{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:37:55Z","timestamp":1759991875398,"version":"3.37.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-89159-x","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T13:04:07Z","timestamp":1739019847000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigating the vascular structure of the conjunctiva in patients using spherical mini-scleral contact lenses utilizing OCT-A imaging"],"prefix":"10.1038","volume":"15","author":[{"given":"Fateme","family":"Alipour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Abdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Asadigandomani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Khodaparast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Montazeriani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzieh","family":"Sajedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,8]]},"reference":[{"key":"89159_CR1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/ICU.0000000000000173","volume":"26","author":"A Parminder","year":"2015","unstructured":"Parminder, A. & Jacobs, D. S. Advances in scleral lenses for refractive surgery complications. Curr. Opin. Ophthalmol. 26, 243\u2013248 (2015).","journal-title":"Curr. Opin. Ophthalmol."},{"key":"89159_CR2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/cxo.12033","volume":"96","author":"AS Bruce","year":"2013","unstructured":"Bruce, A. S. & Nguyen, L. M. Acute red eye (non-ulcerative keratitis) associated with mini\u2010scleral contact lens wear for keratoconus. Clin. Experimental Optometry. 96, 245\u2013248 (2013).","journal-title":"Clin. Experimental Optometry"},{"key":"89159_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.clae.2014.10.001","volume":"38","author":"F Alipour","year":"2015","unstructured":"Alipour, F., Behrouz, M. J. & Samet, B. Mini-scleral lenses in the visual rehabilitation of patients after penetrating keratoplasty and deep lamellar anterior keratoplasty. Contact Lens Anterior Eye. 38, 54\u201358 (2015).","journal-title":"Contact Lens Anterior Eye"},{"key":"89159_CR4","doi-asserted-by":"publisher","first-page":"252","DOI":"10.4103\/2008-322X.188400","volume":"11","author":"F Alipour","year":"2016","unstructured":"Alipour, F. et al. Mini-scleral contact lens for management of poor visual outcomes after intrastromal corneal ring segments implantation in keratoconus. J. Ophthalmic Vis. Res. 11, 252 (2016).","journal-title":"J. Ophthalmic Vis. Res."},{"key":"89159_CR5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13256-024-04429-y","volume":"18","author":"P Abdi","year":"2024","unstructured":"Abdi, P., Asadigandomani, H., Amirkhani, A., Taghizadeh, S. & Nozarian, Z. Familial primary calcific band-shaped keratopathy with late onset systemic disease: a case series and review of the literature. J. Med. Case Rep. 18, 98 (2024).","journal-title":"J. Med. Case Rep."},{"key":"89159_CR6","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.clae.2012.07.006","volume":"35","author":"F Alipour","year":"2012","unstructured":"Alipour, F., Kheirkhah, A. & Behrouz, M. J. Use of mini scleral contact lenses in moderate to severe dry eye. Contact Lens Anterior Eye. 35, 272\u2013276 (2012).","journal-title":"Contact Lens Anterior Eye"},{"key":"89159_CR7","doi-asserted-by":"crossref","unstructured":"Soleimani, M. et al. Clinical characteristics, predisposing factors, and management of moraxella keratitis in a tertiary eye hospital. J. Ophthalmic Inflamm. Infect. 14 (2024).","DOI":"10.1186\/s12348-024-00417-x"},{"key":"89159_CR8","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s10792-024-03106-9","volume":"44","author":"M Soleimani","year":"2024","unstructured":"Soleimani, M., Tabatabaei, S. A., Bahadorifar, S., Mohammadi, A. & Asadigandomani, H. Unveiling the landscape of post-keratoplasty keratitis: a comprehensive epidemiological analysis in a tertiary center. Int. Ophthalmol. 44, 230 (2024).","journal-title":"Int. Ophthalmol."},{"key":"89159_CR9","doi-asserted-by":"publisher","first-page":"S238","DOI":"10.1097\/ICL.0000000000000389","volume":"44","author":"Y Shi","year":"2018","unstructured":"Shi, Y. et al. Evaluated conjunctival blood flow velocity in daily contact lens wearers. Eye Contact lens. 44, S238 (2018).","journal-title":"Eye Contact lens"},{"key":"89159_CR10","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1126\/science.1957169","volume":"254","author":"D Huang","year":"1991","unstructured":"Huang, D. et al. Optical coherence tomography. Science 254, 1178\u20131181 (1991).","journal-title":"Science"},{"key":"89159_CR11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s12880-024-01459-2","volume":"24","author":"J Saeidian","year":"2024","unstructured":"Saeidian, J. et al. Segmentation of choroidal area in optical coherence tomography images using a transfer learning-based conventional neural network: a focus on diabetic retinopathy and a literature review. BMC Med. Imaging. 24, 281 (2024).","journal-title":"BMC Med. Imaging"},{"key":"89159_CR12","doi-asserted-by":"publisher","first-page":"103807","DOI":"10.1016\/j.pdpdt.2023.103807","volume":"44","author":"F Bazvand","year":"2023","unstructured":"Bazvand, F. et al. Short term choroidal microvascular changes following photodynamic therapy in chronic central serous chorioretinopathy. Photodiagn. Photodyn. Ther. 44, 103807 (2023).","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"89159_CR13","doi-asserted-by":"publisher","first-page":"110234","DOI":"10.1016\/j.exer.2025.110234","volume":"251","author":"M Soleimani","year":"2025","unstructured":"Soleimani, M. et al. A deep dive into radiation keratopathy; going beyond the current frontierss. Exp. Eye Res. 251, 110234. https:\/\/doi.org\/10.1016\/j.exer.2025.110234 (2025).","journal-title":"Exp. Eye Res."},{"key":"89159_CR14","doi-asserted-by":"publisher","first-page":"OCT27","DOI":"10.1167\/iovs.15-19043","volume":"57","author":"SS Gao","year":"2016","unstructured":"Gao, S. S. et al. Optical coherence tomography angiography. Investig. Ophthalmol. Vis. Sci. 57, OCT27\u2013OCT36 (2016).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"89159_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1001\/jamaophthalmol.2014.3616","volume":"133","author":"RF Spaide","year":"2015","unstructured":"Spaide, R. F., Klancnik, J. M. & Cooney, M. J. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol. 133, 45\u201350 (2015).","journal-title":"JAMA Ophthalmol."},{"key":"89159_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40942-015-0005-8","volume":"1","author":"TE De Carlo","year":"2015","unstructured":"De Carlo, T. E., Romano, A., Waheed, N. K. & Duker, J. S. A review of optical coherence tomography angiography (OCTA). Int. J. Retina Vitreous. 1, 1\u201315 (2015).","journal-title":"Int. J. Retina Vitreous"},{"key":"89159_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","volume":"64","author":"RF Spaide","year":"2018","unstructured":"Spaide, R. F., Fujimoto, J. G., Waheed, N. K., Sadda, S. R. & Staurenghi, G. Optical coherence tomography angiography. Prog. Retin. Eye Res. 64, 1\u201355 (2018).","journal-title":"Prog. Retin. Eye Res."},{"key":"89159_CR18","doi-asserted-by":"publisher","first-page":"101403","DOI":"10.1016\/j.clae.2020.12.066","volume":"45","author":"J Jesus","year":"2022","unstructured":"Jesus, J., Dias, L., Almeida, I., Costa, T. & Chibante-Pedro, J. Analysis of conjunctival vascular density in scleral contact lens wearers using optical coherence tomography angiography. Contact Lens Anterior Eye. 45, 101403 (2022).","journal-title":"Contact Lens Anterior Eye"},{"key":"89159_CR19","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.jfo.2020.08.016","volume":"44","author":"M El Bahloul","year":"2021","unstructured":"El Bahloul, M., Bennis, A., Chra\u00efbi, F., Abdellaoui, M. & Benatiya, I. Scleral contact lenses: visual outcomes and tolerance. A prospective study about 98 eyes. J. Fr. Ophtalmol. 44, 549\u2013558. https:\/\/doi.org\/10.1016\/j.jfo.2020.08.016 (2021).","journal-title":"J. Fr. Ophtalmol"},{"key":"89159_CR20","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1097\/OPX.0000000000000298","volume":"91","author":"HJ Choi","year":"2014","unstructured":"Choi, H. J. et al. Measurement of anterior scleral curvature using anterior segment OCT. Optom. Vis. Sci. 91, 793\u2013802 (2014).","journal-title":"Optom. Vis. Sci."},{"key":"89159_CR21","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1007\/s10384-014-0329-1","volume":"58","author":"M Kasahara","year":"2014","unstructured":"Kasahara, M., Shoji, N., Morita, T. & Shimizu, K. Comparative optical coherence tomography study of differences in scleral shape between the superonasal and superotemporal quadrants. Jpn J. Ophthalmol. 58, 396\u2013401 (2014).","journal-title":"Jpn J. Ophthalmol."},{"key":"89159_CR22","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/cxo.12814","volume":"102","author":"SJ Vincent","year":"2019","unstructured":"Vincent, S. J., Alonso-Caneiro, D. & Collins, M. J. Optical coherence tomography and scleral contact lenses: clinical and research applications. Clin. Experimental Optometry. 102, 224\u2013241 (2019).","journal-title":"Clin. Experimental Optometry"},{"key":"89159_CR23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.clae.2015.08.003","volume":"39","author":"MK Walker","year":"2016","unstructured":"Walker, M. K., Bergmanson, J. P., Miller, W. L., Marsack, J. D. & Johnson, L. A. Complications and fitting challenges associated with scleral contact lenses: a review. Contact Lens Anterior Eye. 39, 88\u201396 (2016).","journal-title":"Contact Lens Anterior Eye"},{"key":"89159_CR24","doi-asserted-by":"crossref","unstructured":"Gimenez-Sanchis, I. et al. Anterior segment optical coherence tomography angiography to evaluate the peripheral fitting of scleral contact lenses. Clin. Optometry, 103\u2013108 (2018).","DOI":"10.2147\/OPTO.S164454"},{"key":"89159_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ajo.2018.08.009","volume":"196","author":"T Akagi","year":"2018","unstructured":"Akagi, T. et al. Conjunctival and intrascleral vasculatures assessed using anterior segment optical coherence tomography angiography in normal eyes. Am. J. Ophthalmol. 196, 1\u20139 (2018).","journal-title":"Am. J. Ophthalmol."},{"key":"89159_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/ICO.0000000000002114","volume":"39","author":"F Zhao","year":"2020","unstructured":"Zhao, F., Cai, S., Huang, Z., Ding, P. & Du, C. Optical coherence tomography angiography in pinguecula and pterygium. Cornea 39, 99\u2013103 (2020).","journal-title":"Cornea"},{"key":"89159_CR27","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1136\/bjophthalmol-2019-314030","volume":"104","author":"CN Patel","year":"2020","unstructured":"Patel, C. N. et al. Optical coherence tomography angiography of perilimbal vasculature: validation of a standardised imaging algorithm. Br. J. Ophthalmol. 104, 404\u2013409. https:\/\/doi.org\/10.1136\/bjophthalmol-2019-314030 (2020).","journal-title":"Br. J. Ophthalmol."},{"key":"89159_CR28","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1080\/08164622.2022.2097858","volume":"106","author":"J Rojas-Vi\u00f1uela","year":"2023","unstructured":"Rojas-Vi\u00f1uela, J., Frogozo, M. J. & Pi\u00f1ero, D. P. What we know about the scleral profile and its impact on contact lens fitting. Clin. Experimental Optometry. 106, 591\u2013604 (2023).","journal-title":"Clin. Experimental Optometry"},{"key":"89159_CR29","unstructured":"Montani, G. in Poster presented at Global Specialty Lens Symposium, Las Vegas, USA."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-89159-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-89159-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-89159-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T13:04:12Z","timestamp":1739019852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-89159-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,8]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["89159"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-89159-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,8]]},"assertion":[{"value":"26 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study had been approved by the local ethics committee of Tehran University of Medical Sciences according to Helsinki ethical principles (IR.TUMS.MEDICINE.REC.1401.056).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declarations"}}],"article-number":"4759"}}