{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:40:04Z","timestamp":1776789604566,"version":"3.51.2"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-92409-7","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T12:58:21Z","timestamp":1741265901000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autophagy-related biomarkers identified in sepsis-induced ARDS through bioinformatics analysis"],"prefix":"10.1038","volume":"15","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dabing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuiqiao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhitao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"issue":"8","key":"92409_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer, M. et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315 (8), 801\u2013810 (2016).","journal-title":"JAMA"},{"issue":"5","key":"92409_CR2","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/SHK.0b013e3182a64682","volume":"40","author":"ME Mikkelsen","year":"2013","unstructured":"Mikkelsen, M. E. et al. The epidemiology of acute respiratory distress syndrome in patients presenting to the emergency department with severe sepsis. Shock 40 (5), 375\u2013381 (2013).","journal-title":"Shock"},{"key":"92409_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40560-020-0426-9","volume":"8","author":"H Iriyama","year":"2020","unstructured":"Iriyama, H. et al. Risk modifiers of acute respiratory distress syndrome in patients with non-pulmonary sepsis: a retrospective analysis of the FORECAST study. J. Intens. Care. 8, 7 (2020).","journal-title":"J. Intens. Care"},{"issue":"2","key":"92409_CR4","doi-asserted-by":"publisher","first-page":"300060519895659","DOI":"10.1177\/0300060519895659","volume":"48","author":"S Li","year":"2020","unstructured":"Li, S. et al. Prevalence, potential risk factors and mortality rates of acute respiratory distress syndrome in Chinese patients with sepsis. J. Int. Med. Res. 48 (2), 300060519895659 (2020).","journal-title":"J. Int. Med. Res."},{"issue":"1","key":"92409_CR5","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3904\/kjim.2017.204","volume":"34","author":"H Nam","year":"2019","unstructured":"Nam, H. et al. Nonpulmonary risk factors of acute respiratory distress syndrome in patients with septic bacteraemia. Korean J. Intern. Med. 34 (1), 116\u2013124 (2019).","journal-title":"Korean J. Intern. Med."},{"issue":"1","key":"92409_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13613-017-0233-1","volume":"7","author":"RR Seethala","year":"2017","unstructured":"Seethala, R. R. et al. Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients. Ann. Intens. Care. 7 (1), 11 (2017).","journal-title":"Ann. Intens. Care"},{"issue":"1","key":"92409_CR7","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1186\/s12890-022-02015-w","volume":"22","author":"Y Shi","year":"2022","unstructured":"Shi, Y., Wang, L., Yu, S., Ma, X. & Li, X. Risk factors for acute respiratory distress syndrome in sepsis patients: a retrospective study from a tertiary hospital in China. BMC Pulm. Med. 22 (1), 238 (2022).","journal-title":"BMC Pulm. Med."},{"issue":"1","key":"92409_CR8","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12890-023-02365-z","volume":"23","author":"C Xu","year":"2023","unstructured":"Xu, C., Zheng, L., Jiang, Y. & Jin, L. A prediction model for predicting the risk of acute respiratory distress syndrome in sepsis patients: a retrospective cohort study. BMC Pulm. Med. 23 (1), 78 (2023).","journal-title":"BMC Pulm. Med."},{"issue":"1","key":"92409_CR9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","volume":"5","author":"MA Matthay","year":"2019","unstructured":"Matthay, M. A. et al. Acute respiratory distress syndrome. Nat. Rev. Dis. Primers 5 (1), 18 (2019).","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"7","key":"92409_CR10","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41581-018-0005-7","volume":"14","author":"C Lelubre","year":"2018","unstructured":"Lelubre, C. & Vincent, J. L. Mechanisms and treatment of organ failure in sepsis. Nat. Rev. Nephrol. 14 (7), 417\u2013427 (2018).","journal-title":"Nat. Rev. Nephrol."},{"key":"92409_CR11","doi-asserted-by":"publisher","first-page":"922702","DOI":"10.3389\/fimmu.2022.922702","volume":"13","author":"C Liu","year":"2022","unstructured":"Liu, C., Xiao, K. & Xie, L. Progress in preclinical studies of macrophage autophagy in the regulation of ALI\/ARDS. Front. Immunol. 13, 922702 (2022).","journal-title":"Front. Immunol."},{"key":"92409_CR12","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.2147\/JIR.S355225","volume":"15","author":"M Sun","year":"2022","unstructured":"Sun, M., Yang, Q., Hu, C., Zhang, H. & Xing, L. Identification and validation of autophagy-related genes in sepsis-induced acute respiratory distress syndrome and immune infiltration. J. Inflamm. Res. 15, 2199\u20132212 (2022).","journal-title":"J. Inflamm. Res."},{"issue":"6","key":"92409_CR13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.21037\/atm-22-979","volume":"10","author":"D Zhu","year":"2022","unstructured":"Zhu, D. et al. The downregulation of miR-129-5p relieves the inflammatory response in acute respiratory distress syndrome by regulating PPARgamma-mediated autophagy. Ann. Transl. Med. 10 (6), 345 (2022).","journal-title":"Ann. Transl. Med."},{"issue":"6","key":"92409_CR14","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00011-024-01879-4","volume":"73","author":"J Dong","year":"2024","unstructured":"Dong, J. et al. Acute lung injury: a view from the perspective of necroptosis. Inflamm. Res. 73 (6), 997\u20131018 (2024).","journal-title":"Inflamm. Res."},{"issue":"8","key":"92409_CR15","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00011-019-01250-y","volume":"68","author":"M Lei","year":"2019","unstructured":"Lei, M. et al. Different intensity of autophagy regulate interleukin-33 to control the uncontrolled inflammation of acute lung injury. Inflamm. Res. 68 (8), 665\u2013675 (2019).","journal-title":"Inflamm. Res."},{"issue":"22","key":"92409_CR16","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1101\/gad.1599207","volume":"21","author":"N Mizushima","year":"2007","unstructured":"Mizushima, N. Autophagy: process and function. Genes Dev. 21 (22), 2861\u20132873 (2007).","journal-title":"Genes Dev."},{"issue":"7330","key":"92409_CR17","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature09782","volume":"469","author":"B Levine","year":"2011","unstructured":"Levine, B., Mizushima, N. & Virgin, H. W. Autophagy in immunity and inflammation. Nature 469 (7330), 323\u2013335 (2011).","journal-title":"Nature"},{"issue":"2","key":"92409_CR18","doi-asserted-by":"publisher","first-page":"L207","DOI":"10.1152\/ajplung.00562.2016","volume":"313","author":"ZY Li","year":"2017","unstructured":"Li, Z. Y. et al. Autophagy as a double-edged sword in pulmonary epithelial injury: a review and perspective. Am. J. Physiol. Lung Cell. Mol. Physiol. 313 (2), L207\u2013L217 (2017).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"9","key":"92409_CR19","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0962-8924(01)02082-7","volume":"11","author":"K Takei","year":"2001","unstructured":"Takei, K. & Haucke, V. Clathrin-mediated endocytosis: membrane factors pull the trigger. Trends Cell. Biol. 11 (9), 385\u2013391 (2001).","journal-title":"Trends Cell. Biol."},{"issue":"10","key":"92409_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1242\/jcs.228114","volume":"133","author":"AB Birgisdottir","year":"2020","unstructured":"Birgisdottir, A. B. & Johansen, T. Autophagy and endocytosis\u2014Interconnections and interdependencies. J. Cell. Sci. 133 (10), 1 (2020).","journal-title":"J. Cell. Sci."},{"issue":"1","key":"92409_CR21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41573-020-0082-8","volume":"20","author":"AA Zarrin","year":"2021","unstructured":"Zarrin, A. A., Bao, K., Lupardus, P. & Vucic, D. Kinase Inhibition in autoimmunity and inflammation. Nat. Rev. Drug Discov. 20 (1), 39\u201363 (2021).","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"92409_CR22","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1097\/CCM.0000000000001132","volume":"43","author":"JD Christie","year":"2015","unstructured":"Christie, J. D. et al. A randomized dose-escalation study of the safety and anti-inflammatory activity of the p38 mitogen-activated protein kinase inhibitor dilmapimod in severe trauma subjects at risk for acute respiratory distress syndrome. Crit. Care Med. 43 (9), 1859\u20131869 (2015).","journal-title":"Crit. Care Med."},{"issue":"47","key":"92409_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/sciimmunol.abc5367","volume":"5","author":"FR Spinelli","year":"2020","unstructured":"Spinelli, F. R., Conti, F. & Gadina, M. HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19. Sci. Immunol. 5 (47), 1 (2020).","journal-title":"Sci. Immunol."},{"issue":"4","key":"92409_CR24","doi-asserted-by":"publisher","first-page":"R103","DOI":"10.1186\/cc6983","volume":"12","author":"LF Li","year":"2008","unstructured":"Li, L. F., Liao, S. K., Huang, C. C., Hung, M. J. & Quinn, D. A. Serine\/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment. Crit. Care. 12 (4), R103 (2008).","journal-title":"Crit. Care"},{"key":"92409_CR25","doi-asserted-by":"publisher","first-page":"104736","DOI":"10.1016\/j.phrs.2020.104736","volume":"155","author":"F Abedi","year":"2020","unstructured":"Abedi, F., Hayes, A. W., Reiter, R. & Karimi, G. Acute lung injury: the therapeutic role of Rho kinase inhibitors. Pharmacol. Res. 155, 104736 (2020).","journal-title":"Pharmacol. Res."},{"issue":"14","key":"92409_CR26","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.1111\/febs.15803","volume":"289","author":"A Othman","year":"2022","unstructured":"Othman, A., Sekheri, M. & Filep, J. G. Roles of neutrophil granule proteins in orchestrating inflammation and immunity. FEBS J. 289 (14), 3932\u20133953 (2022).","journal-title":"FEBS J."},{"issue":"1","key":"92409_CR27","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12964-024-01571-4","volume":"22","author":"LW Zhu","year":"2024","unstructured":"Zhu, L. W. et al. Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1. Cell. Commun. Signal. 22 (1), 271 (2024).","journal-title":"Cell. Commun. Signal."},{"key":"92409_CR28","doi-asserted-by":"publisher","first-page":"1107063","DOI":"10.3389\/fimmu.2023.1107063","volume":"14","author":"G Gajek","year":"2023","unstructured":"Gajek, G. et al. Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns. Front. Immunol. 14, 1107063 (2023).","journal-title":"Front. Immunol."},{"key":"92409_CR29","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1146\/annurev-physiol-020518-114320","volume":"81","author":"M Sauler","year":"2019","unstructured":"Sauler, M., Bazan, I. S. & Lee, P. J. Cell death in the lung: the apoptosis-necroptosis axis. Annu. Rev. Physiol. 81, 375\u2013402 (2019).","journal-title":"Annu. Rev. Physiol."},{"key":"92409_CR30","doi-asserted-by":"publisher","first-page":"1100461","DOI":"10.3389\/fimmu.2023.1100461","volume":"14","author":"Z Yang","year":"2023","unstructured":"Yang, Z., Nicholson, S. E., Cancio, T. S., Cancio, L. C. & Li, Y. Complement as a vital nexus of the Pathobiological connectome for acute respiratory distress syndrome: an emerging therapeutic target. Front. Immunol. 14, 1100461 (2023).","journal-title":"Front. Immunol."},{"key":"92409_CR31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41392-017-0002-5","volume":"3","author":"C Ye","year":"2018","unstructured":"Ye, C., Brand, D. & Zheng, S. G. Targeting IL-2: an unexpected effect in treating immunological diseases. Signal. Transduct. Target. Ther. 3, 2 (2018).","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"4","key":"92409_CR32","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1164\/rccm.201703-0614LE","volume":"197","author":"ED Morrell","year":"2018","unstructured":"Morrell, E. D. et al. Peripheral and alveolar cell transcriptional programs are distinct in acute respiratory distress syndrome. Am. J. Respir Crit. Care Med. 197 (4), 528\u2013532 (2018).","journal-title":"Am. J. Respir Crit. Care Med."},{"issue":"1","key":"92409_CR33","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12873-022-00733-2","volume":"22","author":"L Yan","year":"2022","unstructured":"Yan, L., Chen, Y., Han, Y. & Tong, C. Role of CD8(+) T cell exhaustion in the progression and prognosis of acute respiratory distress syndrome induced by sepsis: a prospective observational study. BMC Emerg. Med. 22 (1), 182 (2022).","journal-title":"BMC Emerg. Med."},{"issue":"10","key":"92409_CR34","doi-asserted-by":"publisher","first-page":"5556","DOI":"10.4049\/jimmunol.1002828","volume":"186","author":"N Chevalier","year":"2011","unstructured":"Chevalier, N. et al. CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J. Immunol. 186 (10), 5556\u20135568 (2011).","journal-title":"J. Immunol."},{"key":"92409_CR35","doi-asserted-by":"publisher","first-page":"1125737","DOI":"10.3389\/fimmu.2023.1125737","volume":"14","author":"MN Zhang","year":"2023","unstructured":"Zhang, M. N., Yuan, Y. L. & Ao, S. H. Advances in the study of myeloid-derived suppressor cells in infectious lung diseases. Front. Immunol. 14, 1125737 (2023).","journal-title":"Front. Immunol."},{"key":"92409_CR36","doi-asserted-by":"publisher","first-page":"1433028","DOI":"10.3389\/fimmu.2024.1433028","volume":"15","author":"KJ Park","year":"2024","unstructured":"Park, K. J. et al. Deficiency and dysfunctional roles of natural killer T cells in patients with ARDS. Front. Immunol. 15, 1433028 (2024).","journal-title":"Front. Immunol."},{"key":"92409_CR37","doi-asserted-by":"publisher","first-page":"1368446","DOI":"10.3389\/fimmu.2024.1368446","volume":"15","author":"Y Mitsuyama","year":"2024","unstructured":"Mitsuyama, Y. et al. T cell dysfunction in elderly ARDS patients based on MiRNA and mRNA integration analysis. Front. Immunol. 15, 1368446 (2024).","journal-title":"Front. Immunol."},{"key":"92409_CR38","doi-asserted-by":"publisher","first-page":"508","DOI":"10.3389\/fimmu.2018.00508","volume":"9","author":"BM Rotoli","year":"2018","unstructured":"Rotoli, B. M. et al. Downregulation of SLC7A7 triggers an inflammatory phenotype in human macrophages and airway epithelial cells. Front. Immunol. 9, 508 (2018).","journal-title":"Front. Immunol."},{"issue":"11","key":"92409_CR39","doi-asserted-by":"publisher","first-page":"5802","DOI":"10.4049\/jimmunol.171.11.5802","volume":"171","author":"H Lee","year":"2003","unstructured":"Lee, H. et al. Role of antiproliferative B cell translocation gene-1 as an apoptotic sensitizer in activation-induced cell death of brain microglia. J. Immunol. 171 (11), 5802\u20135811 (2003).","journal-title":"J. Immunol."},{"key":"92409_CR40","doi-asserted-by":"publisher","first-page":"651552","DOI":"10.3389\/fmed.2021.651552","volume":"8","author":"M Qu","year":"2021","unstructured":"Qu, M. et al. The role of ferroptosis in acute respiratory distress syndrome. Front. Med. 8, 651552 (2021).","journal-title":"Front. Med."},{"issue":"8","key":"92409_CR41","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/nrm1985","volume":"7","author":"JS Bonifacino","year":"2006","unstructured":"Bonifacino, J. S. & Rojas, R. Retrograde transport from endosomes to the trans-Golgi network. Nat. Rev. Mol. Cell. Biol. 7 (8), 568\u2013579 (2006).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"23","key":"92409_CR42","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1016\/j.febslet.2009.10.075","volume":"583","author":"SR Pfeffer","year":"2009","unstructured":"Pfeffer, S. R. Multiple routes of protein transport from endosomes to the trans golgi network. FEBS Lett. 583 (23), 3811\u20133816 (2009).","journal-title":"FEBS Lett."},{"issue":"7820","key":"92409_CR43","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41586-020-2545-9","volume":"584","author":"SM Banik","year":"2020","unstructured":"Banik, S. M. et al. Lysosome-targeting chimaeras for degradation of extracellular proteins. Nature 584 (7820), 291\u2013297 (2020).","journal-title":"Nature"},{"issue":"24","key":"92409_CR44","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1007\/s00018-011-0768-5","volume":"68","author":"Y Rao","year":"2011","unstructured":"Rao, Y. & Haucke, V. Membrane shaping by the Bin\/amphiphysin\/Rvs (BAR) domain protein superfamily. Cell. Mol. Life Sci. 68 (24), 3983\u20133993 (2011).","journal-title":"Cell. Mol. Life Sci."},{"issue":"4","key":"92409_CR45","doi-asserted-by":"publisher","first-page":"L801","DOI":"10.1152\/ajplung.00335.2003","volume":"286","author":"X Lian","year":"2004","unstructured":"Lian, X., Yan, C., Yang, L., Xu, Y. & Du, H. Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 286 (4), L801\u2013807 (2004).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"3","key":"92409_CR46","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1097\/01.ccm.0000435669.60811.24","volume":"42","author":"ML Terpstra","year":"2014","unstructured":"Terpstra, M. L., Aman, J., van Nieuw Amerongen, G. P. & Groeneveld, A. B. Plasma biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis. Crit. Care Med. 42 (3), 691\u2013700 (2014).","journal-title":"Crit. Care Med."},{"issue":"1","key":"92409_CR47","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s13054-020-02913-7","volume":"24","author":"P van der Zee","year":"2020","unstructured":"van der Zee, P., Rietdijk, W., Somhorst, P., Endeman, H. & Gommers, D. A systematic review of biomarkers multivariately associated with acute respiratory distress syndrome development and mortality. Crit. Care. 24 (1), 243 (2020).","journal-title":"Crit. Care"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92409-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92409-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92409-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T12:58:23Z","timestamp":1741265903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92409-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["92409"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-92409-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"8 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine waived the requirement for ethics approval and consent to participate in this study because it does not involve human subjects, live animals, or sensitive data processing that would typically require ethical oversight.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"7864"}}