{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:10:24Z","timestamp":1790982624994,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82272926"],"award-info":[{"award-number":["82272926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Promoting scientific research cooperation and high-level talent training projects with Canada,\u00a0Australia, New Zealand and Latin America of the National Scholarship Foundation","award":["(2022) 1007"],"award-info":[{"award-number":["(2022) 1007"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-91232-4","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T09:23:08Z","timestamp":1740216188000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between adverse childhood experiences with chronic kidney diseases in middle-aged and older adults in mainland China"],"prefix":"10.1038","volume":"15","author":[{"given":"Ziyi","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"issue":"04","key":"91232_CR1","first-page":"60","volume":"41","author":"Z Zhenwu","year":"2017","unstructured":"Zhenwu, Z., Jiaju, C. & Long, L. Future trends of China\u2019s population and aging: 2015\u20132100. Popul. Res. 41(04), 60\u201371 (2017).","journal-title":"Popul. Res."},{"issue":"4","key":"91232_CR2","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1590\/1806-9282.66.S1.3","volume":"47","author":"C Charles","year":"2020","unstructured":"Charles, C. & Ferris, A. H. Chronic kidney disease. Prim. Care 47(4), 585\u2013595. https:\/\/doi.org\/10.1590\/1806-9282.66.S1.3 (2020).","journal-title":"Prim. Care"},{"issue":"4","key":"91232_CR3","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1001\/jamainternmed.2022.6817","volume":"183","author":"L Wang","year":"2023","unstructured":"Wang, L. et al. Prevalence of chronic kidney disease in China: Results from the sixth china chronic disease and risk factor surveillance. JAMA Intern. Med. 183(4), 298\u2013310. https:\/\/doi.org\/10.1001\/jamainternmed.2022.6817 (2023).","journal-title":"JAMA Intern. Med."},{"issue":"6","key":"91232_CR4","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1053\/j.ajkd.2020.11.021","volume":"77","author":"C Yang","year":"2021","unstructured":"Yang, C. et al. Estimation of prevalence of kidney disease treated with dialysis in China: A study of insurance claims data. Am. J. Kidney Dis. 77(6), 889\u2013897. https:\/\/doi.org\/10.1053\/j.ajkd.2020.11.021 (2021).","journal-title":"Am. J. Kidney Dis."},{"issue":"4","key":"91232_CR5","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1177\/10775595211043122","volume":"27","author":"JA Gette","year":"2022","unstructured":"Gette, J. A. et al. Modeling the adverse childhood experiences questionnaire-international version. Child Maltreat. 27(4), 527\u2013538. https:\/\/doi.org\/10.1177\/10775595211043122 (2022).","journal-title":"Child Maltreat."},{"key":"91232_CR6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.chiabu.2017.03.016","volume":"69","author":"MT Merrick","year":"2017","unstructured":"Merrick, M. T. et al. Unpacking the impact of adverse childhood experiences on adult mental health. Child Abuse Negl. 69, 10\u201319. https:\/\/doi.org\/10.1016\/j.chiabu.2017.03.016 (2017).","journal-title":"Child Abuse Negl."},{"key":"91232_CR7","doi-asserted-by":"publisher","first-page":"116510","DOI":"10.1016\/j.socscimed.2023.116510","volume":"341","author":"K Zhang","year":"2024","unstructured":"Zhang, K. et al. Self-reported childhood adversity, unhealthy lifestyle and risk of new-onset chronic kidney disease in later life: A prospective cohort study. Soc. Sci. Med. 341, 116510. https:\/\/doi.org\/10.1016\/j.socscimed.2023.116510 (2024).","journal-title":"Soc. Sci. Med."},{"key":"91232_CR8","volume-title":"The Correlation Between Adverse Childhood Experiences and Sleep Quality in College Students: The Mediating Effect of Early Maladaptive Schemas","author":"Z Zimo","year":"2022","unstructured":"Zimo, Z. The Correlation Between Adverse Childhood Experiences and Sleep Quality in College Students: The Mediating Effect of Early Maladaptive Schemas (Beihua University, 2022)."},{"issue":"2","key":"91232_CR9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.18043\/ncm.79.2.99","volume":"79","author":"A Austin","year":"2018","unstructured":"Austin, A. Association of adverse childhood experiences with life course health and development. N. C. Med. J. 79(2), 99\u2013103. https:\/\/doi.org\/10.18043\/ncm.79.2.99 (2018).","journal-title":"N. C. Med. J."},{"issue":"3","key":"91232_CR10","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.amepre.2015.07.022","volume":"50","author":"JA Campbell","year":"2016","unstructured":"Campbell, J. A., Walker, R. J. & Egede, L. E. Associations between adverse childhood experiences, high-risk behaviors, and morbidity in adulthood. Am. J. Prev. Med. 50(3), 344\u2013352. https:\/\/doi.org\/10.1016\/j.amepre.2015.07.022 (2016).","journal-title":"Am. J. Prev. Med."},{"issue":"5","key":"91232_CR11","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.amepre.2018.11.030","volume":"56","author":"A Marie-Mitchell","year":"2019","unstructured":"Marie-Mitchell, A. & Kostolansky, R. A systematic review of trials to improve child outcomes associated with adverse childhood experiences. Am. J. Prev. Med. 56(5), 756\u2013764. https:\/\/doi.org\/10.1016\/j.amepre.2018.11.030 (2019).","journal-title":"Am. J. Prev. Med."},{"key":"91232_CR12","doi-asserted-by":"publisher","first-page":"104127","DOI":"10.1016\/j.chiabu.2019.104127","volume":"97","author":"K Petruccelli","year":"2019","unstructured":"Petruccelli, K., Davis, J. & Berman, T. Adverse childhood experiences and associated health outcomes: A systematic review and meta-analysis. Child Abuse Negl. 97, 104127. https:\/\/doi.org\/10.1016\/j.chiabu.2019.104127 (2019).","journal-title":"Child Abuse Negl."},{"key":"91232_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17228548","author":"A Hege","year":"2020","unstructured":"Hege, A. et al. Adverse childhood experiences among adults in North Carolina, USA: Influences on risk factors for poor health across the lifespan and intergenerational implications. Int. J. Environ. Res. Public Health https:\/\/doi.org\/10.3390\/ijerph17228548 (2020).","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"6","key":"91232_CR14","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nrneph.2017.52","volume":"13","author":"C Zoccali","year":"2017","unstructured":"Zoccali, C. et al. The systemic nature of CKD. Nat. Rev. Nephrol. 13(6), 344\u2013358. https:\/\/doi.org\/10.1038\/nrneph.2017.52 (2017).","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"91232_CR15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/ije\/dys203","volume":"43","author":"Y Zhao","year":"2014","unstructured":"Zhao, Y. et al. Cohort profile: The China health and Retirement Longitudinal Study (CHARLS). Int. J. Epidemiol. 43(1), 61\u201368. https:\/\/doi.org\/10.1093\/ije\/dys203 (2014).","journal-title":"Int. J. Epidemiol."},{"issue":"11","key":"91232_CR16","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1016\/j.chiabu.2014.06.003","volume":"38","author":"M Almuneef","year":"2014","unstructured":"Almuneef, M. et al. Adverse childhood experiences, chronic diseases, and risky health behaviors in Saudi Arabian adults: A pilot study. Child Abuse Negl. 38(11), 1787\u20131793. https:\/\/doi.org\/10.1016\/j.chiabu.2014.06.003 (2014).","journal-title":"Child Abuse Negl."},{"issue":"8","key":"91232_CR17","doi-asserted-by":"publisher","first-page":"e43078","DOI":"10.7759\/cureus.43078","volume":"15","author":"A Njoroge","year":"2023","unstructured":"Njoroge, A. et al. Assessment of adverse childhood experiences in the south bronx on the risk of developing chronic disease as adults. Cureus 15(8), e43078. https:\/\/doi.org\/10.7759\/cureus.43078 (2023).","journal-title":"Cureus"},{"issue":"10","key":"91232_CR18","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.3760\/cma.j.cn112338-20201223-01435","volume":"42","author":"J Li","year":"2021","unstructured":"Li, J. et al. A retrospective cohort study of the effects of the adverse childhood experience on chronic diseases of middle-aged and elderly. Chin. J. Epidemiol. 42(10), 1804\u20131808. https:\/\/doi.org\/10.3760\/cma.j.cn112338-20201223-01435 (2021).","journal-title":"Chin. J. Epidemiol."},{"issue":"3","key":"91232_CR19","first-page":"341","volume":"40","author":"X Yudong","year":"2023","unstructured":"Yudong, X., Ya, F. & Yanbing, Z. The incidence of adverse childhood experiences among residents over 45 years old and health effects in China. Chin. J. Health Stat. 40(3), 341\u2013344 (2023).","journal-title":"Chin. J. Health Stat."},{"issue":"44","key":"91232_CR20","doi-asserted-by":"publisher","first-page":"999","DOI":"10.15585\/mmwr.mm6844e1","volume":"68","author":"MT Merrick","year":"2019","unstructured":"Merrick, M. T. et al. Vital signs: Estimated proportion of adult health problems attributable to adverse childhood experiences and implications for prevention\u201425 states, 2015\u20132017. MMWR Morb. Mortal. Wkly. Rep. 68(44), 999\u20131005. https:\/\/doi.org\/10.15585\/mmwr.mm6844e1 (2019).","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"issue":"10","key":"91232_CR21","doi-asserted-by":"publisher","first-page":"e2130143","DOI":"10.1001\/jamanetworkopen.2021.30143","volume":"4","author":"L Lin","year":"2021","unstructured":"Lin, L. et al. Adverse childhood experiences and subsequent chronic diseases among middle-aged or older adults in China and associations with demographic and socioeconomic characteristics. JAMA Netw Open. 4(10), e2130143. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.30143 (2021).","journal-title":"JAMA Netw Open."},{"issue":"1","key":"91232_CR22","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1001\/jamapediatrics.2013.420","volume":"167","author":"D Finkelhor","year":"2013","unstructured":"Finkelhor, D. et al. Improving the adverse childhood experiences study scale. JAMA Pediatr. 167(1), 70\u201375. https:\/\/doi.org\/10.1001\/jamapediatrics.2013.420 (2013).","journal-title":"JAMA Pediatr."},{"issue":"1","key":"91232_CR23","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12916-017-0895-4","volume":"15","author":"AE Berens","year":"2017","unstructured":"Berens, A. E., Jensen, S. & Nelson, C. R. Biological embedding of childhood adversity: From physiological mechanisms to clinical implications. BMC Med. 15(1), 135. https:\/\/doi.org\/10.1186\/s12916-017-0895-4 (2017).","journal-title":"BMC Med."},{"key":"91232_CR24","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.psychres.2018.08.097","volume":"269","author":"S Deighton","year":"2018","unstructured":"Deighton, S. et al. Biomarkers of adverse childhood experiences: A scoping review. Psychiatry Res. 269, 719\u2013732. https:\/\/doi.org\/10.1016\/j.psychres.2018.08.097 (2018).","journal-title":"Psychiatry Res."},{"key":"91232_CR25","first-page":"1","volume":"8","author":"NC Audage","year":"2008","unstructured":"Audage, N. C. & Middlebrooks, J. S. The effects of childhood stress on health across the lifespan. Atlanta 8, 1\u20136 (2008).","journal-title":"Atlanta"},{"issue":"11","key":"91232_CR26","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1037\/dev0000049","volume":"51","author":"CE Hostinar","year":"2015","unstructured":"Hostinar, C. E. et al. Additive contributions of childhood adversity and recent stressors to inflammation at midlife: Findings from the MIDUS study. Dev. Psychol. 51(11), 1630\u20131644. https:\/\/doi.org\/10.1037\/dev0000049 (2015).","journal-title":"Dev. Psychol."},{"issue":"2","key":"91232_CR27","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1016\/j.amepre.2020.04.005","volume":"59","author":"MN Ozieh","year":"2020","unstructured":"Ozieh, M. N. et al. Adverse childhood experiences and decreased renal function: Impact on all-cause mortality in US adults. Am. J. Prev. Med. 59(2), e49\u2013e57. https:\/\/doi.org\/10.1016\/j.amepre.2020.04.005 (2020).","journal-title":"Am. J. Prev. Med."},{"issue":"158","key":"91232_CR28","doi-asserted-by":"publisher","first-page":"107100","DOI":"10.1016\/j.chiabu.2024.107100","volume":"7","author":"Y Liu","year":"2024","unstructured":"Liu, Y. et al. Adverse childhood experiences and multimorbidity among middle-aged and older adults: Evidence from China. Child Abuse Negl. 7(158), 107100. https:\/\/doi.org\/10.1016\/j.chiabu.2024.107100 (2024).","journal-title":"Child Abuse Negl."},{"key":"91232_CR29","doi-asserted-by":"publisher","first-page":"173268","DOI":"10.1016\/j.pbb.2021.173268","volume":"211","author":"JB Gordon","year":"2021","unstructured":"Gordon, J. B. The importance of child abuse and neglect in adult medicine. Pharmacol. Biochem. Behav. 211, 173268. https:\/\/doi.org\/10.1016\/j.pbb.2021.173268 (2021).","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"91232_CR30","doi-asserted-by":"publisher","first-page":"e0211850","DOI":"10.1371\/journal.pone.0211850","volume":"14","author":"X Chang","year":"2019","unstructured":"Chang, X., Jiang, X., Mkandarwire, T. & Shen, M. Associations between adverse childhood experiences and health outcomes in adults aged 18\u201359 years. PLoS One 14(2), e0211850. https:\/\/doi.org\/10.1371\/journal.pone.0211850 (2019).","journal-title":"PLoS One"},{"issue":"2","key":"91232_CR31","doi-asserted-by":"publisher","first-page":"136","DOI":"10.14301\/llcs.v4i2.236","volume":"4","author":"D Blane","year":"2013","unstructured":"Blane, D., Kelly-Irving, M., Errico, A., Bartley, M. & Montgomery, S. Social-biological transitions: How does the social become biological?. Longitud. Life Course Stud. 4(2), 136\u2013146. https:\/\/doi.org\/10.14301\/llcs.v4i2.236 (2013).","journal-title":"Longitud. Life Course Stud."},{"issue":"6","key":"91232_CR32","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.chiabu.2009.09.020","volume":"34","author":"MJ Chartier","year":"2010","unstructured":"Chartier, M. J., Walker, J. R. & Naimark, B. Separate and cumulative effects of adverse childhood experiences in predicting adult health and health care utilization. Child Abuse Negl. 34(6), 454\u2013464. https:\/\/doi.org\/10.1016\/j.chiabu.2009.09.020 (2010).","journal-title":"Child Abuse Negl."},{"issue":"49","key":"91232_CR33","first-page":"1609","volume":"59","author":"L Bynum","year":"2010","unstructured":"Bynum, L. et al. Adverse childhood experiences reported by adults\u2014Five states, 2009. MMWR Morb. Mortal. Wkly. Rep. 59(49), 1609\u20131613 (2010).","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"issue":"4","key":"91232_CR34","first-page":"35","volume":"47","author":"T Li","year":"2023","unstructured":"Li, T. & Yan, Y. Differences in mortality by region in china since the 1980s and their evolution: The staged synergy between medical investment and socio-economic development. Popul. Res. 47(4), 35\u201350 (2023).","journal-title":"Popul. Res."},{"key":"91232_CR35","first-page":"42","volume":"01","author":"L Feng","year":"1992","unstructured":"Feng, L. Change of fertility rate and the analysis of social and economic factors in China in 1980s. Chin. J. Popul. Sci. 01, 42\u201347 (1992).","journal-title":"Chin. J. Popul. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91232-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91232-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91232-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T09:23:15Z","timestamp":1740216195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91232-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,22]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["91232"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-91232-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,22]]},"assertion":[{"value":"20 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6469"}}