{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:53:12Z","timestamp":1792507992884,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-062172"],"award-info":[{"award-number":["INV-062172"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>\n            <jats:italic>Klebsiella pneumoniae<\/jats:italic> (KPn) colonizes multiple anatomical sites and is a leading cause of invasive disease and death in African children; however, there is no comparative genomic analysis between colonizing and invasive strains. This study investigated the genomic relatedness of KPn colonizing and invasive isolates in South African infants; and evaluated the relative invasiveness of KPn isolates based on sequence types (ST), capsular (KL), and lipopolysaccharide (O) loci by calculating case-carrier ratios (CCRs). There was less genomic diversity amongst invasive (22 ST,\u00a017\u00a0K-loci) than colonizing isolates (31 ST,\u00a029\u00a0K-loci), with invasive isolates being 8.59-fold and 3.49-fold more likely to harbour genes encoding for multi-drug resistance and yersiniabactin production compared with colonizing isolates. The CCRs for KL102 and O1\/O2v2 were &gt;\u20091, and &lt;\u20091 for KL8, ST1414, and O1O2v1. Identifying high-risk strains, including KL102 and O1O2v2, that may have a higher potential to cause invasive disease, could enhance risk assessment and management strategies in vulnerable populations.<\/jats:p>","DOI":"10.1038\/s41598-025-92517-4","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T16:07:20Z","timestamp":1741363640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genomic relatedness of colonizing and invasive disease Klebsiella pneumoniae isolates in South African infants"],"prefix":"10.1038","volume":"15","author":[{"given":"Courtney P.","family":"Olwagen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alane","family":"Izu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shama","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Van der Merwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fikile C.","family":"Mabena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Kwatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubomira","family":"Andrew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urvi","family":"Rajyaguru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G. 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W. et al. Initial findings from a novel population-based child mortality surveillance approach: a descriptive study. Lancet Glob.Health. 8 (7), e909\u2013e919 (2020).","journal-title":"Lancet Glob. Health"},{"issue":"4","key":"92517_CR2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/s41564-021-00870-7","volume":"6","author":"K Sands","year":"2021","unstructured":"Sands, K. et al. Characterization of antimicrobial-resistant Gram-negative bacteria that cause neonatal sepsis in seven low-and middle-income countries. Nat. Microbiol. 6 (4), 512\u2013523 (2021).","journal-title":"Nat. Microbiol."},{"issue":"2","key":"92517_CR3","doi-asserted-by":"publisher","first-page":"e131","DOI":"10.1016\/S2666-5247(23)00290-2","volume":"5","author":"JR Verani","year":"2024","unstructured":"Verani, J. R. et al. Child deaths caused by Klebsiella pneumoniae in sub-Saharan Africa and South Asia: a secondary analysis of child health and mortality prevention surveillance (CHAMPS) data. 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Genome Med. 12, 1\u201316 (2020).","journal-title":"Genome Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92517-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92517-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92517-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T16:07:25Z","timestamp":1741363645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-92517-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["92517"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-92517-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"24 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"SAM institution has received grants from Pfizer, Minervax, GSK, the BMGF, and the South African Medical Research Council, and he has received honoraria and support to attend a meeting from GSK and MSD unrelated to this work. CPO has received support from the BMGF to attend a meeting. ZD received consulting fees from the WHO. RS institution has received funding from Gilead Science, Pfizer, Enanta Pharmaceuticals, BIOFABRI SLU, Serum Institute of India, and PENTA \/ Viiv and she has received consulting fees and honoraria from GSK and ENANTA pharmaceuticals, respectively. Authors who are employees of Pfizer (RGKD, RS) may, as a consequence, be shareholders of Pfizer Inc.AI, SK, LVDM, NJD, FCM, SJ, GK, JW, AMN, NN, YR, SCV, LA, and UR declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8043"}}