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The primary statistical analysis was performed using the inverse-variance weighted (IVW) method. False discovery rate (FDR) correction was used to control for false positives in multiple testing. In addition, sensitivity analyses were carried out using the MR Egger intercept test and Cochran\u2019s Q test. The MR analysis revealed that genetically determined IBD (OR = 1.141, 95% CI 1.080\u20131.205, <jats:italic>P<\/jats:italic> = 2.21 \u00d7 10<jats:sup>\u22126<\/jats:sup>, P<jats:sub>FDR<\/jats:sub> = 6.90 \u00d7 10<jats:sup>\u22126<\/jats:sup>), ulcerative colitis (UC) (OR = 1.113, 95% CI 1.032\u20131.201, <jats:italic>P<\/jats:italic> = 0.006, P<jats:sub>FDR<\/jats:sub> = 0.009), and Crohn\u2019s diseases (CD) (OR = 1.073, 95% CI 1.017\u20131.133, <jats:italic>P<\/jats:italic> = 0.010, P<jats:sub>FDR<\/jats:sub> = 0.011) had a causal effect on uveitis. Conversely, the reverse MR analysis did not reveal significant causal link of uveitis on IBD, including its two subtypes. Furthermore, the results of the MR-Egger and weighted median methods were consistent with the IVW method. No evidence of heterogeneity or pleiotropy was detected by sensitivity analysis. Our findings confirm that IBD and its main subtypes had a causal connection with uveitis. Further research is needed to elucidate the underlying pathophysiological mechanisms driving this association.<\/jats:p>","DOI":"10.1038\/s41598-025-90462-w","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T17:33:11Z","timestamp":1739727191000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unraveling the causal association between inflammatory bowel diseases and uveitis through mendelian randomization analysis"],"prefix":"10.1038","volume":"15","author":[{"given":"Min","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjin","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huatian","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,16]]},"reference":[{"key":"90462_CR1","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/S0140-6736(07)60750-8","volume":"369","author":"DC Baumgart","year":"2007","unstructured":"Baumgart, D. 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