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To study the impact of ZIKV on infant brain development, we collected resting-state electroencephalography (EEG) recordings from 28 normocephalic ZIKV-exposed children and 16 socio-demographically similar but unexposed children at 23\u201327\u00a0months of age. We assessed group differences in frequency band power and brain synchrony, as well as the relationship between these metrics and age. A significant difference (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, Bonferroni corrected) in Inter-Site Phase Coherence was observed: median Pearson correlation coefficients were 0.15 in unexposed children and 0.07 in ZIKV-exposed children. Results showed that functional brain networks in the unexposed group were developing rapidly, in part by strengthening distal high-frequency and weakening proximal lower frequency connectivity, presumably reflecting normal synaptic growth, myelination and pruning. These maturation patterns were attenuated in the ZIKV-exposed group, suggesting that ZIKV exposure may contribute to neurodevelopmental vulnerabilities that can be detected and quantified by resting-state EEG.<\/jats:p>","DOI":"10.1038\/s41598-025-90860-0","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:26:50Z","timestamp":1740137210000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Disruption of functional network development in children with prenatal Zika virus exposure revealed by resting-state EEG"],"prefix":"10.1038","volume":"15","author":[{"given":"Ahmet","family":"Omurtag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah","family":"Abdulbaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Waechter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Landon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Dlugos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Chari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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