{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:56:56Z","timestamp":1787003816900,"version":"build-2736575974"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-87589-1","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T02:04:01Z","timestamp":1739757841000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Frequencies of enamel hypomineralisation in permanent and primary molars in a medieval and early-modern-age population (7th \u2212\u200917th c.) in Sains-en-Gohelle (Pas de Calais, France)"],"prefix":"10.1038","volume":"15","author":[{"given":"Julia","family":"Estivals","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Couture","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Rouas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David John","family":"Manton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Garot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"87589_CR1","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1159\/000047479","volume":"35","author":"KL Weerheijm","year":"2001","unstructured":"Weerheijm, K. L., J\u00e4levik, B. & Alaluusua, S. Molar-incisor hypomineralisation. Caries Res. 35, 390\u2013391 (2001).","journal-title":"Caries Res."},{"key":"87589_CR2","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1159\/000135674","volume":"42","author":"MEC Elfrink","year":"2008","unstructured":"Elfrink, M. E. C., Schuller, A. A., Weerheijm, K. L. & Veerkamp, J. S. J. Hypomineralized second primary molars: prevalence data in Dutch 5-year-olds. Caries Res. 42, 282\u2013285 (2008).","journal-title":"Caries Res."},{"key":"87589_CR3","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1177\/0022034512440450","volume":"91","author":"MEC Elfrink","year":"2012","unstructured":"Elfrink, M. E. C. et al. Deciduous molar hypomineralization and molar incisor hypomineralization. J. Dent. Res. 91, 551\u2013555 (2012).","journal-title":"J. Dent. Res."},{"key":"87589_CR4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s40368-020-00557-3","volume":"22","author":"E Alifakioti","year":"2021","unstructured":"Alifakioti, E., Arhakis, A., Oikonomidis, S. & Kotsanos, N. Structural and chemical enamel characteristics of hypomineralised second primary molars. Eur. Arch. Paediatr. Dent. 22, 361\u2013366 (2021).","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"87589_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jdent.2018.03.005","volume":"72","author":"E Garot","year":"2018","unstructured":"Garot, E. et al. Are hypomineralised lesions on second primary molars (HSPM) a predictive sign of molar incisor hypomineralisation (MIH)? A systematic review and a meta-analysis. J. Dent. 72, 8\u201313 (2018).","journal-title":"J. Dent."},{"key":"87589_CR6","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/0003-9969(67)90126-4","volume":"12","author":"PM Butler","year":"1967","unstructured":"Butler, P. M. Comparison of the development of the second deciduous molar and first permanent molar in man. Arch. Oral Biol. 12, 1245\u20131260 (1967).","journal-title":"Arch. Oral Biol."},{"key":"87589_CR7","doi-asserted-by":"publisher","first-page":"5533","DOI":"10.3390\/jcm12175533","volume":"12","author":"M Marcianes","year":"2023","unstructured":"Marcianes, M., Garc\u00eda-Camba, P., Albaladejo, A. & Varela Morales, M. Predictive value of hypomineralization of second primary molars for Molar Incisor Hypomineralization and Other relationships between both developmental defects of Dental Enamel. J. Clin. Med. 12, 5533 (2023).","journal-title":"J. Clin. Med."},{"key":"87589_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s40368-021-00646-x","volume":"23","author":"E Garot","year":"2022","unstructured":"Garot, E. et al. An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis. Eur. Arch. Paediatr. Dent. 23, 23\u201338 (2022).","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"87589_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s40368-021-00668-5","volume":"23","author":"NA Lygidakis","year":"2022","unstructured":"Lygidakis, N. A. et al. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur. Arch. Paediatr. Dent. 23, 3\u201321 (2022).","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"87589_CR10","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/ipd.12892","volume":"32","author":"C McCarra","year":"2022","unstructured":"McCarra, C., Oleg\u00e1rio, I. C., O\u2019Connell, A. C. & Leith, R. Prevalence of hypomineralised second primary molars (HSPM): a systematic review and meta-analysis. Int. J. Paediatr. Dent. 32, 367\u2013382 (2022).","journal-title":"Int. J. Paediatr. Dent."},{"key":"87589_CR11","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/ipd.12323","volume":"28","author":"D Zhao","year":"2018","unstructured":"Zhao, D., Dong, B., Yu, D., Ren, Q. & Sun, Y. The prevalence of molar incisor hypomineralization: evidence from 70 studies. Int. J. Paediatr. Dent. 28, 170\u2013179 (2018).","journal-title":"Int. J. Paediatr. Dent."},{"key":"87589_CR12","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/ipd.13040","volume":"33","author":"J Estivals","year":"2023","unstructured":"Estivals, J. et al. The prevalence and characteristics of and the association between MIH and HSPM in South-Western France. Int. J. Paediatr. Dent. 33, 298\u2013304 (2023).","journal-title":"Int. J. Paediatr. Dent."},{"key":"87589_CR13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/cdoe.12229","volume":"44","author":"MJ Silva","year":"2016","unstructured":"Silva, M. J., Scurrah, K. J., Craig, J. M., Manton, D. J. & Kilpatrick, N. Etiology of molar incisor hypomineralization \u2013 A systematic review. Community Dent. Oral Epidemiol. 44, 342\u2013353 (2016).","journal-title":"Community Dent. Oral Epidemiol."},{"key":"87589_CR14","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1600-0528.2009.00480.x","volume":"37","author":"P Arrow","year":"2009","unstructured":"Arrow, P. Risk factors in the occurrence of enamel defects of the first permanent molars among schoolchildren in Western Australia. Community Dent. Oral Epidemiol. 37, 405\u2013415 (2009).","journal-title":"Community Dent. Oral Epidemiol."},{"key":"87589_CR15","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s40368-016-0235-y","volume":"17","author":"E Garot","year":"2016","unstructured":"Garot, E., Manton, D. & Rouas, P. Peripartum events and molar-incisor hypomineralisation (MIH) amongst young patients in Southwest France. Eur. Arch. Paediatr. Dent. 17, 245\u2013250 (2016).","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"87589_CR16","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s40368-019-00505-w","volume":"21","author":"R Elzein","year":"2020","unstructured":"Elzein, R., Chouery, E., Abdel-Sater, F., Bacho, R. & Ayoub, F. Molar incisor hypomineralisation in Lebanon: prevalence and clinical characteristics. Eur. Arch. Paediatr. Dent. 21, 609\u2013616 (2020).","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"87589_CR17","doi-asserted-by":"publisher","first-page":"106224","DOI":"10.1016\/j.dib.2020.106224","volume":"32","author":"L Ho\u010devar","year":"2020","unstructured":"Ho\u010devar, L., Kova\u010d, J., Podkraj\u0161ek, K. T., Battelino, S. & Pavli\u010d, A. Dataset on amelogenesis-related genes variants (ENAM and ENAM interacting genes) and on human leukocyte antigen alleles (DQ2 and DQ8) distribution in children with and without molar-incisor hypomineralisation (MIH). Data Brief. 32, 106224 (2020).","journal-title":"Data Brief."},{"key":"87589_CR18","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1016\/j.archoralbio.2013.05.005","volume":"58","author":"F Jeremias","year":"2013","unstructured":"Jeremias, F. et al. Genes expressed in dental enamel development are associated with molar-incisor hypomineralization. Arch. Oral Biol. 58, 1434\u20131442 (2013).","journal-title":"Arch. Oral Biol."},{"key":"87589_CR19","doi-asserted-by":"publisher","first-page":"e035","DOI":"10.1590\/1807-3107bor-2021.vol35.0035","volume":"35","author":"F Jeremias","year":"2021","unstructured":"Jeremias, F. et al. Inheritance pattern of molar-incisor hypomineralization. Braz Oral Res. 35, e035 (2021).","journal-title":"Braz Oral Res."},{"key":"87589_CR20","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00784-013-1054-8","volume":"18","author":"J K\u00fchnisch","year":"2014","unstructured":"K\u00fchnisch, J. et al. Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH). Clin. Oral Investig. 18, 677\u2013682 (2014).","journal-title":"Clin. Oral Investig"},{"key":"87589_CR21","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1159\/000445128","volume":"50","author":"AR Vieira","year":"2016","unstructured":"Vieira, A. R. & Kup, E. On the etiology of Molar-Incisor Hypomineralization. Caries Res. 50, 166\u2013169 (2016).","journal-title":"Caries Res."},{"key":"87589_CR22","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/BF03262639","volume":"9","author":"S Laisi","year":"2008","unstructured":"Laisi, S., Kiviranta, H., Lukinmaa, P. L., Vartiainen, T. & Alaluusua, S. Molar-incisor-hypomineralisation and dioxins: new findings. Eur. Arch. Paediatr. Dent. Dent. 9, 224\u2013227 (2008).","journal-title":"Eur. Arch. Paediatr. Dent. Dent."},{"key":"87589_CR23","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ajpath.2013.04.004","volume":"183","author":"K Jedeon","year":"2013","unstructured":"Jedeon, K. et al. Enamel defects reflect perinatal exposure to Bisphenol A. Am. J. Pathol. 183, 108\u2013118 (2013).","journal-title":"Am. J. Pathol."},{"key":"87589_CR24","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1177\/0022034508328334","volume":"88","author":"S Laisi","year":"2009","unstructured":"Laisi, S. et al. Amoxicillin may cause molar incisor hypomineralization. J. Dent. Res. 88, 132\u2013136 (2009).","journal-title":"J. Dent. Res."},{"key":"87589_CR25","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1600-0528.2009.00510.x","volume":"38","author":"P Wogelius","year":"2010","unstructured":"Wogelius, P. et al. Association between use of asthma drugs and prevalence of demarcated opacities in permanent first molars in 6-to-8-year-old Danish children. Community Dent. Oral Epidemiol. 38, 145\u2013151 (2010).","journal-title":"Community Dent. Oral Epidemiol."},{"key":"87589_CR26","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/BF03262632","volume":"9","author":"AR Ogden","year":"2008","unstructured":"Ogden, A. R., Pinhasi, R. & White, W. J. Nothing new under the heavens: MIH in the past? Eur. Arch. Paediatr. Dent. 9, 166\u2013171 (2008).","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"87589_CR27","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1007\/s00784-017-2183-2","volume":"21","author":"J K\u00fchnisch","year":"2017","unstructured":"K\u00fchnisch, J. Was molar-incisor hypomineralisation (MIH) present in archeological case series? Clin. Oral Investig. 21, 2155\u20132156 (2017).","journal-title":"Clin. Oral Investig"},{"key":"87589_CR28","first-page":"343","volume":"73","author":"J Lang","year":"2016","unstructured":"Lang, J., Birkenbeil, S., Bock, S., Heinrich-Weltzien, R. & Kromeyer-Hauschild, K. Dental enamel defects in German medieval and early-modern-age populations. Anthropol. Anz Ber Uber Biol. -Anthropol Lit. 73, 343\u2013354 (2016).","journal-title":"Anthropol. Anz Ber Uber Biol. -Anthropol Lit."},{"key":"87589_CR29","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41598-017-01745-w","volume":"7","author":"E Garot","year":"2017","unstructured":"Garot, E., Couture-Veschambre, C., Manton, D., Beauval, C. & Rouas, P. Analytical evidence of enamel hypomineralisation on permanent and primary molars amongst past populations. Sci. Rep. 7, 1712 (2017).","journal-title":"Sci. Rep."},{"key":"87589_CR30","first-page":"405","volume":"3","author":"Efremov","year":"1940","unstructured":"Efremov Taphonomy, a new branch of paleontology. Biology Serie. 3, 405\u2013413 (1940).","journal-title":"Biology Serie"},{"key":"87589_CR31","first-page":"3","volume":"592","author":"G Turner-Walker","year":"2008","unstructured":"Turner-Walker, G. The chemical and microbial degradation of bones and teeth. Adv. Hum. Palaeopathology. 592, 3\u201329 (2008).","journal-title":"Adv. Hum. Palaeopathology"},{"key":"87589_CR32","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/0003-9969(78)90117-6","volume":"23","author":"DFG Poole","year":"1978","unstructured":"Poole, D. F. G. & Tratman, E. K. Post-mortem changes in human teeth from late upper Palaeolithic\/Mesolithic occupants of an English limestone cave. Arch. Oral Biol. 23, 1115\u20131120 (1978).","journal-title":"Arch. Oral Biol."},{"key":"87589_CR33","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/ajpa.10152","volume":"120","author":"J Mansilla","year":"2003","unstructured":"Mansilla, J., Solis, C., Ch\u00e1vez-Lomeli, M. E. & Gama, J. E. Analysis of colored teeth from precolumbian tlatelolco: postmortem transformation or intravitam processes? Am. J. Phys. Anthropol. 120, 73\u201382 (2003).","journal-title":"Am. J. Phys. Anthropol."},{"key":"87589_CR34","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1600-0722.1996.tb00075.x","volume":"104","author":"EM Stermer","year":"1996","unstructured":"Stermer, E. M., Risnes, S. & Fischer, P. M. Trace element analysis of blackish staining on the crowns of human archaeological teeth. Eur. J. Oral Sci. 104, 253\u2013261 (1996).","journal-title":"Eur. J. Oral Sci."},{"key":"87589_CR35","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1016\/S0016-7037(99)00208-2","volume":"63","author":"MJ Kohn","year":"1999","unstructured":"Kohn, M. J., Schoeninger, M. J. & Barker, W. W. Altered states: effects of diagenesis on fossil tooth chemistry. Geochim. Cosmochim. Acta. 63, 2737\u20132747 (1999).","journal-title":"Geochim. Cosmochim. Acta"},{"key":"87589_CR36","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/sj.bdj.4800959a","volume":"190","author":"A Watts","year":"2001","unstructured":"Watts, A. & Addy, M. Tooth discolouration and staining: a review of the literature. Br. Dent. J. 190, 309\u2013316 (2001).","journal-title":"Br. Dent. J."},{"key":"87589_CR37","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/j.1875-595X.2007.tb00141.x","volume":"57","author":"AH Brook","year":"2007","unstructured":"Brook, A. H., Smith, R. N. & Lath, D. J. The clinical measurement of tooth colour and stain. Int. Dent. J. 57, 324\u2013330 (2007).","journal-title":"Int. Dent. J."},{"key":"87589_CR38","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.archoralbio.2016.11.008","volume":"74","author":"E Garot","year":"2017","unstructured":"Garot, E. et al. Diagnostic guide enabling distinction between taphonomic stains and enamel hypomineralisation in an archaeological context. Arch. Oral Biol. 74, 28\u201336 (2017).","journal-title":"Arch. Oral Biol."},{"key":"87589_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/4743252","volume":"2022","author":"J Damares Lago","year":"2022","unstructured":"Damares Lago, J. et al. Molar-incisor hypomineralization: prevalence comparative study in 6 years of interval. Sci. World J. 2022, 1\u20138 (2022).","journal-title":"Sci. World J."},{"key":"87589_CR40","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s40368-015-0179-7","volume":"16","author":"MEC Elfrink","year":"2015","unstructured":"Elfrink, M. E. C., Ghanim, A., Manton, D. J. & Weerheijm, K. L. Standardised studies on Molar Incisor Hypomineralisation (MIH) and Hypomineralised Second Primary molars (HSPM): a need. Eur. Arch. Paediatr. Dent. 16, 247\u2013255 (2015).","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"87589_CR41","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12903-023-03637-0","volume":"24","author":"B Sluka","year":"2024","unstructured":"Sluka, B. et al. Is there a rise of prevalence for molar Incisor hypomineralization? A meta-analysis of published data. BMC Oral Health. 24, 127 (2024).","journal-title":"BMC Oral Health"},{"key":"87589_CR42","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1002\/ajpa.20608","volume":"133","author":"AR Ogden","year":"2007","unstructured":"Ogden, A. R., Pinhasi, R. & White, W. J. Gross enamel hypoplasia in molars from subadults in a 16th\u201318th century London graveyard. Am. J. Phys. Anthropol. 133, 957\u2013966 (2007).","journal-title":"Am. J. Phys. Anthropol."},{"key":"87589_CR43","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1002\/oa.2785","volume":"29","author":"E Garot","year":"2019","unstructured":"Garot, E., Couture-Veschambre, C., Manton, D. J., Bekvalac, J. & Rouas, P. Differential diagnoses of enamel hypomineralisation in an archaeological context: a postmedieval skeletal collection reassessment. Int. J. Osteoarchaeol. 29, 747\u2013759 (2019).","journal-title":"Int. J. Osteoarchaeol"},{"key":"87589_CR44","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1007\/s00784-016-1717-3","volume":"20","author":"J K\u00fchnisch","year":"2016","unstructured":"K\u00fchnisch, J. et al. Was molar incisor hypomineralisation (MIH) present in archaeological case series? Clin. Oral Investig. 20, 2387\u20132393 (2016).","journal-title":"Clin. Oral Investig"},{"key":"87589_CR45","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.archoralbio.2004.11.014","volume":"50","author":"M Vodanovi\u0107","year":"2005","unstructured":"Vodanovi\u0107, M., Hrvoje, B., Mario, \u0160. & \u017deljko, D. The frequency and distribution of caries in the mediaeval population of Bijelo Brdo in Croatia (10th\u201311th century). Arch. Oral Biol. 50, 669\u2013680 (2005).","journal-title":"Arch. Oral Biol."},{"key":"87589_CR46","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.stomax.2008.04.011","volume":"110","author":"R Esclassan","year":"2009","unstructured":"Esclassan, R. et al. [Study of dental attrition in a medieval adult population from Southwest France]. Rev. Stomatol. Chir. Maxillofac. 110, 9\u201315 (2009).","journal-title":"Rev. Stomatol. Chir. Maxillofac."},{"key":"87589_CR47","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jchb.2010.06.003","volume":"61","author":"S Lucas","year":"2010","unstructured":"Lucas, S. et al. Study of dental caries and periapical lesions in a mediaeval population of the Southwest France: differences in visual and radiographic inspections. HOMO 61, 359\u2013372 (2010).","journal-title":"HOMO"},{"key":"87589_CR48","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.archoralbio.2015.06.004","volume":"60","author":"M Novak","year":"2015","unstructured":"Novak, M. Dental health and diet in early medieval Ireland. Arch. Oral Biol. 60, 1299\u20131309 (2015).","journal-title":"Arch. Oral Biol."},{"key":"87589_CR49","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/ipd.12233","volume":"27","author":"GCA Americano","year":"2017","unstructured":"Americano, G. C. A., Jacobsen, P. E., Soviero, V. M. & Haubek D. A systematic review on the association between molar incisor hypomineralization and dental caries. Int. J. Paediatr. Dent. 27, 11\u201321 (2017).","journal-title":"Int. J. Paediatr. Dent."},{"key":"87589_CR50","doi-asserted-by":"publisher","first-page":"319","DOI":"10.4000\/archeomed.48029","volume":"35","author":"C Polet","year":"2005","unstructured":"Polet, C. & Orban, R. Les dents et les ossements humains. Que mangeait-on Au Moyen \u00c2ge ? Arch\u00e9ologie M\u00e9di\u00e9v. 35, 319\u2013320 (2005).","journal-title":"Arch\u00e9ologie M\u00e9di\u00e9v"},{"key":"87589_CR51","unstructured":"Beauval, C. et al. Rapport d\u2019op\u00e9ration de fouilles arch\u00e9ologiques Sains-en-Gohelle 227 rue Lamartine Pas-de-Calais (62), Arch\u00e9osph\u00e8re, Bordeaux, 2012 5 vol, vol.1."},{"key":"87589_CR52","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1177\/0022034518788283","volume":"98","author":"K Halvorsrud","year":"2019","unstructured":"Halvorsrud, K., Lewney, J., Craig, D. & Moynihan, P. J. Effects of starch on oral health: systematic review to inform WHO Guideline. J. Dent. Res. 98, 46\u201353 (2019).","journal-title":"J. Dent. Res."},{"key":"87589_CR53","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/00005537-200101000-00020","volume":"111","author":"M Qvist","year":"2001","unstructured":"Qvist, M. & Gr\u00f8ntved, A. M. Chronic otitis media sequelae in skeletal material from medieval Denmark. Laryngoscope 111, 114\u2013118 (2001).","journal-title":"Laryngoscope"},{"key":"87589_CR54","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/apt.14157","volume":"46","author":"RJS Costa","year":"2017","unstructured":"Costa, R. J. S., Snipe, R. M. J., Kitic, C. M. & Gibson, P. R. Systematic review: exercise-induced gastrointestinal syndrome-implications for health and intestinal disease. Aliment. Pharmacol. Ther. 46, 246\u2013265 (2017).","journal-title":"Aliment. Pharmacol. Ther."},{"key":"87589_CR55","doi-asserted-by":"publisher","first-page":"513","DOI":"10.4103\/jispcd.JISPCD_130_19","volume":"9","author":"T Villanueva-Guti\u00e9rrez","year":"2019","unstructured":"Villanueva-Guti\u00e9rrez, T. et al. Prevalence and severity of molar-incisor hypomineralization, Maternal education, and Dental caries: a cross-sectional study of Mexican schoolchildren with low socioeconomic status. J. Int. Soc. Prev. Community Dent. 9, 513\u2013521 (2019).","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"87589_CR56","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s40368-023-00820-3","volume":"24","author":"D Harz","year":"2023","unstructured":"Harz, D. et al. Prevalence and severity of molar-incisor hypomineralization, is there an association with socioeconomic status? A cross-sectional study in Chilean schoolchildren. Eur. Arch. Paediatr. Dent. Off J. Eur. Acad. Paediatr. Dent. 24, 577\u2013584 (2023).","journal-title":"Eur. Arch. Paediatr. Dent. Off J. Eur. Acad. Paediatr. Dent."},{"key":"87589_CR57","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/BF03262637","volume":"9","author":"NA Lygidakis","year":"2008","unstructured":"Lygidakis, N. A., Dimou, G. & Marinou, D. Molar-incisor-hypomineralisation (MIH). A retrospective clinical study in Greek children. II. Possible medical aetiological factors. Eur. Arch. Paediatr. Dent. 9, 207\u2013217 (2008).","journal-title":"Eur. Arch. Paediatr. Dent."},{"key":"87589_CR58","doi-asserted-by":"publisher","first-page":"104848","DOI":"10.1016\/j.archoralbio.2020.104848","volume":"118","author":"L Ho\u010devar","year":"2020","unstructured":"Ho\u010devar, L., Kova\u010d, J., Podkraj\u0161ek, K. T., Battelino, S. & Pavli\u010d, A. The possible influence of genetic aetiological factors on molar\u2013incisor hypomineralisation. Arch. Oral Biol. 118, 104848 (2020).","journal-title":"Arch. Oral Biol."},{"key":"87589_CR59","doi-asserted-by":"publisher","first-page":"104637","DOI":"10.1016\/j.archoralbio.2019.104637","volume":"111","author":"L Pang","year":"2020","unstructured":"Pang, L. et al. Interactions with the aquaporin 5 gene increase the susceptibility to molar-incisor hypomineralization. Arch. Oral Biol. 111, 104637 (2020).","journal-title":"Arch. Oral Biol."},{"key":"87589_CR60","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1159\/000445726","volume":"50","author":"F Jeremias","year":"2016","unstructured":"Jeremias, F. et al. Family-based genetic association for molar-Incisor hypomineralization. Caries Res. 50, 310\u2013318 (2016).","journal-title":"Caries Res."},{"key":"87589_CR61","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000491644","volume":"53","author":"DG Bussaneli","year":"2019","unstructured":"Bussaneli, D. G. et al. Genes regulating immune response and amelogenesis interact in increasing the susceptibility to molar-incisor hypomineralization. Caries Res. 53, 217\u2013227 (2019).","journal-title":"Caries Res."},{"key":"87589_CR62","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/ipd.12327","volume":"28","author":"RJPB Teixeira","year":"2018","unstructured":"Teixeira, R. J. P. B. et al. Exploring the association between genetic and environmental factors and molar incisor hypomineralization: evidence from a twin study. Int. J. Paediatr. Dent. 28, 198\u2013206 (2018).","journal-title":"Int. J. Paediatr. Dent."},{"key":"87589_CR63","doi-asserted-by":"publisher","first-page":"S559","DOI":"10.2105\/AJPH.2008.159228","volume":"99","author":"SA Vogel","year":"2009","unstructured":"Vogel, S. A. The politics of Plastics: the making and unmaking of bisphenol A Safety. Am. J. Public. Health. 99, S559\u2013S566 (2009).","journal-title":"Am. J. Public. Health"},{"key":"87589_CR64","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1210\/er.2011-1050","volume":"33","author":"LN Vandenberg","year":"2012","unstructured":"Vandenberg, L. N. et al. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr. Rev. 33, 378\u2013455 (2012).","journal-title":"Endocr. Rev."},{"key":"87589_CR65","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.fct.2016.04.007","volume":"92","author":"L Kristanc","year":"2016","unstructured":"Kristanc, L. & Kreft, S. European medicinal and edible plants associated with subacute and chronic toxicity part I: plants with carcinogenic, teratogenic and endocrine-disrupting effects. Food Chem. Toxicol. 92, 150\u2013164 (2016).","journal-title":"Food Chem. Toxicol."},{"key":"87589_CR66","unstructured":"Universit\u00e9. de Paris (1215\u20131794), Codex, pharmacop\u00e9e fran\u00e7aise. in 535 (1837)."},{"key":"87589_CR67","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/cdoe.12467","volume":"47","author":"AL Fatturi","year":"2019","unstructured":"Fatturi, A. L. et al. A systematic review and meta-analysis of systemic exposure associated with molar incisor hypomineralization. Community Dent. Oral Epidemiol. 47, 407\u2013415 (2019).","journal-title":"Community Dent. Oral Epidemiol."},{"key":"87589_CR68","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ijpp.2023.07.004","volume":"42","author":"E Garot","year":"2023","unstructured":"Garot, E. et al. Insights into molar-incisor hypomineralisation in past populations: a call to anthropologists. Int. J. Paleopathol. 42, 18\u201326 (2023).","journal-title":"Int. J. Paleopathol."},{"key":"87589_CR69","doi-asserted-by":"publisher","first-page":"e79714","DOI":"10.7554\/eLife.79714","volume":"13","author":"ML Antonio","year":"2024","unstructured":"Antonio, M. L. et al. Stable population structure in Europe since the Iron Age, despite high mobility. eLife 13, e79714 (2024).","journal-title":"eLife"},{"key":"87589_CR70","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm, E. et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet Lond. Engl. 370, 1453\u20131457 (2007).","journal-title":"Lancet Lond. Engl."},{"key":"87589_CR71","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1177\/00220345630420062701","volume":"42","author":"CFA Moorrees","year":"1963","unstructured":"Moorrees, C. F. A., Fanning, E. A. & Hunt, E. E. Age variation of formation stages for ten permanent teeth. J. Dent. Res. 42, 1490\u20131502 (1963).","journal-title":"J. Dent. Res."},{"key":"87589_CR72","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/ajpa.1330210212","volume":"21","author":"CFA Moorrees","year":"1963","unstructured":"Moorrees, C. F. A., Fanning, E. A. & Hunt, E. E. Formation and resorption of three deciduous teeth in children. Am. J. Phys. Anthropol. 21, 205\u2013213 (1963).","journal-title":"Am. J. Phys. Anthropol."},{"key":"87589_CR73","doi-asserted-by":"crossref","unstructured":"Scheuer, L. & Black, S. Development and ageing of the juvenile skeleton. in Hum. Osteology Archaeol. Forensic Sci. 9\u201322 (2000).","DOI":"10.1016\/B978-012624000-9\/50003-4"},{"key":"87589_CR74","unstructured":"Holly Smith, B. Standards of human tooth formation and dental age assessment. Advances in Dental Anthropology. (Wiley-Liss Inc, (1991)."},{"key":"87589_CR75","first-page":"110","volume":"4","author":"KL Weerheijm","year":"2003","unstructured":"Weerheijm, K. L. et al. Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur. J. Paediatr. Dent. 4, 110\u2013113 (2003).","journal-title":"Eur. J. Paediatr. Dent."},{"key":"87589_CR76","first-page":"1","volume":"42","author":"J Clarkson","year":"1992","unstructured":"Clarkson, J. A review of the developmental defects of enamel index (DDE Index). Int. Dent. J. 42, 1\u201317 (1992).","journal-title":"Int. Dent. J."},{"key":"87589_CR77","doi-asserted-by":"crossref","unstructured":"Lewis, M. Dental Disease, defects, and variations in dental morphology. in Paleopathology of Children 67\u201389 (Elsevier, (2018).","DOI":"10.1016\/B978-0-12-410402-0.00004-7"},{"key":"87589_CR78","unstructured":"Hammer, \u00d8., Harper, D. A. T., Ryan, P. D. & PAST Paleontological statistics software package for education and data analysis. Palaeontol. Electron. 4, 9 pp."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87589-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87589-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87589-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T02:04:09Z","timestamp":1739757849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87589-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":78,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["87589"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-87589-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,17]]},"assertion":[{"value":"30 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5704"}}