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With the advent of digital seizure collection systems, the development of novel ECT seizure quality metrics and treatment guidance systems in particular will require cutting-edge digital seizure analysis. Using artificial intelligence will offer more analytical degrees of freedom and could play a key role in enhancing the precision of currently available procedures. To this end, we developed the first machine learning (ML) framework that can classify ictal and non-ictal EEG segments, accurately identifying seizure endpoints\u2014a critical step in deriving seizure quality parameters\u2014and computing these metrics at least as reliable as existing precomputed scores. The ML model retained in this study effectively discriminated ictal from non-ictal EEG segments with 89% accuracy, precision, and sensitivity. The reproduced ECT quality parameters showed correlations up to \u03f1\u2009=\u20090.99 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) with the pre-calculated values from the stimulation device and did not significantly differ from the reference values. Mean seizure duration differences were 0.23\u2009\u00b1\u200915.59\u00a0s compared to the expert rater and 0.28\u2009\u00b1\u200916.19\u00a0s compared to the stimulation device. The study highlights the potential of integrating ML into the field of ECT and emphasizes the critical role of a highly sensitive seizure detection method in reliably determining seizure duration and deriving subsequent quality indices, paving the way for more individualized treatment strategies and novel approaches to determine seizure quality.<\/jats:p>","DOI":"10.1038\/s41598-025-88238-3","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:05:53Z","timestamp":1740135953000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Machine learning based seizure classification and digital biosignal analysis of ECT seizures"],"prefix":"10.1038","volume":"15","author":[{"given":"Max","family":"Kayser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Hurlemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Philipsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Freundlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Kiebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"88238_CR1","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/S0140-6736(21)02141-3","volume":"399","author":"H Herrman","year":"2022","unstructured":"Herrman, H. et al. 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