{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:17:06Z","timestamp":1774495026755,"version":"3.50.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82273215"],"award-info":[{"award-number":["82273215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"China Postdoctoral Science Foundation Funded Project","award":["2021M693558"],"award-info":[{"award-number":["2021M693558"]}]},{"DOI":"10.13039\/501100012486","name":"Innovation-Driven Project of Central South University","doi-asserted-by":"crossref","award":["2020CX043"],"award-info":[{"award-number":["2020CX043"]}],"id":[{"id":"10.13039\/501100012486","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Outstanding Youth Fund of Natural Science Foundation of Hunan Province","award":["2021JJ20092"],"award-info":[{"award-number":["2021JJ20092"]}]},{"name":"Project of scientific research plan of hunan provincial health commission","award":["202204022468"],"award-info":[{"award-number":["202204022468"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-91401-5","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T13:35:14Z","timestamp":1740749714000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunogenic cell death signature predicts survival and reveals the role of VEGFA\u2009+\u2009Mast cells in lung adenocarcinoma"],"prefix":"10.1038","volume":"15","author":[{"given":"Meng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guowei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yantao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benliang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanxiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruimin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"91401_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel, R. L., Giaquinto, A. N. & Jemal, A. Cancer statistics, 2024. CA Cancer J. Clin. 74, 12\u201349. https:\/\/doi.org\/10.3322\/caac.21820 (2024).","journal-title":"CA Cancer J. Clin."},{"key":"91401_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H. et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660 (2021).","journal-title":"CA Cancer J. Clin."},{"key":"91401_CR3","doi-asserted-by":"publisher","first-page":"5309","DOI":"10.1016\/j.cell.2021.09.020","volume":"184","author":"G Morad","year":"2021","unstructured":"Morad, G., Helmink, B. A., Sharma, P. & Wargo, J. A. Hallmarks of response, resistance, and toxicity to immune checkpoint Blockade. Cell 184, 5309\u20135337. https:\/\/doi.org\/10.1016\/j.cell.2021.09.020 (2021).","journal-title":"Cell"},{"key":"91401_CR4","doi-asserted-by":"publisher","unstructured":"Guo, H., Hou, Y., Wang, C. & Ding, J. How to optimize the immune checkpoint blockade therapy for cancers? Oncologie 26, 343\u2013348. https:\/\/doi.org\/10.1515\/oncologie-2024-0037  (2024).","DOI":"10.1515\/oncologie-2024-0037"},{"key":"91401_CR5","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41590-022-01132-2","volume":"23","author":"G Kroemer","year":"2022","unstructured":"Kroemer, G., Galassi, C., Zitvogel, L. & Galluzzi, L. Immunogenic cell stress and death. Nat. Immunol. 23, 487\u2013500. https:\/\/doi.org\/10.1038\/s41590-022-01132-2 (2022).","journal-title":"Nat. Immunol."},{"key":"91401_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nri.2016.107","volume":"17","author":"L Galluzzi","year":"2017","unstructured":"Galluzzi, L., Buque, A., Kepp, O., Zitvogel, L. & Kroemer, G. Immunogenic cell death in cancer and infectious disease. Nat. Rev. Immunol. 17, 97\u2013111. https:\/\/doi.org\/10.1038\/nri.2016.107 (2017).","journal-title":"Nat. Rev. Immunol."},{"key":"91401_CR7","doi-asserted-by":"publisher","unstructured":"Galluzzi, L. et al. Consensus guidelines for the definition, detection and interpretation of Immunogenic cell death. J. Immunother Cancer. 8. https:\/\/doi.org\/10.1136\/jitc-2019-000337 (2020).","DOI":"10.1136\/jitc-2019-000337"},{"key":"91401_CR8","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41419-020-03221-2","volume":"11","author":"J Fucikova","year":"2020","unstructured":"Fucikova, J. et al. Detection of Immunogenic cell death and its relevance for cancer therapy. Cell. Death Dis. 11, 1013. https:\/\/doi.org\/10.1038\/s41419-020-03221-2 (2020).","journal-title":"Cell. Death Dis."},{"key":"91401_CR9","doi-asserted-by":"publisher","first-page":"781466","DOI":"10.3389\/fimmu.2021.781466","volume":"12","author":"X Wang","year":"2021","unstructured":"Wang, X. et al. An Immunogenic cell death-related classification predicts prognosis and response to immunotherapy in head and neck squamous cell carcinoma. Front. Immunol. 12, 781466. https:\/\/doi.org\/10.3389\/fimmu.2021.781466 (2021).","journal-title":"Front. Immunol."},{"key":"91401_CR10","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1007\/s10495-023-01879-5","volume":"28","author":"Z Liu","year":"2023","unstructured":"Liu, Z. et al. An Immunogenic cell death-related signature predicts prognosis and immunotherapy response in stomach adenocarcinoma. Apoptosis 28, 1564\u20131583. https:\/\/doi.org\/10.1007\/s10495-023-01879-5 (2023).","journal-title":"Apoptosis"},{"key":"91401_CR11","doi-asserted-by":"publisher","first-page":"994034","DOI":"10.3389\/fimmu.2022.994034","volume":"13","author":"J Yang","year":"2022","unstructured":"Yang, J. et al. Integration of single-cell RNA sequencing and bulk RNA sequencing to reveal an Immunogenic cell death-related 5-gene panel as a prognostic model for osteosarcoma. Front. Immunol. 13, 994034. https:\/\/doi.org\/10.3389\/fimmu.2022.994034 (2022).","journal-title":"Front. Immunol."},{"key":"91401_CR12","doi-asserted-by":"publisher","first-page":"110130","DOI":"10.1016\/j.intimp.2023.110130","volume":"119","author":"Z Tian","year":"2023","unstructured":"Tian, Z., Li, X. & Jiang, D. Analysis of immunogenic cell death in atherosclerosis based on scRNA-seq and bulk RNA-seq data. Int. Immunopharmacol. 119, 110130. https:\/\/doi.org\/10.1016\/j.intimp.2023.110130 (2023).","journal-title":"Int. Immunopharmacol."},{"key":"91401_CR13","doi-asserted-by":"publisher","unstructured":"Gan, X., Tang, X. & Li, Z. Identification of Immunogenic cell-death-related subtypes and development of a prognostic signature in gastric cancer. Biomolecules 13. https:\/\/doi.org\/10.3390\/biom13030528 (2023).","DOI":"10.3390\/biom13030528"},{"key":"91401_CR14","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/all.13657","volume":"74","author":"A Wilcock","year":"2019","unstructured":"Wilcock, A., Bahri, R., Bulfone-Paus, S. & Arkwright, P. D. Mast cell disorders: from infancy to maturity. Allergy 74, 53\u201363. https:\/\/doi.org\/10.1111\/all.13657 (2019).","journal-title":"Allergy"},{"key":"91401_CR15","doi-asserted-by":"publisher","first-page":"107718","DOI":"10.1016\/j.pharmthera.2020.107718","volume":"220","author":"GH Falduto","year":"2021","unstructured":"Falduto, G. H., Pfeiffer, A., Luker, A., Metcalfe, D. D. & Olivera, A. Emerging mechanisms contributing to mast cell-mediated pathophysiology with therapeutic implications. Pharmacol. Ther. 220, 107718. https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107718 (2021).","journal-title":"Pharmacol. Ther."},{"key":"91401_CR16","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/ng.2764","volume":"45","author":"Cancer Genome Atlas Research","year":"2013","unstructured":"Cancer Genome Atlas Research. The Cancer genome atlas Pan-Cancer analysis project. Nat. Genet. 45, 1113\u20131120. https:\/\/doi.org\/10.1038\/ng.2764 (2013).","journal-title":"Nat. Genet."},{"key":"91401_CR17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.lungcan.2008.03.033","volume":"63","author":"R Kuner","year":"2009","unstructured":"Kuner, R. et al. Global gene expression analysis reveals specific patterns of cell junctions in non-small cell lung cancer subtypes. Lung Cancer 63, 32\u201338. https:\/\/doi.org\/10.1016\/j.lungcan.2008.03.033 (2009).","journal-title":"Lung Cancer"},{"key":"91401_CR18","doi-asserted-by":"publisher","first-page":"4417","DOI":"10.1200\/JCO.2009.26.4325","volume":"28","author":"CQ Zhu","year":"2010","unstructured":"Zhu, C. Q. et al. Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer. J. Clin. Oncol. 28, 4417\u20134424. https:\/\/doi.org\/10.1200\/JCO.2009.26.4325 (2010).","journal-title":"J. Clin. Oncol."},{"key":"91401_CR19","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1158\/1541-7786.MCR-12-0634-T","volume":"11","author":"M Sato","year":"2013","unstructured":"Sato, M. et al. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol. Cancer Res. 11, 638\u2013650. https:\/\/doi.org\/10.1158\/1541-7786.MCR-12-0634-T (2013).","journal-title":"Mol. Cancer Res."},{"key":"91401_CR20","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1158\/1078-0432.CCR-12-2321","volume":"19","author":"H Tang","year":"2013","unstructured":"Tang, H. et al. A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients. Clin. Cancer Res. 19, 1577\u20131586. https:\/\/doi.org\/10.1158\/1078-0432.CCR-12-2321 (2013).","journal-title":"Clin. Cancer Res."},{"key":"91401_CR21","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/nm.1790","volume":"14","author":"Director\u2019s Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma","year":"2008","unstructured":"Director\u2019s Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma. Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat. Med. 14, 822\u2013827. https:\/\/doi.org\/10.1038\/nm.1790 (2008).","journal-title":"Nat. Med."},{"key":"91401_CR22","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1038\/onc.2015.375","volume":"35","author":"MB Schabath","year":"2016","unstructured":"Schabath, M. B. et al. Differential association of STK11 and TP53 with KRAS mutation-associated gene expression, proliferation and immune surveillance in lung adenocarcinoma. Oncogene 35, 3209\u20133216. https:\/\/doi.org\/10.1038\/onc.2015.375 (2016).","journal-title":"Oncogene"},{"key":"91401_CR23","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1200\/JCO.2008.19.7053","volume":"27","author":"S Tomida","year":"2009","unstructured":"Tomida, S. et al. Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis. J. Clin. Oncol. 27, 2793\u20132799. https:\/\/doi.org\/10.1200\/JCO.2008.19.7053 (2009).","journal-title":"J. Clin. Oncol."},{"key":"91401_CR24","doi-asserted-by":"publisher","first-page":"3540","DOI":"10.1158\/0008-5472.CAN-16-3556","volume":"77","author":"A Prat","year":"2017","unstructured":"Prat, A. et al. Immune-related gene expression profiling after PD-1 Blockade in non-small cell lung carcinoma, head and neck squamous cell carcinoma, and melanoma. Cancer Res. 77, 3540\u20133550. https:\/\/doi.org\/10.1158\/0008-5472.CAN-16-3556 (2017).","journal-title":"Cancer Res."},{"key":"91401_CR25","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/s41588-023-01355-5","volume":"55","author":"A Ravi","year":"2023","unstructured":"Ravi, A. et al. Genomic and transcriptomic analysis of checkpoint Blockade response in advanced non-small cell lung cancer. Nat. Genet. 55, 807\u2013819. https:\/\/doi.org\/10.1038\/s41588-023-01355-5 (2023).","journal-title":"Nat. Genet."},{"key":"91401_CR26","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1200\/JCO.2012.44.3762","volume":"31","author":"F Ulloa-Montoya","year":"2013","unstructured":"Ulloa-Montoya, F. et al. Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy. J. Clin. Oncol. 31, 2388\u20132395. https:\/\/doi.org\/10.1200\/JCO.2012.44.3762 (2013).","journal-title":"J. Clin. Oncol."},{"key":"91401_CR27","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.cell.2017.09.028","volume":"171","author":"N Riaz","year":"2017","unstructured":"Riaz, N. et al. Tumor and microenvironment evolution during immunotherapy with nivolumab. Cell 171, 934\u2013949. https:\/\/doi.org\/10.1016\/j.cell.2017.09.028 (2017). e916.","journal-title":"Cell"},{"key":"91401_CR28","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/nature25501","volume":"554","author":"S Mariathasan","year":"2018","unstructured":"Mariathasan, S. et al. TGFbeta attenuates tumour response to PD-L1 Blockade by contributing to exclusion of T cells. Nature 554, 544\u2013548. https:\/\/doi.org\/10.1038\/nature25501 (2018).","journal-title":"Nature"},{"key":"91401_CR29","doi-asserted-by":"publisher","unstructured":"Gide, T. N. et al. Distinct immune cell populations define response to anti-PD-1 monotherapy and anti-PD-1\/anti-CTLA-4 combined therapy. Cancer Cell 35, 238\u2013255 e236. https:\/\/doi.org\/10.1016\/j.ccell.2019.01.003 (2019).","DOI":"10.1016\/j.ccell.2019.01.003"},{"key":"91401_CR30","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1126\/science.aan5951","volume":"359","author":"D Miao","year":"2018","unstructured":"Miao, D. et al. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science 359, 801\u2013806. https:\/\/doi.org\/10.1126\/science.aan5951 (2018).","journal-title":"Science"},{"key":"91401_CR31","doi-asserted-by":"publisher","unstructured":"Yang, L. et al. Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma. J. Immunother. Cancer 10. https:\/\/doi.org\/10.1136\/jitc-2021-003534 (2022).","DOI":"10.1136\/jitc-2021-003534"},{"key":"91401_CR32","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1038\/s12276-022-00896-9","volume":"54","author":"J Zhu","year":"2022","unstructured":"Zhu, J. et al. Delineating the dynamic evolution from preneoplasia to invasive lung adenocarcinoma by integrating single-cell RNA sequencing and Spatial transcriptomics. Exp. Mol. Med. 54, 2060\u20132076. https:\/\/doi.org\/10.1038\/s12276-022-00896-9 (2022).","journal-title":"Exp. Mol. Med."},{"key":"91401_CR33","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13073-023-01164-9","volume":"15","author":"J Hu","year":"2023","unstructured":"Hu, J. et al. Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing. Genome Med. 15, 14. https:\/\/doi.org\/10.1186\/s13073-023-01164-9 (2023).","journal-title":"Genome Med."},{"key":"91401_CR34","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon, A. et al. The molecular signatures database (MSigDB) hallmark gene set collection. Cell. Syst. 1, 417\u2013425. https:\/\/doi.org\/10.1016\/j.cels.2015.12.004 (2015).","journal-title":"Cell. Syst."},{"key":"91401_CR35","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s13059-016-1070-5","volume":"17","author":"E Becht","year":"2016","unstructured":"Becht, E. et al. Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression. Genome Biol. 17, 218. https:\/\/doi.org\/10.1186\/s13059-016-1070-5 (2016).","journal-title":"Genome Biol."},{"key":"91401_CR36","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.cell.2014.12.033","volume":"160","author":"MS Rooney","year":"2015","unstructured":"Rooney, M. S., Shukla, S. A., Wu, C. J., Getz, G. & Hacohen, N. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160, 48\u201361. https:\/\/doi.org\/10.1016\/j.cell.2014.12.033 (2015).","journal-title":"Cell"},{"key":"91401_CR37","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1172\/JCI91190","volume":"127","author":"M Ayers","year":"2017","unstructured":"Ayers, M. et al. IFN-gamma-related mRNA profile predicts clinical response to PD-1 Blockade. J. Clin. Investig. 127, 2930\u20132940. https:\/\/doi.org\/10.1172\/JCI91190 (2017).","journal-title":"J. Clin. Investig"},{"key":"91401_CR38","doi-asserted-by":"publisher","unstructured":"Hernando-Calvo, A. et al. A pan-cancer clinical platform to predict immunotherapy outcomes and prioritize immuno-oncology combinations in early-phase trials. Medicine 4, 710\u2013727 e715. https:\/\/doi.org\/10.1016\/j.medj.2023.07.006 (2023).","DOI":"10.1016\/j.medj.2023.07.006"},{"key":"91401_CR39","doi-asserted-by":"publisher","unstructured":"Thorsson, V. et al. The immune landscape of cancer. Immunity 48, 812\u2013830 e814. https:\/\/doi.org\/10.1016\/j.immuni.2018.03.023 (2018).","DOI":"10.1016\/j.immuni.2018.03.023"},{"key":"91401_CR40","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nmeth.4150","volume":"14","author":"X Qiu","year":"2017","unstructured":"Qiu, X. et al. Single-cell mRNA quantification and differential analysis with census. Nat. Methods 14, 309\u2013315. https:\/\/doi.org\/10.1038\/nmeth.4150 (2017).","journal-title":"Nat. Methods"},{"key":"91401_CR41","doi-asserted-by":"publisher","unstructured":"Venteicher, A. S. et al. Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science 355. https:\/\/doi.org\/10.1126\/science.aai8478 (2017).","DOI":"10.1126\/science.aai8478"},{"key":"91401_CR42","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S. et al. Inference and analysis of cell-cell communication using cellchat. Nat. Commun. 12, 1088. https:\/\/doi.org\/10.1038\/s41467-021-21246-9 (2021).","journal-title":"Nat. Commun."},{"key":"91401_CR43","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","volume":"17","author":"R Browaeys","year":"2020","unstructured":"Browaeys, R., Saelens, W. & Saeys, Y. NicheNet: modeling intercellular communication by linking ligands to target genes. Nat. Methods 17, 159\u2013162. https:\/\/doi.org\/10.1038\/s41592-019-0667-5 (2020).","journal-title":"Nat. Methods"},{"key":"91401_CR44","doi-asserted-by":"publisher","first-page":"e1069938","DOI":"10.1080\/2162402X.2015.1069938","volume":"5","author":"AD Garg","year":"2016","unstructured":"Garg, A. D., De Ruysscher, D. & Agostinis, P. Immunological metagene signatures derived from Immunogenic cancer cell death associate with improved survival of patients with lung, breast or ovarian malignancies: A large-scale meta-analysis. Oncoimmunology 5, e1069938. https:\/\/doi.org\/10.1080\/2162402X.2015.1069938 (2016).","journal-title":"Oncoimmunology"},{"key":"91401_CR45","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nature13385","volume":"511","author":"Cancer Genome Atlas Research Network","year":"2014","unstructured":"Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 511, 543\u2013550. https:\/\/doi.org\/10.1038\/nature13385 (2014).","journal-title":"Nature"},{"key":"91401_CR46","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41467-023-35832-6","volume":"14","author":"CJ Hanley","year":"2023","unstructured":"Hanley, C. J. et al. Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer. Nat. Commun. 14, 387. https:\/\/doi.org\/10.1038\/s41467-023-35832-6 (2023).","journal-title":"Nat. Commun."},{"key":"91401_CR47","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1164\/ajrccm.157.3.9709027","volume":"157","author":"M Saetta","year":"1998","unstructured":"Saetta, M. et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 157, 822\u2013826. https:\/\/doi.org\/10.1164\/ajrccm.157.3.9709027 (1998).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"91401_CR48","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.ajpath.2013.10.017","volume":"184","author":"VR Stolberg","year":"2014","unstructured":"Stolberg, V. R. et al. Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure. Am. J. Pathol. 184, 454\u2013463. https:\/\/doi.org\/10.1016\/j.ajpath.2013.10.017 (2014).","journal-title":"Am. J. Pathol."},{"key":"91401_CR49","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature12213","volume":"499","author":"MS Lawrence","year":"2013","unstructured":"Lawrence, M. S. et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214\u2013218. https:\/\/doi.org\/10.1038\/nature12213 (2013).","journal-title":"Nature"},{"key":"91401_CR50","doi-asserted-by":"publisher","unstructured":"Cheng, S. et al. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell 184, 792\u2013809 e723. https:\/\/doi.org\/10.1016\/j.cell.2021.01.010 (2021).","DOI":"10.1016\/j.cell.2021.01.010"},{"key":"91401_CR51","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nrc3627","volume":"13","author":"HL Goel","year":"2013","unstructured":"Goel, H. L. & Mercurio, A. M. VEGF targets the tumour cell. Nat. Rev. Cancer 13, 871\u2013882. https:\/\/doi.org\/10.1038\/nrc3627 (2013).","journal-title":"Nat. Rev. Cancer"},{"key":"91401_CR52","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1165\/rcmb.2019-0164OC","volume":"63","author":"X Sun","year":"2020","unstructured":"Sun, X. et al. Direct extracellular NAMPT involvement in pulmonary hypertension and vascular remodeling. Transcriptional regulation by SOX and HIF-2alpha. Am. J. Respir Cell. Mol. Biol. 63, 92\u2013103. https:\/\/doi.org\/10.1165\/rcmb.2019-0164OC (2020).","journal-title":"Am. J. Respir Cell. Mol. Biol."},{"key":"91401_CR53","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.immuni.2014.06.010","volume":"41","author":"R Noy","year":"2014","unstructured":"Noy, R. & Pollard, J. W. Tumor-associated macrophages: from mechanisms to therapy. Immunity 41, 49\u201361. https:\/\/doi.org\/10.1016\/j.immuni.2014.06.010 (2014).","journal-title":"Immunity"},{"key":"91401_CR54","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/nm.3337","volume":"19","author":"SM Pyonteck","year":"2013","unstructured":"Pyonteck, S. M. et al. CSF-1R Inhibition alters macrophage polarization and blocks glioma progression. Nat. Med. 19, 1264\u20131272. https:\/\/doi.org\/10.1038\/nm.3337 (2013).","journal-title":"Nat. Med."},{"key":"91401_CR55","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s40425-017-0257-y","volume":"5","author":"MA Cannarile","year":"2017","unstructured":"Cannarile, M. A. et al. Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy. J. Immunother. Cancer 5, 53. https:\/\/doi.org\/10.1186\/s40425-017-0257-y (2017).","journal-title":"J. Immunother. Cancer"},{"key":"91401_CR56","doi-asserted-by":"publisher","first-page":"6559","DOI":"10.1158\/1078-0432.CCR-20-2748","volume":"26","author":"A Stahler","year":"2020","unstructured":"Stahler, A. et al. Amphiregulin expression is a predictive biomarker for EGFR Inhibition in metastatic colorectal cancer: combined analysis of three randomized trials. Clin. Cancer Res. 26, 6559\u20136567. https:\/\/doi.org\/10.1158\/1078-0432.CCR-20-2748 (2020).","journal-title":"Clin. Cancer Res."},{"key":"91401_CR57","doi-asserted-by":"publisher","first-page":"108211","DOI":"10.1016\/j.pharmthera.2022.108211","volume":"240","author":"MT Bu","year":"2022","unstructured":"Bu, M. T., Chandrasekhar, P., Ding, L. & Hugo, W. The roles of TGF-beta and VEGF pathways in the suppression of antitumor immunity in melanoma and other solid tumors. Pharmacol. Ther. 240, 108211. https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108211 (2022).","journal-title":"Pharmacol. Ther."},{"key":"91401_CR58","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.semcancer.2022.04.002","volume":"85","author":"E Levantini","year":"2022","unstructured":"Levantini, E., Maroni, G., Del Re, M. & Tenen, D. G. EGFR signaling pathway as therapeutic target in human cancers. Semin. Cancer Biol. 85, 253\u2013275. https:\/\/doi.org\/10.1016\/j.semcancer.2022.04.002 (2022).","journal-title":"Semin. Cancer Biol."},{"key":"91401_CR59","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41571-023-00844-0","volume":"21","author":"J LoPiccolo","year":"2024","unstructured":"LoPiccolo, J., Gusev, A., Christiani, D. C. & Janne, P. A. Lung cancer in patients who have never smoked - an emerging disease. Nat. Rev. Clin. Oncol. 21, 121\u2013146. https:\/\/doi.org\/10.1038\/s41571-023-00844-0 (2024).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"91401_CR60","doi-asserted-by":"publisher","first-page":"e108130","DOI":"10.15252\/embj.2021108130","volume":"40","author":"O Kepp","year":"2021","unstructured":"Kepp, O. et al. ATP and cancer immunosurveillance. EMBO J. 40, e108130. https:\/\/doi.org\/10.15252\/embj.2021108130 (2021).","journal-title":"EMBO J."},{"key":"91401_CR61","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s41568-018-0037-0","volume":"18","author":"F Di Virgilio","year":"2018","unstructured":"Di Virgilio, F., Sarti, A. C., Falzoni, S., De Marchi, E. & Adinolfi, E. Extracellular ATP and P2 purinergic signalling in the tumour microenvironment. Nat. Rev. Cancer. 18, 601\u2013618. https:\/\/doi.org\/10.1038\/s41568-018-0037-0 (2018).","journal-title":"Nat. Rev. Cancer"},{"key":"91401_CR62","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.ccell.2019.10.007","volume":"36","author":"D Boison","year":"2019","unstructured":"Boison, D. & Yegutkin, G. G. Adenosine metabolism: emerging concepts for cancer therapy. Cancer Cell 36, 582\u2013596. https:\/\/doi.org\/10.1016\/j.ccell.2019.10.007 (2019).","journal-title":"Cancer Cell"},{"key":"91401_CR63","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/s41577-020-0376-4","volume":"20","author":"AK Moesta","year":"2020","unstructured":"Moesta, A. K., Li, X. Y. & Smyth, M. J. Targeting CD39 in cancer. Nat. Rev. Immunol. 20, 739\u2013755. https:\/\/doi.org\/10.1038\/s41577-020-0376-4 (2020).","journal-title":"Nat. Rev. Immunol."},{"key":"91401_CR64","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nri1460","volume":"4","author":"JS Marshall","year":"2004","unstructured":"Marshall, J. S. Mast-cell responses to pathogens. Nat. Rev. Immunol. 4, 787\u2013799. https:\/\/doi.org\/10.1038\/nri1460 (2004).","journal-title":"Nat. Rev. Immunol."},{"key":"91401_CR65","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nrc2618","volume":"9","author":"JA Joyce","year":"2009","unstructured":"Joyce, J. A. & Pollard, J. W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer. 9, 239\u2013252. https:\/\/doi.org\/10.1038\/nrc2618 (2009).","journal-title":"Nat. Rev. Cancer"},{"key":"91401_CR66","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrd.2015.17","volume":"15","author":"N Ferrara","year":"2016","unstructured":"Ferrara, N. & Adamis, A. P. Ten years of anti-vascular endothelial growth factor therapy. Nat. Rev. Drug Discov. 15, 385\u2013403. https:\/\/doi.org\/10.1038\/nrd.2015.17 (2016).","journal-title":"Nat. Rev. Drug Discov."},{"key":"91401_CR67","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1038\/s12276-020-00500-y","volume":"52","author":"WS Lee","year":"2020","unstructured":"Lee, W. S., Yang, H., Chon, H. J. & Kim, C. Combination of anti-angiogenic therapy and immune checkpoint Blockade normalizes vascular-immune crosstalk to potentiate cancer immunity. Exp. Mol. Med. 52, 1475\u20131485. https:\/\/doi.org\/10.1038\/s12276-020-00500-y (2020).","journal-title":"Exp. Mol. Med."},{"key":"91401_CR68","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1200\/JCO.23.01891","volume":"42","author":"S Park","year":"2024","unstructured":"Park, S. et al. Phase III, randomized study of Atezolizumab plus bevacizumab and chemotherapy in patients with EGFR- or ALK-mutated non-small-cell lung cancer (ATTLAS, KCSG-LU19-04). J. Clin. Oncol. 42, 1241\u20131251. https:\/\/doi.org\/10.1200\/JCO.23.01891 (2024).","journal-title":"J. Clin. Oncol."},{"key":"91401_CR69","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1016\/j.jtho.2021.07.009","volume":"16","author":"MA Socinski","year":"2021","unstructured":"Socinski, M. A. et al. IMpower150 final overall survival analyses for Atezolizumab plus bevacizumab and chemotherapy in first-line metastatic nonsquamous NSCLC. J. Thorac. Oncol. 16, 1909\u20131924. https:\/\/doi.org\/10.1016\/j.jtho.2021.07.009 (2021).","journal-title":"J. Thorac. Oncol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91401-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91401-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91401-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T13:35:24Z","timestamp":1740749724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91401-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["91401"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-91401-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"27 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7213"}}