{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:18:00Z","timestamp":1789179480240,"version":"build-2803163510"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002352","name":"Ain Shams University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Despite the diverse applications of \u03b3 radiation in radiotherapy, industrial processes, and sterilization, it causes hazardous effects on living organisms, such as cellular senescence, persistent cell cycle arrest, and mitochondrial dysfunction. This study evaluated the efficacy of curcumin nanoparticles (CNPs) in mitigating mitochondrial dysfunction and cellular senescence induced by \u03b3 radiation in rat brain tissues. Four groups of male Wistar albino rats (<jats:italic>n<\/jats:italic>\u2009=\u20098 per group) were included: (Gr1) the control group; (Gr2) the CNPs group (healthy rats receiving oral administration of curcumin nanoparticles at a dose of 10\u00a0mg\/kg\/day, three times per week for eight weeks); (Gr3) the irradiated group (rats exposed to a single dose of 10\u00a0Gy head \u03b3 irradiation); and (Gr4) the irradiated\u2009+\u2009CNPs group (irradiated rats treated with CNPs). The data obtained demonstrated that oral administration of CNPs for eight weeks attenuated oxidative stress in \u03b3-irradiated rats by lowering the brain\u2019s lipid peroxidation level [malondialdehyde (MDA)] and enhancing antioxidant markers [superoxide dismutase (SOD), reduced glutathione (GSH), and total antioxidant capacity (TAC)] (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In addition, CNPs significantly increased mitochondrial function by improving complex I, complex II, and ATP production levels compared to the irradiated group. In irradiated rats, CNPs also showed anti-neuroinflammatory effects by reducing brain interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-\u03b1), and nuclear factor-kappa B (NF-\u0138B) levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Moreover, CNPs administered to irradiated rats significantly reduced brain \u03b2-galactosidase activity and the expression levels of p53, p21, and p16 genes (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) while concurrently inducing a significant increase in AMPK mRNA expression compared to the irradiated group. In conclusion, CNPs ameliorated the neurotoxicity of \u03b3 radiation and hold promise as a novel agent to delay cellular senescence via their combined antioxidant, anti-inflammatory, and mitochondrial-enhancing properties.<\/jats:p>","DOI":"10.1038\/s41598-025-87635-y","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T05:47:13Z","timestamp":1738302433000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Curcumin nanoparticles alleviate brain mitochondrial dysfunction and cellular senescence in \u03b3-irradiated rats"],"prefix":"10.1038","volume":"15","author":[{"given":"Omnia A.","family":"Moselhy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahed","family":"Abdel-Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza","family":"El-bahkery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said S.","family":"Moselhy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"87635_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13014-022-02184-2","volume":"18","author":"JH Kim","year":"2023","unstructured":"Kim, J. H., Brown, S. L. & Gordon, M. N. Radiation-induced senescence: therapeutic opportunities. Radiat. Oncol. 18, 10 (2023).","journal-title":"Radiat. Oncol."},{"key":"87635_CR2","doi-asserted-by":"publisher","first-page":"550","DOI":"10.3390\/cells13060550","volume":"13","author":"M Ibragimova","year":"2024","unstructured":"Ibragimova, M., Kussainova, A., Aripova, A., Bersimbaev, R. & Bulgakova, O. The Mmolecular mechanisms in senescent cells induced by natural aging and ionizing radiation. Cells 13, 550 (2024).","journal-title":"Cells"},{"key":"87635_CR3","doi-asserted-by":"crossref","unstructured":"Miwa, S., Kashyap, S., Chini, E. & von Zglinicki, T. Mitochondrial dysfunction in cell senescence and aging. J. Clin. Invest. 132 (2022).","DOI":"10.1172\/JCI158447"},{"key":"87635_CR4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3390\/cells13040353","volume":"13","author":"M Camacho-Encina","year":"2024","unstructured":"Camacho-Encina, M. et al. Cellular senescence, mitochondrial dysfunction, and their link to cardiovascular disease. Cells 13, 353 (2024).","journal-title":"Cells"},{"key":"87635_CR5","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s41232-024-00342-5","volume":"44","author":"Y Saito","year":"2024","unstructured":"Saito, Y., Yamamoto, S. & Chikenji, T. S. Role of cellular senescence in inflammation and regeneration. Inflamm. Regen. 44, 28 (2024).","journal-title":"Inflamm. Regen"},{"key":"87635_CR6","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3390\/biom14040402","volume":"14","author":"SC Bondy","year":"2024","unstructured":"Bondy, S. C. Mitochondrial dysfunction as the major basis of brain aging. Biomolecules 14, 402 (2024).","journal-title":"Biomolecules"},{"key":"87635_CR7","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/j.bbabio.2015.05.021","volume":"1847","author":"RK Lane","year":"2015","unstructured":"Lane, R. K., Hilsabeck, T. & Rea, S. L. The role of mitochondrial dysfunction in age-related diseases. Biochim. Biophys. Acta (BBA)-Bioenergetics. 1847, 1387\u20131400 (2015).","journal-title":"Biochim. Biophys. Acta (BBA)-Bioenergetics"},{"key":"87635_CR8","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3390\/antiox13040394","volume":"13","author":"J Yang","year":"2024","unstructured":"Yang, J. et al. Progress in understanding oxidative stress, aging, and aging-related diseases. Antioxidants 13, 394 (2024).","journal-title":"Antioxidants"},{"key":"87635_CR9","doi-asserted-by":"crossref","unstructured":"Rea, I. M. et al. Age and age-related diseases: role of inflammation triggers and cytokines. Front. Immunol.  9, 586 (2018).","DOI":"10.3389\/fimmu.2018.00586"},{"key":"87635_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","volume":"22","author":"R Di Micco","year":"2021","unstructured":"Di Micco, R., Krizhanovsky, V., Baker, D.  & d\u2019Adda Di Fagagna, F. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat. Rev. Mol. Cell. Biol. 22, 75\u201395 (2021).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"87635_CR11","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/mco2.55","volume":"2","author":"Y Liu","year":"2021","unstructured":"Liu, Y. et al. Molecular mechanisms of chemo-and radiotherapy resistance and the potential implications for cancer treatment. MedComm 2, 315\u2013340 (2021).","journal-title":"MedComm"},{"key":"87635_CR12","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1080\/15384101.2022.2131163","volume":"22","author":"YJ Zhou","year":"2023","unstructured":"Zhou, Y. J. et al. Radiation-induced liver disease: beyond DNA damage. Cell. Cycle. 22, 506\u2013526 (2023).","journal-title":"Cell. Cycle"},{"key":"87635_CR13","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.3390\/plants12051178","volume":"12","author":"GT Duarte","year":"2023","unstructured":"Duarte, G. T., Volkova, P. Y., Perez, F., Horemans, N. & F. & Chronic ionizing radiation of plants: an evolutionary factor from direct damage to non-target effects. Plants 12, 1178 (2023).","journal-title":"Plants"},{"key":"87635_CR14","first-page":"98","volume":"13","author":"NA Ruprecht","year":"2024","unstructured":"Ruprecht, N. A. et al. A review: multi-omics approach to studying the association between ionizing radiation effects on biological aging. Biology (Basel). 13, 98 (2024).","journal-title":"Biology (Basel)"},{"key":"87635_CR15","first-page":"653","volume":"60","author":"J Talapko","year":"2024","unstructured":"Talapko, J. et al. Health effects of Ionizing Radiation on the human body. Med. (B Aires). 60, 653 (2024).","journal-title":"Med. (B Aires)"},{"key":"87635_CR16","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.3390\/cells11091418","volume":"11","author":"N Cai","year":"2022","unstructured":"Cai, N., Wu, Y. & Huang, Y. Induction of accelerated aging in a mouse model. Cells 11, 1418 (2022).","journal-title":"Cells"},{"key":"87635_CR17","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/febs.15570","volume":"288","author":"E Gonz\u00e1lez-Gualda","year":"2021","unstructured":"Gonz\u00e1lez-Gualda, E., Baker, A. G., Fruk, L. & Mu\u00f1oz\u2010Esp\u00edn D. A guide to assessing cellular senescence in vitro and in vivo. FEBS J. 288, 56\u201380 (2021).","journal-title":"FEBS J."},{"key":"87635_CR18","doi-asserted-by":"crossref","unstructured":"Muthamil, S. et al. Biomarkers of Cellular Senescence and Aging: current state-of\u2010the\u2010Art, challenges and Future perspectives. Adv. Biol. 2400079 (2024).","DOI":"10.1002\/adbi.202400079"},{"key":"87635_CR19","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.3390\/cells10061430","volume":"10","author":"LK McKay","year":"2021","unstructured":"McKay, L. K. & White, J. P. The AMPK\/p27Kip1 pathway as a novel target to promote autophagy and resilience in aged cells. Cells 10, 1430 (2021).","journal-title":"Cells"},{"key":"87635_CR20","doi-asserted-by":"publisher","first-page":"250","DOI":"10.31083\/j.fbl2810250","volume":"28","author":"Y Han","year":"2023","unstructured":"Han, Y. et al. The role and application of the AMPK-sirtuins network in cellular senescence. Front. Biosci. 28, 250 (2023).","journal-title":"Front. Biosci."},{"key":"87635_CR21","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1111\/febs.16325","volume":"290","author":"E Sheekey","year":"2023","unstructured":"Sheekey, E. & Narita, M. p53 in senescence\u2013it\u2019s a marathon, not a sprint. FEBS J. 290, 1212\u20131220 (2023).","journal-title":"FEBS J."},{"key":"87635_CR22","doi-asserted-by":"crossref","unstructured":"Yan, J. et al. The role of p21 in cellular senescence and aging-related diseases. Mol. Cells 100113 (2024).","DOI":"10.1016\/j.mocell.2024.100113"},{"key":"87635_CR23","doi-asserted-by":"publisher","first-page":"5732","DOI":"10.21037\/tcr.2020.03.39","volume":"9","author":"HB Muss","year":"2020","unstructured":"Muss, H. B. et al. p16 a biomarker of aging and tolerance for cancer therapy. Transl Cancer Res. 9, 5732 (2020).","journal-title":"Transl Cancer Res."},{"key":"87635_CR24","doi-asserted-by":"publisher","first-page":"2300461","DOI":"10.1002\/adbi.202300461","volume":"8","author":"SK Kureel","year":"2024","unstructured":"Kureel, S. K., Blair, B. & Sheetz, M. P. Recent advancement in elimination strategies and potential rejuvenation targets of Senescence. Adv. Biol. 8, 2300461 (2024).","journal-title":"Adv. Biol."},{"key":"87635_CR25","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3390\/antiox13030331","volume":"13","author":"C Bertoncini-Silva","year":"2024","unstructured":"Bertoncini-Silva, C. et al. Enhancing the bioavailability and bioactivity of curcumin for disease prevention and treatment. Antioxidants 13, 331 (2024).","journal-title":"Antioxidants"},{"key":"87635_CR26","doi-asserted-by":"publisher","first-page":"e14282","DOI":"10.1111\/and.14282","volume":"54","author":"MR Sadraei","year":"2022","unstructured":"Sadraei, M. R., Tavalaee, M., Forouzanfar, M. & Nasr-Esfahani, M. H. Effect of curcumin, and nano\u2010curcumin on sperm function in varicocele rat model. Andrologia 54, e14282 (2022).","journal-title":"Andrologia"},{"key":"87635_CR27","doi-asserted-by":"publisher","first-page":"889816","DOI":"10.3389\/fphar.2022.889816","volume":"13","author":"M Costantino","year":"2022","unstructured":"Costantino, M., Corno, C., Colombo, D. & Perego, P. Curcumin and related compounds in cancer cells: New avenues for old molecules. Front. Pharmacol. 13, 889816 (2022).","journal-title":"Front. Pharmacol."},{"key":"87635_CR28","doi-asserted-by":"publisher","first-page":"1233652","DOI":"10.3389\/fimmu.2023.1233652","volume":"14","author":"P Hu","year":"2023","unstructured":"Hu, P. et al. Curcumin derived from medicinal homologous foods: its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis. Front. Immunol. 14, 1233652 (2023).","journal-title":"Front. Immunol."},{"key":"87635_CR29","doi-asserted-by":"publisher","first-page":"12681","DOI":"10.1038\/s41598-023-39919-4","volume":"13","author":"MA Rahman","year":"2023","unstructured":"Rahman, M. A. et al. Combination of epigallocatechin 3 gallate and curcumin improves d-galactose and normal-aging associated memory impairment in mice. Sci. Rep. 13, 12681 (2023).","journal-title":"Sci. Rep."},{"key":"87635_CR30","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.3390\/nu13072385","volume":"13","author":"L Beltzig","year":"2021","unstructured":"Beltzig, L., Frumkina, A., Schwarzenbach, C. & Kaina, B. Cytotoxic, genotoxic and senolytic potential of native and micellar curcumin. Nutrients 13, 2385 (2021).","journal-title":"Nutrients"},{"key":"87635_CR31","doi-asserted-by":"crossref","unstructured":"Perales-Salinas, V., Purushotham, S. S. & Buskila, Y. Curcumin as a potential therapeutic agent for treating neurodegenerative diseases. Neurochem Int. 105790 (2024).","DOI":"10.1016\/j.neuint.2024.105790"},{"key":"87635_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2019.02.020","volume":"406","author":"S Abrahams","year":"2019","unstructured":"Abrahams, S., Haylett, W. L., Johnson, G., Carr, J. A. & Bardien, S. Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: a review. Neuroscience 406, 1\u201321 (2019).","journal-title":"Neuroscience"},{"key":"87635_CR33","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.3390\/cancers16081554","volume":"16","author":"V Zoi","year":"2024","unstructured":"Zoi, V. et al. The role of curcumin in cancer: a focus on the PI3K\/Akt pathway. Cancers (Basel). 16, 1554 (2024).","journal-title":"Cancers (Basel)"},{"key":"87635_CR34","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3390\/foods6100092","volume":"6","author":"SJ Hewlings","year":"2017","unstructured":"Hewlings, S. J.  &  Kalman, D. S. Curcumin: A review of its effects on human health. Foods 6, 92 (2017).","journal-title":"Foods"},{"key":"87635_CR35","doi-asserted-by":"publisher","first-page":"550909","DOI":"10.3389\/fphar.2020.01021","volume":"11","author":"J Sharifi-Rad","year":"2020","unstructured":"Sharifi-Rad, J. et al. Turmeric and its major compound curcumin on health: bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications. Front. Pharmacol. 11, 550909 (2020).","journal-title":"Front. Pharmacol."},{"key":"87635_CR36","doi-asserted-by":"publisher","first-page":"104326","DOI":"10.1016\/j.jddst.2023.104326","volume":"82","author":"K Gayathri","year":"2023","unstructured":"Gayathri, K., Bhaskaran, M., Selvam, C. & Thilagavathi, R. Nano formulation approaches for curcumin delivery-a review. J. Drug Deliv Sci. Technol. 82, 104326 (2023).","journal-title":"J. Drug Deliv Sci. Technol."},{"key":"87635_CR37","doi-asserted-by":"crossref","unstructured":"Han, Y. et al. Recent nanotechnology improvements in curcumin bioavailability and related applications. Food Biosci. 104660 (2024).","DOI":"10.1016\/j.fbio.2024.104660"},{"key":"87635_CR38","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.ijpharm.2011.06.030","volume":"416","author":"YM Tsai","year":"2011","unstructured":"Tsai, Y. M., Chien, C. F., Lin, L. C. & Tsai, T. H. Curcumin and its nano-formulation: the kinetics of tissue distribution and blood\u2013brain barrier penetration. Int. J. Pharm. 416, 331\u2013338 (2011).","journal-title":"Int. J. Pharm."},{"key":"87635_CR39","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s10876-022-02281-y","volume":"34","author":"OM Meabed","year":"2023","unstructured":"Meabed, O. M., Shamaa, A., Abdelrahman, I. Y., El-Sayyed, G. S. & Mohammed, S. S. The effect of nano-chitosan and nano-curcumin on radiated parotid glands of albino rats: comparative study. J. Clust Sci. 34, 977\u2013989 (2023).","journal-title":"J. Clust Sci."},{"key":"87635_CR40","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","volume":"28","author":"W Brand-Williams","year":"1995","unstructured":"Brand-Williams, W., Cuvelier, M. E. & Berset, C. Use of a free radical method to evaluate antioxidant activity. LWT-Food Sci. Technol. 28, 25\u201330 (1995).","journal-title":"LWT-Food Sci. Technol."},{"key":"87635_CR41","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0367-326X(99)00030-1","volume":"70","author":"UA Shinde","year":"1999","unstructured":"Shinde, U. A. et al. Membrane stabilizing activity\u2014a possible mechanism of action for the anti-inflammatory activity of Cedrus deodara wood oil. Fitoterapia 70, 251\u2013257 (1999).","journal-title":"Fitoterapia"},{"key":"87635_CR42","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1177\/0023677215597136","volume":"50","author":"S Shekarforoush","year":"2016","unstructured":"Shekarforoush, S., Fatahi, Z. & Safari, F. The effects of pentobarbital, ketamine\u2013pentobarbital and ketamine\u2013xylazine anesthesia in a rat myocardial ischemic reperfusion injury model. Lab. Anim. 50, 179\u2013184 (2016).","journal-title":"Lab. Anim."},{"key":"87635_CR43","doi-asserted-by":"crossref","unstructured":"Forbes, M. E., Robbins, M. E. & Riddle, D. R. Aging-dependent changes in the Radiation response of the adult rat brain. Int. J. Radiat. Oncol. Biol. Phys. 70, (2008).","DOI":"10.1016\/j.ijrobp.2007.10.054"},{"key":"87635_CR44","doi-asserted-by":"publisher","first-page":"583","DOI":"10.14336\/AD.2021.0829","volume":"13","author":"S Attaluri","year":"2022","unstructured":"Attaluri, S. et al. Oral nano-curcumin in a model of chronic Gulf War illness alleviates brain dysfunction with modulation of oxidative stress, mitochondrial function, neuroinflammation, neurogenesis, and gene expression. Aging Dis. 13, 583 (2022).","journal-title":"Aging Dis."},{"key":"87635_CR45","doi-asserted-by":"publisher","first-page":"1347286","DOI":"10.3389\/fcell.2024.1347286","volume":"12","author":"J Song","year":"2024","unstructured":"Song, J. et al. Effects of reactive oxygen species and mitochondrial dysfunction on reproductive aging. Front. Cell. Dev. Biol. 12, 1347286 (2024).","journal-title":"Front. Cell. Dev. Biol."},{"key":"87635_CR46","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3390\/antiox13030312","volume":"13","author":"Y Hong","year":"2024","unstructured":"Hong, Y., Boiti, A., Vallone, D. & Foulkes, N. S. Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution. Antioxidants 13, 312 (2024).","journal-title":"Antioxidants"},{"key":"87635_CR47","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","volume":"97","author":"K Jomova","year":"2023","unstructured":"Jomova, K. et al. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch. Toxicol. 97, 2499\u20132574 (2023).","journal-title":"Arch. Toxicol."},{"key":"87635_CR48","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.2174\/1389201024666221121160822","volume":"24","author":"Z Roy","year":"2023","unstructured":"Roy, Z., Bansal, R., Siddiqui, L. & Chaudhary, N. Understanding the role of free radicals and antioxidant enzymes in human diseases. Curr. Pharm. Biotechnol. 24, 1265\u20131276 (2023).","journal-title":"Curr. Pharm. Biotechnol."},{"key":"87635_CR49","doi-asserted-by":"crossref","unstructured":"Jomova, K. et al. Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants. Arch. Toxicol. 1\u201345 (2024).","DOI":"10.1007\/s00204-024-03696-4"},{"key":"87635_CR50","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fcvm.2020.00020","volume":"7","author":"K Livingston","year":"2020","unstructured":"Livingston, K., Schlaak, R. A., Puckett, L. L. & Bergom, C. The role of mitochondrial dysfunction in radiation-induced heart disease: from bench to bedside. Front. Cardiovasc. Med. 7, 20 (2020).","journal-title":"Front. Cardiovasc. Med."},{"key":"87635_CR51","doi-asserted-by":"crossref","unstructured":"Soloviev, A. & Sydorenko, V. Oxidative and nitrous stress underlies vascular Malfunction Induced by Ionizing Radiation and Diabetes. Cardiovasc. Toxicol. 1\u201313 (2024).","DOI":"10.1007\/s12012-024-09878-x"},{"key":"87635_CR52","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41420-021-00634-6","volume":"7","author":"W Zhu","year":"2021","unstructured":"Zhu, W., Zhang, X., Yu, M., Lin, B. & Yu, C. Radiation-induced liver injury and hepatocyte senescence. Cell. Death Discov. 7, 244 (2021).","journal-title":"Cell. Death Discov"},{"key":"87635_CR53","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/s41580-020-0228-x","volume":"21","author":"E Zlotorynski","year":"2020","unstructured":"Zlotorynski, E. Defective mitochondria ignite the SASP. Nat. Rev. Mol. Cell. Biol. 21, 179\u2013180 (2020).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"87635_CR54","doi-asserted-by":"publisher","first-page":"908","DOI":"10.2174\/0113895575259219230920093214","volume":"24","author":"S Kumar","year":"2024","unstructured":"Kumar, S. et al. Role of flavonoids in modulation of mitochondria dynamics during oxidative stress. Mini Rev. Med. Chem. 24, 908\u2013919 (2024).","journal-title":"Mini Rev. Med. Chem."},{"key":"87635_CR55","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s11010-023-04757-5","volume":"479","author":"D Khayatan","year":"2024","unstructured":"Khayatan, D. et al. Superoxide dismutase: a key target for the neuroprotective effects of curcumin. Mol. Cell. Biochem. 479, 693\u2013705 (2024).","journal-title":"Mol. Cell. Biochem."},{"key":"87635_CR56","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1007\/s11033-024-09639-7","volume":"51","author":"A Singh","year":"2024","unstructured":"Singh, A., Yadawa, A. K. & Rizvi, S. I. Curcumin protects against aging-related stress and dysfunction through autophagy activation in rat brain. Mol. Biol. Rep. 51, 694 (2024).","journal-title":"Mol. Biol. Rep."},{"key":"87635_CR57","doi-asserted-by":"crossref","unstructured":"Salimi, A., Jamali, Z. & Shirmard, L. R. Curcumin for protecting mitochondria and downregulating inflammation. In Molecular Nutrition and Mitochondria 461\u2013500 (Elsevier, 2023).","DOI":"10.1016\/B978-0-323-90256-4.00014-X"},{"key":"87635_CR58","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41580-021-00415-0","volume":"23","author":"I Vercellino","year":"2022","unstructured":"Vercellino, I. & Sazanov, L. A. The assembly, regulation and function of the mitochondrial respiratory chain. Nat. Rev. Mol. cell. Biol. 23, 141\u2013161 (2022).","journal-title":"Nat. Rev. Mol. cell. Biol."},{"key":"87635_CR59","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/13510002.2022.2046423","volume":"27","author":"B Zhang","year":"2022","unstructured":"Zhang, B. et al. Role of mitochondrial reactive oxygen species in homeostasis regulation. Redox Rep. 27, 45\u201352 (2022).","journal-title":"Redox Rep."},{"key":"87635_CR60","doi-asserted-by":"publisher","first-page":"972","DOI":"10.3390\/pharmaceutics16080972","volume":"16","author":"M Yang","year":"2024","unstructured":"Yang, M. et al. Polyphenolic nanomedicine regulating mitochondria REDOX for innovative cancer treatment. Pharmaceutics 16, 972 (2024).","journal-title":"Pharmaceutics"},{"key":"87635_CR61","doi-asserted-by":"publisher","first-page":"3570","DOI":"10.3390\/cells10123570","volume":"10","author":"QQ Wang","year":"2021","unstructured":"Wang, Q. Q. et al. Ionizing radiation-induced brain cell aging and the potential underlying molecular mechanisms. Cells 10, 3570 (2021).","journal-title":"Cells"},{"key":"87635_CR62","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1089\/dna.2019.5347","volume":"39","author":"M Kowalska","year":"2020","unstructured":"Kowalska, M. et al. Mitochondrial and nuclear DNA oxidative damage in physiological and pathological aging. DNA Cell. Biol. 39, 1410\u20131420 (2020).","journal-title":"DNA Cell. Biol."},{"key":"87635_CR63","doi-asserted-by":"publisher","first-page":"148032","DOI":"10.1016\/j.brainres.2022.148032","volume":"1792","author":"F Hu","year":"2022","unstructured":"Hu, F. et al. Vinpocetine and coenzyme Q10 combination alleviates cognitive impairment caused by ionizing radiation by improving mitophagy. Brain Res. 1792, 148032 (2022).","journal-title":"Brain Res."},{"key":"87635_CR64","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s12640-011-9249-8","volume":"20","author":"PK Sood","year":"2011","unstructured":"Sood, P. K., Nahar, U. & Nehru, B. Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brain. Neurotox. Res. 20, 351\u2013361 (2011).","journal-title":"Neurotox. Res."},{"key":"87635_CR65","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.pbb.2016.09.002","volume":"150","author":"DK Khatri","year":"2016","unstructured":"Khatri, D. K. & Juvekar, A. R. Neuroprotective effect of curcumin as evinced by abrogation of rotenone-induced motor deficits, oxidative and mitochondrial dysfunctions in mouse model of Parkinson\u2019s disease. Pharmacol. Biochem. Behav. 150, 39\u201347 (2016).","journal-title":"Pharmacol. Biochem. Behav."},{"key":"87635_CR66","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/biof.1566","volume":"46","author":"H Bagheri","year":"2020","unstructured":"Bagheri, H. et al. Effects of curcumin on mitochondria in neurodegenerative diseases. Biofactors 46, 5\u201320 (2020).","journal-title":"Biofactors"},{"key":"87635_CR67","doi-asserted-by":"publisher","first-page":"6328","DOI":"10.3390\/ijms24076328","volume":"24","author":"MC Chiang","year":"2023","unstructured":"Chiang, M. C., Tsai, T. Y. & Wang, C. J. The potential benefits of quercetin for brain health: a review of anti-inflammatory and neuroprotective mechanisms. Int. J. Mol. Sci. 24, 6328 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"87635_CR68","first-page":"3275","volume":"13","author":"C Gan","year":"2023","unstructured":"Gan, C. et al. Advances in the study of the molecular biological mechanisms of radiation-induced brain injury. Am. J. Cancer Res. 13, 3275 (2023).","journal-title":"Am. J. Cancer Res."},{"key":"87635_CR69","doi-asserted-by":"publisher","first-page":"e14794","DOI":"10.1111\/cns.14794","volume":"30","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. Microglia in radiation-induced brain injury: Cellular and molecular mechanisms and therapeutic potential. CNS Neurosci. Ther. 30, e14794 (2024).","journal-title":"CNS Neurosci. Ther."},{"key":"87635_CR70","doi-asserted-by":"publisher","first-page":"9183","DOI":"10.3390\/molecules20059183","volume":"20","author":"Y He","year":"2015","unstructured":"He, Y. et al. Curcumin, inflammation, and chronic diseases: how are they linked? Molecules 20, 9183\u20139213 (2015).","journal-title":"Molecules"},{"key":"87635_CR71","doi-asserted-by":"publisher","first-page":"100226","DOI":"10.1016\/j.phanu.2020.100226","volume":"14","author":"A Vaiserman","year":"2020","unstructured":"Vaiserman, A., Koliada, A., Zayachkivska, A. & Lushchak, O. Curcumin: a therapeutic potential in ageing-related disorders. PharmaNutrition 14, 100226 (2020).","journal-title":"PharmaNutrition"},{"key":"87635_CR72","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","volume":"7","author":"K Lingappan","year":"2018","unstructured":"Lingappan, K. NF-\u03baB in oxidative stress. Curr. Opin. Toxicol. 7, 81\u201386 (2018).","journal-title":"Curr. Opin. Toxicol."},{"key":"87635_CR73","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1007\/s11357-024-01092-5","volume":"46","author":"M Izadi","year":"2024","unstructured":"Izadi, M. et al. Longevity and anti-aging effects of curcumin supplementation. GeroScience 46, 2933\u20132950 (2024).","journal-title":"GeroScience"},{"key":"87635_CR74","doi-asserted-by":"publisher","first-page":"110544","DOI":"10.1016\/j.fct.2019.05.052","volume":"131","author":"M Cano","year":"2019","unstructured":"Cano, M., Guerrero-Castilla, A., Nabavi, S. M., Ayala, A. & Arg\u00fcelles, S. Targeting pro-senescence mitogen activated protein kinase (Mapk) enzymes with bioactive natural compounds. Food Chem. Toxicol. 131, 110544 (2019).","journal-title":"Food Chem. Toxicol."},{"key":"87635_CR75","first-page":"1108","volume":"11","author":"SJ Lee","year":"2022","unstructured":"Lee, S. J., Lee, D. Y., O\u2019Connell, J. F., Egan, J. M. & Kim, Y. Black ginseng ameliorates cellular senescence via p53-p21\/p16 pathway in aged mice. Biology (Basel). 11, 1108 (2022).","journal-title":"Biology (Basel)"},{"key":"87635_CR76","doi-asserted-by":"publisher","first-page":"645593","DOI":"10.3389\/fcell.2021.645593","volume":"9","author":"R Kumari","year":"2021","unstructured":"Kumari, R. & Jat, P. Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front. cell. Dev. Biol. 9, 645593 (2021).","journal-title":"Front. cell. Dev. Biol."},{"key":"87635_CR77","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1002\/ijc.32253","volume":"145","author":"X Luo","year":"2019","unstructured":"Luo, X. et al. Posttranslational regulation of PGC-1\u03b1 and its implication in cancer metabolism. Int. J. cancer. 145, 1475\u20131483 (2019).","journal-title":"Int. J. cancer"},{"key":"87635_CR78","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3390\/biom10030420","volume":"10","author":"M Mijit","year":"2020","unstructured":"Mijit, M., Caracciolo, V., Melillo, A., Amicarelli, F. & Giordano, A. Role of p53 in the regulation of cellular senescence. Biomolecules 10, 420 (2020).","journal-title":"Biomolecules"},{"key":"87635_CR79","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1073\/pnas.1818313116","volume":"116","author":"JY Liu","year":"2019","unstructured":"Liu, J. Y. et al. Cells exhibiting strong p16 INK4a promoter activation in vivo display features of senescence. Proc. Natl. Acad. Sci. 116, 2603\u20132611 (2019).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"87635_CR80","doi-asserted-by":"publisher","first-page":"jcs259114","DOI":"10.1242\/jcs.259114","volume":"135","author":"G Lossaint","year":"2022","unstructured":"Lossaint, G. et al. Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest. J. Cell. Sci. 135, jcs259114 (2022).","journal-title":"J. Cell. Sci."},{"key":"87635_CR81","doi-asserted-by":"publisher","first-page":"950","DOI":"10.3390\/nu13030950","volume":"13","author":"SC Wong","year":"2021","unstructured":"Wong, S. C., Kamarudin, M. N. A. & Naidu, R. Anticancer mechanism of curcumin on human glioblastoma. Nutrients 13, 950 (2021).","journal-title":"Nutrients"},{"key":"87635_CR82","doi-asserted-by":"crossref","unstructured":"Yang, L., Shi, J., Wang, X. & Zhang, R. Curcumin alleviates D-galactose\u2010induced cardiomyocyte senescence by promoting autophagy via the SIRT1\/AMPK\/mTOR pathway Evidence-Based Complement. Altern. Med. 2022, 2990843 (2022).","DOI":"10.1155\/2022\/2990843"},{"key":"87635_CR83","doi-asserted-by":"publisher","first-page":"102363","DOI":"10.1016\/j.jchemneu.2023.102363","volume":"134","author":"S Shao","year":"2023","unstructured":"Shao, S., Ye, X., Su, W. & Wang, Y. Curcumin alleviates Alzheimer\u2019s disease by inhibiting inflammatory response, oxidative stress and activating the AMPK pathway. J. Chem. Neuroanat. 134, 102363 (2023).","journal-title":"J. Chem. Neuroanat."},{"key":"87635_CR84","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1007\/s10787-023-01399-3","volume":"32","author":"MA Sadek","year":"2024","unstructured":"Sadek, M. A., Rabie, M. A., El Sayed, N. S., Sayed, H. M. & Kandil, E. A. Neuroprotective effect of curcumin against experimental autoimmune encephalomyelitis-induced cognitive and physical impairments in mice: an insight into the role of the AMPK\/SIRT1 pathway. Inflammopharmacology 32, 1499\u20131518 (2024).","journal-title":"Inflammopharmacology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87635-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87635-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87635-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T05:49:28Z","timestamp":1738302568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87635-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":84,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["87635"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-87635-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"assertion":[{"value":"5 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3857"}}