{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:35:57Z","timestamp":1762432557360,"version":"3.38.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-93316-7","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T12:36:57Z","timestamp":1741869417000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of potent multi-target antiviral natural compounds from the fungal metabolites against aspartyl viral polymerases"],"prefix":"10.1038","volume":"15","author":[{"given":"Zohreh Sahhaf","family":"Razavi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ramazani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Zarei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"93316_CR1","doi-asserted-by":"publisher","first-page":"173746","DOI":"10.1016\/j.ejphar.2020.173746","volume":"890","author":"AZ Mirza","year":"2021","unstructured":"Mirza, A. Z., Shamshad, H., Osra, F. A., Habeebullah, T. M. & Morad, M. An overview of viruses discovered over the last decades and drug development for the current pandemic. Eur. J. Pharmacol. 890, 173746 (2021).","journal-title":"Eur. J. Pharmacol."},{"key":"93316_CR2","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/978-1-4614-0980-9_12","volume":"726","author":"KH Choi","year":"2012","unstructured":"Choi, K. H. Viral polymerases. Adv. Exp. Med. Biol. 726, 267\u2013304 (2012).","journal-title":"Adv. Exp. Med. Biol."},{"key":"93316_CR3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/molecules27217370","volume":"27","author":"S Peng","year":"2022","unstructured":"Peng, S., Wang, H., Wang, Z. & Wang, Q. Progression of Antiviral Agents Targeting Viral Polymerases. Molecules (Basel, Switzerland). 27, 21 (2022).","journal-title":"Molecules (Basel, Switzerland)."},{"key":"93316_CR4","doi-asserted-by":"publisher","first-page":"6503","DOI":"10.1128\/JVI.00386-12","volume":"86","author":"RT Mosley","year":"2012","unstructured":"Mosley, R. T. et al. Structure of hepatitis C virus polymerase in complex with primer-template RNA. J. Virol. 86, 6503\u20136511 (2012).","journal-title":"J. Virol."},{"key":"93316_CR5","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1126\/science.abb7498","volume":"368","author":"Y Gao","year":"2020","unstructured":"Gao, Y. et al. Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science. 368, 779\u2013782 (2020).","journal-title":"Science."},{"key":"93316_CR6","doi-asserted-by":"publisher","first-page":"17006","DOI":"10.1038\/nrdp.2017.6","volume":"3","author":"MP Manns","year":"2017","unstructured":"Manns, M. P. et al. Hepatitis C virus infection. Nat. Rev. Dis. Primers. 3, 17006 (2017).","journal-title":"Nat. Rev. Dis. Primers."},{"key":"93316_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41580-021-00432-z","volume":"23","author":"B Malone","year":"2022","unstructured":"Malone, B., Urakova, N., Snijder, E. J. & Campbell, E. A. Structures and functions of coronavirus replication-transcription complexes and their relevance for SARS-CoV-2 drug design. Nat. Rev. Mol. Cell Biol. 23, 21\u201339 (2022).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"93316_CR8","doi-asserted-by":"publisher","first-page":"115726","DOI":"10.1016\/j.ejmech.2023.115726","volume":"260","author":"J-H Zhao","year":"2023","unstructured":"Zhao, J.-H. et al. Natural products as potential lead compounds to develop new antiviral drugs over the past decade. Eur. J. Med. Chem. 260, 115726 (2023).","journal-title":"Eur. J. Med. Chem."},{"key":"93316_CR9","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.2174\/1385272824999200616114037","volume":"24","author":"M Dodangeh","year":"2020","unstructured":"Dodangeh, M., Ramazani, A., Maghsoodlou, M.-T., Zarei, A. & Rezayati, S. Application of readily available metals for CH activation. Curr. Org. Chem. 24, 1582\u20131609 (2020).","journal-title":"Curr. Org. Chem."},{"key":"93316_CR10","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/978-3-030-03589-1_7","volume-title":"Advances in Endophytic Fungal Research: Present Status and Future Challenges","author":"H Meena","year":"2019","unstructured":"Meena, H., Hnamte, S. & Siddhardha, B. Secondary Metabolites from Endophytic Fungi: Chemical Diversity and Application. In Advances in Endophytic Fungal Research: Present Status and Future Challenges (ed. Singh, B. P.) 145\u2013169 (Springer International Publishing, 2019)."},{"key":"93316_CR11","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1248\/cpb.52.1005","volume":"52","author":"H Fujimoto","year":"2004","unstructured":"Fujimoto, H., Nakamura, E., Okuyama, E. & Ishibashi, M. Six immunosuppressive features from an ascomycete, <i>Zopfiella longicaudata<\/i>, found in a screening study monitored by immunomodulatory activity. Chem. Pharmaceutical Bulletin 52, 1005\u20131008 (2004).","journal-title":"Chem. Pharmaceutical Bulletin"},{"key":"93316_CR12","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1021\/np900512k","volume":"72","author":"F Zhang","year":"2009","unstructured":"Zhang, F. et al. Allenyl and Alkynyl Phenyl Ethers from the Endolichenic Fungus Neurospora terricola. J. Nat. Prod. 72, 1782\u20131785 (2009).","journal-title":"J. Nat. Prod."},{"key":"93316_CR13","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3390\/jof6040188","volume":"6","author":"L Shao","year":"2020","unstructured":"Shao, L., Marin-Felix, Y., Surup, F., Stchigel, A. M. & Stadler, M. Seven new cytotoxic and Antimicrobial Xanthoquinodins from Jugulospora vestita. J. Fungi 6, 188 (2020).","journal-title":"J. Fungi"},{"key":"93316_CR14","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1016\/j.tetlet.2016.05.014","volume":"57","author":"T Li","year":"2016","unstructured":"Li, T., Wang, X., Luo, J., Yang, M. & Kong, L. Antioxidant sordariol dimers from Sordaria macrospora and the absolute configuration determinations of their two simultaneous linear 1,2-diols. Tetrahedron Letters 57, 2754\u20132757 (2016).","journal-title":"Tetrahedron Letters"},{"key":"93316_CR15","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1021\/np070624j","volume":"71","author":"S-H Wu","year":"2008","unstructured":"Wu, S.-H. et al. Ten-Membered Lactones from Phomopsis sp., an Endophytic Fungus of Azadirachta indica. J. Nat. Prod. 71, 731\u2013734 (2008).","journal-title":"J. Nat. Prod."},{"key":"93316_CR16","first-page":"119","volume":"44","author":"S Takahashi","year":"1992","unstructured":"Takahashi, S., Kagasaki, T. & Furuya, K. Apiodionen, inhibitor of topoisomerase and suppressor of chemiluminescence: taxonomy, fermentation, isolation, structural elucidation and biological activity. Annu Rep Sankyo Res Lab 44, 119\u2013127 (1992).","journal-title":"Annu Rep Sankyo Res Lab"},{"key":"93316_CR17","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s11557-022-01775-3","volume":"21","author":"E Charria-Gir\u00f3n","year":"2022","unstructured":"Charria-Gir\u00f3n, E., Surup, F. & Marin-Felix, Y. Diversity of biologically active secondary metabolites in the ascomycete order Sordariales. Mycol. Progress 21, 43 (2022).","journal-title":"Mycol. Progress"},{"key":"93316_CR18","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.2174\/138161206776361156","volume":"12","author":"CH Tsai","year":"2006","unstructured":"Tsai, C. H., Lee, P. Y., Stollar, V. & Li, M. L. Antiviral therapy targeting viral polymerase. Current Pharmaceutical Design 12, 1339\u20131355 (2006).","journal-title":"Current Pharmaceutical Design"},{"key":"93316_CR19","doi-asserted-by":"publisher","first-page":"204020662098407","DOI":"10.1177\/2040206620984076","volume":"28","author":"OM Ogunyemi","year":"2020","unstructured":"Ogunyemi, O. M. et al. Alkaloids and flavonoids from African phytochemicals as potential inhibitors of SARS-Cov-2 RNA-dependent RNA polymerase: an in silico perspective. Antiviral Chem. Chemotherapy 28, 2040206620984076 (2020).","journal-title":"Antiviral Chem. Chemotherapy"},{"key":"93316_CR20","doi-asserted-by":"publisher","first-page":"104613","DOI":"10.1016\/j.compbiomed.2021.104613","volume":"135","author":"KS Ebrahimi","year":"2021","unstructured":"Ebrahimi, K. S. et al. In silico investigation on the inhibitory effect of fungal secondary metabolites on RNA dependent RNA polymerase of SARS-CoV-II: A docking and molecular dynamic simulation study. Comput. Biol. Med. 135, 104613 (2021).","journal-title":"Comput. Biol. Med."},{"key":"93316_CR21","doi-asserted-by":"publisher","first-page":"4254","DOI":"10.1080\/14786419.2021.1974435","volume":"36","author":"A Zarei","year":"2022","unstructured":"Zarei, A. et al. In silico evaluation of COVID-19 main protease interactions with honeybee natural products for discovery of high potential antiviral compounds. Nat. Prod. Res. 36, 4254\u20134260 (2022).","journal-title":"Nat. Prod. Res."},{"key":"93316_CR22","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.fitote.2014.10.011","volume":"99","author":"TS Wahyuni","year":"2014","unstructured":"Wahyuni, T. S. et al. Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves. Fitoterapia 99, 276\u2013283 (2014).","journal-title":"Fitoterapia"},{"key":"93316_CR23","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/S0026-895X(25)09567-7","volume":"38","author":"R Fernandez-Larsson","year":"1990","unstructured":"Fernandez-Larsson, R. & Patterson, J. L. Ribavirin is an inhibitor of human immunodeficiency virus reverse transcriptase. Mol. Pharmacol. 38, 766\u2013770 (1990).","journal-title":"Mol. Pharmacol."},{"key":"93316_CR24","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1128\/AAC.44.4.859-866.2000","volume":"44","author":"W Markland","year":"2000","unstructured":"Markland, W., McQuaid, T., Jain, J. & Kwong, A. Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon. Antimicrobial Agents Chemotherapy 44, 859\u2013866 (2000).","journal-title":"Antimicrobial Agents Chemotherapy"},{"key":"93316_CR25","first-page":"836","volume":"7","author":"N Yellasubbaiah","year":"2025","unstructured":"Yellasubbaiah, N. Design, synthesis, insilco docking and biological evaluation of new 5-oxo-imidazoline derivatives as potent polo\u2013 like kinase 1 inhibitors. J. Med. Pharmaceutical Chem. Res. 7, 836\u2013858 (2025).","journal-title":"J. Med. Pharmaceutical Chem. Res."},{"key":"93316_CR26","first-page":"85","volume":"8","author":"R Amirkhani","year":"2024","unstructured":"Amirkhani, R., Zarei, A., Gholampour, M., Tavakoli, H. & Ramazani, A. Computational study on inhibitory potential of natural compounds against SARS-CoV-2 main protease. Chem. Methodol. 8, 85\u201395 (2024).","journal-title":"Chem. Methodol."},{"key":"93316_CR27","unstructured":"Muralidharan, V. et al. Molecular Docking and Dynamic Simulation with ADMET Exploration of Natural Products Atlas Compound Library to search for Potential Alpha Amylase Inhibitors for the T2DM Treatment. Chemical Methodologies, 81\u2013102, (2025)."},{"key":"93316_CR28","first-page":"883","volume":"7","author":"N Tadayon","year":"2023","unstructured":"Tadayon, N. & Ramazani, A. Molecular Docking and Dynamics Analysis of COVID-19 Main Protease Interactions with Alkaloids from Hyoscyamus Niger and Datura Stramonium. Chem. Methodol. 7, 883\u2013903 (2023).","journal-title":"Chem. Methodol."},{"key":"93316_CR29","first-page":"613","volume":"7","author":"N Tadayon","year":"2023","unstructured":"Tadayon, N. & Ramazani, A. In silico Analysis of Sars-CoV-2 Main protease interactions with selected hyoscyamus niger and datura stramonium compounds for finding new antiviral agents. Chem. Methodol. 7, 613\u2013636 (2023).","journal-title":"Chem. Methodol."},{"key":"93316_CR30","first-page":"969","volume":"5","author":"A Zarei","year":"2023","unstructured":"Zarei, A., Amirkhani, R., Gholampour, M., Tavakoli, H. & Ramazani, A. Natural compounds as strong SARS-CoV-2 main protease inhibitors: computer-based study. J. Med. Pharmaceutical Chem. Res. 5, 969\u2013986 (2023).","journal-title":"J. Med. Pharmaceutical Chem. Res."},{"key":"93316_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.105625","volume":"146","author":"S Pourmand","year":"2022","unstructured":"Pourmand, S., Zareei, S., Shahlaei, M. & Moradi, S. Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding region. Computers in biology and medicine 146, 105625 (2022).","journal-title":"Computers in biology and medicine"},{"key":"93316_CR32","first-page":"1838","volume":"7","author":"D Ardiana","year":"2025","unstructured":"Ardiana, D., Riyanto, E., Ariwibowo, L., Prameswari, R. & Praditapuspa, E. N. In silico and molecular dynamics metabolite compounds of rhizophora mucronata leaves on ETRB target as potential inducing melanogenesis. J. Med. Pharmaceutical Chem. Res. 7, 1838\u20131851 (2025).","journal-title":"J. Med. Pharmaceutical Chem. Res."},{"key":"93316_CR33","doi-asserted-by":"publisher","first-page":"6131","DOI":"10.1021\/acs.jctc.7b00520","volume":"13","author":"B Doherty","year":"2017","unstructured":"Doherty, B., Zhong, X., Gathiaka, S., Li, B. & Acevedo, O. Revisiting OPLS Force Field Parameters for Ionic Liquid Simulations. J. Chem. Theory Comput. 13, 6131\u20136145 (2017).","journal-title":"J. Chem. Theory Comput."},{"key":"93316_CR34","doi-asserted-by":"publisher","first-page":"W331","DOI":"10.1093\/nar\/gkx312","volume":"45","author":"LS Dodda","year":"2017","unstructured":"Dodda, L. S., Cabeza de Vaca, I., Tirado-Rives, J. & Jorgensen, W. L. LigParGen web server: an automatic OPLS-AA parameter generator for organic ligands. Nucleic acids Res. 45, W331\u2013W336 (2017).","journal-title":"Nucleic acids Res."},{"key":"93316_CR35","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1107\/S0907444904011679","volume":"60","author":"AW Sch\u00fcttelkopf","year":"2004","unstructured":"Sch\u00fcttelkopf, A. W. & Van Aalten, D. M. PRODRG: a tool for high-throughput crystallography of protein\u2013ligand complexes. Acta Crystallographica Sect. D: Biol. Crystallography 60, 1355\u20131363 (2004).","journal-title":"Acta Crystallographica Sect. D: Biol. Crystallography"},{"key":"93316_CR36","doi-asserted-by":"crossref","unstructured":"Hirshman, S. P. & Whitson, J. Steepest descent moment method for three-dimensional magnetohydrodynamic equilibria. (Oak Ridge National Lab.(ORNL), Oak Ridge, TN (United States), (1983).","DOI":"10.2172\/5537804"},{"key":"93316_CR37","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","volume":"18","author":"B Hess","year":"1997","unstructured":"Hess, B., Bekker, H., Berendsen, H. J. & Fraaije, J. G. LINCS: A linear constraint solver for molecular simulations. J. Comput. Chem. 18, 1463\u20131472 (1997).","journal-title":"J. Comput. Chem."},{"key":"93316_CR38","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/08927028808080941","volume":"1","author":"WF Van Gunsteren","year":"1988","unstructured":"Van Gunsteren, W. F. & Berendsen, H. J. A leap-frog algorithm for stochastic dynamics. Mol. Simul. 1, 173\u2013185 (1988).","journal-title":"Mol. Simul."},{"key":"93316_CR39","volume-title":"ACS Publications: Washington","author":"R Laskowski","year":"2011","unstructured":"Laskowski, R. & Swindells, M. ACS Publications: Washington (DC, 2011)."},{"key":"93316_CR40","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","volume":"10","author":"S Genheden","year":"2015","unstructured":"Genheden, S. & Ryde, U. The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities. Expert Opinion on Drug Discovery 10, 449\u2013461 (2015).","journal-title":"Expert Opinion on Drug Discovery"},{"key":"93316_CR41","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1021\/acs.jnatprod.6b00498","volume":"79","author":"Y Li","year":"2016","unstructured":"Li, Y. et al. Emestrins: Anti-Cryptococcus Epipolythiodioxopiperazines from Podospora australis. J. Nat. Prod. 79, 2357\u20132363 (2016).","journal-title":"J. Nat. Prod."},{"key":"93316_CR42","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.simyco.2019.08.002","volume":"93","author":"XW Wang","year":"2019","unstructured":"Wang, X. W. et al. Phylogenetic re-evaluation of Thielavia with the introduction of a new family Podosporaceae. Stud. Mycol. 93, 155\u2013252 (2019).","journal-title":"Stud. Mycol."},{"key":"93316_CR43","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1248\/cpb.52.1005","volume":"52","author":"H Fujimoto","year":"2004","unstructured":"Fujimoto, H., Nakamura, E., Okuyama, E. & Ishibashi, M. Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory activity. Chem. Pharmaceutical Bulletin 52, 1005\u20131008 (2004).","journal-title":"Chem. Pharmaceutical Bulletin"},{"key":"93316_CR44","doi-asserted-by":"publisher","first-page":"7781","DOI":"10.1016\/S0040-4020(02)00942-0","volume":"58","author":"M Daferner","year":"2002","unstructured":"Daferner, M., Anke, T. & Sterner, O. Zopfiellamides A and B, antimicrobial pyrrolidinone derivatives from the marine fungus Zopfiella latipes. Tetrahedron 58, 7781\u20137784 (2002).","journal-title":"Tetrahedron"},{"key":"93316_CR45","doi-asserted-by":"publisher","first-page":"7117","DOI":"10.1093\/nar\/gkg916","volume":"31","author":"X Xu","year":"2003","unstructured":"Xu, X. et al. Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design. Nucleic Acids Res. 31, 7117\u20137130 (2003).","journal-title":"Nucleic Acids Res."},{"key":"93316_CR46","unstructured":"Wang, Q. et al. COVID-19 literature knowledge graph construction and drug repurposing report generation. arXiv preprint arXiv:2007.00576, (2020)."},{"key":"93316_CR47","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1038\/s41467-019-10280-3","volume":"10","author":"RN Kirchdoerfer","year":"2019","unstructured":"Kirchdoerfer, R. N. & Ward, A. B. Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors. Nat. Commun. 10, 2342 (2019).","journal-title":"Nat. Commun."},{"key":"93316_CR48","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.coviro.2021.03.010","volume":"48","author":"HS Hillen","year":"2021","unstructured":"Hillen, H. S. Structure and function of SARS-CoV-2 polymerase. Current Opinion Virol. 48, 82\u201390 (2021).","journal-title":"Current Opinion Virol."},{"key":"93316_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.123153","volume":"390","author":"M Ansari","year":"2023","unstructured":"Ansari, M. et al. Computational investigation on the potential inhibitory effect of fungal metabolites against viral RdRp of SARS-CoV-2 and HCV. J. Mol. Liq. 390, 123153 (2023).","journal-title":"J. Mol. Liq."},{"key":"93316_CR50","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1093\/bib\/bbaa378","volume":"22","author":"CB Mishra","year":"2021","unstructured":"Mishra, C. B. et al. Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach. Briefings iBioinformatics 22, 1346\u20131360 (2021).","journal-title":"Briefings iBioinformatics"},{"key":"93316_CR51","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/s41586-022-05664-3","volume":"614","author":"BF Malone","year":"2023","unstructured":"Malone, B. F. et al. Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature 614, 781\u2013787 (2023).","journal-title":"Nature"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-93316-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-93316-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-93316-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T12:59:21Z","timestamp":1741870761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-93316-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["93316"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-93316-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]},"assertion":[{"value":"8 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8704"}}