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However, it\u2019s clinical interest is limited by it\u2019s toxic side effects on vital organs. <jats:italic>Sarcophyton<\/jats:italic> soft coral is a source of natural products with a range of bioactivities. As such, the objective of this work was to assess how well <jats:italic>Sarcophyton<\/jats:italic> extract mitigated the gentamicin toxicity in rats. Four equal groups, each with five adult male albino rats, were randomly assigned: the control group, the <jats:italic>Sarcophyton<\/jats:italic> group given a <jats:italic>Sarcophyton<\/jats:italic> extract dose of 200\u00a0mg\/kg\/day orally for seven days, the gentamicin group receiving an intraperitoneal gentamicin dose of 100\u00a0mg\/kg\/day for seven days, and the combined administration group. Rats that received gentamicin injections saw a fall in body weight along with a decrease in liver function and all hematological parameters except the white blood cell count. The tissue\u2019s total antioxidant capacity (TAC) dropped as a result of gentamicin, indicating oxidative stress. Gentamicin additionally caused histological alterations and significant increases in DNA fragmentation levels in the spleen and liver tissues. In contrast, the combined administration of gentamicin and <jats:italic>Sarcophyton<\/jats:italic> extract preserved body weight, maintained liver tissue structure and function, and improved hematological markers. Moreover, it strengthened the tissue\u2019s TAC, restored the normal structure of the spleen tissues, and decreased the tissue\u2019s DNA fragmentation. <jats:italic>Sarcophyton<\/jats:italic>\u2019s chemical components, identified using gas chromatography-mass spectrometry, have hepatoprotective, antioxidant, and anti-inflammatory qualities, which are responsible for the extract\u2019s ameliorative effects. Finally, <jats:italic>Sarcophyton<\/jats:italic> extract is a natural medication that may help reduce the toxicity caused by gentamicin.<\/jats:p>","DOI":"10.1038\/s41598-025-90316-5","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T13:32:55Z","timestamp":1741008775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antioxidant efficiency of Sarcophyton\u00a0crude extract against gentamicin toxicity in male albino rats"],"prefix":"10.1038","volume":"15","author":[{"given":"Aml","family":"Talaat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada S.","family":"Badr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aml Z.","family":"Ghoneim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwa A.","family":"El-Saidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"issue":"1","key":"90316_CR1","doi-asserted-by":"publisher","first-page":"9719906","DOI":"10.1155\/2021\/9719906","volume":"2021","author":"H Laaroussi","year":"2021","unstructured":"Laaroussi, H. et al. Protective effect of honey and propolis against gentamicin-induced oxidative stress and hepatorenal damages. Oxid. Med. Cell. Longev. 2021 (1), 9719906. https:\/\/doi.org\/10.1155\/2021\/9719906 (2021).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"90316_CR2","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.biopha.2017.05.100","volume":"92","author":"P Arjinajarn","year":"2017","unstructured":"Arjinajarn, P. et al. Anthocyanin-rich Riceberry bran extract attenuates gentamicin-induced hepatotoxicity by reducing oxidative stress, inflammation and apoptosis in rats. Biomed. Pharmacother. 92, 412\u2013420. https:\/\/doi.org\/10.1016\/j.biopha.2017.05.100 (2017).","journal-title":"Biomed. Pharmacother"},{"key":"90316_CR3","doi-asserted-by":"publisher","first-page":"108635","DOI":"10.1016\/j.biopha.2019.108635","volume":"112","author":"ZM Yarijani","year":"2019","unstructured":"Yarijani, Z. M. et al. 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