Bielory, L. Clinical implications of mast cell involvement in allergic conjunctivitis. Allergy 73, 528\u2013539 (2018).","journal-title":"Allergy"},{"key":"87518_CR15","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/pai.13035","volume":"30","author":"JL Fauquert","year":"2019","unstructured":"Fauquert, J. L. Diagnosing and managing allergic conjunctivitis in childhood: The allergist\u2019s perspective. Pediatr. Allergy Immunol. 30, 405\u2013414 (2019).","journal-title":"Pediatr. Allergy Immunol."},{"key":"87518_CR16","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1097\/ACI.0000000000000675","volume":"20","author":"J Vazirani","year":"2020","unstructured":"Vazirani, J. et al. Allergic conjunctivitis in children: Current understanding and future perspectives. Curr. Opin. Allergy Clin. Immunol. 20, 507\u2013515 (2020).","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"87518_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018618","volume":"99","author":"Y Zi","year":"2020","unstructured":"Zi, Y. et al. The effectiveness of olopatadine hydrochloride eye drops for allergic conjunctivitis: Protocol for a systematic review. Medicine (Baltimore) 99, e18618 (2020).","journal-title":"Medicine (Baltimore)"},{"key":"87518_CR18","doi-asserted-by":"publisher","first-page":"2073757","DOI":"10.1080\/21645515.2022.2073757","volume":"18","author":"L Gao","year":"2022","unstructured":"Gao, L. et al. Medical and non-medical students\u2019 knowledge, attitude and willingness towards the COVID-19 vaccine in China: A cross-sectional online survey. Hum. Vaccin. Immunother. 18, 2073757 (2022).","journal-title":"Hum. Vaccin. Immunother."},{"key":"87518_CR19","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2147\/RMHP.S287379","volume":"14","author":"N Twinamasiko","year":"2021","unstructured":"Twinamasiko, N. et al. Assessing knowledge, attitudes and practices towards COVID-19 public health preventive measures among patients at Mulago National Referral Hospital. Risk Manag. Healthc. Policy 14, 221\u2013230 (2021).","journal-title":"Risk Manag. Healthc. Policy"},{"key":"87518_CR20","doi-asserted-by":"publisher","first-page":"388","DOI":"10.21037\/apm.2020.03.01","volume":"9","author":"J Wang","year":"2020","unstructured":"Wang, J., Chen, L., Yu, M. & He, J. Impact of knowledge, attitude, and practice (KAP)-based rehabilitation education on the KAP of patients with intervertebral disc herniation. Ann. Palliat. Med. 9, 388\u2013393 (2020).","journal-title":"Ann. Palliat. Med."},{"key":"87518_CR21","doi-asserted-by":"publisher","first-page":"722","DOI":"10.3390\/ijerph19020722","volume":"19","author":"RL Peters","year":"2022","unstructured":"Peters, R. L., Mavoa, S. & Koplin, J. J. An overview of environmental risk factors for food allergy. Int. J. Environ. Res. Public Health 19, 722 (2022).","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"87518_CR22","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1016\/j.jaip.2020.07.004","volume":"8","author":"TB Casale","year":"2020","unstructured":"Casale, T. B. et al. The role of aeroallergen sensitization testing in asthma management. J. Allergy Clin. Immunol. Pract. 8, 2526\u20132532 (2020).","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"87518_CR23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.5414\/ALX02120E","volume":"3","author":"L Klimek","year":"2019","unstructured":"Klimek, L. et al. ARIA guideline 2019: Treatment of allergic rhinitis in the German health system. Allergol. Sel. 3, 22\u201350 (2019).","journal-title":"Allergol. Sel."},{"key":"87518_CR24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.arbres.2013.02.004","volume":"49","author":"A Roger","year":"2013","unstructured":"Roger, A. et al. Knowledge of their own allergic sensitizations in asthmatic patients and its impact on the level of asthma control. Arch. Bronconeumol. 49, 289\u2013296 (2013).","journal-title":"Arch. Bronconeumol."},{"key":"87518_CR25","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1111\/all.13317","volume":"73","author":"G Roberts","year":"2018","unstructured":"Roberts, G. et al. EAACI guidelines on allergen immunotherapy: Allergic rhinoconjunctivitis. Allergy 73, 765\u2013798 (2018).","journal-title":"Allergy"},{"key":"87518_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.957630","volume":"10","author":"F Lee","year":"2022","unstructured":"Lee, F. & Suryohusodo, A. A. Knowledge, attitude, and practice assessment toward COVID-19 among communities in East Nusa Tenggara, Indonesia: A cross-sectional study. Front. Public Health 10, 957630 (2022).","journal-title":"Front. Public Health"},{"key":"87518_CR27","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3928\/01913913-20210426-02","volume":"58","author":"M Wadhwani","year":"2021","unstructured":"Wadhwani, M., Kursange, S., Chopra, K., Singh, R. & Kumari, S. Knowledge, attitude, and practice among caregivers of children with vernal keratoconjunctivitis in a tertiary care pediatric hospital. J. Pediatr. Ophthalmol. Strabismus 58, 390\u2013395 (2021).","journal-title":"J. Pediatr. Ophthalmol. Strabismus"},{"key":"87518_CR28","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1186\/s12889-023-16607-6","volume":"23","author":"W Gu","year":"2023","unstructured":"Gu, W. et al. Knowledge, attitudes, and practice towards allergic rhinitis in patients with allergic rhinitis: A cross-sectional study. BMC Public Health 23, 1633 (2023).","journal-title":"BMC Public Health"},{"key":"87518_CR29","doi-asserted-by":"publisher","first-page":"10010","DOI":"10.3390\/ijerph191610010","volume":"19","author":"G Brandt","year":"2022","unstructured":"Brandt, G. et al. Medical students\u2019 perspectives on LGBTQI+ healthcare and education in Germany: Results of a nationwide online survey. Int. J. Environ. Res. Public Health 19, 10010 (2022).","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"87518_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.884947","volume":"13","author":"S Ghuloum","year":"2022","unstructured":"Ghuloum, S., Mahfoud, Z. R., Al-Amin, H., Marji, T. & Kehyayan, V. Healthcare professionals\u2019 attitudes toward patients with mental illness: A cross-sectional study in Qatar. Front. Psychiatry 13, 884947 (2022).","journal-title":"Front. Psychiatry"},{"key":"87518_CR31","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12912-019-0378-3","volume":"18","author":"TO Oshodi","year":"2019","unstructured":"Oshodi, T. O. et al. Registered nurses\u2019 perceptions and experiences of autonomy: A descriptive phenomenological study. BMC Nurs. 18, 51 (2019).","journal-title":"BMC Nurs."},{"key":"87518_CR32","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1111\/jocn.15802","volume":"30","author":"L Jiang","year":"2021","unstructured":"Jiang, L., Liu, S., Li, H., Xie, L. & Jiang, Y. The role of health beliefs in affecting patients\u2019 chronic diabetic complication screening: A path analysis based on the health belief model. J. Clin. Nurs. 30, 2948\u20132959 (2021).","journal-title":"J. Clin. Nurs."},{"key":"87518_CR33","volume":"8","author":"E Cilli","year":"2022","unstructured":"Cilli, E., Ranieri, J., Guerra, F., Ferri, C. & Di Giacomo, D. Naturalizing digital and quality of life in chronic diseases: Systematic review to research perspective into technological advancing and personalized medicine. Digit. Health 8, 20552076221144857 (2022).","journal-title":"Digit. Health"},{"key":"87518_CR34","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.anai.2019.11.014","volume":"124","author":"L Bielory","year":"2020","unstructured":"Bielory, L. et al. ICON: Diagnosis and management of allergic conjunctivitis. Ann. Allergy Asthma Immunol. 124, 118\u2013134 (2020).","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"87518_CR35","first-page":"8","volume":"66","author":"A Iordache","year":"2022","unstructured":"Iordache, A. et al. Relationship between allergic rhinitis and allergic conjunctivitis (allergic rhinoconjunctivitis)\u2014Review. Rom. J. Ophthalmol. 66, 8\u201312 (2022).","journal-title":"Rom. J. Ophthalmol."},{"key":"87518_CR36","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s11882-024-01150-0","volume":"24","author":"A Leonardi","year":"2024","unstructured":"Leonardi, A. et al. Allergic conjunctivitis management: Update on ophthalmic solutions. Curr. Allergy Asthma Rep. 24, 347\u2013360 (2024).","journal-title":"Curr. Allergy Asthma Rep."},{"key":"87518_CR37","first-page":"49","volume":"32","author":"M Sacchetti","year":"2018","unstructured":"Sacchetti, M. et al. Allergic conjunctivitis: Current concepts on pathogenesis and management. J. Biol. Regul. Homeost. Agents 32, 49\u201360 (2018).","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"87518_CR38","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s00347-024-01996-9","volume":"121","author":"S Kassumeh","year":"2024","unstructured":"Kassumeh, S., Brunner, B. S., Priglinger, S. G. & Messmer, E. M. New and future treatment approaches for allergic conjunctivitis. Ophthalmologie 121, 180\u2013186 (2024).","journal-title":"Ophthalmologie"},{"key":"87518_CR39","doi-asserted-by":"publisher","first-page":"135","DOI":"10.55519\/JAMC-01-9432","volume":"34","author":"A Kausar","year":"2022","unstructured":"Kausar, A., Akhtar, N. & Akbar, N. Epidemiological aspects of allergic conjunctivitis. J. Ayub Med. Coll. Abbottabad 34, 135\u2013140 (2022).","journal-title":"J. Ayub Med. Coll. Abbottabad"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87518-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87518-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87518-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T17:18:48Z","timestamp":1740071928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87518-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,20]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["87518"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-87518-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,20]]},"assertion":[{"value":"6 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This work has been carried out in accordance with the Declaration of Helsinki (2000) of the World Medical Association. This work was approved by the Medical Ethics Committee of the Eye Hospital, China Academy of Chinese Medical Sciences (YKEC-KT-2022-007-P004). Informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"6238"}}