{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:53:29Z","timestamp":1781013209901,"version":"3.54.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Key Laboratory Project of Digestive Diseases in Jiangxi Province","award":["2024SSY06101"],"award-info":[{"award-number":["2024SSY06101"]}]},{"name":"Jiangxi Clinical Research Center for Gastroenterology","award":["20223BCG74011"],"award-info":[{"award-number":["20223BCG74011"]}]},{"name":"2024 graduate Innovation project of Jiangxi Province","award":["YC2024-S188"],"award-info":[{"award-number":["YC2024-S188"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-91265-9","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T21:02:38Z","timestamp":1741208558000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Construction and validation of a nomogram based on the log odds of positive lymph nodes to predict the prognosis of T1 gastric cancer"],"prefix":"10.1038","volume":"15","author":[{"given":"Xiaqin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaini","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"91265_CR1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","volume":"396","author":"EC Smyth","year":"2020","unstructured":"Smyth, E. C., Nilsson, M., Grabsch, H. I., van Grieken, N. C. & Lordick, F. Gastric cancer. Lancet 396, 635\u2013648 (2020).","journal-title":"Lancet"},{"key":"91265_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209\u2013249 (2021).","journal-title":"CA Cancer J. Clin."},{"key":"91265_CR3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3322\/caac.21657","volume":"71","author":"SS Joshi","year":"2021","unstructured":"Joshi, S. S. & Badgwell, B. D. Current treatment and recent progress in gastric cancer. CA Cancer J. Clin. 71, 264\u2013279 (2021).","journal-title":"CA Cancer J. Clin."},{"key":"91265_CR4","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.cgh.2019.07.045","volume":"18","author":"AP Thrift","year":"2020","unstructured":"Thrift, A. P. & El-Serag, H. B. Burden of gastric cancer. Clin. Gastroenterol. Hepatol. 18, 534\u2013542 (2020).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"91265_CR5","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.3748\/wjg.v29.i16.2452","volume":"29","author":"W-J Yang","year":"2023","unstructured":"Yang, W.-J. et al. Updates on global epidemiology, risk and prognostic factors of gastric cancer. World J. Gastroenterol. 29, 2452\u20132468 (2023).","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"91265_CR6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3322\/caac.21388","volume":"67","author":"MB Amin","year":"2017","unstructured":"Amin, M. B. et al. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging. CA Cancer J. Clin. 67(2), 93\u201399. https:\/\/doi.org\/10.3322\/caac.21388 (2017).","journal-title":"CA Cancer J. Clin."},{"key":"91265_CR7","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1245\/s10434-018-6462-1","volume":"25","author":"MR Weiser","year":"2018","unstructured":"Weiser, M. R. AJCC 8th edition: colorectal cancer. Ann. Surg. Oncol. 25, 1454\u20131455 (2018).","journal-title":"Ann. Surg. Oncol."},{"key":"91265_CR8","doi-asserted-by":"publisher","first-page":"e173","DOI":"10.1016\/S1470-2045(14)71116-7","volume":"16","author":"VP Balachandran","year":"2015","unstructured":"Balachandran, V. P., Gonen, M., Smith, J. J. & DeMatteo, R. P. Nomograms in oncology: more than meets the eye. Lancet Oncol. 16, e173-180 (2015).","journal-title":"Lancet Oncol."},{"key":"91265_CR9","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1590\/1806-9282.64.07.611","volume":"64","author":"MFKP Ramos","year":"2018","unstructured":"Ramos, M. F. K. P. et al. Risk factors associated with the development of gastric cancer\u2014case-control study. Rev. Assoc. Med. Bras. 64, 611\u2013619 (2018).","journal-title":"Rev. Assoc. Med. Bras."},{"key":"91265_CR10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ijsu.2018.08.002","volume":"57","author":"J Zhu","year":"2018","unstructured":"Zhu, J. et al. Integrated analysis of the prognostic role of the lymph node ratio in node-positive gastric cancer: A meta-analysis. Int. J. Surg. 57, 76\u201383 (2018).","journal-title":"Int. J. Surg."},{"key":"91265_CR11","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1097\/SLA.0000000000001040","volume":"262","author":"G Spolverato","year":"2015","unstructured":"Spolverato, G. et al. Prognostic performance of different lymph node staging systems after curative intent resection for gastric adenocarcinoma. Ann. Surg. 262, 991\u2013998 (2015).","journal-title":"Ann. Surg."},{"key":"91265_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.806162","volume":"11","author":"S Kinami","year":"2021","unstructured":"Kinami, S., Saito, H. & Takamura, H. Significance of lymph node metastasis in the treatment of gastric cancer and current challenges in determining the extent of metastasis. Front. Oncol. 11, 806162 (2021).","journal-title":"Front. Oncol."},{"key":"91265_CR13","doi-asserted-by":"publisher","first-page":"3967","DOI":"10.3748\/wjg.v20.i14.3967","volume":"20","author":"J-Y Deng","year":"2014","unstructured":"Deng, J.-Y. & Liang, H. Clinical significance of lymph node metastasis in gastric cancer. World J. Gastroenterol. 20, 3967\u20133975 (2014).","journal-title":"World J. Gastroenterol."},{"key":"91265_CR14","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.3748\/wjg.v25.i14.1640","volume":"25","author":"S Kinami","year":"2019","unstructured":"Kinami, S. et al. Precision surgical approach with lymph-node dissection in early gastric cancer. World J. Gastroenterol. 25, 1640\u20131652 (2019).","journal-title":"World J. Gastroenterol."},{"key":"91265_CR15","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00423-016-1395-2","volume":"401","author":"T Haist","year":"2016","unstructured":"Haist, T., Pritzer, H., Pauthner, M., Fisseler-Eckhoff, A. & Lorenz, D. Prognostic risk factors of early gastric cancer-a western experience. Langenbeck\u2019s Arch. Surg. 401, 667\u2013676 (2016).","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"91265_CR16","doi-asserted-by":"publisher","first-page":"5527","DOI":"10.7150\/jca.46563","volume":"11","author":"Y Zhu","year":"2020","unstructured":"Zhu, Y., Fang, X., Wang, L., Zhang, T. & Yu, D. A predictive nomogram for early death of metastatic gastric cancer: a retrospective study in the SEER database and China. J. Cancer 11, 5527\u20135535 (2020).","journal-title":"J. Cancer"},{"key":"91265_CR17","first-page":"1463","volume":"11","author":"X Zheng","year":"2021","unstructured":"Zheng, X., Guo, K., Wasan, H. S. & Ruan, S. A population-based study: how to identify high-risk T1 gastric cancer patients?. Am. J. Cancer Res. 11, 1463\u20131479 (2021).","journal-title":"Am. J. Cancer Res."},{"key":"91265_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.845313","volume":"13","author":"C Zhang","year":"2022","unstructured":"Zhang, C., Zhao, S. & Wang, X. Prognostic nomogram for early gastric cancer after surgery to assist decision-making for treatment with adjuvant chemotherapy. Front. Pharmacol. 13, 845313 (2022).","journal-title":"Front. Pharmacol."},{"key":"91265_CR19","doi-asserted-by":"crossref","unstructured":"Weso\u0142owska, M., Pawlik, P. & Jagodzi\u0144ski, P. P. The clinicopathologic significance of estrogen receptors in human gastric carcinoma. Biomed. Pharmacother. 83, 314\u2013322 (2016).","DOI":"10.1016\/j.biopha.2016.06.048"},{"key":"91265_CR20","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41568-019-0222-9","volume":"20","author":"M Fane","year":"2020","unstructured":"Fane, M. & Weeraratna, A. T. How the ageing microenvironment influences tumour progression. Nat. Rev. Cancer 20, 89\u2013106 (2020).","journal-title":"Nat. Rev. Cancer"},{"key":"91265_CR21","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/cac2.12067","volume":"40","author":"J Wu","year":"2020","unstructured":"Wu, J. et al. A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis. Cancer Commun. 40, 301\u2013312 (2020).","journal-title":"Cancer Commun."},{"key":"91265_CR22","unstructured":"A log odds of positive lymph nodes-based predictive model effectively forecasts prognosis and guides postoperative adjuvant chemotherapy duration in stage III colon cancer: a multi-center retrospective cohort study - PMC. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11370012\/."},{"key":"91265_CR23","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jcma.2016.09.010","volume":"80","author":"M-E Chang","year":"2017","unstructured":"Chang, M.-E. et al. Evaluation of prognostic factors and implication of lymph node dissection in intrahepatic cholangiocarcinoma: 10-year experience at a tertiary referral center. J. Chin. Med. Assoc. 80, 140\u2013146 (2017).","journal-title":"J. Chin. Med. Assoc."},{"key":"91265_CR24","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12885-022-09352-3","volume":"22","author":"G-W Ji","year":"2022","unstructured":"Ji, G.-W. et al. Development and validation of a gradient boosting machine to predict prognosis after liver resection for intrahepatic cholangiocarcinoma. BMC Cancer 22, 258 (2022).","journal-title":"BMC Cancer"},{"key":"91265_CR25","doi-asserted-by":"crossref","unstructured":"Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer 14, 113\u2013123 (2011).","DOI":"10.1007\/s10120-011-0042-4"},{"key":"91265_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.641962","volume":"11","author":"X Huo","year":"2021","unstructured":"Huo, X. & Wang, S. A lymph node count-based AJCC Staging system facilitates a more accurate prediction of the prognosis of patients with endometrial cancer. Front. Oncol. 11, 641962 (2021).","journal-title":"Front. Oncol."},{"key":"91265_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s12672-025-01849-0","volume":"16","author":"C Chen","year":"2025","unstructured":"Chen, C. et al. Developing a novel model for predicting overall survival in late-onset colon adenocarcinoma patients based on LODDS: a study based on the SEER database and external validation. Discov. Oncol. 16, 99 (2025).","journal-title":"Discov. Oncol."},{"key":"91265_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2024.08.012","author":"A Kar","year":"2024","unstructured":"Kar, A. et al. Evaluation of lymph node ratios and log odds of positive nodes as prognostic indicators in primary organ malignancy. Med. J. Armed Forces India https:\/\/doi.org\/10.1016\/j.mjafi.2024.08.012 (2024).","journal-title":"Med. J. Armed Forces India"},{"key":"91265_CR29","doi-asserted-by":"crossref","unstructured":"Chen, C. et al. Developing a novel model for predicting overall survival in late-onset colon adenocarcinoma patients based on LODDS: a study based on the SEER database and external validation. Discov. Onc. 16, 99 (2025).","DOI":"10.1007\/s12672-025-01849-0"},{"key":"91265_CR30","unstructured":"Evaluation of lymph node ratios and log odds of positive nodes as prognostic indicators in primary organ malignancy - ScienceDirect. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0377123724001473."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91265-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91265-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91265-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T08:44:07Z","timestamp":1741250647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91265-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["91265"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-91265-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,5]]},"assertion":[{"value":"29 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7788"}}