{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:32:07Z","timestamp":1788474727861,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-88249-0","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T15:21:41Z","timestamp":1740410501000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Burden of periodontal diseases in young adults"],"prefix":"10.1038","volume":"15","author":[{"given":"Yifeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidan","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"88249_CR1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41368-024-00325-9","volume":"16","author":"J Ge","year":"2024","unstructured":"Ge, J. et al. Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches. Int. J. Oral Sci. 16, 58 (2024).","journal-title":"Int. J. Oral Sci."},{"key":"88249_CR2","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/prd.12329","volume":"83","author":"N Nwizu","year":"2020","unstructured":"Nwizu, N., Wactawski-Wende, J. & Genco, R. J. Periodontal disease and cancer: epidemiologic studies and possible mechanisms. Periodontology 83, 213\u2013233 (2020).","journal-title":"Periodontology"},{"key":"88249_CR3","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/jcpe.13189","volume":"47","author":"M Sanz","year":"2020","unstructured":"Sanz, M. et al. Periodontitis and cardiovascular diseases: Consensus report. J. Clin. Periodontol. 47, 268\u2013288 (2020).","journal-title":"J. Clin. Periodontol."},{"key":"88249_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s40292-020-00392-z","volume":"27","author":"R Del Pinto","year":"2020","unstructured":"Del Pinto, R. et al. Periodontitis and hypertension: is the association causal? High Blood Press. Cardiovasc. Prev. 27, 281\u2013289 (2020).","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"88249_CR5","doi-asserted-by":"crossref","unstructured":"Baeza, M. et al. Effect of periodontal treatment in patients with periodontitis and diabetes: systematic review and meta-analysis. J. Appl. Oral Sci. 28, e20190248 (2020).","DOI":"10.1590\/1678-7757-2019-0248"},{"key":"88249_CR6","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/idj.12630","volume":"71","author":"T Kwon","year":"2021","unstructured":"Kwon, T., Lamster, I. B. & Levin, L. Current concepts in the management of periodontitis. Int. Dent. J. 71, 462\u2013476 (2021).","journal-title":"Int. Dent. J."},{"key":"88249_CR7","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.adaj.2018.04.023","volume":"149","author":"PI Eke","year":"2018","unstructured":"Eke, P. I. et al. Periodontitis in US adults: National Health and Nutrition Examination Survey 2009\u20132014. J. Am. Dent. Assoc. 149, 576\u2013588 (2018).","journal-title":"J. Am. Dent. Assoc."},{"key":"88249_CR8","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1111\/jcpe.13447","volume":"48","author":"LS Luo","year":"2021","unstructured":"Luo, L. S. et al. Secular trends in severe periodontitis incidence, prevalence and disability-adjusted life years in five Asian countries: a comparative study from 1990 to 2017. J. Clin. Periodontol. 48, 627\u2013637 (2021).","journal-title":"J. Clin. Periodontol."},{"key":"88249_CR9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1600-0757.2012.00457.x","volume":"62","author":"RJ Genco","year":"2013","unstructured":"Genco, R. J. & Borgnakke, W. S. Risk factors for periodontal disease. Periodontology 62, 59\u201394 (2013).","journal-title":"Periodontology"},{"key":"88249_CR10","doi-asserted-by":"crossref","unstructured":"AlJehani, Y. A. Risk factors of periodontal disease: review of the literature. Int. J. Dent. 2014, 182513 (2014).","DOI":"10.1155\/2014\/182513"},{"key":"88249_CR11","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","volume":"93","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum, N. J. et al. Global burden of severe periodontitis in 1990\u20132010: a systematic review and meta-regression. J. Dent. Res. 93, 1045\u20131053 (2014).","journal-title":"J. Dent. Res."},{"key":"88249_CR12","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/jcpe.13396","volume":"48","author":"J Jiao","year":"2021","unstructured":"Jiao, J. et al. The prevalence and severity of periodontal disease in Mainland China: data from the Fourth National oral health survey (2015\u20132016). J. Clin. Periodontol. 48, 168\u2013179 (2021).","journal-title":"J. Clin. Periodontol."},{"key":"88249_CR13","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/jcpe.13506","volume":"48","author":"MX Chen","year":"2021","unstructured":"Chen, M. X., Zhong, Y. J., Dong, Q. Q., Wong, H. M. & Wen, Y. F. Global, regional, and national burden of severe periodontitis, 1990\u20132019: an analysis of the global burden of Disease Study 2019. Clin. Periodontol. 48, 1165\u20131188 (2021).","journal-title":"Clin. Periodontol."},{"issue":"2","key":"88249_CR14","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1111\/odi.14436","volume":"30","author":"X Zhang","year":"2024","unstructured":"Zhang, X. et al. The global burden of periodontal diseases in 204 countries and territories from 1990 to 2019. Oral Dis. 30 (2), 754\u2013768 (2024).","journal-title":"Oral Dis."},{"key":"88249_CR15","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","volume":"396","author":"Collaborators","year":"2020","unstructured":"Collaborators Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the global burden of Disease Study 2019. Lancet 396, 1204\u20131222 (2020).","journal-title":"Lancet"},{"key":"88249_CR16","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1080\/07853890.2022.2074535","volume":"54","author":"D Zhang","year":"2022","unstructured":"Zhang, D., Liu, S., Li, Z. & Wang, R. Global, regional and national burden of gastroesophageal reflux disease, 1990\u20132019: update from the GBD 2019 study. Ann. Med. 54, 1372\u20131384 (2022).","journal-title":"Ann. Med."},{"issue":"10","key":"88249_CR17","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1002\/JPER.21-0469","volume":"93","author":"L Wu","year":"2022","unstructured":"Wu, L., Zhang, S. Q., Zhao, L., Ren, Z. H. & Hu, C. Y. Global, regional, and national burden of periodontitis from 1990 to 2019: results from the Global Burden of Disease study 2019. J. Periodontol. 93 (10), 1445\u20131454 (2022).","journal-title":"J. Periodontol."},{"key":"88249_CR18","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1007\/s11606-019-05317-8","volume":"34","author":"JM Nagata","year":"2019","unstructured":"Nagata, J. M. et al. Food insecurity and chronic disease in US young adults: findings from the National Longitudinal Study of Adolescent to Adult Health. J. Gen. Intern. Med. 34, 2756\u20132762 (2019).","journal-title":"J. Gen. Intern. Med."},{"key":"88249_CR19","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2105\/AJPH.94.2.326","volume":"94","author":"L Biener","year":"2004","unstructured":"Biener, L. & Albers, A. B. Young adults: vulnerable new targets of tobacco marketing. Am. J. Public Health 94, 326\u2013330 (2004).","journal-title":"Am. J. Public Health"},{"key":"88249_CR20","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1834-7819.2001.tb00267.x","volume":"46","author":"DF Kinane","year":"2001","unstructured":"Kinane, D. F. & Marshall, G. J. Periodontal manifestations of systemic disease. Aust. Dent. J. 46, 2\u201312 (2001).","journal-title":"Aust. Dent. J."},{"key":"88249_CR21","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00784-021-04031-2","volume":"26","author":"RA Charupinijkul","year":"2022","unstructured":"Charupinijkul, R. A. et al. The effect of obesity on periodontitis progression: the 10-year retrospective cohort study. Clin. Oral Investig. 26, 535\u2013542 (2022).","journal-title":"Clin. Oral Investig."},{"key":"88249_CR22","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","volume":"384","author":"M Ng","year":"2014","unstructured":"Ng, M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: a systematic analysis for the global burden of Disease Study 2013. Lancet 384, 766\u2013781 (2014).","journal-title":"Lancet"},{"key":"88249_CR23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1601-5037.2007.00267.x","volume":"5","author":"M Reners","year":"2007","unstructured":"Reners, M. & Brecx, M. Stress and periodontal disease. Int. J. Dent. Hyg. 5, 199\u2013204 (2007).","journal-title":"Int. J. Dent. Hyg."},{"key":"88249_CR24","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/bjd.16808","volume":"179","author":"F Rajabi","year":"2018","unstructured":"Rajabi, F., Drake, L. A., Senna, M. M. & Rezaei, N. Alopecia Areata: a review of disease pathogenesis. Br. J. Dermatol. 179, 1033\u20131048 (2018).","journal-title":"Br. J. Dermatol."},{"key":"88249_CR25","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1177\/00220345010800051901","volume":"80","author":"EF Corbet","year":"2001","unstructured":"Corbet, E. F., Wong, M. C. & Lin, H. C. Periodontal conditions in adult Southern Chinese. J. Dent. Res. 80, 1480\u20131485 (2001).","journal-title":"J. Dent. Res."},{"key":"88249_CR26","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1034\/j.1600-0757.2002.290104.x","volume":"29","author":"P Gjermo","year":"2002","unstructured":"Gjermo, P., R\u00f6sing, C. K., Susin, C. & Oppermann, R. Periodontal diseases in Central and South America. Periodontology 29, 70\u201378 (2002).","journal-title":"Periodontology"},{"key":"88249_CR27","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1600-0528.1982.tb00377.x","volume":"10","author":"RA Hugoson","year":"1982","unstructured":"Hugoson, R. A. & Jordan, T. Frequency distribution of individuals aged 20\u201370 years according to severity of periodontal disease. Community Dent. Oral Epidemiol. 10, 187\u2013192 (1982).","journal-title":"Community Dent. Oral Epidemiol."},{"key":"88249_CR28","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/j.1752-7325.2002.tb03428.x","volume":"62","author":"LN Borrell","year":"2002","unstructured":"Borrell, L. N., Burt, B. A., Gillespie, B. W., Lynch, J. & Neighbors, H. Periodontitis in the United States: beyond black and white. J. Public Health Dent. 62, 92\u2013101 (2002).","journal-title":"J. Public Health Dent."},{"key":"88249_CR29","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1600-0528.2007.00406.x","volume":"36","author":"LN Borrell","year":"2008","unstructured":"Borrell, L. N. & Crawford, N. D. Social disparities in periodontitis among United States adults 1999\u20132004. Community Dent. Oral Epidemiol. 36, 383\u2013391 (2008).","journal-title":"Community Dent. Oral Epidemiol."},{"key":"88249_CR30","doi-asserted-by":"crossref","unstructured":"Nazir, M. et al. Global prevalence of periodontal disease and lack of its surveillance. Sci. World J. 2020, 2146160 (2020).","DOI":"10.1155\/2020\/2146160"},{"key":"88249_CR31","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1056\/NEJMp048310","volume":"352","author":"B Caballero","year":"2005","unstructured":"Caballero, B. A nutrition paradox\u2013underweight and obesity in developing countries. N. Engl. J. Med. 352, 1514\u20131516 (2005).","journal-title":"N. Engl. J. Med."},{"key":"88249_CR32","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3233\/s12349-009-0055-1","volume":"2","author":"JM Morillo","year":"2009","unstructured":"Morillo, J. M. et al. Nutrition-linked chronic disease and periodontitis: are they the two faces of the same coin? Mediterr. J. Nutr. Metab. 2, 103\u2013109 (2009).","journal-title":"Mediterr. J. Nutr. Metab."},{"key":"88249_CR33","first-page":"201","volume":"10","author":"D Doku","year":"2010","unstructured":"Doku, D. The tobacco industry tactics-a challenge for tobacco control in low and middle income countries. Afr. Health Sci. 10, 201\u2013203 (2010).","journal-title":"Afr. Health Sci."},{"key":"88249_CR34","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1600-0765.2004.00718.x","volume":"39","author":"T Alpagot","year":"2004","unstructured":"Alpagot, T., Duzgunes, N., Wolff, L. F. & Lee, A. Risk factors for periodontitis in HIV patients. J. Periodontal Res. 39, 149\u2013157 (2004).","journal-title":"J. Periodontal Res."},{"key":"88249_CR35","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s40496-014-0019-6","volume":"1","author":"M Tellez","year":"2014","unstructured":"Tellez, M., Zini, A. & Estupi\u00f1an-Day, S. Social determinants and oral health: an update. Curr. Oral Health Rep. 1, 148\u2013152 (2014).","journal-title":"Curr. Oral Health Rep."},{"key":"88249_CR36","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.diabres.2017.11.015","volume":"137","author":"SF Awad","year":"2018","unstructured":"Awad, S. F., O\u2019Flaherty, M., Critchley, J. & Abu-Raddad, L. J. Forecasting the burden of type 2 diabetes mellitus in Qatar to 2050: a novel modeling approach. Diabetes Res. Clin. Pract. 137, 100\u2013108 (2018).","journal-title":"Diabetes Res. Clin. Pract."},{"key":"88249_CR37","first-page":"197","volume":"60","author":"SM Morgano","year":"2010","unstructured":"Morgano, S. M. et al. Burden of oral disease in the Middle East: opportunities for dental public health. Int. Dent. J. 60, 197\u2013199 (2010).","journal-title":"Int. Dent. J."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-88249-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-88249-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-88249-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T15:21:45Z","timestamp":1740410505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-88249-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["88249"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-88249-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"1 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study is based on a publicly available database and does not require ethical approval.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"6653"}}