{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:27:26Z","timestamp":1788956846607,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-87744-8","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T14:01:50Z","timestamp":1737727310000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of perfluorolauric acid exposure on intestinal microbial community and physiological health indicators in mice"],"prefix":"10.1038","volume":"15","author":[{"given":"Jiaqiong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulang","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouping","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"issue":"2","key":"87744_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","volume":"99","author":"C Lau","year":"2007","unstructured":"Lau, C. et al. Perfluoroalkyl acids: A review of monitoring and toxicological findings. Toxicol. Sci. 99(2), 366\u2013394 (2007).","journal-title":"Toxicol. Sci."},{"issue":"4","key":"87744_CR2","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/ieam.258","volume":"7","author":"RC Buck","year":"2011","unstructured":"Buck, R. C. et al. Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr. Environ. Assess. Manag. 7(4), 513\u2013541 (2011).","journal-title":"Integr. Environ. Assess. Manag."},{"issue":"3\u20134","key":"87744_CR3","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.reprotox.2009.02.008","volume":"27","author":"Z Shi","year":"2009","unstructured":"Shi, Z. et al. The effect of perfluorododecanonic acid on endocrine status, sex hormones and expression of steroidogenic genes in pubertal female rats. Reprod. Toxicol. 27(3\u20134), 352\u2013359 (2009).","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"87744_CR4","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1021\/acs.chemrestox.8b00241","volume":"32","author":"Y Chen","year":"2018","unstructured":"Chen, Y. et al. Perfluorododecanoic acid blocks rat leydig cell development during prepuberty. Chem. Res. Toxicol. 32(1), 146\u2013155 (2018).","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"87744_CR5","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/toxsci\/kfm070","volume":"98","author":"Z Shi","year":"2007","unstructured":"Shi, Z. et al. Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Toxicol. Sci. 98(1), 206\u2013215 (2007).","journal-title":"Toxicol. Sci."},{"issue":"11","key":"87744_CR6","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1177\/0748233720957534","volume":"36","author":"X Fang","year":"2020","unstructured":"Fang, X., Zhang, X. & Li, H. Oxidative stress and mitochondrial membrane potential are involved in the cytotoxicity of perfluorododecanoic acid to neurons. Toxicol. Ind. Health 36(11), 892\u2013897 (2020).","journal-title":"Toxicol. Ind. Health"},{"key":"87744_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111041","volume":"203","author":"L Min","year":"2020","unstructured":"Min, L., Chi, Y. & Dong, S. Gut microbiota health closely associates with PCB153-derived risk of host diseases. Ecotoxicol. Environ. Saf. 203, 111041 (2020).","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7415","key":"87744_CR8","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nature11550","volume":"489","author":"CA Lozupone","year":"2012","unstructured":"Lozupone, C. A. et al. Diversity, stability and resilience of the human gut microbiota. Nature 489(7415), 220\u2013230 (2012).","journal-title":"Nature"},{"issue":"1","key":"87744_CR9","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1038\/s41467-018-05184-7","volume":"9","author":"MA Jackson","year":"2018","unstructured":"Jackson, M. A. et al. Gut microbiota associations with common diseases and prescription medications in a population-based cohort. Nat. Commun. 9(1), 2655 (2018).","journal-title":"Nat. Commun."},{"issue":"5","key":"87744_CR10","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.3390\/nu12051474","volume":"12","author":"F Magne","year":"2020","unstructured":"Magne, F. et al. The Firmicutes\/bacteroidetes ratio: A relevant marker of gut dysbiosis in obese patients?. Nutrients 12(5), 1474 (2020).","journal-title":"Nutrients"},{"key":"87744_CR11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3389\/fmicb.2018.00235","volume":"9","author":"JG Kers","year":"2018","unstructured":"Kers, J. G. et al. Host and environmental factors affecting the intestinal microbiota in chickens. Front. Microbiol. 9, 235 (2018).","journal-title":"Front. Microbiol."},{"issue":"6","key":"87744_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2015.9","volume":"5","author":"LK Brahe","year":"2015","unstructured":"Brahe, L. K. et al. Specific gut microbiota features and metabolic markers in postmenopausal women with obesity. Nutr. Diabetes 5(6), e159 (2015).","journal-title":"Nutr. Diabetes"},{"key":"87744_CR13","doi-asserted-by":"publisher","first-page":"152365","DOI":"10.1016\/j.tox.2020.152365","volume":"431","author":"L Zhang","year":"2020","unstructured":"Zhang, L. et al. Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice. Toxicology 431, 152365 (2020).","journal-title":"Toxicology"},{"issue":"1","key":"87744_CR14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.toxlet.2013.01.012","volume":"218","author":"H Zhang","year":"2013","unstructured":"Zhang, H. et al. Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity. Toxicol. Lett. 218(1), 61\u201369 (2013).","journal-title":"Toxicol. Lett."},{"key":"87744_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-1-4939-3774-5_2","volume":"1452","author":"M Panova","year":"2016","unstructured":"Panova, M. et al. DNA extraction protocols for whole-genome sequencing in marine organisms. Methods Mol. Biol. 1452, 13\u201344 (2016).","journal-title":"Methods Mol. Biol."},{"key":"87744_CR16","doi-asserted-by":"publisher","first-page":"15032","DOI":"10.1038\/nmicrobiol.2015.32","volume":"1","author":"EA Eloe-Fadrosh","year":"2016","unstructured":"Eloe-Fadrosh, E. A. et al. Metagenomics uncovers gaps in amplicon-based detection of microbial diversity. Nat. Microbiol. 1, 15032 (2016).","journal-title":"Nat. Microbiol."},{"issue":"10","key":"87744_CR17","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nmeth.2604","volume":"10","author":"RC Edgar","year":"2013","unstructured":"Edgar, R. C. UPARSE: Highly accurate OTU sequences from microbial amplicon reads. Nat. Methods 10(10), 996\u2013998 (2013).","journal-title":"Nat. Methods"},{"issue":"7505","key":"87744_CR18","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nature13421","volume":"510","author":"S Subramanian","year":"2014","unstructured":"Subramanian, S. et al. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature 510(7505), 417\u2013421 (2014).","journal-title":"Nature"},{"issue":"8","key":"87744_CR19","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1096\/fj.10-173716","volume":"25","author":"E Moran-Salvador","year":"2011","unstructured":"Moran-Salvador, E. et al. Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. FASEB J. 25(8), 2538\u20132550 (2011).","journal-title":"FASEB J."},{"key":"87744_CR20","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fcimb.2014.00028","volume":"4","author":"KK Gkouskou","year":"2014","unstructured":"Gkouskou, K. K. et al. The gut microbiota in mouse models of inflammatory bowel disease. Front. Cell Infect. Microbiol. 4, 28 (2014).","journal-title":"Front. Cell Infect. Microbiol."},{"key":"87744_CR21","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.envpol.2019.07.066","volume":"253","author":"KM Rude","year":"2019","unstructured":"Rude, K. M. et al. Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice. Environ. Pollut. 253, 708\u2013721 (2019).","journal-title":"Environ. Pollut."},{"key":"87744_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fnut.2019.00057","volume":"6","author":"G Pinget","year":"2019","unstructured":"Pinget, G. et al. Impact of the food additive titanium dioxide (E171) on gut microbiota\u2013host interaction. Front. Nutr. 6, 57 (2019).","journal-title":"Front. Nutr."},{"issue":"6","key":"87744_CR23","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1289\/ehp.1306534","volume":"121","author":"JJ Choi","year":"2013","unstructured":"Choi, J. J. et al. Exercise attenuates PCB-induced changes in the mouse gut microbiome. Environ. Health Perspect. 121(6), 725\u2013730 (2013).","journal-title":"Environ. Health Perspect."},{"issue":"7410","key":"87744_CR24","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nature11319","volume":"488","author":"MJ Claesson","year":"2012","unstructured":"Claesson, M. J. et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 488(7410), 178\u2013184 (2012).","journal-title":"Nature"},{"issue":"4","key":"87744_CR25","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1021\/acs.chemrestox.6b00401","volume":"30","author":"B Gao","year":"2017","unstructured":"Gao, B. et al. Multi-omics reveals that lead exposure disturbs gut microbiome development, key metabolites, and metabolic pathways. Chem. Res. Toxicol. 30(4), 996\u20131005 (2017).","journal-title":"Chem. Res. Toxicol."},{"issue":"3","key":"87744_CR26","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1152\/physrev.00045.2009","volume":"90","author":"I Sekirov","year":"2010","unstructured":"Sekirov, I. et al. Gut microbiota in health and disease. Physiol. Rev. 90(3), 859\u2013904 (2010).","journal-title":"Physiol. Rev."},{"issue":"3","key":"87744_CR27","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/hep.28356","volume":"63","author":"J Boursier","year":"2016","unstructured":"Boursier, J. et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology 63(3), 764\u2013775 (2016).","journal-title":"Hepatology"},{"issue":"4","key":"87744_CR28","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1021\/acs.est.7b06322","volume":"52","author":"L Chen","year":"2018","unstructured":"Chen, L. et al. Dysregulation of intestinal health by environmental pollutants: involvement of the estrogen receptor and aryl hydrocarbon receptor. Environ. Sci. Technol. 52(4), 2323\u20132330 (2018).","journal-title":"Environ. Sci. Technol."},{"key":"87744_CR29","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.envint.2018.07.016","volume":"119","author":"BY Yang","year":"2018","unstructured":"Yang, B. Y. et al. Exposure to ambient air pollution and blood lipids in adults: The 33 Communities Chinese Health Study. Environ. Int. 119, 485\u2013492 (2018).","journal-title":"Environ. Int."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87744-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87744-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87744-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T14:01:51Z","timestamp":1737727311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-87744-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["87744"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-87744-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"assertion":[{"value":"22 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3106"}}