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This study was conducted and reported in accordance with the ARRIVE guidelines to ensure transparency and reproducibility in animal research. All procedures were carried out in accordance with the relevant institutional guidelines and regulations. Informed consent was obtained from all subjects involved and the study with human samples was approved by the Ethics Committee of Jinghai Hospital, Tianjin, China. This study was performed in accordance with the Declaration of Helsinki and relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5365"}}