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The present study aimed to evaluate the trends of incidence, mortality, and morbidity of lips and oral cavity cancers (LOCC) in Iran from 1990 to 2019 according to GBD 2019 data. Indicators including prevalence, incidence, death, years of life lost (YLL), years lived with disability (YLD), disability adjusted life years (DALY), and mortality-to-incidence ratio (MIR) for two genders and three age groups including 15\u201349 years, 50\u201369 years, and 70\u2009+\u2009years in Iran were extracted from GBD 2019\/calculated. The annual percentage changes of different indicators were analyzed. A joinpoint regression analysis was used to examine the pattern of changes. LOCC incidence in Iran has increased during the studied period, in both genders and all age groups. The average annual percent change (AAPC) of incidence increase was much higher in women (1.36) than in men (0.007), while the highest growth was observed in middle-aged women from 2010 to 2015 (6.9). The general trend (AAPC (Confidence interval (CI)) of YLL in total patients (-0.20 (-0.23, -0.17)), and DALY in total patients (-0.17 (-0.21, -0.14)) had a significant decrease. However, YLL in women (0.48 (0.44, 0.50)) and DALY in women (0.51 (0.48, 0.54)) significantly increased. Moreover, MIR has been declining during the studied period except for the time range of 2002 to 2010, in each of the two sexes (-0.46 in men and \u2212\u20090.64 in women) and both together (-0.53). A declining trend of YLL\/DALY\/MIR, and an improvement in screening\/diagnosis\/treatment\/patient care of LOCC in Iran has happened that still needs to be improved. Due to the increase in incidence\/mortality\/morbidity of LOCC in Iranian women, risk factors exposure and disease screening should be followed seriously.<\/jats:p>","DOI":"10.1038\/s41598-025-92090-w","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T04:36:06Z","timestamp":1740976566000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lip and oral cavity cancer in Iran from 1990 to 2019 based on the global burden of disease study"],"prefix":"10.1038","volume":"15","author":[{"given":"Leyla","family":"Roghanizadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saede","family":"Atarbashi-Moghadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Masaebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Akbarzadeh","family":"Baghban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"92090_CR1","unstructured":"WHO. 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