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LASIK was performed to correct myopia and hypermetropia with and without astigmatism in 2435 eyes of 2435 patients. Participants fulfilled the seven-item anxiety sub-score of the Hospital Anxiety and Depression scale questionnaire for scaling patients\u2019 anxiety levels before LASIK into normal, borderline, and anxiety case groups. The eye-tracking pupil center position plots, patient\u2019s heart rate, and surgeon-reported level of patient\u2019s cooperation during the procedure were analyzed. An anxiety-related fixation instability score (FIS) was calculated, for which the best cut-off points to differentiate between normal, borderline, and anxiety case groups were defined. The FIS showed a high performance in separating participants into normal, borderline, and anxiety case groups and when used as a scale (0\u201390), values from 0 to 12 are considered normal, from 13 to 36 are considered borderline, and from 37 to 90 are considered anxiety cases. 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All patients signed a written informed consent to participate in the study. Clinical trial registration information is publicly available at ClinicalTrials.gov: NCT06148428.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"All patients signed a written informed consent for publication of their clinical data and\/or clinical images.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"We used the Python programming language (version 3.9.13) to write scripts for our statistical analyses. We performed all our statistical analyses using the Scipy (Scientific Computing tools for Python, version 1.8.1) and scikit-learn (version 1.1.1) libraries for Python.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of generative AI in scientific writing"}}],"article-number":"9389"}}