{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T19:51:03Z","timestamp":1775937063926,"version":"3.50.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Scientific and Technological Innovation Foundation of Sichuan Provincial Maternity and Child Health Care Hospital","award":["CXZD2022-01"],"award-info":[{"award-number":["CXZD2022-01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-91998-7","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:27:41Z","timestamp":1740986861000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharmacology and experimental validation"],"prefix":"10.1038","volume":"15","author":[{"given":"Ling","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianwen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinghan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"91998_CR1","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S2352-4642(24)00169-X","volume":"8","author":"M Day-Lewis","year":"2024","unstructured":"Day-Lewis, M., Son, M. B. F. & Lo, M. S. Kawasaki disease: Contemporary perspectives. Lancet Child Adolesc. Health 8, 781\u2013792. https:\/\/doi.org\/10.1016\/S2352-4642(24)00169-X (2024).","journal-title":"Lancet Child Adolesc. Health"},{"key":"91998_CR2","doi-asserted-by":"publisher","first-page":"1259094","DOI":"10.3389\/fimmu.2023.1259094","volume":"14","author":"R Aggarwal","year":"2023","unstructured":"Aggarwal, R. et al. Kawasaki disease and the environment: An enigmatic interplay. Front. Immunol. 14, 1259094. https:\/\/doi.org\/10.3389\/fimmu.2023.1259094 (2023).","journal-title":"Front. Immunol."},{"key":"91998_CR3","first-page":"178","volume":"16","author":"T Kawasaki","year":"1967","unstructured":"Kawasaki, T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi 16, 178\u2013222 (1967).","journal-title":"Arerugi"},{"key":"91998_CR4","doi-asserted-by":"publisher","first-page":"13948","DOI":"10.3390\/ijms241813948","volume":"24","author":"HC Kuo","year":"2023","unstructured":"Kuo, H. C. Diagnosis, progress, and treatment update of Kawasaki disease. Int. J. Mol. Sci. 24, 13948. https:\/\/doi.org\/10.3390\/ijms241813948 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"91998_CR5","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1056\/nejm199106063242305","volume":"324","author":"JW Newburger","year":"1991","unstructured":"Newburger, J. W. et al. A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N. Engl. J. Med. 324, 1633\u20131639. https:\/\/doi.org\/10.1056\/nejm199106063242305 (1991).","journal-title":"N. Engl. J. Med."},{"key":"91998_CR6","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1056\/nejm198608073150601","volume":"315","author":"JW Newburger","year":"1986","unstructured":"Newburger, J. W. et al. The treatment of Kawasaki syndrome with intravenous gamma globulin. N. Engl. J. Med. 315, 341\u2013347. https:\/\/doi.org\/10.1056\/nejm198608073150601 (1986).","journal-title":"N. Engl. J. Med."},{"key":"91998_CR7","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s40272-020-00421-3","volume":"22","author":"G Ferrara","year":"2020","unstructured":"Ferrara, G. et al. Anakinra for treatment-resistant Kawasaki disease: Evidence from a literature review. Paediatr. Drugs 22, 645\u2013652. https:\/\/doi.org\/10.1007\/s40272-020-00421-3 (2020).","journal-title":"Paediatr. Drugs"},{"key":"91998_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153208","volume":"70","author":"B Tang","year":"2020","unstructured":"Tang, B. et al. Adjuvant herbal therapy for targeting susceptibility genes to Kawasaki disease: An overview of epidemiology, pathogenesis, diagnosis and pharmacological treatment of Kawasaki disease. Phytomedicine 70, 153208. https:\/\/doi.org\/10.1016\/j.phymed.2020.153208 (2020).","journal-title":"Phytomedicine"},{"key":"91998_CR9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.jmii.2012.05.002","volume":"47","author":"CH Chen","year":"2014","unstructured":"Chen, C. H. et al. Kawasaki disease with G6PD deficiency\u2013report of one case and literature review. J. Microbiol. Immunol. Infect. 47, 261\u2013263. https:\/\/doi.org\/10.1016\/j.jmii.2012.05.002 (2014).","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"91998_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2174\/157016106775203144","volume":"4","author":"C Tang","year":"2006","unstructured":"Tang, C., Li, X. & Du, J. Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular system. Curr. Vasc. Pharmacol. 4, 17\u201322. https:\/\/doi.org\/10.2174\/157016106775203144 (2006).","journal-title":"Curr. Vasc. Pharmacol."},{"key":"91998_CR11","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.3390\/cells12232684","volume":"12","author":"CMC Andr\u00e9s","year":"2023","unstructured":"Andr\u00e9s, C. M. C. et al. Chemistry of hydrogen sulfide-pathological and physiological functions in mammalian cells. Cells 12, 2684. https:\/\/doi.org\/10.3390\/cells12232684 (2023).","journal-title":"Cells"},{"key":"91998_CR12","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41569-022-00741-6","volume":"20","author":"GK Kolluru","year":"2023","unstructured":"Kolluru, G. K. et al. Sulfide regulation of cardiovascular function in health and disease. Nat. Rev. Cardiol. 20, 109\u2013125. https:\/\/doi.org\/10.1038\/s41569-022-00741-6 (2023).","journal-title":"Nat. Rev. Cardiol."},{"key":"91998_CR13","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1002\/med.21913","volume":"42","author":"ZL Song","year":"2022","unstructured":"Song, Z. L. et al. Progress and perspective on hydrogen sulfide donors and their biomedical applications. Med. Res. Rev. 42, 1930\u20131977. https:\/\/doi.org\/10.1002\/med.21913 (2022).","journal-title":"Med. Res. Rev."},{"key":"91998_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.33549\/physiolres.934928","volume":"72","author":"Y Xia","year":"2023","unstructured":"Xia, Y. et al. Hydrogen sulfide alleviates lipopolysaccharide-induced myocardial injury through TLR4-NLRP3 pathway. Physiol. Res. 72, 15\u201325. https:\/\/doi.org\/10.33549\/physiolres.934928 (2023).","journal-title":"Physiol. Res."},{"key":"91998_CR15","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s12012-022-09729-7","volume":"22","author":"Y Liao","year":"2022","unstructured":"Liao, Y. et al. Exogenous H(2)S ameliorates high salt-induced hypertension by alleviating oxidative stress and inflammation in the paraventricular nucleus in Dahl S Rats. Cardiovasc. Toxicol. 22, 477\u2013491. https:\/\/doi.org\/10.1007\/s12012-022-09729-7 (2022).","journal-title":"Cardiovasc. Toxicol."},{"key":"91998_CR16","doi-asserted-by":"publisher","first-page":"682","DOI":"10.3390\/antiox10050682","volume":"10","author":"HY Lu","year":"2021","unstructured":"Lu, H. Y. et al. Hydrogen sulfide attenuates aortic remodeling in aortic dissection associating with moderated inflammation and oxidative stress through a NO-dependent pathway. Antioxidants (Basel) 10, 682. https:\/\/doi.org\/10.3390\/antiox10050682 (2021).","journal-title":"Antioxidants (Basel)"},{"key":"91998_CR17","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nchembio.118","volume":"4","author":"AL Hopkins","year":"2008","unstructured":"Hopkins, A. L. Network pharmacology: The next paradigm in drug discovery. Nat. Chem. Biol. 4, 682\u2013690. https:\/\/doi.org\/10.1038\/nchembio.118 (2008).","journal-title":"Nat. Chem. Biol."},{"key":"91998_CR18","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1021\/acs.jcim.3c01613","volume":"64","author":"Z Yu","year":"2024","unstructured":"Yu, Z. et al. Network-based methods and their applications in drug discovery. J. Chem. Inf. Model 64, 57\u201375. https:\/\/doi.org\/10.1021\/acs.jcim.3c01613 (2024).","journal-title":"J. Chem. Inf. Model"},{"key":"91998_CR19","doi-asserted-by":"publisher","first-page":"D1180","DOI":"10.1093\/nar\/gkad1004","volume":"52","author":"B Zdrazil","year":"2024","unstructured":"Zdrazil, B. et al. The ChEMBL Database in 2023: A drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res. 52, D1180\u2013D1192. https:\/\/doi.org\/10.1093\/nar\/gkad1004 (2024).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113913","volume":"178","author":"Y Wang","year":"2023","unstructured":"Wang, Y. et al. Integrated metabolomics and network pharmacology revealing the mechanism of arsenic-induced hepatotoxicity in mice. Food Chem. Toxicol. 178, 113913. https:\/\/doi.org\/10.1016\/j.fct.2023.113913 (2023).","journal-title":"Food Chem. Toxicol."},{"key":"91998_CR21","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s10822-016-9915-2","volume":"30","author":"ZJ Yao","year":"2016","unstructured":"Yao, Z. J. et al. TargetNet: A web service for predicting potential drug-target interaction profiling via multi-target SAR models. J. Comput. Aided Mol. Des. 30, 413\u2013424. https:\/\/doi.org\/10.1007\/s10822-016-9915-2 (2016).","journal-title":"J. Comput. Aided Mol. Des."},{"key":"91998_CR22","doi-asserted-by":"publisher","first-page":"D380","DOI":"10.1093\/nar\/gkv1277","volume":"44","author":"D Szklarczyk","year":"2016","unstructured":"Szklarczyk, D. et al. STITCH 5: Augmenting protein-chemical interaction networks with tissue and affinity data. Nucleic Acids Res. 44, D380-384. https:\/\/doi.org\/10.1093\/nar\/gkv1277 (2016).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR23","doi-asserted-by":"publisher","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","volume":"51","author":"S Kim","year":"2023","unstructured":"Kim, S. et al. PubChem 2023 update. Nucleic Acids Res. 51, D1373\u2013D1380. https:\/\/doi.org\/10.1093\/nar\/gkac956 (2023).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cpbi.5","volume":"54","author":"G Stelzer","year":"2016","unstructured":"Stelzer, G. et al. The GeneCards suite: From gene data mining to disease genome sequence analyses. Curr. Protoc. Bioinform. 54, 1\u201330. https:\/\/doi.org\/10.1002\/cpbi.5 (2016).","journal-title":"Curr. Protoc. Bioinform."},{"key":"91998_CR25","doi-asserted-by":"publisher","first-page":"D845","DOI":"10.1093\/nar\/gkz1021","volume":"48","author":"J Pi\u00f1ero","year":"2020","unstructured":"Pi\u00f1ero, J. et al. The DisGeNET knowledge platform for disease genomics: 2019 update. Nucleic Acids Res. 48, D845\u2013D855. https:\/\/doi.org\/10.1093\/nar\/gkz1021 (2020).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR26","doi-asserted-by":"publisher","first-page":"D789","DOI":"10.1093\/nar\/gku1205","volume":"43","author":"JS Amberger","year":"2015","unstructured":"Amberger, J. S. et al. OMIM.org: Online Mendelian inheritance in Man (OMIM\u00ae), an online catalog of human genes and genetic disorders. Nucleic Acids Res. 43, D789-798. https:\/\/doi.org\/10.1093\/nar\/gku1205 (2015).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR27","doi-asserted-by":"publisher","first-page":"D1265","DOI":"10.1093\/nar\/gkad976","volume":"52","author":"C Knox","year":"2024","unstructured":"Knox, C. et al. DrugBank 6.0: The DrugBank knowledgebase for 2024. Nucleic Acids Res. 52, D1265\u2013D1275. https:\/\/doi.org\/10.1093\/nar\/gkad976 (2024).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR28","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/1471-2105-15-293","volume":"15","author":"P Bardou","year":"2014","unstructured":"Bardou, P. et al. jvenn: An interactive Venn diagram viewer. BMC Bioinform. 15, 293. https:\/\/doi.org\/10.1186\/1471-2105-15-293 (2014).","journal-title":"BMC Bioinform."},{"key":"91998_CR29","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk, D. et al. The STRING database in 2023: Protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 51, D638\u2013D646. https:\/\/doi.org\/10.1093\/nar\/gkac1000 (2023).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175215","volume":"931","author":"C Liu","year":"2022","unstructured":"Liu, C. et al. Integrating network pharmacology, transcriptomics, and molecular simulation to reveal the mechanism of tert-butylhydroquinone for treating diabetic retinopathy. Eur. J. Pharmacol. 931, 175215. https:\/\/doi.org\/10.1016\/j.ejphar.2022.175215 (2022).","journal-title":"Eur. J. Pharmacol."},{"key":"91998_CR31","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1016\/10.1093\/nar\/gkac194","volume":"50","author":"BT Sherman","year":"2022","unstructured":"Sherman, B. T. et al. DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 50, W216\u2013W221. https:\/\/doi.org\/10.1016\/10.1093\/nar\/gkac194 (2022).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR32","doi-asserted-by":"publisher","first-page":"W501","DOI":"10.1093\/nar\/gkx372","volume":"45","author":"W Luo","year":"2017","unstructured":"Luo, W. et al. Pathview Web: User friendly pathway visualization and data integration. Nucleic Acids Res. 45, W501\u2013W508. https:\/\/doi.org\/10.1093\/nar\/gkx372 (2017).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR33","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.7499\/j.issn.1008-8830.2003147","volume":"22","author":"SH Qi","year":"2020","unstructured":"Qi, S. H. et al. Value of ginsenoside Rb1 in alleviating coronary artery lesion in a mouse model of Kawasaki disease. Zhongguo Dang Dai Er Ke Za Zhi 22, 1034\u20131040. https:\/\/doi.org\/10.7499\/j.issn.1008-8830.2003147 (2020).","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"91998_CR34","doi-asserted-by":"publisher","first-page":"1411979","DOI":"10.3389\/fimmu.2024.1411979","volume":"15","author":"AP Lombardi Pereira","year":"2024","unstructured":"Lombardi Pereira, A. P. et al. Long-term cardiovascular inflammation and fibrosis in a murine model of vasculitis induced by Lactobacillus casei cell wall extract. Front. Immunol. 15, 1411979. https:\/\/doi.org\/10.3389\/fimmu.2024.1411979 (2024).","journal-title":"Front. Immunol."},{"key":"91998_CR35","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR36","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"key":"91998_CR37","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M. et al. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013D592. https:\/\/doi.org\/10.1093\/nar\/gkac963 (2023).","journal-title":"Nucleic Acids Res."},{"key":"91998_CR38","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/1744666X.2017.1232165","volume":"13","author":"S Agarwal","year":"2017","unstructured":"Agarwal, S. & Agrawal, D. K. Kawasaki disease: etiopathogenesis and novel treatment strategies. Expert. Rev. Clin. Immunol. 13, 247\u2013258. https:\/\/doi.org\/10.1080\/1744666X.2017.1232165 (2017).","journal-title":"Expert. Rev. Clin. Immunol."},{"key":"91998_CR39","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ijcard.2016.03.017","volume":"214","author":"T Kibata","year":"2016","unstructured":"Kibata, T. et al. Coronary artery lesions and the increasing incidence of Kawasaki disease resistant to initial immunoglobulin. Int. J. Cardiol. 214, 209\u2013215. https:\/\/doi.org\/10.1016\/j.ijcard.2016.03.017 (2016).","journal-title":"Int. J. Cardiol."},{"key":"91998_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217274","volume":"14","author":"X Zheng","year":"2019","unstructured":"Zheng, X. et al. Efficacy between low and high dose aspirin for the initial treatment of Kawasaki disease: Current evidence based on a meta-analysis. PLoS One 14, e0217274. https:\/\/doi.org\/10.1371\/journal.pone.0217274 (2019).","journal-title":"PLoS One"},{"key":"91998_CR41","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1152\/physrev.00028.2021","volume":"103","author":"G Cirino","year":"2023","unstructured":"Cirino, G., Szabo, C. & Papapetropoulos, A. Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs. Physiol. Rev. 103, 31\u2013276. https:\/\/doi.org\/10.1152\/physrev.00028.2021 (2023).","journal-title":"Physiol. Rev."},{"key":"91998_CR42","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.3389\/fphar.2018.01134","volume":"9","author":"Z Wu","year":"2018","unstructured":"Wu, Z. et al. Network-based methods for prediction of drug-target interactions. Front. Pharmacol. 9, 1134. https:\/\/doi.org\/10.3389\/fphar.2018.01134 (2018).","journal-title":"Front. Pharmacol."},{"key":"91998_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116306","volume":"309","author":"L Zhao","year":"2023","unstructured":"Zhao, L. et al. Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula. J. Ethnopharmacol. 309, 116306. https:\/\/doi.org\/10.1016\/j.jep.2023.116306 (2023).","journal-title":"J. Ethnopharmacol."},{"key":"91998_CR44","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.3390\/ijms20236008","volume":"20","author":"S Kany","year":"2019","unstructured":"Kany, S., Vollrath, J. T. & Relja, B. Cytokines in inflammatory disease. Int. J. Mol. Sci. 20, 6008. https:\/\/doi.org\/10.3390\/ijms20236008 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"91998_CR45","doi-asserted-by":"publisher","first-page":"1237670","DOI":"10.3389\/fimmu.2023.1237670","volume":"14","author":"J Chen","year":"2023","unstructured":"Chen, J. et al. Current knowledge of TNF-\u03b1 monoclonal antibody infliximab in treating Kawasaki disease: A comprehensive review. Front. Immunol. 14, 1237670. https:\/\/doi.org\/10.3389\/fimmu.2023.1237670 (2023).","journal-title":"Front. Immunol."},{"key":"91998_CR46","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.15252\/embj.201488856","volume":"33","author":"JJ Fuster","year":"2014","unstructured":"Fuster, J. J. & Walsh, K. The good, the bad, and the ugly of interleukin-6 signaling. Embo J. 33, 1425\u20131427. https:\/\/doi.org\/10.15252\/embj.201488856 (2014).","journal-title":"Embo J."},{"key":"91998_CR47","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","volume":"1813","author":"J Scheller","year":"2011","unstructured":"Scheller, J. et al. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim. Biophys. Acta 1813, 878\u2013888. https:\/\/doi.org\/10.1016\/j.bbamcr.2011.01.034 (2011).","journal-title":"Biochim. Biophys. Acta"},{"key":"91998_CR48","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1186\/s13073-014-0102-6","volume":"6","author":"LT Hoang","year":"2014","unstructured":"Hoang, L. T. et al. Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease. Genome Med. 6, 541. https:\/\/doi.org\/10.1186\/s13073-014-0102-6 (2014).","journal-title":"Genome Med."},{"key":"91998_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110028","volume":"117","author":"Y Ding","year":"2023","unstructured":"Ding, Y. et al. The protective roles of liraglutide on Kawasaki disease via AMPK\/mTOR\/NF-\u03baB pathway. Int. Immunopharmacol. 117, 110028. https:\/\/doi.org\/10.1016\/j.intimp.2023.110028 (2023).","journal-title":"Int. Immunopharmacol."},{"key":"91998_CR50","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/pr.2016.266","volume":"81","author":"E Suganuma","year":"2017","unstructured":"Suganuma, E. et al. Losartan attenuates the coronary perivasculitis through its local and systemic anti-inflammatory properties in a murine model of Kawasaki disease. Pediatr. Res. 81, 593\u2013600. https:\/\/doi.org\/10.1038\/pr.2016.266 (2017).","journal-title":"Pediatr. Res."},{"key":"91998_CR51","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s10557-021-07277-w","volume":"37","author":"J Zhang","year":"2023","unstructured":"Zhang, J. et al. Protective roles of Xijiao Dihuang tang on coronary artery injury in Kawasaki disease. Cardiovasc. Drugs Ther. 37, 257\u2013270. https:\/\/doi.org\/10.1007\/s10557-021-07277-w (2023).","journal-title":"Cardiovasc. Drugs Ther."},{"key":"91998_CR52","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","volume":"7","author":"Q Zhang","year":"2022","unstructured":"Zhang, Q. et al. Signaling pathways and targeted therapy for myocardial infarction. Signal Transduct. Target Ther. 7, 78. https:\/\/doi.org\/10.1038\/s41392-022-00925-z (2022).","journal-title":"Signal Transduct. Target Ther."},{"key":"91998_CR53","doi-asserted-by":"publisher","first-page":"73","DOI":"10.15212\/CVIA.2022.0020","volume":"7","author":"J Zhou","year":"2022","unstructured":"Zhou, J. et al. Inappropriate activation of TLR4\/NF-\u03baB is a cause of heart failure. CVIA 7, 73\u201389. https:\/\/doi.org\/10.15212\/CVIA.2022.0020 (2022).","journal-title":"CVIA"},{"key":"91998_CR54","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.cell.2020.02.041","volume":"180","author":"KA Fitzgerald","year":"2020","unstructured":"Fitzgerald, K. A. & Kagan, J. C. Toll-like receptors and the control of immunity. Cell 180, 1044\u20131066. https:\/\/doi.org\/10.1016\/j.cell.2020.02.041 (2020).","journal-title":"Cell"},{"key":"91998_CR55","first-page":"49","volume":"46","author":"GB Wang","year":"2008","unstructured":"Wang, G. B. et al. Changes and significance for regulatory factors for signal pathways of Toll-like receptors in immunological pathogenesis of Kawasaki disease. Zhonghua Er Ke Za Zhi 46, 49\u201354 (2008).","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"91998_CR56","first-page":"333","volume":"44","author":"GB Wang","year":"2006","unstructured":"Wang, G. B. et al. The role of activation of toll-like receptors in immunological pathogenesis of Kawasaki disease. Zhonghua Er Ke Za Zhi 44, 333\u2013336 (2006).","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"91998_CR57","first-page":"258","volume":"66","author":"S Furukawa","year":"2008","unstructured":"Furukawa, S., Matsubara, T. & Ichiyama, T. Regulation of proinflammatory cytokine cascade in Kawasaki disease. Nihon Rinsho 66, 258\u2013264 (2008).","journal-title":"Nihon Rinsho"},{"key":"91998_CR58","first-page":"3714","volume":"21","author":"XL Qi","year":"2017","unstructured":"Qi, X. L. et al. 1,25-Dihydroxyvitamin D3 regulates T lymphocyte proliferation through activation of P53 and inhibition of ERK1\/2 signaling pathway in children with Kawasaki disease. Eur. Rev. Med. Pharmacol. Sci. 21, 3714\u20133722 (2017).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"91998_CR59","doi-asserted-by":"publisher","first-page":"6717212","DOI":"10.1155\/2018\/6717212","volume":"2018","author":"Y Chen","year":"2018","unstructured":"Chen, Y. et al. Hydrogen sulfide attenuates LPS-induced acute kidney injury by inhibiting inflammation and oxidative stress. Oxid. Med. Cell Longev. 2018, 6717212. https:\/\/doi.org\/10.1155\/2018\/6717212 (2018).","journal-title":"Oxid. Med. Cell Longev."},{"key":"91998_CR60","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.653601","volume":"12","author":"YH Chen","year":"2021","unstructured":"Chen, Y. H. et al. Hydrogen sulfide attenuated sepsis-induced myocardial dysfunction through TLR4 pathway and endoplasmic reticulum stress. Front. Physiol. 12, 653601. https:\/\/doi.org\/10.3389\/fphys.2021.653601 (2021).","journal-title":"Front. Physiol."},{"key":"91998_CR61","doi-asserted-by":"publisher","first-page":"9647809","DOI":"10.1155\/2018\/9647809","volume":"2018","author":"GY Zhang","year":"2018","unstructured":"Zhang, G. Y. et al. Hydrogen sulfide alleviates lipopolysaccharide-induced diaphragm dysfunction in rats by reducing apoptosis and inflammation through ROS\/MAPK and TLR4\/NF-\u03baB signaling pathways. Oxid. Med. Cell Longev. 2018, 9647809. https:\/\/doi.org\/10.1155\/2018\/9647809 (2018).","journal-title":"Oxid. Med. Cell Longev."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91998-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91998-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91998-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:00:01Z","timestamp":1741348801000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-91998-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["91998"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-91998-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]},"assertion":[{"value":"23 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7410"}}