{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:55:44Z","timestamp":1782269744348,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-91276-6","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T10:36:21Z","timestamp":1740220581000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multiple respiratory assessment and thresholds for noninvasive ventilation in adult patients with spinal muscular atrophy"],"prefix":"10.1038","volume":"15","author":[{"given":"Grazia","family":"Crescimanno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Lupica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Tomasello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Brighina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oreste","family":"Marrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"91276_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41572-022-00380-8","volume":"8","author":"E Mercuri","year":"2022","unstructured":"Mercuri, E., Sumner, C. J., Muntoni, F., Darras, B. T. & Finkel, R. S. Spinal muscular atrophy. Nat. Rev. Dis. Primers. 8, 52 (2022).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"91276_CR2","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.chest.2023.03.011","volume":"164","author":"A Khan","year":"2023","unstructured":"Khan, A. et al. Respiratory management of patients with neuromuscular weakness: an American college of chest physicians clinical practice guideline and expert panel report. Chest 164, 394\u2013413 (2023).","journal-title":"Chest"},{"key":"91276_CR3","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s10072-018-3590-0","volume":"40","author":"G Crescimanno","year":"2019","unstructured":"Crescimanno, G., Romano, M., Spataro, R., La Bella, V. & Marrone, O. Early and rapidly progressing respiratory failure in a patient with amyotrophic lateral sclerosis: when FVC% is misleading. Neurol. Sci. 40, 421\u2013422 (2019).","journal-title":"Neurol. Sci."},{"key":"91276_CR4","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1136\/thx.35.8.603","volume":"35","author":"A De Troyer","year":"1990","unstructured":"De Troyer, A., Borenstein, S. & Cordier, R. Analysis of lung volume restriction in patients with respiratory muscle weakness. Thorax 35, 603\u2013610 (1990).","journal-title":"Thorax"},{"key":"91276_CR5","doi-asserted-by":"publisher","unstructured":"Sheers, N. L. et al. Rapidly and slowly progressive neuromuscular disease: differences in pulmonary function, respiratory tract infections and response to lung volume recruitment therapy (LVR). BMJ Open. Respir Res. 9. https:\/\/doi.org\/10.1136\/bmjresp-2022-001241 (2022).","DOI":"10.1136\/bmjresp-2022-001241"},{"key":"91276_CR6","doi-asserted-by":"publisher","first-page":"1900753","DOI":"10.1183\/13993003.00753-2019","volume":"55","author":"GG King","year":"2020","unstructured":"King, G. G. et al. Technical standards for respiratory oscillometry. Eur. Respir J. 55, 1900753 (2020).","journal-title":"Eur. Respir J."},{"key":"91276_CR7","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/j.1469-8749.2004.tb00508.x","volume":"46","author":"LM Gauld","year":"2004","unstructured":"Gauld, L. M., Kappers, J., Carlin, J. B. & Robertson, C. F. Height prediction from ulna length. Dev. Med. Child. Neurol. 46, 475\u2013480 (2004).","journal-title":"Dev. Med. Child. Neurol."},{"key":"91276_CR8","doi-asserted-by":"publisher","first-page":"e70","DOI":"10.1164\/rccm.201908-1590st","volume":"200","author":"BL Graham","year":"2019","unstructured":"Graham, B. L. et al. Standardization of spirometry 2019 update. An official American thoracic society and European respiratory society technical statement. Am. J. Respir Crit. Care Med. 200, e70\u2013e88. https:\/\/doi.org\/10.1164\/rccm.201908-1590st (2019).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"91276_CR9","doi-asserted-by":"publisher","first-page":"2101499","DOI":"10.1183\/13993003.01499-2021","volume":"60","author":"S Stanojevic","year":"2022","unstructured":"Stanojevic, S. et al. ERS\/ATS technical standard on interpretive strategies for routine lung function tests. Eur. Respir J. 60, 2101499 (2022).","journal-title":"Eur. Respir J."},{"key":"91276_CR10","doi-asserted-by":"publisher","first-page":"1801214","DOI":"10.1183\/13993003.01214-2018","volume":"53","author":"P Laveneziana","year":"2019","unstructured":"Laveneziana, P. et al. ERS statement on respiratory muscle testing at rest and during exercise. Eur. Respir J. 53, 1801214 (2019).","journal-title":"Eur. Respir J."},{"key":"91276_CR11","doi-asserted-by":"publisher","first-page":"e0177723","DOI":"10.1371\/journal.pone.0177723","volume":"12","author":"M Kaminska","year":"2017","unstructured":"Kaminska, M., Noel, F. & Petrof, B. J. Optimal method for assessment of respiratory muscle strength in neuromuscular disorders using Sniff nasal inspiratory pressure (SNIP). PLoS One. 12, e0177723. https:\/\/doi.org\/10.1371\/journal.pone.0177723 (2017).","journal-title":"PLoS One"},{"key":"91276_CR12","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1136\/thx.2004.037424","volume":"60","author":"S Ward","year":"2005","unstructured":"Ward, S., Chatwin, M., Heather, S. & Simonds, A. K. Randomised controlled trial of non-invasive ventilation (NIV) for nocturnal hypoventilation in neuromuscular and chest wall disease patients with daytime normocapnia. Thorax 60, 1019\u20131024 (2005).","journal-title":"Thorax"},{"key":"91276_CR13","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s11325-015-1247-2","volume":"20","author":"A Ogna","year":"2016","unstructured":"Ogna, A. et al. Nocturnal hypoventilation in neuromuscular disease: prevalence according to different definitions issued from the literature. Sleep. Breath. 20, 575\u2013581 (2016).","journal-title":"Sleep. Breath."},{"key":"91276_CR14","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1183\/09031936.03.00089403","volume":"22","author":"E Oostveen","year":"2003","unstructured":"Oostveen, E. et al. The forced Oscillation technique in clinical practice: methodology, recommendations, and future developments. Eur. Respir J. 22, 1026\u20131041 (2003).","journal-title":"Eur. Respir J."},{"key":"91276_CR15","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1164\/rccm.202306-0975OC","volume":"209","author":"C Veneroni","year":"2024","unstructured":"Veneroni, C. et al. Diagnostic potential of oscillometry: A Population-based approach. Am. J. Respir Crit. Care Med. 209, 444\u2013453 (2024).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"91276_CR16","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1136\/thx.48.7.702","volume":"48","author":"S Nava","year":"1993","unstructured":"Nava, S., Ambrosino, N., Crotti, P., Fracchia, C. & Rampulla, C. Recruitment of some respiratory muscles during three maximal inspiratory manoeuvres. Thorax 48, 702\u2013707 (1993).","journal-title":"Thorax"},{"key":"91276_CR17","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1212\/WNL.0000000000000796","volume":"83","author":"RI Wadman","year":"2014","unstructured":"Wadman, R. I. et al. Bulbar muscle MRI changes in patients with SMA with reduced mouth opening and dysphagia. Neurology 83, 1060\u20131066 (2014).","journal-title":"Neurology"},{"key":"91276_CR18","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1212\/WNL.0000000000002348","volume":"86","author":"HW van Bruggen","year":"2016","unstructured":"van Bruggen, H. W. et al. Mandibular dysfunction as a reflection of bulbar involvement in SMA type 2 and 3. Neurology 86, 552\u2013559 (2016).","journal-title":"Neurology"},{"key":"91276_CR19","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.ejpn.2013.04.004","volume":"17","author":"S Khirani","year":"2013","unstructured":"Khirani, S. et al. Longitudinal course of lung function and respiratory muscle strength in spinal muscular atrophy type 2 and 3. Eur. J. Paediatr. Neurol. 17, 552\u2013560 (2013).","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"91276_CR20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13023-022-02227-7","volume":"17","author":"ES Veldhoen","year":"2022","unstructured":"Veldhoen, E. S. et al. Natural history of respiratory muscle strength in spinal muscular atrophy: a prospective National cohort study. Orphanet J. Rare Dis. 17, 70 (2022).","journal-title":"Orphanet J. Rare Dis."},{"key":"91276_CR21","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1164\/ajrccm.162.4.9910034","volume":"162","author":"D Stefanutti","year":"2000","unstructured":"Stefanutti, D., Benoist, M. R., Scheinmann, P., Chaussain, M. & Fitting, J. W. Usefulness of Sniff nasal pressure in patients with neuromuscular or skeletal disorders. Am. J. Respir Crit. Care Med. 162, 1507\u20131511 (2000).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"91276_CR22","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/j.1468-1331.2011.03501.x","volume":"19","author":"EFNS Task Force on Diagnosis and Management of Amyotrophic Lateral Sclerosis","year":"2012","unstructured":"EFNS Task Force on Diagnosis and Management of Amyotrophic Lateral Sclerosis et al. EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--revised report of an EFNS task force. Eur. J. Neurol. 19, 360\u2013375 (2012).","journal-title":"Eur. J. Neurol."},{"key":"91276_CR23","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3109\/21678421.2013.776086","volume":"14","author":"J Gonzalez-Bermejo","year":"2013","unstructured":"Gonzalez-Bermejo, J. et al. Prognostic value of efficiently correcting nocturnal desaturations after one month of non-invasive ventilation in amyotrophic lateral sclerosis: a retrospective monocentre observational cohort study. Amyotroph. Lateral Scler. Frontotemporal Degener. 14, 373\u2013379 (2013).","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener"},{"key":"91276_CR24","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1164\/rccm.200403-314OC","volume":"171","author":"RK Morgan","year":"2005","unstructured":"Morgan, R. K. et al. Use of Sniff nasal-inspiratory force to predict survival in amyotrophic lateral sclerosis. Am. J. Respir Crit. Care Med. 171, 269\u2013274 (2005).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"91276_CR25","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/j.1469-8749.1989.tb04029.x","volume":"31","author":"L Merlini","year":"1989","unstructured":"Merlini, L. et al. Scoliosis in spinal muscular atrophy: natural history and management. Dev. Med. Child. Neurol. 31, 501\u2013508 (1989).","journal-title":"Dev. Med. Child. Neurol."},{"key":"91276_CR26","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1378\/chest.14-0166","volume":"146","author":"LM Gauld","year":"2014","unstructured":"Gauld, L. M., Keeling, L. A., Shackleton, C. E. & Sly, P. D. Forced Oscillation technique in spinal muscular atrophy. Chest 146, 795\u2013803 (2014).","journal-title":"Chest"},{"key":"91276_CR27","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1002\/ppul.24455","volume":"54","author":"N Kapur","year":"2019","unstructured":"Kapur, N., Deegan, S., Parakh, A. & Gauld, L. Relationship between respiratory function and need for NIV in childhood SMA. Pediatr. Pulmonol. 54, 1774\u20131780 (2019).","journal-title":"Pediatr. Pulmonol."},{"key":"91276_CR28","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1378\/chest.102.6.1752","volume":"102","author":"G Wesseling","year":"1992","unstructured":"Wesseling, G., Quaedvlieg, F. C. & Wouters, E. F. Oscillatory mechanics of the respiratory system in neuromuscular disease. Chest 102, 1752\u20131757 (1992).","journal-title":"Chest"},{"key":"91276_CR29","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1002\/ppul.25923","volume":"57","author":"ES Veldhoen","year":"2022","unstructured":"Veldhoen, E. S. et al. A substitute of spirometry in children with neuromuscular diseases? Pediatr. Pulmonol. 57, 1618\u20131624 (2022).","journal-title":"Pediatr. Pulmonol."},{"key":"91276_CR30","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1002\/ppul.23434","volume":"51","author":"L Gochicoa-Rangel","year":"2016","unstructured":"Gochicoa-Rangel, L. et al. Respiratory impedance in patients with Duchenne muscular dystrophy. Pediatr. Pulmonol. 51, 1072\u20131079 (2016).","journal-title":"Pediatr. Pulmonol."},{"key":"91276_CR31","doi-asserted-by":"publisher","first-page":"106931","DOI":"10.1016\/j.rmed.2022.106931","volume":"200","author":"S Iliaz","year":"2022","unstructured":"Iliaz, S. et al. The clinical use of impulse oscillometry in neuromuscular diseases. Respir Med. 200, 106931 (2022).","journal-title":"Respir Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91276-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91276-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91276-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T10:36:22Z","timestamp":1740220582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91276-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,22]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["91276"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-91276-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,22]]},"assertion":[{"value":"7 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by our ethics committee Palermo 1 on 31.01.2024 (N\u00b0 02\/2024). Written informed consent was obtained from patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6478"}}