{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:16:23Z","timestamp":1789578983855,"version":"build-2803163510"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Top Talent Support Program for young and middle-aged people of Wuxi Health Committee","award":["HB2023076"],"award-info":[{"award-number":["HB2023076"]}]},{"name":"Traditional Chinese Medicine Bureau of Jiangsu Province and National Clinical base of Traditional Chinese Medicine open subject","award":["JD2023SZ2"],"award-info":[{"award-number":["JD2023SZ2"]}]},{"name":"Natural Science Foundation of Nanjing University of Traditional Chinese Medicine","award":["XZR2023092"],"award-info":[{"award-number":["XZR2023092"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274427"],"award-info":[{"award-number":["82274427"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taihu Talent Program for senior medical team project of Wuxi City","award":["Talent Office of Wuxi [p2021] No.9"],"award-info":[{"award-number":["Talent Office of Wuxi [p2021] No.9"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-88009-0","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T10:48:21Z","timestamp":1739184501000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacological and toxicological effects of Jiangfangbaoxin and determination of its components in the blood of spontaneously hypertensive rats"],"prefix":"10.1038","volume":"15","author":[{"given":"Zhiqi","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"88009_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.ccl.2016.12.005","volume":"35","author":"KC Ferdinand","year":"2017","unstructured":"Ferdinand, K. C. & Nasser, S. A. Management of essential hypertension. Cardiol. Clin. 35, 231\u2013246. https:\/\/doi.org\/10.1016\/j.ccl.2016.12.005 (2017).","journal-title":"Cardiol. Clin."},{"key":"88009_CR2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S0140-6736(07)61299-9","volume":"370","author":"FH Messerli","year":"2007","unstructured":"Messerli, F. H., Williams, B. & Ritz, E. Essential hypertension. Lancet 370, 591\u2013603. https:\/\/doi.org\/10.1016\/S0140-6736(07)61299-9 (2007).","journal-title":"Lancet"},{"key":"88009_CR3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s40292-017-0245-9","volume":"25","author":"RM Bruno","year":"2018","unstructured":"Bruno, R. M., Masi, S., Taddei, M., Taddei, S. & Virdis, A. Essential hypertension and functional microvascular ageing. High. Blood Press. Cardiovasc. Prev. 25, 35\u201340. https:\/\/doi.org\/10.1007\/s40292-017-0245-9 (2018).","journal-title":"High. Blood Press. Cardiovasc. Prev."},{"key":"88009_CR4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1001\/jama.2016.19043","volume":"317","author":"MH Forouzanfar","year":"2017","unstructured":"Forouzanfar, M. H. et al. Global Burden of Hypertension and systolic blood pressure of at least 110 to 115\u00a0mm hg, 1990\u20132015. JAMA 317, 165. https:\/\/doi.org\/10.1001\/jama.2016.19043 (2017).","journal-title":"JAMA"},{"key":"88009_CR5","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.117.032380","volume":"137","author":"Z Wang","year":"2018","unstructured":"Wang, Z. et al. Status of hypertension in China. Circulation 137, 2344\u20132356. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.032380 (2018).","journal-title":"Circulation"},{"key":"88009_CR6","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.2174\/138161211798157766","volume":"17","author":"I Sudano","year":"2011","unstructured":"Sudano, I., Roas, S. & Noll, G. Vascular abnormalities in essential hypertension. Curr. Pharm. Des. 17, 3039\u20133044. https:\/\/doi.org\/10.2174\/138161211798157766 (2011).","journal-title":"Curr. Pharm. Des."},{"key":"88009_CR7","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1161\/HYPERTENSIONAHA.120.15026","volume":"75","author":"T Unger","year":"2020","unstructured":"Unger, T. et al. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension 75, 1334\u20131357. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.120.15026 (2020).","journal-title":"Hypertension"},{"key":"88009_CR8","doi-asserted-by":"publisher","first-page":"e920682","DOI":"10.12659\/MSM.920682","volume":"26","author":"T Liu","year":"2020","unstructured":"Liu, T. et al. Network Pharmacology Identifies the Mechanisms of Action of TaohongSiwu Decoction against Essential Hypertension. Med. Sci. Monit. 26, e920682. https:\/\/doi.org\/10.12659\/MSM.920682 (2020).","journal-title":"Med. Sci. Monit."},{"key":"88009_CR9","doi-asserted-by":"publisher","first-page":"e32133","DOI":"10.1097\/MD.0000000000032133","volume":"101","author":"P Xie","year":"2022","unstructured":"Xie, P. et al. The effect of Taohong Siwu decoction combined with antihypertensive medicine in the treatment of hypertension: Meta-analysis. Med. (Baltim). 101, e32133. https:\/\/doi.org\/10.1097\/MD.0000000000032133 (2022).","journal-title":"Med. (Baltim)."},{"key":"88009_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/8676490","volume":"2019","author":"J Li","year":"2019","unstructured":"Li, J. et al. The mechanism of acupuncture in treating essential hypertension: a narrative review. Int. J. Hypertens. 2019, 1\u201310. https:\/\/doi.org\/10.1155\/2019\/8676490 (2019).","journal-title":"Int. J. Hypertens."},{"key":"88009_CR11","first-page":"17","volume":"14","author":"L Shu","year":"1998","unstructured":"Shu, L., Xinyu, W., Xiaosheng, W., Lihua, Z. & Shaoyu, G. Effects of JiangFangBaoXin tablets on left ventricular hypertrophy in hypertension. J. Nanjing Unverisity TCM. 14, 17\u201319 (1998).","journal-title":"J. Nanjing Unverisity TCM"},{"key":"88009_CR12","first-page":"13","volume":"19","author":"L Shu","year":"1999","unstructured":"Shu, L. et al. Effects of Jiangfangbaozhong herbal compound on left ventricular hypertrophy in renovascular hypertensive rats. Chin. J. Integr. Med. 19, 13\u201314 (1999).","journal-title":"Chin. J. Integr. Med."},{"key":"88009_CR13","first-page":"78","volume":"11","author":"Z Zhibin","year":"2009","unstructured":"Zhibin, Z., Shu, L., Ping, L., Chengxia, X. & Shaoyu, G. Regulation of JiangFangBaoXin Capsule to insulin resistance of essential hypertension patients. J. Liaoning Univ. TCM. 11, 78\u201379 (2009).","journal-title":"J. Liaoning Univ. TCM"},{"key":"88009_CR14","first-page":"28","volume":"5","author":"L Shu","year":"1999","unstructured":"Shu, L. et al. Effect of JiangFangBaoXin Decotion on Renin Angiotension System in Renovascular Hypertensive rats. Chin. J. Expertimental Traditional Med. Formula. 5, 28\u201332 (1999).","journal-title":"Chin. J. Expertimental Traditional Med. Formula"},{"key":"88009_CR15","unstructured":"Shu, L., Di, Y., Xiaosheng, W., Jinxing, G. & Hong, X. Effect of Jiangfang Baoxin Decoction on renin angiotensin system in renovascular hypertensive rats. Chin. J. Exp. Trad. Med. Formula  28\u201332 (1999)."},{"key":"88009_CR16","first-page":"254","volume":"17","author":"Z Zhibin","year":"2011","unstructured":"Zhibin, Z., Shu, L. & Chungang, Z. Regulation of JiangFangBaoXin Capsule to vascular endothelial cell dysfunction in essential hypertension patients. Chin. J. Experimental Traditional Med. Formula. 17, 254\u2013257 (2011).","journal-title":"Chin. J. Experimental Traditional Med. Formula"},{"key":"88009_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-023-10440-3","author":"W Wei","year":"2023","unstructured":"Wei, W. et al. Total glucosides of paeony ameliorate myocardial injury in chronic heart failure rats by suppressing PARP-1. J. Cardiovasc. Transl Res. https:\/\/doi.org\/10.1007\/s12265-023-10440-3 (2023).","journal-title":"J. Cardiovasc. Transl Res."},{"key":"88009_CR18","doi-asserted-by":"publisher","unstructured":"Liu, B. et al. Clinical safety of total glucosides of paeony adjuvant therapy for rheumatoid arthritis treatment: a systematic review and meta-analysis. BMC Complement. Med. Ther. 21 https:\/\/doi.org\/10.1186\/s12906-021-03252-y (2021).","DOI":"10.1186\/s12906-021-03252-y"},{"key":"88009_CR19","doi-asserted-by":"publisher","first-page":"110139","DOI":"10.1016\/j.intimp.2023.110139","volume":"119","author":"W Li","year":"2023","unstructured":"Li, W. et al. Tetrandrine alleviates atherosclerosis via inhibition of STING-TBK1 pathway and inflammation in macrophages. Int. Immunopharmacol. 119, 110139. https:\/\/doi.org\/10.1016\/j.intimp.2023.110139 (2023).","journal-title":"Int. Immunopharmacol."},{"key":"88009_CR20","doi-asserted-by":"publisher","unstructured":"Xiao, Y. et al. Quercetin and kaempferol increase the intestinal absorption of isorhamnetin coexisting in Elaeagnus rhamnoides (L.) A. Nelson (Elaeagnaceae) extracts via regulating multidrug resistance-associated protein 2. Phytomedicine 154\u2013162. https:\/\/doi.org\/10.1016\/j.phymed.2018.09.028 (2019).","DOI":"10.1016\/j.phymed.2018.09.028"},{"key":"88009_CR21","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.trsl.2014.07.005","volume":"164","author":"C Tsai","year":"2014","unstructured":"Tsai, C., Kuo, H., Hsu, C., Huang, L. & Tain, Y. Metformin reduces asymmetric dimethylarginine and prevents hypertension in spontaneously hypertensive rats. Transl Res. 164, 452\u2013459. https:\/\/doi.org\/10.1016\/j.trsl.2014.07.005 (2014).","journal-title":"Transl Res."},{"key":"88009_CR22","doi-asserted-by":"publisher","unstructured":"Diego, L. M. et al. Modulation of TNF -\u03b1, interleukin\u20106, and interleukin\u201010 by nebivolol\u2013valsartan and nebivolol\u2013lisinopril polytherapy in SHR rats. Pharmacol. Res. Perspect. 12 https:\/\/doi.org\/10.1002\/prp2.1189 (2024).","DOI":"10.1002\/prp2.1189"},{"key":"88009_CR23","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/s0014-2999(97)01268-5","volume":"337","author":"J Friese","year":"1997","unstructured":"Friese, J. et al. Aconitum sp. alkaloids: the modulation of voltage-dependent Na+\u2009channels, toxicity and antinociceptive properties. Eur. J. Pharmacol. 337, 165\u2013174. https:\/\/doi.org\/10.1016\/s0014-2999(97)01268-5 (1997).","journal-title":"Eur. J. Pharmacol."},{"key":"88009_CR24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.phytochem.2015.11.008","volume":"122","author":"S Tankeu","year":"2016","unstructured":"Tankeu, S., Vermaak, I., Chen, W., Sandasi, M. & Viljoen, A. Differentiation between two Fang Ji herbal medicines, Stephania Tetrandra and the nephrotoxic Aristolochia Fangchi, using hyperspectral imaging. Phytochemistry 122, 213\u2013222. https:\/\/doi.org\/10.1016\/j.phytochem.2015.11.008 (2016).","journal-title":"Phytochemistry"},{"key":"88009_CR25","doi-asserted-by":"publisher","first-page":"112995","DOI":"10.1016\/j.jep.2020.112995","volume":"260","author":"Y Zhang","year":"2020","unstructured":"Zhang, Y. et al. History of uses, phytochemistry, pharmacological activities, quality control and toxicity of the root of Stephania Tetrandra S. Moore: a review. J. Ethnopharmacol. 260, 112995. https:\/\/doi.org\/10.1016\/j.jep.2020.112995 (2020).","journal-title":"J. Ethnopharmacol."},{"key":"88009_CR26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.phytochem.2016.02.005","volume":"125","author":"N Bhagya","year":"2016","unstructured":"Bhagya, N. & Chandrashekar, K. R. Tetrandrine \u2013 a molecule of wide bioactivity. Phytochemistry 125, 5\u201313. https:\/\/doi.org\/10.1016\/j.phytochem.2016.02.005 (2016).","journal-title":"Phytochemistry"},{"key":"88009_CR27","doi-asserted-by":"publisher","first-page":"1230608","DOI":"10.3389\/fphar.2023.1230608","volume":"14","author":"M Han","year":"2023","unstructured":"Han, M., Wang, Z., Li, Y., Song, Y. & Wang, Z. The application and sustainable development of coral in traditional medicine and its chemical composition, pharmacology, toxicology, and clinical research. Front. Pharmacol. 14, 1230608. https:\/\/doi.org\/10.3389\/fphar.2023.1230608 (2023).","journal-title":"Front. Pharmacol."},{"key":"88009_CR28","doi-asserted-by":"publisher","first-page":"e35443","DOI":"10.1097\/MD.0000000000035443","volume":"102","author":"L Huang","year":"2023","unstructured":"Huang, L., Yu, Q., Peng, H. & Zhen, Z. Network pharmacology and molecular docking technology for exploring the effect and mechanism of Radix Bupleuri and Radix Paeoniae Alba herb-pair on anti-hepatitis: a review. Med. (Baltim). 102, e35443. https:\/\/doi.org\/10.1097\/MD.0000000000035443 (2023).","journal-title":"Med. (Baltim)."},{"key":"88009_CR29","doi-asserted-by":"publisher","first-page":"123380","DOI":"10.1016\/j.jchromb.2022.123380","volume":"1208","author":"Y Xiao","year":"2022","unstructured":"Xiao, Y. et al. Spectrum-effect relationship between HPLC fingerprint and antioxidant of San-Bai decoction extracts. J. Chromatogr. B. 1208, 123380. https:\/\/doi.org\/10.1016\/j.jchromb.2022.123380 (2022).","journal-title":"J. Chromatogr. B"},{"key":"88009_CR30","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1093\/jaoacint\/qsac079","volume":"105","author":"D Xiao","year":"2022","unstructured":"Xiao, D. et al. Study on HPLC fingerprint, network pharmacology, and antifungal activity of Rumex japonicus Houtt. J. AOAC Int. 105, 1741\u20131754. https:\/\/doi.org\/10.1093\/jaoacint\/qsac079 (2022).","journal-title":"J. AOAC Int."},{"key":"88009_CR31","doi-asserted-by":"publisher","first-page":"115247","DOI":"10.1016\/j.jpba.2023.115247","volume":"226","author":"J Xue","year":"2023","unstructured":"Xue, J. et al. An integrated strategy for characterization of chemical constituents in Stephania Tetrandra using LC\u2013QTOF\u2013MS\/MS and the target isolation of two new biflavonoids. J. Pharm. Biomed. Anal. 226, 115247. https:\/\/doi.org\/10.1016\/j.jpba.2023.115247 (2023).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"88009_CR32","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1208\/s12249-011-9665-3","volume":"12","author":"S Li","year":"2011","unstructured":"Li, S. et al. Preparation, characterization, Pharmacokinetics and tissue distribution of solid lipid nanoparticles loaded with Tetrandrine. AAPS PharmSciTech. 12, 1011\u20131018. https:\/\/doi.org\/10.1208\/s12249-011-9665-3 (2011).","journal-title":"AAPS PharmSciTech"},{"key":"88009_CR33","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1093\/chromsci\/bmac085","volume":"61","author":"W Cui","year":"2023","unstructured":"Cui, W. et al. Rapid quantitative analysis of 19 bioactive components in fangji huangqi decoction based on UHPLC\u2013MS\/MS. J. Chromatogr. Sci. 61, 852\u2013862. https:\/\/doi.org\/10.1093\/chromsci\/bmac085 (2023).","journal-title":"J. Chromatogr. Sci."},{"key":"88009_CR34","doi-asserted-by":"publisher","first-page":"115638","DOI":"10.1016\/j.jpba.2023.115638","volume":"235","author":"L Zhang","year":"2023","unstructured":"Zhang, L. et al. Comparative pharmacokinetic analysis of six major bioactive constituents using UPLC-MS\/MS in samples isolated from normal and diabetic nephropathy rats after oral administration of Gushen Jiedu capsule. J. Pharm. Biomed. Anal. 235, 115638. https:\/\/doi.org\/10.1016\/j.jpba.2023.115638 (2023).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"88009_CR35","doi-asserted-by":"publisher","unstructured":"Tao, Y., Chen, X., Jiang, Y. & Cai, B. A UPLC\u2013MS\/MS approach for simultaneous determination of eight flavonoids in rat plasma, and its application to pharmacokinetic studies of Fu-Zhu\u2010Jiang\u2010Tang tablet in rats. Biomed. Chromatogr. 31 https:\/\/doi.org\/10.1002\/bmc.3828 (2017).","DOI":"10.1002\/bmc.3828"},{"key":"88009_CR36","doi-asserted-by":"publisher","unstructured":"Yao, D. et al. Integrated UHPLC\u2013QE\/MS, transcriptomics and network pharmacology reveal the mechanisms via which Liang-Yan\u2010Yi\u2010Zhen\u2010San promotes the browning of white adipose tissue. Biomed. Chromatogr. 37 https:\/\/doi.org\/10.1002\/bmc.5734 (2023).","DOI":"10.1002\/bmc.5734"},{"key":"88009_CR37","doi-asserted-by":"publisher","first-page":"113293","DOI":"10.1016\/j.jpba.2020.113293","volume":"187","author":"X Gao","year":"2020","unstructured":"Gao, X. et al. Exploration of chemical composition and absorption characteristics of Chaigui granules based on UHPLC-Q-orbitrap-MS\/MS. J. Pharm. Biomed. Anal. 187, 113293. https:\/\/doi.org\/10.1016\/j.jpba.2020.113293 (2020).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"88009_CR38","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmae001","author":"Y Mei","year":"2024","unstructured":"Mei, Y. et al. Chemical profiling of Shen-Wu-Yi-Shen tablets using UPLC-Q-TOF-MS\/MS and its quality evaluation based on UPLC-DAD combined with Multivariate Statistical Analysis. J. Chromatogr. Sci. https:\/\/doi.org\/10.1093\/chromsci\/bmae001 (2024).","journal-title":"J. Chromatogr. Sci."},{"key":"88009_CR39","doi-asserted-by":"publisher","unstructured":"Seo, C. S. & Lee, M. Y. Simultaneous determination of fourteen marker compounds in the traditional herbal prescription, Geumgwesingihwan, using Ultra-performance Liquid Chromatography-Tandem Mass Spectrometry. Molecules 27 https:\/\/doi.org\/10.3390\/molecules27123890 (2022).","DOI":"10.3390\/molecules27123890"},{"key":"88009_CR40","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3390\/molecules29020480","volume":"29","author":"AR Ndhlala","year":"2024","unstructured":"Ndhlala, A. R., I\u015f\u0131k, M., Kavaz Y\u00fcksel, A. & Dikici, E. Phenolic content analysis of two species belonging to the Lamiaceae Family: antioxidant, anticholinergic, and Antibacterial activities. Molecules 29, 480. https:\/\/doi.org\/10.3390\/molecules29020480 (2024).","journal-title":"Molecules"},{"key":"88009_CR41","doi-asserted-by":"publisher","first-page":"464110","DOI":"10.1016\/j.chroma.2023.464110","volume":"1703","author":"X Xie","year":"2023","unstructured":"Xie, X. et al. Profiling and annotation of carbonyl compounds in Baijiu Daqu by chlorine isotope labeling-assisted ultrahigh-performance liquid chromatography-high resolution mass spectrometry. J. Chromatogr. A. 1703, 464110. https:\/\/doi.org\/10.1016\/j.chroma.2023.464110 (2023).","journal-title":"J. Chromatogr. A"},{"key":"88009_CR42","doi-asserted-by":"publisher","first-page":"115914","DOI":"10.1016\/j.jpba.2023.115914","volume":"239","author":"J Bayer","year":"2024","unstructured":"Bayer, J. & H\u00f6gger, P. Development and validation of a LC\u2013MS\/MS method for the quantification of phenolic compounds in human saliva after intake of a procyanidin-rich pine bark extract. J. Pharm. Biomed. Anal. 239, 115914. https:\/\/doi.org\/10.1016\/j.jpba.2023.115914 (2024).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"88009_CR43","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1002\/pca.2963","volume":"31","author":"F Wang","year":"2020","unstructured":"Wang, F. et al. Chemical characterisation and quantification of the major constituents in the Chinese herbal formula Jian-Pi\u2010Yi\u2010Shen pill by UPLC\u2010Q\u2010TOF\u2010MS\/MS and HPLC\u2010QQQ\u2010MS\/MS. Phytochem Anal. 31, 915\u2013929. https:\/\/doi.org\/10.1002\/pca.2963 (2020).","journal-title":"Phytochem Anal."},{"key":"88009_CR44","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1055\/s-2003-39709","volume":"69","author":"SL Li","year":"2003","unstructured":"Li, S. L. et al. Simultaneous analysis of seventeen chemical ingredients of Ligusticum Chuanxiong by on-line high performance liquid chromatography-diode array detector-mass spectrometry. Planta Med. 69, 445\u2013451. https:\/\/doi.org\/10.1055\/s-2003-39709 (2003).","journal-title":"Planta Med."},{"key":"88009_CR45","doi-asserted-by":"publisher","unstructured":"Kostic, O. et al. The phytoremediation potential and physiological adaptive response of Tamarix tetrandra Pall. Ex M. Bieb. During the restoration of Chronosequence fly Ash deposits. Plants (Basel) 11 https:\/\/doi.org\/10.3390\/plants11070855 (2022).","DOI":"10.3390\/plants11070855"},{"key":"88009_CR46","doi-asserted-by":"publisher","first-page":"100966","DOI":"10.1016\/j.fochx.2023.100966","volume":"20","author":"L Chen","year":"2023","unstructured":"Chen, L. et al. Identification of metabolite biomarkers in Salmonella enteritidis-contaminated chickens using UHPLC-QTRAP-MS-based targeted metabolomics. Food Chemistry: X. 20, 100966. https:\/\/doi.org\/10.1016\/j.fochx.2023.100966 (2023).","journal-title":"Food Chemistry: X"},{"key":"88009_CR47","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.jsps.2020.08.001","volume":"28","author":"S Abdelaziz","year":"2020","unstructured":"Abdelaziz, S. et al. Phytochemical profile, antioxidant and cytotoxic potential of Parkinsonia aculeata L. growing in Saudi Arabia. Saudi Pharm. J. 28, 1129\u20131137. https:\/\/doi.org\/10.1016\/j.jsps.2020.08.001 (2020).","journal-title":"Saudi Pharm. J."},{"key":"88009_CR48","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1055\/s-2006-957394","volume":"64","author":"SC Chan","year":"1998","unstructured":"Chan, S. C., Chang, Y. S., Wang, J. P., Chen, S. C. & Kuo, S. C. Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera. Planta Med. 64, 153\u2013158. https:\/\/doi.org\/10.1055\/s-2006-957394 (1998).","journal-title":"Planta Med."},{"key":"88009_CR49","doi-asserted-by":"publisher","unstructured":"Dossou, S. et al. Comparative metabolomics analysis of different Perilla varieties provides insights into variation in seed metabolite profiles and antioxidant activities. Foods  https:\/\/doi.org\/10.3390\/foods12234370 (2023).","DOI":"10.3390\/foods12234370"},{"key":"88009_CR50","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.jpba.2005.04.007","volume":"39","author":"R Liu","year":"2005","unstructured":"Liu, R. et al. Simultaneous determination of 10 major flavonoids in Dalbergia odorifera by high performance liquid chromatography. J. Pharm. Biomed. Anal. 39, 469\u2013476. https:\/\/doi.org\/10.1016\/j.jpba.2005.04.007 (2005).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"88009_CR51","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jchromb.2013.04.022","volume":"929","author":"P Liu","year":"2013","unstructured":"Liu, P. et al. Simultaneous determination of bioactive components in essential oil of Xiang\u2013Fu\u2013Si\u2013Wu Formula in Beagle dog plasma by UPLC\u2013MS\/MS and its application to pharmacokinetics. J. Chromatogr. B. 929, 63\u201369. https:\/\/doi.org\/10.1016\/j.jchromb.2013.04.022 (2013).","journal-title":"J. Chromatogr. B"},{"key":"88009_CR52","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1016\/j.phymed.2016.10.021","volume":"23","author":"Y Huang","year":"2016","unstructured":"Huang, Y. et al. Tetrandrine, an alkaloid from S. tetrandra exhibits anti-hypertensive and sleep-enhancing effects in SHR via different mechanisms. Phytomedicine 23, 1821\u20131829. https:\/\/doi.org\/10.1016\/j.phymed.2016.10.021 (2016).","journal-title":"Phytomedicine"},{"key":"88009_CR53","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1021\/np030022","volume":"66","author":"P Iturriaga-V\u00e1squez","year":"2003","unstructured":"Iturriaga-V\u00e1squez, P., Miquel, R., Ivorra, M. D., D\u2019Ocon, M. P. & Cassels, B. K. Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action. J. Nat. Prod. 66, 954\u2013957. https:\/\/doi.org\/10.1021\/np030022 (2003).","journal-title":"J. Nat. Prod."},{"key":"88009_CR54","doi-asserted-by":"publisher","first-page":"S488","DOI":"10.4103\/0973-1296.191467","volume":"12","author":"L Kakarla","year":"2016","unstructured":"Kakarla, L. et al. Free radical scavenging, alpha-glucosidase inhibitory and anti-inflammatory constituents from Indian sedges, Cyperus Scariosus R.Br and Cyperus rotundus L. Pharmacogn. Mag. 12, S488\u2013S496. https:\/\/doi.org\/10.4103\/0973-1296.191467 (2016).","journal-title":"Pharmacogn Mag"},{"key":"88009_CR55","first-page":"44","volume":"39","author":"Y Li","year":"2022","unstructured":"Li, Y. & Wang, W. Effects of Benzoyl paeoniflorin on Cardiac function in rats with myocardial infarction via promoting Nrf2\/ho-1 pathway. Lab. Anim. Sci. 39, 44\u201348 (2022).","journal-title":"Lab. Anim. Sci."},{"key":"88009_CR56","doi-asserted-by":"publisher","first-page":"e92216","DOI":"10.1371\/journal.pone.0092216","volume":"9","author":"H Pang","year":"2014","unstructured":"Pang, H., Han, B., Yu, T. & Peng, Z. The complex regulation of tanshinone IIA in rats with hypertension-induced left ventricular hypertrophy. PLoS ONE  9, e92216. https:\/\/doi.org\/10.1371\/journal.pone.0092216 (2014).","journal-title":"PLoS One"},{"key":"88009_CR57","doi-asserted-by":"publisher","first-page":"5065","DOI":"10.18632\/aging.205589","volume":"16","author":"S Hao","year":"2024","unstructured":"Hao, S., He, Q., Yuan, Y. & Mu, Q. The protective effects of Irbesartan in cognitive impairment in hypertension. Aging (Albany NY). 16, 5065\u20135076. https:\/\/doi.org\/10.18632\/aging.205589 (2024).","journal-title":"Aging (Albany NY)"},{"key":"88009_CR58","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4103\/ijpvm.IJPVM_567_18","volume":"11","author":"H Al-kuraishy","year":"2020","unstructured":"Al-kuraishy, H., Al-Gareeb, A. & Al-nami, M. Irbesartan attenuates gentamicin-induced nephrotoxicity in rats through modulation of oxidative stress and endogenous antioxidant capacity. Int. J. Prev. Med. 11, 16. https:\/\/doi.org\/10.4103\/ijpvm.IJPVM_567_18 (2020).","journal-title":"Int. J. Prev. Med."},{"key":"88009_CR59","doi-asserted-by":"publisher","first-page":"422","DOI":"10.29271\/jcpsp.2019.05.422","volume":"29","author":"X Zhao","year":"2019","unstructured":"Zhao, X., Yang, D., Xu, W., Xu, W. & Guo, Z. Effect of Irbesartan on oxidative stress and serum inflammatory factors in renal tissues of type 2 Diabetic rats. J. Coll. Physicians Surg. Pak. 29, 422\u2013425. https:\/\/doi.org\/10.29271\/jcpsp.2019.05.422 (2019).","journal-title":"J. Coll. Physicians Surg. Pak"},{"key":"88009_CR60","doi-asserted-by":"publisher","unstructured":"Li, J. et al. Salidroside enhances NO bioavailability and modulates arginine metabolism to alleviate pulmonary arterial hypertension. Eur. J. Med. Res.  https:\/\/doi.org\/10.1186\/s40001-024-02016-x (2024).","DOI":"10.1186\/s40001-024-02016-x"},{"key":"88009_CR61","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1007\/s11418-020-01387-9","volume":"74","author":"J Wu","year":"2020","unstructured":"Wu, J., Nakashima, S., Nakamura, S. & Matsuda, H. Effects of Sanoshashinto on left ventricular hypertrophy and gut microbiota in spontaneously hypertensive rats. J. Nat. Med. 74, 482\u2013486. https:\/\/doi.org\/10.1007\/s11418-020-01387-9 (2020).","journal-title":"J. Nat. Med."},{"key":"88009_CR62","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.3390\/cells11193032","volume":"11","author":"TK Bednarski","year":"2022","unstructured":"Bednarski, T. K., Duda, M. K. & Dobrzyn, P. Alterations of lipid metabolism in the heart in spontaneously hypertensive rats precedes left ventricular hypertrophy and Cardiac Dysfunction. Cells 11, 3032. https:\/\/doi.org\/10.3390\/cells11193032 (2022).","journal-title":"Cells"},{"key":"88009_CR63","doi-asserted-by":"publisher","first-page":"112810","DOI":"10.1016\/j.ejmech.2020.112810","volume":"207","author":"R Sch\u00fctz","year":"2020","unstructured":"Sch\u00fctz, R. et al. Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. Eur. J. Med. Chem. 207, 112810. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112810 (2020).","journal-title":"Eur. J. Med. Chem."},{"key":"88009_CR64","doi-asserted-by":"publisher","unstructured":"Jiang, M. et al. An efficient approach addressing the chemical complexity of Jiawei Fangji Huangqi decoction by integrating ultra-high\u2010performance liquid chromatography\/ion mobility\u2010quadrupole time\u2010of\u2010flight mass spectrometry and intelligent data processing workflows. J. Sep. Sci. 46 https:\/\/doi.org\/10.1002\/jssc.202300374 (2023).","DOI":"10.1002\/jssc.202300374"},{"key":"88009_CR65","doi-asserted-by":"publisher","first-page":"117","DOI":"10.7150\/ntno.78102","volume":"7","author":"N Dudhipala","year":"2023","unstructured":"Dudhipala, N., Ettireddy, S., Youssef, A. A. A. & Puchchakayala, G. Development and In vivo pharmacokinetic and pharmacodynamic evaluation of an oral innovative cyclodextrin complexed lipid nanoparticles of Irbesartan Formulation for enhanced bioavailability. Nanotheranostics 7, 117\u2013127. https:\/\/doi.org\/10.7150\/ntno.78102 (2023).","journal-title":"Nanotheranostics"},{"key":"88009_CR66","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1097\/MBP.0000000000000554","volume":"26","author":"D Zhang","year":"2021","unstructured":"Zhang, D., Huang, Q., Li, Y. & Wang, J. Incident Hyperuricemia in relation to antihypertensive therapy with the irbesartan\/hydrochlorothiazide combination. Blood Press. Monit. 26, 413\u2013418. https:\/\/doi.org\/10.1097\/MBP.0000000000000554 (2021).","journal-title":"Blood Press. Monit."},{"key":"88009_CR67","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1186\/s12906-023-04264-6","volume":"23","author":"L Xiang","year":"2023","unstructured":"Xiang, L. et al. Ethanol extract of Paridis rhizoma attenuates carrageenan-induced paw swelling in rats by inhibiting the production of inflammatory factors. BMC Complement. Med. Ther. 23, 437. https:\/\/doi.org\/10.1186\/s12906-023-04264-6 (2023).","journal-title":"BMC Complement. Med. Ther."},{"key":"88009_CR68","doi-asserted-by":"publisher","first-page":"100442","DOI":"10.1016\/j.phyplu.2023.100442","volume":"3","author":"Z Shi","year":"2023","unstructured":"Shi, Z., Xu, F., Xia, T., Bian, Z. & Li, S. Pharmacokinetics and anti-ulcerogenic effects of Zuojin gastric floating bio-adhesive pellets in rats with acetic acid-induced gastric ulcer. Phytomed. Plus 3, 100442. https:\/\/doi.org\/10.1016\/j.phyplu.2023.100442 (2023).","journal-title":"Phytomedicine Plus"},{"key":"88009_CR69","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1080\/15569527.2022.2077750","volume":"41","author":"T Cai","year":"2022","unstructured":"Cai, T. et al. Subacute dermal toxicity study of bensulfuron-methyl in Sprague-Dawley rats. Cutan. Ocul Toxicol. 41, 162\u2013167. https:\/\/doi.org\/10.1080\/15569527.2022.2077750 (2022).","journal-title":"Cutan. Ocul Toxicol."},{"key":"88009_CR70","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3390\/antibiotics12020199","volume":"12","author":"Q Liu","year":"2023","unstructured":"Liu, Q., Liu, L., Yuan, Y. & Xie, F. A validated UHPLC\u2013MS\/MS method to quantify eight antibiotics in quantitative dried blood spots in support of pharmacokinetic studies in neonates. Antibiotics 12, 199. https:\/\/doi.org\/10.3390\/antibiotics12020199 (2023).","journal-title":"Antibiotics"},{"key":"88009_CR71","doi-asserted-by":"publisher","unstructured":"Mykhailenko, O. et al. Bio-guided bioactive profiling and HPLC-DAD fingerprinting of Ukrainian saffron (Crocus sativus stigmas): moving from correlation toward causation. BMC Complement. Med. Ther.  https:\/\/doi.org\/10.1186\/s12906-021-03374-3 (2021).","DOI":"10.1186\/s12906-021-03374-3"},{"key":"88009_CR72","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jchromb.2015.09.033","volume":"1006","author":"M Liu","year":"2015","unstructured":"Liu, M., Su, X., Li, G., Zhao, G. & Zhao, L. Validated UPLC\u2013MS\/MS method for simultaneous determination of simvastatin, simvastatin hydroxy acid and berberine in rat plasma: application to the drug\u2013drug pharmacokinetic interaction study of simvastatin combined with berberine after oral administration in rats. J. Chromatogr. B. 1006, 8\u201315. https:\/\/doi.org\/10.1016\/j.jchromb.2015.09.033 (2015).","journal-title":"J. Chromatogr. B"},{"key":"88009_CR73","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1111\/jphp.13170","volume":"71","author":"Z Zeng","year":"2019","unstructured":"Zeng, Z. et al. Myocardial hypertrophy is improved with berberine treatment via long non-coding RNA MIAT\u2010mediated autophagy. J. Pharm. Pharmacol. 71, 1822\u20131831. https:\/\/doi.org\/10.1111\/jphp.13170 (2019).","journal-title":"J. Pharm. Pharmacol."},{"key":"88009_CR74","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.25122\/jml-2023-0156","volume":"16","author":"G Yadav","year":"2023","unstructured":"Yadav, G. et al. Utility of bone marrow examination in retinoblastoma and their correlation with hematological features. J. Med. Life. 16, 1245\u20131250. https:\/\/doi.org\/10.25122\/jml-2023-0156 (2023).","journal-title":"J. Med. Life"},{"key":"88009_CR75","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.biopha.2018.05.118","volume":"105","author":"AM Abdelrahman","year":"2018","unstructured":"Abdelrahman, A. M., Al Suleimani, Y. M., Ashique, M., Manoj, P. & Ali, B. H. Effect of infliximab and tocilizumab on fructose-induced hyperinsulinemia and hypertension in rats. Biomed. Pharmacother. 105, 182\u2013186. https:\/\/doi.org\/10.1016\/j.biopha.2018.05.118 (2018).","journal-title":"Biomed. Pharmacother"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-88009-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-88009-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-88009-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T10:48:34Z","timestamp":1739184514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-88009-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["88009"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-88009-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]},"assertion":[{"value":"23 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in compliance with the ARRIVE guidelines. The experimental protocols and treatments were approved by the Ethics Committee of Wuxi Hospital of Traditional Chinese Medicine. All methods were performed in accordance with the Jiangsu Province Laboratory Animal Care and Use Guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"4934"}}