{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:29:20Z","timestamp":1790710160415,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-92501-y","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T13:24:26Z","timestamp":1742217866000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["ZIP13 marks muscle satellite cells and contributes to their quiescent and active phase balance"],"prefix":"10.1038","volume":"15","author":[{"given":"Emi","family":"Yoshigai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenao","family":"Tsuzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuto","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Fukada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"92501_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s12576-017-0521-4","volume":"67","author":"T Hara","year":"2017","unstructured":"Hara, T. et al. Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis. J. Physiol. Sci. 67, 283\u2013301 (2017).","journal-title":"J. Physiol. Sci. JPS"},{"key":"92501_CR2","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1093\/nutrit\/nuad094","volume":"82","author":"HM Abeywickrama","year":"2024","unstructured":"Abeywickrama, H. M., Uchiyama, M., Sumiyoshi, T., Okuda, A. & Koyama, Y. The role of zinc on nutritional status, sarcopenia, and frailty in older adults: a scoping review. Nutr. Rev. 82, 988\u20131011 (2024).","journal-title":"Nutr. Rev."},{"key":"92501_CR3","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/0002-9343(61)90137-1","volume":"31","author":"AS Prasad","year":"1961","unstructured":"Prasad, A. S., Halsted, J. A. & Nadimi, M. Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia. Am. J. Med. 31, 532\u2013546 (1961).","journal-title":"Am. J. Med."},{"key":"92501_CR4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3945\/an.112.003210","volume":"4","author":"AS Prasad","year":"2013","unstructured":"Prasad, A. S. Discovery of human zinc deficiency: its impact on human health and disease. Adv. Nutr. 4, 176\u2013190 (2013).","journal-title":"Adv. Nutr. Bethesda Md."},{"key":"92501_CR5","doi-asserted-by":"publisher","first-page":"127276","DOI":"10.1016\/j.jtemb.2023.127276","volume":"80","author":"T Fukada","year":"2023","unstructured":"Fukada, T. Late Prof Dr. Ananda Prasad \u2018the legend and the father of zinc biology\u2019. J. Trace Elem. Med. Biol. 80, 127276 (2023).","journal-title":"J. Trace Elem. Med. Biol."},{"key":"92501_CR6","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jphs.2021.11.007","volume":"148","author":"T Hara","year":"2022","unstructured":"Hara, T., Yoshigai, E., Ohashi, T. & Fukada, T. Zinc transporters as potential therapeutic targets: an updated review. J. Pharmacol. Sci. 148, 221\u2013228 (2022).","journal-title":"J. Pharmacol. Sci."},{"key":"92501_CR7","doi-asserted-by":"publisher","first-page":"e3642","DOI":"10.1371\/journal.pone.0003642","volume":"3","author":"T Fukada","year":"2008","unstructured":"Fukada, T. et al. The zinc transporter SLC39A13\/ZIP13 is required for connective tissue development; its involvement in BMP\/TGF-beta signaling pathways. PLoS One 3, e3642 (2008).","journal-title":"PLoS One"},{"key":"92501_CR8","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1016\/j.ajhg.2008.05.001","volume":"82","author":"C Giunta","year":"2008","unstructured":"Giunta, C. et al. Spondylocheiro dysplastic form of the Ehlers-Danlos syndrome\u2013an autosomal-recessive entity caused by mutations in the zinc transporter gene SLC39A13. Am. J. Hum. Genet. 82, 1290\u20131305 (2008).","journal-title":"Am. J. Hum. Genet."},{"key":"92501_CR9","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.15252\/emmm.201303809","volume":"6","author":"BH Bin","year":"2014","unstructured":"Bin, B. H. et al. Molecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins. EMBO Mol. Med. 6, 1028\u20131042 (2014).","journal-title":"EMBO Mol. Med."},{"key":"92501_CR10","doi-asserted-by":"publisher","first-page":"40255","DOI":"10.1074\/jbc.M111.256784","volume":"286","author":"BH Bin","year":"2011","unstructured":"Bin, B. H. et al. Biochemical characterization of human ZIP13 protein: a homo-dimerized zinc transporter involved in the Spondylocheiro dysplastic Ehlers-Danlos syndrome. J. Biol. Chem. 286, 40255\u201340265 (2011).","journal-title":"J. Biol. Chem."},{"key":"92501_CR11","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3390\/genes11040420","volume":"11","author":"C Kumps","year":"2020","unstructured":"Kumps, C. et al. The connective tissue disorder associated with recessive variants in the SLC39A13 zinc transporter gene (Spondylo-Dysplastic Ehlers\u2013Danlos syndrome type 3): insights from four novel patients and Follow-Up on two original cases. Genes 11, 420 (2020).","journal-title":"Genes"},{"key":"92501_CR12","doi-asserted-by":"crossref","unstructured":"Agrawal, P., Kaur, H., Kondekar, A. & Rathi, S. A case of Ehlers-Danlos syndrome presenting as short stature: a novel mutation in SLC39A13 causing spondylodysplastic Ehlers-Danlos syndrome. Oxf. Med. Case Rep. 2023, omac107 (2023).","DOI":"10.1093\/omcr\/omac107"},{"key":"92501_CR13","doi-asserted-by":"publisher","first-page":"8052","DOI":"10.1038\/s41598-024-56912-7","volume":"14","author":"M Shoji","year":"2024","unstructured":"Shoji, M. et al. Possible involvement of zinc transporter ZIP13 in myogenic differentiation. Sci. Rep. 14, 8052 (2024).","journal-title":"Sci. Rep."},{"key":"92501_CR14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1152\/physrev.00019.2003","volume":"84","author":"SBP Charg\u00e9","year":"2004","unstructured":"Charg\u00e9, S. B. P. & Rudnicki, M. A. Cellular and molecular regulation of muscle regeneration. Physiol. Rev. 84, 209\u2013238 (2004).","journal-title":"Physiol. Rev."},{"key":"92501_CR15","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature11438","volume":"490","author":"JV Chakkalakal","year":"2012","unstructured":"Chakkalakal, J. V., Jones, K. M., Basson, M. A. & Brack, A. S. The aged niche disrupts muscle stem cell quiescence. Nature 490, 355\u2013360 (2012).","journal-title":"Nature"},{"key":"92501_CR16","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1242\/dev.067595","volume":"138","author":"C Lepper","year":"2011","unstructured":"Lepper, C., Partridge, T. A. & Fan, C. M. An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration. Development 138, 3639\u20133646 (2011).","journal-title":"Development"},{"key":"92501_CR17","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1101\/gad.345505","volume":"19","author":"L Kassar-Duchossoy","year":"2005","unstructured":"Kassar-Duchossoy, L. et al. Pax3\/Pax7 mark a novel population of primitive myogenic cells during development. Genes Dev. 19, 1426\u20131431 (2005).","journal-title":"Genes Dev."},{"key":"92501_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13395-014-0024-4","volume":"4","author":"AS Brack","year":"2014","unstructured":"Brack, A. S. Pax7 is back. Skelet. Muscle. 4, 24 (2014).","journal-title":"Skelet. Muscle"},{"key":"92501_CR19","doi-asserted-by":"crossref","unstructured":"von Maltzahn, J., Jones, A. E., Parks, R. J. & Rudnicki, M. A. Pax7 is critical for the normal function of satellite cells in adult skeletal muscle. Proc. Natl. Acad. Sci. U. S. A. 110, 16474\u201316479 (2013).","DOI":"10.1073\/pnas.1307680110"},{"key":"92501_CR20","doi-asserted-by":"crossref","unstructured":"Seale, P. et al. Pax7 is required for the specification of myogenic satellite cells. Cell 102, 777\u2013786 (2000).","DOI":"10.1016\/S0092-8674(00)00066-0"},{"key":"92501_CR21","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1242\/dev.067587","volume":"138","author":"R Sambasivan","year":"2011","unstructured":"Sambasivan, R. et al. Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration. Development 138, 3647\u20133656 (2011).","journal-title":"Development"},{"issue":"Pt 17","key":"92501_CR22","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1242\/jcs.112.17.2895","volume":"112","author":"RN Cooper","year":"1999","unstructured":"Cooper, R. N. et al. In vivo satellite cell activation via Myf5 and myod in regenerating mouse skeletal muscle. J. Cell. Sci. 112 (Pt 17), 2895\u20132901 (1999).","journal-title":"J. Cell. Sci."},{"key":"92501_CR23","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/364501a0","volume":"364","author":"P Hasty","year":"1993","unstructured":"Hasty, P. et al. Muscle deficiency and neonatal death in mice with a targeted mutation in the Myogenin gene. Nature 364, 501\u2013506 (1993).","journal-title":"Nature"},{"key":"92501_CR24","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/364532a0","volume":"364","author":"Y Nabeshima","year":"1993","unstructured":"Nabeshima, Y. et al. Myogenin gene disruption results in perinatal lethality because of severe muscle defect. Nature 364, 532\u2013535 (1993).","journal-title":"Nature"},{"key":"92501_CR25","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1006\/dbio.1997.8721","volume":"191","author":"DD Cornelison","year":"1997","unstructured":"Cornelison, D. D. & Wold, B. J. Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells. Dev. Biol. 191, 270\u2013283 (1997).","journal-title":"Dev. Biol."},{"key":"92501_CR26","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.stem.2013.07.016","volume":"13","author":"S G\u00fcnther","year":"2013","unstructured":"G\u00fcnther, S. et al. Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells. Cell. Stem Cell. 13, 590\u2013601 (2013).","journal-title":"Cell. Stem Cell."},{"key":"92501_CR27","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1242\/dev.111.4.1097","volume":"111","author":"MO Ott","year":"1991","unstructured":"Ott, M. O., Bober, E., Lyons, G., Arnold, H. & Buckingham, M. Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo. Development 111, 1097\u20131107 (1991).","journal-title":"Development"},{"key":"92501_CR28","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41580-021-00421-2","volume":"23","author":"P Sousa-Victor","year":"2022","unstructured":"Sousa-Victor, P., Garc\u00eda-Prat, L. & Mu\u00f1oz-C\u00e1noves, P. Control of satellite cell function in muscle regeneration and its disruption in ageing. Nat. Rev. Mol. Cell. Biol. 23, 204\u2013226 (2022).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"92501_CR29","doi-asserted-by":"publisher","first-page":"a008342","DOI":"10.1101\/cshperspect.a008342","volume":"4","author":"CF Bentzinger","year":"2012","unstructured":"Bentzinger, C. F., Wang, Y. X. & Rudnicki, M. A. Building muscle: molecular regulation of myogenesis. Cold Spring Harb Perspect. Biol. 4, a008342 (2012).","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"92501_CR30","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/nrm3265","volume":"13","author":"YX Wang","year":"2012","unstructured":"Wang, Y. X. & Rudnicki, M. A. Satellite cells, the engines of muscle repair. Nat. Rev. Mol. Cell. Biol. 13, 127\u2013133 (2012).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"92501_CR31","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1101\/sqb.2008.73.064","volume":"73","author":"MA Rudnicki","year":"2008","unstructured":"Rudnicki, M. A., Le Grand, F., McKinnell, I. & Kuang, S. The molecular regulation of muscle stem cell function. Cold Spring Harb. Symp. Quant. Biol. 73, 323\u2013331 (2008).","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"92501_CR32","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.stem.2007.12.012","volume":"2","author":"S Kuang","year":"2008","unstructured":"Kuang, S., Gillespie, M. A. & Rudnicki, M. A. Niche regulation of muscle satellite cell self-renewal and differentiation. Cell. Stem Cell. 2, 22\u201331 (2008).","journal-title":"Cell. Stem Cell."},{"key":"92501_CR33","first-page":"534","volume":"91","author":"TJ Hawke","year":"2001","unstructured":"Hawke, T. J. & Garry, D. J. Myogenic satellite cells: physiology to molecular biology. J. Appl. Physiol. 1985 91, 534\u2013551 (2001).","journal-title":"J. Appl. Physiol. 1985"},{"key":"92501_CR34","doi-asserted-by":"publisher","first-page":"e102455","DOI":"10.1371\/journal.pone.0102455","volume":"9","author":"S Li","year":"2014","unstructured":"Li, S. et al. Dual fluorescent reporter pig for Cre recombination: transgene placement at the ROSA26 locus. PLoS One 9, e102455 (2014).","journal-title":"PLoS One"},{"key":"92501_CR35","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4235\/agmr.19.0012","volume":"23","author":"HW Jung","year":"2019","unstructured":"Jung, H. W., Choi, J. H., Jo, T., Shin, H. & Suh, J. M. Systemic and local phenotypes of barium chloride induced skeletal muscle injury in mice. Ann. Geriatr. Med. Res. 23, 83\u201389 (2019).","journal-title":"Ann. Geriatr. Med. Res."},{"key":"92501_CR36","doi-asserted-by":"publisher","first-page":"669","DOI":"10.5692\/clinicalneurol.51.669","volume":"51","author":"I Nishino","year":"2011","unstructured":"Nishino, I. ABC in muscle pathology. Rinsho Shinkeigaku. 51, 669\u2013676 (2011).","journal-title":"Rinsho Shinkeigaku"},{"key":"92501_CR37","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s12020-012-9751-7","volume":"43","author":"JP Gumucio","year":"2013","unstructured":"Gumucio, J. P. & Mendias, C. L. Atrogin-1, MuRF-1, and sarcopenia. Endocrine 43, 12\u201321 (2013).","journal-title":"Endocrine"},{"key":"92501_CR38","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1007\/s10620-019-05561-2","volume":"64","author":"W Ohashi","year":"2019","unstructured":"Ohashi, W., Hara, T., Takagishi, T., Hase, K. & Fukada, T. Maintenance of intestinal epithelial homeostasis by zinc transporters. Dig. Dis. Sci. 64, 2404\u20132415 (2019).","journal-title":"Dig. Dis. Sci."},{"key":"92501_CR39","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1007\/s00018-019-03093-6","volume":"76","author":"M Schmidt","year":"2019","unstructured":"Schmidt, M., Sch\u00fcler, S. C., H\u00fcttner, S. S., von Eyss, B. & von Maltzahn, J. Adult stem cells at work: regenerating skeletal muscle. Cell. Mol. Life Sci. 76, 2559\u20132570 (2019).","journal-title":"Cell. Mol. Life Sci."},{"key":"92501_CR40","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3389\/fphys.2013.00317","volume":"4","author":"SI Fukada","year":"2013","unstructured":"Fukada, S. I. et al. Isolation, characterization, and molecular regulation of muscle stem cells. Front. Physiol. 4, 317 (2013).","journal-title":"Front. Physiol."},{"key":"92501_CR41","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1242\/dev.114223","volume":"142","author":"NA Dumont","year":"2015","unstructured":"Dumont, N. A., Wang, Y. X. & Rudnicki, M. A. Intrinsic and extrinsic mechanisms regulating satellite cell function. Development 142, 1572\u20131581 (2015).","journal-title":"Development"},{"key":"92501_CR42","doi-asserted-by":"publisher","first-page":"e0276452","DOI":"10.1371\/journal.pone.0276452","volume":"17","author":"T Hara","year":"2022","unstructured":"Hara, T. et al. Role of Scl39a13\/ZIP13 in cardiovascular homeostasis. PLoS One 17, e0276452 (2022).","journal-title":"PLoS One"},{"key":"92501_CR43","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1002\/stem.759","volume":"29","author":"LAS Alfaro","year":"2011","unstructured":"Alfaro, L. A. S. et al. CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration. Stem Cells 29, 2030\u20132041 (2011).","journal-title":"Stem Cells"},{"key":"92501_CR44","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.cell.2011.11.049","volume":"148","author":"P Rocheteau","year":"2012","unstructured":"Rocheteau, P., Gayraud-Morel, B., Siegl-Cachedenier, I., Blasco, M. A. & Tajbakhsh, S. A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell division. Cell 148, 112\u2013125 (2012).","journal-title":"Cell"},{"key":"92501_CR45","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nature13255","volume":"510","author":"JT Rodgers","year":"2014","unstructured":"Rodgers, J. T. et al. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert. Nature 510, 393\u2013396 (2014).","journal-title":"Nature"},{"key":"92501_CR46","doi-asserted-by":"publisher","first-page":"111625","DOI":"10.1016\/j.nut.2022.111625","volume":"98","author":"SS Reddy","year":"2022","unstructured":"Reddy, S. S., Addi, U. R., Pullakhandam, R. & Reddy, G. B. Dietary zinc deficiency disrupts skeletal muscle proteostasis and mitochondrial biology in rats. Nutrition 98, 111625 (2022).","journal-title":"Nutrition"},{"key":"92501_CR47","doi-asserted-by":"publisher","first-page":"107653","DOI":"10.1016\/j.celrep.2020.107653","volume":"31","author":"T Abe","year":"2020","unstructured":"Abe, T., Inoue, K. I., Furuta, Y. & Kiyonari, H. Pronuclear microinjection during S-Phase increases the efficiency of CRISPR-Cas9-Assisted knockin of large DNA donors in mouse zygotes. Cell. Rep. 31, 107653 (2020).","journal-title":"Cell. Rep."},{"key":"92501_CR48","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1093\/bioinformatics\/btu743","volume":"31","author":"Y Naito","year":"2015","unstructured":"Naito, Y., Hino, K., Bono, H. & Ui-Tei, K. CRISPRdirect: software for designing CRISPR\/Cas guide RNA with reduced off-target sites. Bioinformatics 31, 1120\u20131123 (2015).","journal-title":"Bioinforma"},{"key":"92501_CR49","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1126\/science.1184733","volume":"327","author":"HJ Snippert","year":"2010","unstructured":"Snippert, H. J. et al. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 327, 1385\u20131389 (2010).","journal-title":"Science"},{"key":"92501_CR50","doi-asserted-by":"publisher","first-page":"e1558","DOI":"10.21769\/BioProtoc.1558","volume":"5","author":"A Gromova","year":"2015","unstructured":"Gromova, A., Tierney, M. T. & Sacco, A. FACS-based satellite cell isolation from mouse Hind limb muscles. Bio-Protoc 5, e1558 (2015).","journal-title":"Bio-Protoc"},{"key":"92501_CR51","doi-asserted-by":"crossref","unstructured":"Pasut, A., Jones, A. E. & Rudnicki, M. A. Isolation and culture of individual myofibers and their satellite cells from adult skeletal muscle. J. Vis. Exp. (73), e50074 (2013).","DOI":"10.3791\/50074-v"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92501-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92501-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92501-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T13:26:23Z","timestamp":1742217983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92501-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["92501"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-92501-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5035100\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,17]]},"assertion":[{"value":"5 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9206"}}