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MicroRNAs are small, non-coding RNA molecules that play a crucial role in post-transcriptional gene regulation. This study investigates miR-16-5p, miR-21-5p, and miR-155-5p expression in psoriasis EVs and assesses their biomarker potential, exploring associated target genes and pathways via bioinformatics. A cross-sectional and case-control study included 40 psoriasis patients, with blood samples collected in EDTA tubes. RNA from extracellular vesicles was isolated using Qiagen kits, and miRNAs were quantified via RT-qPCR. Bioinformatic analysis predicted target genes using databases like miRDB and TargetScan. Gene expression data from GEO was processed, and differentially expressed genes were identified. This study assessed miR-16-5p, miR-21-5p, and miR-155-5p expression in psoriasis patients\u2019 circulating vesicles versus controls, finding significantly lower levels in patients. ROC analysis confirmed their diagnostic potential. A positive correlation of miR-16-5p with the Psoriasis Area Severity Index (PASI) suggests severity marker potential. Bioinformatics identified 378 common dysregulated genes, revealing key pathways and gene interactions in psoriasis. A heat map confirmed miRNA-mediated gene suppression in the disease. This study identifies miR-16-5p, miR-21-5p, and miR-155-5p as potential psoriasis biomarkers, in addition to finding significant gene interactions and pathways involved in psoriasis pathophysiology.<\/jats:p>","DOI":"10.1038\/s41598-025-91532-9","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T17:15:16Z","timestamp":1740590116000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["miR-16-5p, miR-21-5p, and miR-155-5p in circulating vesicles as psoriasis biomarkers"],"prefix":"10.1038","volume":"15","author":[{"given":"Carlos A.","family":"Guzm\u00e1n-Mart\u00edn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio F.","family":"Jim\u00e9nez-Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Fernanda","family":"Ortega-Springall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Pe\u00f1a-Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Elena","family":"Guerrero-Ponce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Elisa","family":"Vega-Memije","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Amezcua-Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"S\u00e1nchez-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashidi","family":"Springall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"issue":"9583","key":"91532_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","volume":"370","author":"CE Griffiths","year":"2007","unstructured":"Griffiths, C. 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