{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:29:41Z","timestamp":1790933381035,"version":"4.1.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Shanghai Shen-Kang Hospital Management Center Project","award":["No. SHDC2020CR2044B"],"award-info":[{"award-number":["No. SHDC2020CR2044B"]}]},{"name":"Shanghai Shen-Kang Hospital Management Center Project","award":["No. SHDC2020CR3056B"],"award-info":[{"award-number":["No. SHDC2020CR3056B"]}]},{"name":"National STI2030-Major Projects of China","award":["No. 2021ZD0201900"],"award-info":[{"award-number":["No. 2021ZD0201900"]}]},{"name":"Hospital Level Scientific Research Fund Program of Shanghai Sixth People\u2019s Hospital","award":["No. ynts202404"],"award-info":[{"award-number":["No. ynts202404"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81970869"],"award-info":[{"award-number":["No. 81970869"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 82171125"],"award-info":[{"award-number":["No. 82171125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 82371131"],"award-info":[{"award-number":["No. 82371131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Municipal Commission of Science and Technology","award":["No. 18DZ2260200"],"award-info":[{"award-number":["No. 18DZ2260200"]}]},{"name":"Shanghai Science and Technology Innovation Program of Science and Technology Commission","award":["No. 20Y11902100"],"award-info":[{"award-number":["No. 20Y11902100"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-93915-4","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T09:04:29Z","timestamp":1742547869000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Identifying and validating immunological biomarkers in obstructive sleep apnea through bioinformatics analysis"],"prefix":"10.1038","volume":"15","author":[{"given":"En-hui","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-jiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-kai","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-liang","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-yin","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"issue":"9918","key":"93915_CR1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0140-6736(13)60734-5","volume":"383","author":"AS Jordan","year":"2014","unstructured":"Jordan, A. S., McSharry, D. G. & Malhotra, A. Adult obstructive sleep Apnoea. Lancet 383(9918), 736\u2013747 (2014).","journal-title":"Lancet"},{"issue":"8","key":"93915_CR2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","volume":"7","author":"AV Benjafield","year":"2019","unstructured":"Benjafield, A. V. et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir. Med. 7(8), 687\u2013698 (2019).","journal-title":"Lancet Respir. Med."},{"key":"93915_CR3","doi-asserted-by":"crossref","first-page":"15015","DOI":"10.1038\/nrdp.2015.15","volume":"1","author":"P L\u00e9vy","year":"2015","unstructured":"L\u00e9vy, P. et al. Obstructive sleep Apnoea syndrome. Nat. Rev. Dis. Primers 1, 15015 (2015).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"93915_CR4","doi-asserted-by":"crossref","unstructured":"Fang, Y. et al. Autoantibodies of inflammatory cytokines as serum biomarkers in OSA patients. Clin. Chim. Acta 547, 89 (2023).","DOI":"10.1016\/j.cca.2023.117399"},{"issue":"1","key":"93915_CR5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12974-020-01905-2","volume":"17","author":"X Liu","year":"2020","unstructured":"Liu, X. et al. The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome. J. Neuroinflammation. 17(1), 229 (2020).","journal-title":"J. Neuroinflammation"},{"key":"93915_CR6","first-page":"35","volume":"34","author":"S Kuhle","year":"2020","unstructured":"Kuhle, S. & Urschitz, M. S. Anti-inflammatory medications for the treatment of pediatric obstructive sleep apnea. Paediatr. Respir Rev. 34, 35\u201336 (2020).","journal-title":"Paediatr. Respir Rev."},{"key":"93915_CR7","doi-asserted-by":"crossref","unstructured":"Marchi, N. et al. Obstructive sleep Apnoea and 5-year cognitive decline in the elderly. Eur. Respir. J. 61, 4 (2023).","DOI":"10.1183\/13993003.01621-2022"},{"key":"93915_CR8","doi-asserted-by":"crossref","unstructured":"Gleeson, M. & McNicholas, W. Bidirectional relationships of comorbidity with obstructive sleep Apnoea. Eur. Respir Rev. 31, 164 (2022).","DOI":"10.1183\/16000617.0256-2021"},{"issue":"8","key":"93915_CR9","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41569-023-00846-6","volume":"20","author":"S Redline","year":"2023","unstructured":"Redline, S., Azarbarzin, A. & Peker, Y. Obstructive sleep Apnoea heterogeneity and cardiovascular disease. Nat. Rev. Cardiol. 20(8), 560\u2013573 (2023).","journal-title":"Nat. Rev. Cardiol."},{"key":"93915_CR10","doi-asserted-by":"crossref","unstructured":"Cortese, R. et al. Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep Apnoea. Eur. Respir. J. 61, 2 (2023).","DOI":"10.1183\/13993003.01465-2022"},{"key":"93915_CR11","doi-asserted-by":"crossref","unstructured":"Song, R., Baker, T. L., Watters, J. J. & Kumar, S. Obstructive sleep Apnea-Associated intermittent Hypoxia-Induced immune responses in males, pregnancies, and offspring. Int. J. Mol. Sci. 25, 3 (2024).","DOI":"10.3390\/ijms25031852"},{"issue":"4","key":"93915_CR12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.dsx.2016.06.024","volume":"11","author":"MR Alzoubi","year":"2017","unstructured":"Alzoubi, M. R. & Aldomi Al-Domi, H. Could omega-3 fatty acids a therapeutic treatment of the immune-metabolic consequence of intermittent hypoxia in obstructive sleep apnea? Diabetes Metab. Syndr. 11(4), 297\u2013304 (2017).","journal-title":"Diabetes Metab. Syndr."},{"key":"93915_CR13","doi-asserted-by":"crossref","first-page":"1277551","DOI":"10.3389\/fimmu.2023.1277551","volume":"14","author":"E D\u00edaz-Garc\u00eda","year":"2023","unstructured":"D\u00edaz-Garc\u00eda, E. et al. Cubillos-Zapata, PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea. Front. Immunol. 14, 1277551 (2023).","journal-title":"Front. Immunol."},{"key":"93915_CR14","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Jim\u00e9nez, E. et al. E. L\u00f3pez-Collazo, monocytes inhibit NK activity via TGF-\u03b2 in patients with obstructive sleep Apnoea. Eur. Respir. J. 49, 6 (2017).","DOI":"10.1183\/13993003.02456-2016"},{"key":"93915_CR15","doi-asserted-by":"crossref","first-page":"7373921","DOI":"10.1155\/2018\/7373921","volume":"2018","author":"C Cubillos-Zapata","year":"2018","unstructured":"Cubillos-Zapata, C. et al. Obstructive sleep apnea monocytes exhibit high levels of vascular endothelial growth factor secretion, augmenting tumor progression. Mediators Inflamm. 2018, 7373921 (2018).","journal-title":"Mediators Inflamm."},{"issue":"8","key":"93915_CR16","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/s41366-020-0549-z","volume":"44","author":"I Almendros","year":"2020","unstructured":"Almendros, I., Martinez-Garcia, M. A., Farr\u00e9, R. & Gozal, D. Obesity, sleep apnea, and cancer. Int. J. Obes. (Lond).  44(8), 1653\u20131667 (2020).","journal-title":"Int. J. Obes. (Lond.)"},{"issue":"7","key":"93915_CR17","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/mnfr.200500273","volume":"50","author":"PK Akalin","year":"2006","unstructured":"Akalin, P. K. Introduction to bioinformatics. Mol. Nutr. Food Res. 50(7), 610\u2013619 (2006).","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"93915_CR18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28(1), 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"93915_CR19","doi-asserted-by":"crossref","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51(D1), D587\u2013D592 (2023).","journal-title":"Nucleic Acids Res."},{"key":"93915_CR20","doi-asserted-by":"crossref","unstructured":"Ryan, S. et al. Adipose tissue as a key player in obstructive sleep Apnoea. Eur. Respir Rev. 28, 152 (2019).","DOI":"10.1183\/16000617.0006-2019"},{"issue":"1","key":"93915_CR21","first-page":"23","volume":"36","author":"SA Gharib","year":"2013","unstructured":"Gharib, S. A., Hayes, A. L., Rosen, M. J. & Patel, S. R. A pathway-based analysis on the effects of obstructive sleep apnea in modulating visceral fat transcriptome. Sleep 36(1), 23\u201330 (2013).","journal-title":"Sleep"},{"issue":"4","key":"93915_CR22","doi-asserted-by":"crossref","first-page":"e32265","DOI":"10.1371\/journal.pone.0032265","volume":"7","author":"K Chechi","year":"2012","unstructured":"Chechi, K., Gelinas, Y., Mathieu, P., Deshaies, Y. & Richard, D. Validation of reference genes for the relative quantification of gene expression in human epicardial adipose tissue. PLoS One 7(4), e32265 (2012).","journal-title":"PLoS One"},{"issue":"1","key":"93915_CR23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.gene.2016.01.001","volume":"580","author":"X Liu","year":"2016","unstructured":"Liu, X. et al. Identification and validation of reference genes for quantitative RT-PCR analysis of retinal pigment epithelium cells under hypoxia and\/or hyperglycemia. Gene 580(1), 41\u201346 (2016).","journal-title":"Gene"},{"key":"93915_CR24","doi-asserted-by":"crossref","unstructured":"Agata, G., Piotr, K., Adam, A., Piotr, B. & Micha\u0142, P. IL-33 mediated inflammation in chronic respiratory Diseases-Understanding the role of the member of IL-1 superfamily. Front. Immunol. 10, 10 (2019).","DOI":"10.3389\/fimmu.2019.00692"},{"key":"93915_CR25","doi-asserted-by":"crossref","first-page":"109604","DOI":"10.1016\/j.intimp.2022.109604","volume":"115","author":"Z Dandan","year":"2023","unstructured":"Dandan, Z. et al. IL-33\/ST2 mediating systemic inflammation and neuroinflammation through NF-kB participated in the neurocognitive impairment in obstructive sleep apnea. Int. Immunopharmacol. 115, 109604 (2023).","journal-title":"Int. Immunopharmacol."},{"key":"93915_CR26","doi-asserted-by":"crossref","unstructured":"Dmitriy, K. et al. Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell. Metab. 21, 4 (2015).","DOI":"10.1016\/j.cmet.2015.03.005"},{"key":"93915_CR27","doi-asserted-by":"crossref","unstructured":"Dileep, U., Jonathan, J. & Vsevolod, P. Inflammation in sleep apnea: an update. Rev. Endocr. Metab. Disord 16, 1 (2014).","DOI":"10.1007\/s11154-014-9304-x"},{"key":"93915_CR28","doi-asserted-by":"crossref","unstructured":"Liu, J. et al. IL-33 Initiates vascular remodelling in hypoxic pulmonary hypertension by up-regulating HIF-1\u03b1 and VEGF expression in vascular endothelial cells. EBioMedicine 33, 196\u2013210  (2018).","DOI":"10.1016\/j.ebiom.2018.06.003"},{"issue":"6","key":"93915_CR29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nri2097","volume":"7","author":"A O\u2019Garra","year":"2007","unstructured":"O\u2019Garra, A. & Vieira, P. T(H)1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 7(6), 425\u2013428 (2007).","journal-title":"Nat. Rev. Immunol."},{"key":"93915_CR30","doi-asserted-by":"crossref","unstructured":"Hanna, B. S. et al. Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1\u2009+\u2009CD8\u2009+\u2009T cell population that sustains anti-tumor immunity. Immunity 54, 12 (2021).","DOI":"10.1016\/j.immuni.2021.11.004"},{"issue":"2","key":"93915_CR31","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1007\/s11033-012-2232-5","volume":"40","author":"HK Park","year":"2013","unstructured":"Park, H. K., Kim, D. H., Yun, D. H. & Ban, J. Y. Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population. Mol. Biol. Rep. 40(2), 1785\u20131790 (2013).","journal-title":"Mol. Biol. Rep."},{"issue":"5","key":"93915_CR32","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.apsb.2022.12.009","volume":"13","author":"W Wei","year":"2023","unstructured":"Wei, W. et al. Discovery and identification of EIF2AK2 as a direct key target of Berberine for anti-inflammatory effects. Acta Pharm. Sin. B 13(5), 2138\u20132151 (2023).","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"93915_CR33","doi-asserted-by":"crossref","first-page":"H571","DOI":"10.1152\/ajpheart.00038.2018","volume":"315","author":"Y Li","year":"2018","unstructured":"Li, Y. et al. Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence. Am. J. Physiol. Heart Circ. Physiol. 315(3), H571\u2013H580 (2018).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"93915_CR34","doi-asserted-by":"crossref","unstructured":"Hugon, J. & Paquet, C. The PKR\/P38\/RIPK1 signaling pathway as a therapeutic target in alzheimer\u2019s disease. Int. J. Mol. Sci. 22, 6 (2021).","DOI":"10.3390\/ijms22063136"},{"issue":"1","key":"93915_CR35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13046-017-0548-7","volume":"36","author":"H Chen","year":"2017","unstructured":"Chen, H. et al. ANGPTL1 attenuates colorectal cancer metastasis by up-regulating microRNA-138. J. Exp. Clin. Cancer Res. 36(1), 78 (2017).","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"12","key":"93915_CR36","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.cjca.2023.06.002","volume":"39","author":"E Thorin","year":"2023","unstructured":"Thorin, E. et al. Angiopoietin-Like proteins: cardiovascular biology and therapeutic targeting for the prevention of cardiovascular diseases. Can. J. Cardiol. 39(12), 1736\u20131756 (2023).","journal-title":"Can. J. Cardiol."},{"issue":"4","key":"93915_CR37","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1742-4658.2010.07979.x","volume":"278","author":"T Kadomatsu","year":"2011","unstructured":"Kadomatsu, T., Tabata, M. & Oike, Y. Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases. FEBS J. 278(4), 559\u2013564 (2011).","journal-title":"FEBS J."},{"issue":"6","key":"93915_CR38","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s41590-022-01217-y","volume":"23","author":"Systemic hypoxia drives","year":"2022","unstructured":"Systemic hypoxia drives. Inflammation persistence via suppression of monocytes. Nat. Immunol. 23(6), 830\u2013831 (2022).","journal-title":"Nat. Immunol."},{"key":"93915_CR39","doi-asserted-by":"crossref","unstructured":"Jaipersad, A. S., Lip, G. Y. H., Silverman, S. & Shantsila, E. The role of monocytes in angiogenesis and atherosclerosis. J. Am. Coll. Cardiol. 63, 1 (2014).","DOI":"10.1016\/j.jacc.2013.09.019"},{"issue":"9","key":"93915_CR40","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1182\/blood-2008-02-142091","volume":"112","author":"A Mancino","year":"2008","unstructured":"Mancino, A. et al. Divergent effects of hypoxia on dendritic cell functions. Blood 112(9), 3723\u20133734 (2008).","journal-title":"Blood"},{"issue":"7","key":"93915_CR41","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/cbf.3737","volume":"40","author":"A Barroeta Seijas","year":"2022","unstructured":"Barroeta Seijas, A. et al. Mouse dendritic cells in the steady State: hypoxia, autophagy, and stem cell factor. Cell Biochem. Funct. 40(7), 718\u2013728 (2022).","journal-title":"Cell Biochem. Funct."},{"key":"93915_CR42","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3389\/fimmu.2017.00541","volume":"8","author":"H M\u00f6llerherm","year":"2017","unstructured":"M\u00f6llerherm, H. et al. K\u00f6ckritz-Blickwede, hypoxia modulates the response of mast cells to Staphylococcus aureus infection. Front. Immunol. 8, 541 (2017).","journal-title":"Front. Immunol."},{"key":"93915_CR43","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3389\/fimmu.2019.01462","volume":"10","author":"A Viola","year":"2019","unstructured":"Viola, A., Munari, F., S\u00e1nchez-Rodr\u00edguez, R., Scolaro, T. & Castegna, A. The metabolic signature of macrophage responses. Front. Immunol. 10, 1462 (2019).","journal-title":"Front. Immunol."},{"issue":"6","key":"93915_CR44","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/CIRCRESAHA.119.312321","volume":"126","author":"A Mouton","year":"2020","unstructured":"Mouton, A., Li, X., Hall, M. & Hall, J. Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation. Circul. Res. 126(6), 789\u2013806 (2020).","journal-title":"Circul. Res."},{"issue":"7619","key":"93915_CR45","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nature19334","volume":"537","author":"SH Cho","year":"2016","unstructured":"Cho, S. H. et al. Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Nature 537(7619), 234\u2013238 (2016).","journal-title":"Nature"},{"key":"93915_CR46","doi-asserted-by":"crossref","unstructured":"Liu, D. H., Mou, F. F., An, M. & Xia, P. Human leukocyte antigen and tumor immunotherapy (Review). Int. J. Oncol. 62, 6 (2023).","DOI":"10.3892\/ijo.2023.5516"},{"issue":"12","key":"93915_CR47","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1158\/0008-5472.CAN-08-0054","volume":"68","author":"DR Siemens","year":"2008","unstructured":"Siemens, D. R. et al. Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide. Cancer Res. 68(12), 4746\u20134753 (2008).","journal-title":"Cancer Res."},{"issue":"3","key":"93915_CR48","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.apsb.2021.08.020","volume":"12","author":"S Dong","year":"2022","unstructured":"Dong, S., Guo, X., Han, F., He, Z. & Wang, Y. Emerging role of natural products in cancer immunotherapy. Acta Pharm. Sin B. 12(3), 1163\u20131185 (2022).","journal-title":"Acta Pharm. Sin B"},{"key":"93915_CR49","doi-asserted-by":"crossref","unstructured":"Cubillos-Zapata, C. et al. Hypoxia-induced PD-L1\/PD-1 crosstalk impairs T-cell function in sleep Apnoea. Eur. Respir. J. 50, 4 (2017).","DOI":"10.1183\/13993003.00833-2017"},{"key":"93915_CR50","doi-asserted-by":"crossref","unstructured":"Bartel, D. P.  Metazoan MicroRNAs. Cell 173(1) 20\u201351 (2018).","DOI":"10.1016\/j.cell.2018.03.006"},{"issue":"2","key":"93915_CR51","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molcel.2010.09.022","volume":"40","author":"AJ Majmundar","year":"2010","unstructured":"Majmundar, A. J., Wong, W. J. & Simon, M. C. Hypoxia-inducible factors and the response to hypoxic stress. Mol. Cell. 40(2), 294\u2013309 (2010).","journal-title":"Mol. Cell"},{"issue":"3","key":"93915_CR52","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1164\/rccm.202202-0394OC","volume":"207","author":"F Shang","year":"2023","unstructured":"Shang, F. et al. Obstructive sleep Apnea-induced endothelial dysfunction is mediated by miR-210. Am. J. Respir. Crit. Care Med. 207(3), 323\u2013335 (2023).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"93915_CR53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.freeradbiomed.2013.05.022","volume":"64","author":"S Nallamshetty","year":"2013","unstructured":"Nallamshetty, S., Chan, S. Y. & Loscalzo, J. Hypoxia: a master regulator of MicroRNA biogenesis and activity. Free Radic Biol. Med. 64, 20\u201330 (2013).","journal-title":"Free Radic Biol. Med."},{"issue":"10","key":"93915_CR54","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.arbres.2023.07.001","volume":"59","author":"G Moriondo","year":"2023","unstructured":"Moriondo, G. et al. Lacedonia, intermittent hypoxia mediates cancer development and progression through HIF-1 and MiRNA regulation. Arch. Bronconeumol. 59(10), 629\u2013637 (2023).","journal-title":"Arch. Bronconeumol."},{"issue":"12","key":"93915_CR55","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1164\/rccm.202306-1036OC","volume":"208","author":"PK Schweitzer","year":"2023","unstructured":"Schweitzer, P. K. et al. The combination of Aroxybutynin and Atomoxetine in the treatment of obstructive sleep apnea (MARIPOSA): a randomized controlled trial. Am. J. Respir Crit. Care Med. 208(12), 1316\u20131327 (2023).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"93915_CR56","first-page":"CD003002","volume":"5","author":"M Mason","year":"2013","unstructured":"Mason, M., Welsh, E. J. & Smith, I. Drug therapy for obstructive sleep Apnoea in adults. Cochrane Database Syst. Rev. 5, CD003002 (2013).","journal-title":"Cochrane Database Syst. Rev."},{"issue":"14","key":"93915_CR57","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1001\/jama.2020.3514","volume":"323","author":"DJ Gottlieb","year":"2020","unstructured":"Gottlieb, D. J. & Punjabi, N. M. Diagnosis and management of obstructive sleep apnea: a review. JAMA 323(14), 1389\u20131400 (2020).","journal-title":"JAMA"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-93915-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-93915-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-93915-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T09:06:23Z","timestamp":1742547983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-93915-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["93915"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-93915-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"15 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Ethics Committee of Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Approval No: 2019-KY-050[K]) and registered at the Chinese Clinical Trial Registry (No. ChiCTR1900025714; URL: ). The research was conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All patients provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"9746"}}