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Females with PCOS also experience chronic inflammation. This hormonal imbalance and persistent inflammation can reduce muscle strength and mass. Consequently, this may affect the lumbopelvic muscles, potentially leading to postural abnormalities and spinal misalignment. The study\u2019s goals were to find out how the biomechanics of women with PCOS differ from those who did not have the condition and to confirm the link between lumbopelvic parameters and the LH\/FSH ratio in women with PCOS. The researcher conducted a case\u2013control study on 95 nulliparous females, with 52 having PCOS and classified as a study group and 43 as a control group. The participants ranged in age from 25 to 35 years, and their body mass index ranged from 25 to 29.9\u00a0kg\/m<jats:sup>2<\/jats:sup>. All participants were selected from the gynecological outpatient clinic of Om El-Masryeen Hospital. The researcher used a pelvic inclinometer to evaluate the pelvic inclination angle and an inclinometer to examine the lumbar angle. Additionally, the researcher simultaneously collected blood samples on the third day of the menstrual cycle. Females with PCOS had significantly higher pelvic inclination and lumbar curve angles than controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). LH\/FSH ratio strongly correlated with lumbar angle and pelvic inclination. Females with PCOS had greater pelvic tilting and exaggerated lumbar lordosis than controls. The LH\/FSH ratio showed a strong correlation with both the lumbar curve angle and pelvic inclination in PCOS.<\/jats:p>\n          <jats:p>Clinical trial: The clinical trial number [NCT03740932] with initial release date at 09\/17\/2024.<\/jats:p>","DOI":"10.1038\/s41598-025-93481-9","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T07:02:06Z","timestamp":1743663726000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biomechanical changes in females with poly cystic ovarian syndrome: a case\u2013control study"],"prefix":"10.1038","volume":"15","author":[{"given":"Eman E.","family":"Kamal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamada A.","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda Sayed","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel M.","family":"Yousef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rovan M.","family":"Elbesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"93481_CR1","doi-asserted-by":"crossref","first-page":"e1003132","DOI":"10.1371\/journal.pmed.1003132","volume":"17","author":"M Dapas","year":"2020","unstructured":"Dapas, M. et al. 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