{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:17:08Z","timestamp":1785453428325,"version":"3.56.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-91367-4","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T10:08:50Z","timestamp":1740564530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between serum vitamin A and bone mineral density in adolescents"],"prefix":"10.1038","volume":"15","author":[{"given":"Li","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"91367_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/jbmr.4168","volume":"36","author":"VL Bland","year":"2021","unstructured":"Bland, V. L. et al. Influence of changes in soft tissue composition on changes in bone strength in peripubertal girls: the STAR longitudinal study. J. Bone Min. Res. 36, 123\u2013132. https:\/\/doi.org\/10.1002\/jbmr.4168 (2021).","journal-title":"J. Bone Min. Res."},{"key":"91367_CR2","doi-asserted-by":"publisher","first-page":"e1229","DOI":"10.1542\/peds.2014-2173","volume":"134","author":"NH Golden","year":"2014","unstructured":"Golden, N. H. & Abrams, S. A. Optimizing bone health in children and adolescents. Pediatrics 134, e1229\u20131243. https:\/\/doi.org\/10.1542\/peds.2014-2173 (2014).","journal-title":"Pediatrics"},{"key":"91367_CR3","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1007\/s00431-022-04455-2","volume":"181","author":"S Ciancia","year":"2022","unstructured":"Ciancia, S. et al. Osteoporosis in children and adolescents: when to suspect and how to diagnose it. Eur. J. Pediatr. 181, 2549\u20132561. https:\/\/doi.org\/10.1007\/s00431-022-04455-2 (2022).","journal-title":"Eur. J. Pediatr."},{"key":"91367_CR4","doi-asserted-by":"publisher","unstructured":"Liu, H. et al. The association between serum copper and bone mineral density among adolescents aged 12 to 19 in the united States. Nutrients 16 https:\/\/doi.org\/10.3390\/nu16030453 (2024).","DOI":"10.3390\/nu16030453"},{"key":"91367_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1385\/endo:17:1","volume":"17","author":"CM Weaver","year":"2002","unstructured":"Weaver, C. M. Adolescence: the period of dramatic bone growth. Endocrine 17, 43\u201348. https:\/\/doi.org\/10.1385\/endo:17:1 (2002).","journal-title":"Endocrine"},{"key":"91367_CR6","doi-asserted-by":"publisher","first-page":"1101403","DOI":"10.3389\/fendo.2022.1101403","volume":"13","author":"F Baronio","year":"2022","unstructured":"Baronio, F., Baptista, F. & Editorial Bone health and development in children and adolescents. Front. Endocrinol. (Lausanne). 13, 1101403. https:\/\/doi.org\/10.3389\/fendo.2022.1101403 (2022).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"91367_CR7","doi-asserted-by":"publisher","first-page":"1298851","DOI":"10.3389\/fendo.2024.1298851","volume":"15","author":"UH Lerner","year":"2024","unstructured":"Lerner, U. H. Vitamin A - discovery, metabolism, receptor signaling and effects on bone mass and fracture susceptibility. Front. Endocrinol. (Lausanne). 15, 1298851. https:\/\/doi.org\/10.3389\/fendo.2024.1298851 (2024).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"91367_CR8","doi-asserted-by":"publisher","unstructured":"Sinopoli, A., Caminada, S., Isonne, C., Santoro, M. M. & Baccolini, V. What Are the Effects of Vitamin A Oral Supplementation in the Prevention and Management of Viral Infections? A Systematic Review of Randomized Clinical Trials. Nutrients 14, (2022). https:\/\/doi.org\/10.3390\/nu14194081","DOI":"10.3390\/nu14194081"},{"key":"91367_CR9","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1001\/jama.2023.0636","volume":"329","author":"TD Cheng","year":"2023","unstructured":"Cheng, T. D., Ferderber, C., Kinder, B. & Wei, Y. J. Trends in dietary vitamin A intake among US adults by race and ethnicity, 2003\u20132018. JAMA 329, 1026\u20131029. https:\/\/doi.org\/10.1001\/jama.2023.0636 (2023).","journal-title":"JAMA"},{"key":"91367_CR10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fendo.2015.00031","volume":"6","author":"P Henning","year":"2015","unstructured":"Henning, P., Conaway, H. H. & Lerner, U. H. Retinoid receptors in bone and their role in bone remodeling. Front. Endocrinol. (Lausanne). 6, 31. https:\/\/doi.org\/10.3389\/fendo.2015.00031 (2015).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"91367_CR11","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bone.2015.05.028","volume":"79","author":"GD Chen","year":"2015","unstructured":"Chen, G. D. et al. Association of dietary consumption and serum levels of vitamin A and \u03b2-carotene with bone mineral density in Chinese adults. Bone 79, 110\u2013115. https:\/\/doi.org\/10.1016\/j.bone.2015.05.028 (2015).","journal-title":"Bone"},{"key":"91367_CR12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12891-021-03997-0","volume":"22","author":"X Li","year":"2021","unstructured":"Li, X. & Liu, X. Associations of serum vitamins levels with bone mineral density in the different race-ethnicities US adults. BMC Musculoskelet. Disord. 22, 137. https:\/\/doi.org\/10.1186\/s12891-021-03997-0 (2021).","journal-title":"BMC Musculoskelet. Disord"},{"key":"91367_CR13","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1056\/NEJMoa021171","volume":"348","author":"K Micha\u00eblsson","year":"2003","unstructured":"Micha\u00eblsson, K., Lithell, H., Vessby, B. & Melhus, H. Serum retinol levels and the risk of fracture. N Engl. J. Med. 348, 287\u2013294. https:\/\/doi.org\/10.1056\/NEJMoa021171 (2003).","journal-title":"N Engl. J. Med."},{"key":"91367_CR14","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.3945\/ajcn.115.110528","volume":"102","author":"K Holvik","year":"2015","unstructured":"Holvik, K. et al. No increase in risk of hip fracture at high serum retinol concentrations in community-dwelling older Norwegians: the Norwegian epidemiologic osteoporosis studies. Am. J. Clin. Nutr. 102, 1289\u20131296. https:\/\/doi.org\/10.3945\/ajcn.115.110528 (2015).","journal-title":"Am. J. Clin. Nutr."},{"key":"91367_CR15","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1530\/joe-18-0316","volume":"239","author":"V Lionikaite","year":"2018","unstructured":"Lionikaite, V. et al. Clinically relevant doses of vitamin A decrease cortical bone mass in mice. J. Endocrinol. 239, 389\u2013402. https:\/\/doi.org\/10.1530\/joe-18-0316 (2018).","journal-title":"J. Endocrinol."},{"key":"91367_CR16","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1038\/s41430-018-0193-z","volume":"72","author":"MSW Teigmo","year":"2018","unstructured":"Teigmo, M. S. W., Gundersen, T. E., Emaus, N. & Grimnes, G. Distribution and determinants of retinol in Norwegian adolescents, and its relation to bone mineral density: the Troms\u00f8 study: fit futures. Eur. J. Clin. Nutr. 72, 1373\u20131384. https:\/\/doi.org\/10.1038\/s41430-018-0193-z (2018).","journal-title":"Eur. J. Clin. Nutr."},{"key":"91367_CR17","doi-asserted-by":"publisher","unstructured":"Zhang, X. et al. Vitamin A nutritional status is a key determinant of bone mass in children. Nutrients 14 https:\/\/doi.org\/10.3390\/nu14214694 (2022).","DOI":"10.3390\/nu14214694"},{"key":"91367_CR18","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00198-015-3440-3","volume":"27","author":"CM Weaver","year":"2016","unstructured":"Weaver, C. M. et al. The National osteoporosis foundation\u2019s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations. Osteoporos. Int. 27, 1281\u20131386. https:\/\/doi.org\/10.1007\/s00198-015-3440-3 (2016).","journal-title":"Osteoporos. Int."},{"key":"91367_CR19","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.psj.2020.09.001","volume":"100","author":"VDL Savaris","year":"2021","unstructured":"Savaris, V. D. L. et al. Interactions between lipid source and vitamin A on broiler performance, blood parameters, fat and protein deposition rate, and bone development. Poult. Sci. 100, 174\u2013185. https:\/\/doi.org\/10.1016\/j.psj.2020.09.001 (2021).","journal-title":"Poult. Sci."},{"key":"91367_CR20","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s11102-024-01464-2","volume":"27","author":"S Bolamperti","year":"2024","unstructured":"Bolamperti, S., Villa, I. & di Filippo, L. Growth hormone and bone: a basic perspective. Pituitary 27, 745\u2013751. https:\/\/doi.org\/10.1007\/s11102-024-01464-2 (2024).","journal-title":"Pituitary"},{"key":"91367_CR21","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1007\/s00198-011-1776-x","volume":"23","author":"JM Paik","year":"2012","unstructured":"Paik, J. M., Farwell, W. R. & Taylor, E. N. Demographic, dietary, and serum factors and parathyroid hormone in the National health and nutrition examination survey. Osteoporos. Int. 23, 1727\u20131736. https:\/\/doi.org\/10.1007\/s00198-011-1776-x (2012).","journal-title":"Osteoporos. Int."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91367-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91367-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91367-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T10:08:52Z","timestamp":1740564532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91367-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["91367"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-91367-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"assertion":[{"value":"20 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6892"}}