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While traditional T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub> weighted MRI can assess macro-structural brain atrophy, diffusion tensor imaging (DTI) unveils these hidden microstructural alterations. This study explores the use of DTI data, specifically visual patterns in Fractional Anisotropy (FA), Mean Diffusivity (MD), and Radial Diffusivity (RD) maps, to characterize AD progression. This paper proposes a computer-aided diagnosis (CAD) framework employing SIFT and SURF descriptors and a bag-of-words approach to build AD-specific signatures for the hippocampus region, known to be heavily affected by the disease. These signatures are extracted from MD, FA, and RD maps and used to differentiate between AD, mild cognitive impairment (MCI), and normal controls (NC) in both multiclass and binary classification scenarios. Additionally, we investigate late fusion of visual map features for enhanced decision-making. The experiments were accomplished with a subset of participants from the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) dataset formed of AD patients (<jats:italic>n<\/jats:italic>\u2009=\u200935), Early Mild Cognitive Impairment (EMCI) (<jats:italic>n<\/jats:italic>\u2009=\u20096), Late Mild Cognitive Impairment (LMCI) (<jats:italic>n<\/jats:italic>\u2009=\u200924) and cognitively healthy elderly Normal Controls (NC) (<jats:italic>n<\/jats:italic>\u2009=\u200931). Promising preliminary results demonstrate the potential of the proposed system as a useful tool to capture the AD leanness with achieving accuracies of 87.5%, 87.4%, 89%, and 95.2% for MD, FA, RD, and fusion of features respectively for the multiclass system using SIFT features. Using FA features for binary discrimination achieves 97.5%. Moreover, the fusion based on the decision level model reached an accuracy of 93.3% AD\/MCI, 95.7% AD\/NC, and 93.3% MCI\/NC (96.2\u2009\u00b1\u20093.6 MCI vs. NC, 97.5\u2009\u00b1\u20095 AD vs. NC). Furthermore, fusion of features led to a noteworthy precision boost of 96%. These findings suggest that our DTI-based CAD framework holds promise as a reliable and accurate tool for capturing AD progression, paving the way for earlier diagnosis and potentially improved patient outcomes.<\/jats:p>","DOI":"10.1038\/s41598-025-92759-2","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T21:22:03Z","timestamp":1742592123000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Classification method based on surf and sift features for alzheimer diagnosis using diffusion tensor magnetic resonance imaging"],"prefix":"10.1038","volume":"15","author":[{"given":"Nourhan","family":"Zayed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaidaa","family":"Eldeep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inas A.","family":"Yassine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"92759_CR1","doi-asserted-by":"publisher","unstructured":"Murphy, S. 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