{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:42:36Z","timestamp":1793889756642,"version":"4.8.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100022083","name":"VLIRUOS","doi-asserted-by":"publisher","award":["No. VN2022TEA534A105"],"award-info":[{"award-number":["No. VN2022TEA534A105"]}],"id":[{"id":"10.13039\/501100022083","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the European Union\u2019s Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska- Curie grant","award":["No. 945380"],"award-info":[{"award-number":["No. 945380"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-90557-4","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:14:27Z","timestamp":1739992467000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuroprotective effects of melanins and melanin derivatives from Calvatia Craniiformis and Xylaria plebeja against Parkinsonian toxins"],"prefix":"10.1038","volume":"15","author":[{"given":"Duong Thuy","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh Phuong","family":"Nguyen Vo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby","family":"Mangelings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Van Eeckhaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Vander Heyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanh T. M.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"90557_CR1","doi-asserted-by":"publisher","first-page":"7528","DOI":"10.1039\/D3TB01132A","volume":"11","author":"W Song","year":"2023","unstructured":"Song, W. et al. Melanin: insights into structure, analysis, and biological activities for future development. J. Mater. Chem. B. 11, 32:7528\u20137543 (2023).","journal-title":"J. Mater. Chem. B"},{"key":"90557_CR2","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1021\/jacs.0c12322","volume":"143","author":"W Cao","year":"2021","unstructured":"Cao, W. et al. Unraveling the structure and function of melanin through synthesis. J. Am. Chem. Soc. 143, 2622\u20132637 (2021).","journal-title":"J. Am. Chem. Soc."},{"key":"90557_CR3","doi-asserted-by":"crossref","unstructured":"Pombeiro-Sponchiado, S. R., Sousa, G. S., Andrade, J. C. R., Lisboa, H. F. & Gon\u00e7alves, R. C. R. Production of melanin pigment by fungi and its biotechnological applications. In Melanin; Blumenberg, M., Ed.; InTech, ISBN 978-953-51-2979-0 (2017).","DOI":"10.5772\/67375"},{"key":"90557_CR4","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.3390\/ijms20163943","volume":"20","author":"IE Pralea","year":"2019","unstructured":"Pralea, I. E. et al. From extraction to advanced analytical methods: the challenges of melanin analysis. Int. J. Mol. Sci. 20, 3943 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"90557_CR5","doi-asserted-by":"publisher","first-page":"16649","DOI":"10.1038\/s41598-021-94598-3","volume":"11","author":"Y Li","year":"2021","unstructured":"Li, Y., Ye, Z., Lu, P. & Lu, L. Pyomelanin produced by streptomyces sp. ZL-24 and its protective effects against sh-sy5y cells injury induced by hydrogen peroxide. Sci. Rep. 11, 16649 (2021).","journal-title":"Sci. Rep."},{"key":"90557_CR6","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3390\/antiox12020517","volume":"12","author":"EO Olufunmilayo","year":"2023","unstructured":"Olufunmilayo, E. O., Gerke-Duncan, M. B. & Holsinger R.M.D. oxidative stress and antioxidants in neurodegenerative disorders. Antioxidants 12, 517 (2023).","journal-title":"Antioxidants"},{"key":"90557_CR7","doi-asserted-by":"publisher","first-page":"581191","DOI":"10.3389\/fncel.2020.581191","volume":"14","author":"S Wen","year":"2020","unstructured":"Wen, S., Aki, T., Unuma, K., Uemura, K. & Chemically Induced models of Parkinson\u2019s disease: history and perspectives for the involvement of ferroptosis. Front. Cell. Neurosci. 14, 581191 (2020).","journal-title":"Front. Cell. Neurosci."},{"key":"90557_CR8","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.yexcr.2003.11.007","volume":"294","author":"MJ Hoogduijn","year":"2004","unstructured":"Hoogduijn, M. J. et al. Melanin protects melanocytes and keratinocytes against H2O2-induced dna strand breaks through its ability to bind Ca2+. Exp. Cell. Res. 294, 60\u201367 (2004).","journal-title":"Exp. Cell. Res."},{"key":"90557_CR9","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1248\/bpb.28.1129","volume":"28","author":"RDCR Goncalves","year":"2005","unstructured":"Goncalves, R. D. C. R. & Pombeiro-Sponchiado, S. R. Antioxidant activity of the melanin pigment extracted from aspergillus nidulans. Biol. Pharm. Bull. 28, 1129\u20131131 (2005).","journal-title":"Biol. Pharm. Bull."},{"key":"90557_CR10","unstructured":"Berliner, D. L., Erwin, R. L. & McGee, D. R. Therapeutic uses of Melanin. US Patent 5,703,051. United States Patent and Trademark Office (1997)."},{"key":"90557_CR11","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1016\/j.foodchem.2012.06.120","volume":"135","author":"M Ye","year":"2012","unstructured":"Ye, M. et al. Physicochemical characteristics and antioxidant activity of arginine-modified melanin from lachnum YM-346. Food Chem. 135, 2490\u20132497 (2012).","journal-title":"Food Chem."},{"key":"90557_CR12","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1039\/C8MD00035B","volume":"9","author":"F Shi","year":"2018","unstructured":"Shi, F. et al. Antitumor effects of melanin from lachnum YM226 and its derivative in H22 tumor-bearing mice. MedChemComm 9, 1059\u20131068 (2018).","journal-title":"MedChemComm"},{"key":"90557_CR13","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.1039\/C6FO00333H","volume":"7","author":"S Song","year":"2016","unstructured":"Song, S. et al. Structural characterization, molecular modification and hepatoprotective effect of melanin from Lachnum YM226 on acute alcohol-induced liver injury in mice. Food Funct. 7, 3617\u20133627 (2016).","journal-title":"Food Funct."},{"key":"90557_CR14","doi-asserted-by":"publisher","first-page":"4919","DOI":"10.5943\/mycosphere\/15\/1\/22","volume":"15","author":"JX Li","year":"2024","unstructured":"Li, J. X. et al. The revision of the taxonomic system of Lycoperdaceae. Mycosphere 15, 4919\u20135016 (2024).","journal-title":"Mycosphere"},{"key":"90557_CR15","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/S0031-9422(97)00066-6","volume":"45","author":"Y Takaishi","year":"1997","unstructured":"Takaishi, Y. et al. Hydroxyphenylazoformamide derivatives from Calvatia Craniformis. Phytochem 45, 997\u20131001 (1997).","journal-title":"Phytochem"},{"issue":"4","key":"90557_CR16","first-page":"311","volume":"8","author":"IA Al-Ezzy","year":"2017","unstructured":"Al-Ezzy, I. A., Jameel, G. H. & Minnat, T. R. Isolation of Malassezia furfur and evaluation of Ivermectin and Calvatia Craniiformis as a Novel Antifungal agents for Pityriasis Versi-Color with Special Refer to Risk factors in Iraqi patients. Int. J. Curr. Pharm. Rev. Res. 8 (4), 311\u2013319 (2017).","journal-title":"Int. J. Curr. Pharm. Rev. Res."},{"key":"90557_CR17","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1021\/acs.jafc.8b05071","volume":"67","author":"J Ribera","year":"2018","unstructured":"Ribera, J. et al. Scalable biosynthesis of melanin by the basidiomycete Armillaria cepistipes. J. Agric. Food Chem. 67, 132\u2013139 (2018).","journal-title":"J. Agric. Food Chem."},{"key":"90557_CR18","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12896-024-00918-6","volume":"24","author":"H Nguyen","year":"2024","unstructured":"Nguyen, H. et al. Antioxidant, neuroprotective, and neuroblastoma cells (SH-SY5Y) differentiation effects of melanins and arginine-modified melanins from Daedaleopsis Tricolor and Fomes Fomentarius. BMC Biotechnol. 24, 89 (2024).","journal-title":"BMC Biotechnol."},{"key":"90557_CR19","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1007\/s11274-008-9718-2","volume":"24","author":"P Selvakumar","year":"2008","unstructured":"Selvakumar, P., Rajasekar, S., Periasamy, K. & Raaman, N. Isolation and characterization of melanin pigment from Pleurotus Cystidiosus (Telomorph of Antromycopsis macrocarpa). World J. Microbiol. Biotechnol. 24, 2125\u20132131 (2008).","journal-title":"World J. Microbiol. Biotechnol."},{"key":"90557_CR20","doi-asserted-by":"publisher","first-page":"42129","DOI":"10.1038\/srep42129","volume":"7","author":"NEA El-Naggar","year":"2017","unstructured":"El-Naggar, N. E. A., El-Ewasy, S. M. & Bioproduction Characterization, anticancer and antioxidant activities of extracellular melanin pigment produced by newly isolated microbial cell factories Streptomyces glaucescens NEAE-H. Sci. Rep. 7, 42129 (2017).","journal-title":"Sci. Rep."},{"key":"90557_CR21","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0308-8146(96)00215-4","volume":"58","author":"E Harki","year":"1997","unstructured":"Harki, E., Talou, T., Dargent, R. & Purification Characterisation and analysis of melanin extracted from Tuber Melanosporum Vitt. Food Chem. 58, 69\u201373 (1997).","journal-title":"Food Chem."},{"key":"90557_CR22","doi-asserted-by":"crossref","unstructured":"Chetsawang, J., Govitrapong, P. & Chetsawang, B. Hydrogen peroxide toxicity induces Ras signaling in human neuroblastoma SH-SY5Y cultured cells. J. Biomed. Biotechnol. 2010, 803815 (2010).","DOI":"10.1155\/2010\/803815"},{"key":"90557_CR23","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.4014\/jmb.1002.02006","volume":"20","author":"S Sajjan","year":"2010","unstructured":"Sajjan, S., Kulkarni, G., Yaligara, V., Lee, K. & Karegoudar, T. B. Purification and physiochemical characterization of melanin pigment from Klebsiella Sp. GSK. J. Microbiol. Biotechnol. 20, 1513\u20131520 (2010).","journal-title":"J. Microbiol. Biotechnol."},{"key":"90557_CR24","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ijbiomac.2013.10.046","volume":"63","author":"M Ye","year":"2014","unstructured":"Ye, M. et al. Purification, structure and anti-radiation activity of melanin from Lachnum YM404. Int. J. Biol. Macromol. 63, 170\u2013176 (2014).","journal-title":"Int. J. Biol. Macromol."},{"key":"90557_CR25","doi-asserted-by":"publisher","first-page":"847246","DOI":"10.3389\/fimmu.2022.847246","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang, Y. et al. Oxidative stress following intracerebral hemorrhage: from molecular mechanisms to therapeutic targets. Front. Immunol. 13, 847246 (2022).","journal-title":"Front. Immunol."},{"key":"90557_CR26","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.foodchem.2018.11.002","volume":"277","author":"R Hou","year":"2019","unstructured":"Hou, R. et al. Characterization of the physicochemical properties and extraction optimization of natural melanin from Inonotus hispidus mushroom. Food Chem. 277, 533\u2013542 (2019).","journal-title":"Food Chem."},{"key":"90557_CR27","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1002\/jobm.202000430","volume":"60","author":"L Xu","year":"2020","unstructured":"Xu, L. et al. Comparison of physicochemical and biochemical properties of natural and arginine-modified melanin from medicinal mushroom Ganoderma Lucidum. J. Basic. Microbiol. 60, 1014\u20131028 (2020).","journal-title":"J. Basic. Microbiol."},{"key":"90557_CR28","doi-asserted-by":"publisher","first-page":"e0185674","DOI":"10.1371\/journal.pone.0185674","volume":"12","author":"VL Nguyen","year":"2017","unstructured":"Nguyen, V. L. et al. Anti-inflammatory and wound healing activities of calophyllolide isolated from Calophyllum Inophyllum Linn. PLOS ONE. 12, e0185674 (2017).","journal-title":"PLOS ONE"},{"key":"90557_CR29","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.3390\/nu10091139","volume":"10","author":"S Johnson","year":"2018","unstructured":"Johnson, S. et al. Levodopa-reduced Mucuna pruriens seed extract shows neuroprotective effects against Parkinson\u2019s disease in murine microglia and human neuroblastoma cells, Caenorhabditis Elegans, and Drosophila Melanogaster. Nutrients 10, 1139 (2018).","journal-title":"Nutrients"}],"updated-by":[{"DOI":"10.1038\/s41598-025-97773-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-90557-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-90557-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-90557-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T10:57:13Z","timestamp":1744887433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-90557-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["90557"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-90557-4","relation":{"correction":[{"id-type":"doi","id":"10.1038\/s41598-025-97773-y","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,19]]},"assertion":[{"value":"12 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-025-97773-y","URL":"https:\/\/doi.org\/10.1038\/s41598-025-97773-y","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6106"}}