{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:36:45Z","timestamp":1790437005252,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82471454"],"award-info":[{"award-number":["82471454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82130036"],"award-info":[{"award-number":["82130036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"STI2030-Major Projects","award":["2022ZD0211800"],"award-info":[{"award-number":["2022ZD0211800"]}]},{"name":"Jiangsu Province Key Medical Discipline","award":["ZDXK202216"],"award-info":[{"award-number":["ZDXK202216"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-94472-6","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T13:14:37Z","timestamp":1745673277000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between high plasma p-tau181 level and gait changes in patients with mild cognitive impairment"],"prefix":"10.1038","volume":"15","author":[{"given":"Chenglu","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheqi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"94472_CR1","doi-asserted-by":"publisher","first-page":"560","DOI":"10.23736\/S1973-9087.20.06550-8","volume":"57","author":"YC Kuan","year":"2021","unstructured":"Kuan, Y. C. et al. Balance and gait performance in older adults with early-stage cognitive impairment. Eur J Phys Rehabil Med 57, 560\u2013567. https:\/\/doi.org\/10.23736\/S1973-9087.20.06550-8 (2021).","journal-title":"Eur J Phys Rehabil Med"},{"key":"94472_CR2","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1001\/jamaneurol.2022.3543","volume":"79","author":"JJ Manly","year":"2022","unstructured":"Manly, J. J. et al. Estimating the prevalence of dementia and mild cognitive impairment in the US: The 2016 health and retirement study harmonized cognitive assessment protocol project. JAMA Neurol 79, 1242\u20131249. https:\/\/doi.org\/10.1001\/jamaneurol.2022.3543 (2022).","journal-title":"JAMA Neurol"},{"key":"94472_CR3","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.jamda.2015.07.007","volume":"16","author":"T Doi","year":"2015","unstructured":"Doi, T. et al. Mild cognitive impairment, slow gait, and risk of disability: A prospective study. J Am Med Dir Assoc 16, 1082\u20131086. https:\/\/doi.org\/10.1016\/j.jamda.2015.07.007 (2015).","journal-title":"J Am Med Dir Assoc"},{"key":"94472_CR4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1159\/000499334","volume":"53","author":"L Yu","year":"2019","unstructured":"Yu, L. et al. Incident mobility disability, mild cognitive impairment, and mortality in community-dwelling older adults. Neuroepidemiology 53, 55\u201362. https:\/\/doi.org\/10.1159\/000499334 (2019).","journal-title":"Neuroepidemiology"},{"key":"94472_CR5","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.jamda.2015.12.092","volume":"17","author":"O Beauchet","year":"2016","unstructured":"Beauchet, O. et al. Poor gait performance and prediction of dementia: Results from a meta-analysis. J Am Med Dir Assoc 17, 482\u2013490. https:\/\/doi.org\/10.1016\/j.jamda.2015.12.092 (2016).","journal-title":"J Am Med Dir Assoc"},{"key":"94472_CR6","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1056\/NEJMoa020441","volume":"347","author":"J Verghese","year":"2002","unstructured":"Verghese, J. et al. Abnormality of gait as a predictor of non-Alzheimer\u2019s dementia. N Engl J Med 347, 1761\u20131768. https:\/\/doi.org\/10.1056\/NEJMoa020441 (2002).","journal-title":"N Engl J Med"},{"key":"94472_CR7","first-page":"135","volume":"87","author":"JG Nutt","year":"2001","unstructured":"Nutt, J. G. Classification of gait and balance disorders. Adv Neurol 87, 135\u2013141 (2001).","journal-title":"Adv Neurol"},{"key":"94472_CR8","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/gerona\/glw121","volume":"72","author":"M Quan","year":"2017","unstructured":"Quan, M. et al. Walking pace and the risk of cognitive decline and dementia in elderly populations: A meta-analysis of prospective cohort studies. J Gerontol A Biol Sci Med Sci 72, 266\u2013270. https:\/\/doi.org\/10.1093\/gerona\/glw121 (2017).","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"94472_CR9","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1093\/gerona\/gls256","volume":"68","author":"MM Mielke","year":"2013","unstructured":"Mielke, M. M. et al. Assessing the temporal relationship between cognition and gait: Slow gait predicts cognitive decline in the Mayo Clinic Study of Aging. J Gerontol A Biol Sci Med Sci 68, 929\u2013937. https:\/\/doi.org\/10.1093\/gerona\/gls256 (2013).","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"94472_CR10","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1002\/alz.12537","volume":"18","author":"T Skillback","year":"2022","unstructured":"Skillback, T. et al. Slowing gait speed precedes cognitive decline by several years. Alzheimers Dement 18, 1667\u20131676. https:\/\/doi.org\/10.1002\/alz.12537 (2022).","journal-title":"Alzheimers Dement"},{"key":"94472_CR11","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1093\/gerona\/glab346","volume":"77","author":"O Jayakody","year":"2022","unstructured":"Jayakody, O. et al. Relative trajectories of gait and cognitive decline in aging. J Gerontol A Biol Sci Med Sci 77, 1230\u20131238. https:\/\/doi.org\/10.1093\/gerona\/glab346 (2022).","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"94472_CR12","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1159\/000489927","volume":"45","author":"S Byun","year":"2018","unstructured":"Byun, S. et al. Gait variability can predict the risk of cognitive decline in cognitively normal older people. Dement Geriatr Cognit Disord 45, 251\u2013261. https:\/\/doi.org\/10.1159\/000489927 (2018).","journal-title":"Dement Geriatr Cognit Disord"},{"key":"94472_CR13","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.3233\/JAD-181157","volume":"71","author":"O Jayakody","year":"2019","unstructured":"Jayakody, O., Breslin, M., Srikanth, V. K. & Callisaya, M. L. Gait characteristics and cognitive decline: A longitudinal population-based study. J Alzheimers Dis 71, S5\u2013S14. https:\/\/doi.org\/10.3233\/JAD-181157 (2019).","journal-title":"J Alzheimers Dis"},{"key":"94472_CR14","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1186\/s12877-022-03405-9","volume":"22","author":"S Bovonsunthonchai","year":"2022","unstructured":"Bovonsunthonchai, S. et al. Quantitative gait analysis in mild cognitive impairment, dementia, and cognitively intact individuals: A cross-sectional case-control study. BMC Geriatr 22, 767. https:\/\/doi.org\/10.1186\/s12877-022-03405-9 (2022).","journal-title":"BMC Geriatr"},{"key":"94472_CR15","doi-asserted-by":"publisher","first-page":"981632","DOI":"10.3389\/fnagi.2022.981632","volume":"14","author":"PH Chen","year":"2022","unstructured":"Chen, P. H., Lin, S. I., Liao, Y. Y., Hsu, W. L. & Cheng, F. Y. Associations between blood-based biomarkers of Alzheimer\u2019s disease with cognition in motoric cognitive risk syndrome: A pilot study using plasma Abeta42 and total tau. Front Aging Neurosci 14, 981632. https:\/\/doi.org\/10.3389\/fnagi.2022.981632 (2022).","journal-title":"Front Aging Neurosci"},{"key":"94472_CR16","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12987-023-00475-8","volume":"20","author":"R Gronning","year":"2023","unstructured":"Gronning, R. et al. Association between ventricular CSF biomarkers and outcome after shunt surgery in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS 20, 77. https:\/\/doi.org\/10.1186\/s12987-023-00475-8 (2023).","journal-title":"Fluids Barriers CNS"},{"key":"94472_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859","author":"CR Jack Jr","year":"2024","unstructured":"Jack, C. R. Jr. et al. Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup. Alzheimers Dement https:\/\/doi.org\/10.1002\/alz.13859 (2024).","journal-title":"Alzheimers Dement"},{"key":"94472_CR18","doi-asserted-by":"publisher","first-page":"125529","DOI":"10.1016\/j.talanta.2023.125529","volume":"270","author":"R Dong","year":"2024","unstructured":"Dong, R., Yi, N. & Jiang, D. Advances in single molecule arrays (SIMOA) for ultra-sensitive detection of biomolecules. Talanta 270, 125529. https:\/\/doi.org\/10.1016\/j.talanta.2023.125529 (2024).","journal-title":"Talanta"},{"key":"94472_CR19","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13195-021-00939-9","volume":"13","author":"S Bayoumy","year":"2021","unstructured":"Bayoumy, S. et al. Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217, and P-tau231. Alzheimers Res Ther 13, 198. https:\/\/doi.org\/10.1186\/s13195-021-00939-9 (2021).","journal-title":"Alzheimers Res Ther"},{"key":"94472_CR20","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1002\/alz.12724","volume":"19","author":"P Chatterjee","year":"2023","unstructured":"Chatterjee, P. et al. Plasma Abeta42\/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer\u2019s disease continuum: A cross-sectional and longitudinal study in the AIBL cohort. Alzheimers Dement 19, 1117\u20131134. https:\/\/doi.org\/10.1002\/alz.12724 (2023).","journal-title":"Alzheimers Dement"},{"key":"94472_CR21","doi-asserted-by":"publisher","first-page":"404","DOI":"10.5607\/en.2019.28.3.404","volume":"28","author":"H Jang","year":"2019","unstructured":"Jang, H. et al. Gait ignition failure in JNPL3 human tau-mutant mice. Exp Neurobiol 28, 404\u2013413. https:\/\/doi.org\/10.5607\/en.2019.28.3.404 (2019).","journal-title":"Exp Neurobiol"},{"key":"94472_CR22","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1093\/gerona\/glaa143","volume":"76","author":"MH Nilsson","year":"2021","unstructured":"Nilsson, M. H. et al. The effects of tau, amyloid, and white matter lesions on mobility, dual tasking, and balance in older people. J Gerontol A Biol Sci Med Sci 76, 683\u2013691. https:\/\/doi.org\/10.1093\/gerona\/glaa143 (2021).","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"94472_CR23","doi-asserted-by":"publisher","first-page":"S75","DOI":"10.3233\/JAD-181265","volume":"71","author":"HB Ahman","year":"2019","unstructured":"Ahman, H. B. et al. Dual-task performance and neurodegeneration: Correlations between timed up-and-go dual-task test outcomes and Alzheimer\u2019s disease cerebrospinal fluid biomarkers. J Alzheimers Dis 71, S75\u2013S83. https:\/\/doi.org\/10.3233\/JAD-181265 (2019).","journal-title":"J Alzheimers Dis"},{"key":"94472_CR24","doi-asserted-by":"publisher","first-page":"1101306","DOI":"10.3389\/fnagi.2023.1101306","volume":"15","author":"GG Tangen","year":"2023","unstructured":"Tangen, G. G. et al. Mobility and associations with levels of cerebrospinal fluid amyloid beta and tau in a memory clinic cohort. Front Aging Neurosci 15, 1101306. https:\/\/doi.org\/10.3389\/fnagi.2023.1101306 (2023).","journal-title":"Front Aging Neurosci"},{"key":"94472_CR25","doi-asserted-by":"publisher","first-page":"111776","DOI":"10.1016\/j.exger.2022.111776","volume":"163","author":"CE Shaaban","year":"2022","unstructured":"Shaaban, C. E. et al. Brain health correlates of mobility-related confidence. Exp Gerontol 163, 111776. https:\/\/doi.org\/10.1016\/j.exger.2022.111776 (2022).","journal-title":"Exp Gerontol"},{"key":"94472_CR26","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0895-4356(88)90034-0","volume":"41","author":"R Katzman","year":"1988","unstructured":"Katzman, R. et al. A Chinese version of the Mini-Mental State Examination; impact of illiteracy in a Shanghai dementia survey. J Clin Epidemiol 41, 971\u2013978. https:\/\/doi.org\/10.1016\/0895-4356(88)90034-0 (1988).","journal-title":"J Clin Epidemiol"},{"key":"94472_CR27","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/0891988711422528","volume":"24","author":"J Lu","year":"2011","unstructured":"Lu, J. et al. Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: a population-based study. J Geriatr Psychiatry Neurol 24, 184\u2013190. https:\/\/doi.org\/10.1177\/0891988711422528 (2011).","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"94472_CR28","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/nbt.1641","volume":"28","author":"DM Rissin","year":"2010","unstructured":"Rissin, D. M. et al. Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Nat Biotechnol 28, 595\u2013599. https:\/\/doi.org\/10.1038\/nbt.1641 (2010).","journal-title":"Nat Biotechnol"},{"key":"94472_CR29","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1093\/clinchem\/hvac149","volume":"68","author":"Z Xiao","year":"2022","unstructured":"Xiao, Z. et al. Plasma Abeta42\/Abeta40 and p-tau181 predict long-term clinical progression in a cohort with amnestic mild cognitive impairment. Clin Chem 68, 1552\u20131563. https:\/\/doi.org\/10.1093\/clinchem\/hvac149 (2022).","journal-title":"Clin Chem"},{"key":"94472_CR30","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1093\/brain\/awac128","volume":"146","author":"J Stevenson-Hoare","year":"2023","unstructured":"Stevenson-Hoare, J. et al. Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer\u2019s disease. Brain 146, 690\u2013699. https:\/\/doi.org\/10.1093\/brain\/awac128 (2023).","journal-title":"Brain"},{"key":"94472_CR31","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1001\/jamaneurol.2020.0387","volume":"77","author":"RA Sperling","year":"2020","unstructured":"Sperling, R. A. et al. Association of factors with elevated amyloid burden in clinically normal older individuals. JAMA Neurol 77, 735\u2013745. https:\/\/doi.org\/10.1001\/jamaneurol.2020.0387 (2020).","journal-title":"JAMA Neurol"},{"key":"94472_CR32","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1212\/wnl.46.3.707","volume":"46","author":"JC Morris","year":"1996","unstructured":"Morris, J. C. et al. Cerebral amyloid deposition and diffuse plaques in \u201cnormal\u201d aging: Evidence for presymptomatic and very mild Alzheimer\u2019s disease. Neurology 46, 707\u2013719. https:\/\/doi.org\/10.1212\/wnl.46.3.707 (1996).","journal-title":"Neurology"},{"key":"94472_CR33","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/alz.12674","volume":"19","author":"F Jessen","year":"2023","unstructured":"Jessen, F. et al. Subjective cognitive decline and stage 2 of Alzheimer disease in patients from memory centers. Alzheimers Dement 19, 487\u2013497. https:\/\/doi.org\/10.1002\/alz.12674 (2023).","journal-title":"Alzheimers Dement"},{"key":"94472_CR34","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1001\/jama.2019.7437","volume":"321","author":"CR Jack Jr","year":"2019","unstructured":"Jack, C. R. Jr. et al. Associations of Amyloid, Tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia. JAMA 321, 2316\u20132325. https:\/\/doi.org\/10.1001\/jama.2019.7437 (2019).","journal-title":"JAMA"},{"key":"94472_CR35","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","volume":"7","author":"RA Sperling","year":"2011","unstructured":"Sperling, R. A. et al. Toward defining the preclinical stages of Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement 7, 280\u2013292. https:\/\/doi.org\/10.1016\/j.jalz.2011.03.003 (2011).","journal-title":"Alzheimers Dement"},{"key":"94472_CR36","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00401-022-02408-5","volume":"143","author":"DS Smirnov","year":"2022","unstructured":"Smirnov, D. S. et al. Plasma biomarkers for Alzheimer\u2019s disease in relation to neuropathology and cognitive change. Acta Neuropathol 143, 487\u2013503. https:\/\/doi.org\/10.1007\/s00401-022-02408-5 (2022).","journal-title":"Acta Neuropathol"},{"key":"94472_CR37","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.3233\/JAD-180622","volume":"65","author":"I Koychev","year":"2018","unstructured":"Koychev, I. et al. Abeta42\/Abeta40 and Abeta42\/Abeta38 Ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer\u2019s disease: A pilot study. J Alzheimers Dis 65, 1377\u20131383. https:\/\/doi.org\/10.3233\/JAD-180622 (2018).","journal-title":"J Alzheimers Dis"},{"key":"94472_CR38","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13195-020-00697-0","volume":"12","author":"L He","year":"2020","unstructured":"He, L. et al. Plasma Abeta and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults. Alzheimers Res Ther 12, 128. https:\/\/doi.org\/10.1186\/s13195-020-00697-0 (2020).","journal-title":"Alzheimers Res Ther"},{"key":"94472_CR39","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1093\/brain\/awv181","volume":"138","author":"T Skillback","year":"2015","unstructured":"Skillback, T. et al. Cerebrospinal fluid tau and amyloid-beta1-42 in patients with dementia. Brain 138, 2716\u20132731. https:\/\/doi.org\/10.1093\/brain\/awv181 (2015).","journal-title":"Brain"},{"key":"94472_CR40","doi-asserted-by":"publisher","first-page":"5967","DOI":"10.1038\/s41380-020-0838-x","volume":"26","author":"A O'Connor","year":"2021","unstructured":"O\u2019Connor, A. et al. Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer\u2019s disease: a longitudinal cohort study. Mol Psychiatry 26, 5967\u20135976. https:\/\/doi.org\/10.1038\/s41380-020-0838-x (2021).","journal-title":"Mol Psychiatry"},{"key":"94472_CR41","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1001\/archneurol.2010.159","volume":"67","author":"T Buracchio","year":"2010","unstructured":"Buracchio, T., Dodge, H. H., Howieson, D., Wasserman, D. & Kaye, J. The trajectory of gait speed preceding mild cognitive impairment. Arch Neurol 67, 980\u2013986. https:\/\/doi.org\/10.1001\/archneurol.2010.159 (2010).","journal-title":"Arch Neurol"},{"key":"94472_CR42","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bbi.2018.04.014","volume":"71","author":"D Yan","year":"2018","unstructured":"Yan, D. et al. Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin. Brain Behav Immun 71, 66\u201380. https:\/\/doi.org\/10.1016\/j.bbi.2018.04.014 (2018).","journal-title":"Brain Behav Immun"},{"key":"94472_CR43","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3233\/JAD-221303","volume":"96","author":"M Lindh-Rengifo","year":"2023","unstructured":"Lindh-Rengifo, M. et al. Effects of brain pathologies on spatiotemporal gait parameters in patients with mild cognitive impairment. J Alzheimers Dis 96, 161\u2013171. https:\/\/doi.org\/10.3233\/JAD-221303 (2023).","journal-title":"J Alzheimers Dis"},{"key":"94472_CR44","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1177\/0891988702250580","volume":"16","author":"JM Hausdorff","year":"2003","unstructured":"Hausdorff, J. M., Balash, J. & Giladi, N. Effects of cognitive challenge on gait variability in patients with Parkinson\u2019s disease. J Geriatr Psychiatry Neurol 16, 53\u201358. https:\/\/doi.org\/10.1177\/0891988702250580 (2003).","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"94472_CR45","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1111\/j.1532-5415.2012.04209.x","volume":"60","author":"M Montero-Odasso","year":"2012","unstructured":"Montero-Odasso, M., Verghese, J., Beauchet, O. & Hausdorff, J. M. Gait and cognition: A complementary approach to understanding brain function and the risk of falling. J Am Geriatr Soc 60, 2127\u20132136. https:\/\/doi.org\/10.1111\/j.1532-5415.2012.04209.x (2012).","journal-title":"J Am Geriatr Soc"},{"key":"94472_CR46","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3233\/JAD-160428","volume":"54","author":"G Allali","year":"2016","unstructured":"Allali, G., Garibotto, V. & Assal, F. Parkinsonism differentiates idiopathic normal pressure hydrocephalus from its mimics. J Alzheimers Dis 54, 123\u2013127. https:\/\/doi.org\/10.3233\/JAD-160428 (2016).","journal-title":"J Alzheimers Dis"},{"key":"94472_CR47","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.3233\/JAD-200225","volume":"76","author":"M Muurling","year":"2020","unstructured":"Muurling, M. et al. Gait disturbances are associated with increased cognitive impairment and cerebrospinal fluid tau levels in a memory clinic cohort. J Alzheimers Dis 76, 1061\u20131070. https:\/\/doi.org\/10.3233\/JAD-200225 (2020).","journal-title":"J Alzheimers Dis"},{"key":"94472_CR48","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/gerona\/gls191","volume":"68","author":"J Verghese","year":"2013","unstructured":"Verghese, J., Wang, C., Lipton, R. B. & Holtzer, R. Motoric cognitive risk syndrome and the risk of dementia. J Gerontol A Biol Sci Med Sci 68, 412\u2013418. https:\/\/doi.org\/10.1093\/gerona\/gls191 (2013).","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"94472_CR49","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1186\/s12877-023-04175-8","volume":"23","author":"C Tuena","year":"2023","unstructured":"Tuena, C. et al. Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment. BMC Geriatr 23, 462. https:\/\/doi.org\/10.1186\/s12877-023-04175-8 (2023).","journal-title":"BMC Geriatr"},{"key":"94472_CR50","doi-asserted-by":"publisher","first-page":"e44274","DOI":"10.2196\/44274","volume":"9","author":"H Li","year":"2023","unstructured":"Li, H. et al. The Bidirectional Association Between Cognitive Function and Gait Speed in Chinese Older Adults: Longitudinal Observational Study. JMIR Public Health Surveill 9, e44274. https:\/\/doi.org\/10.2196\/44274 (2023).","journal-title":"JMIR Public Health Surveill"},{"key":"94472_CR51","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1002\/alz.13517","volume":"20","author":"J Lin","year":"2024","unstructured":"Lin, J. et al. A detection model of cognitive impairment via the integrated gait and eye movement analysis from a large Chinese community cohort. Alzheimers Dement 20, 1089\u20131101. https:\/\/doi.org\/10.1002\/alz.13517 (2024).","journal-title":"Alzheimers Dement"},{"key":"94472_CR52","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","volume":"112","author":"H Braak","year":"2006","unstructured":"Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H. & Del Tredici, K. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112, 389\u2013404. https:\/\/doi.org\/10.1007\/s00401-006-0127-z (2006).","journal-title":"Acta Neuropathol"},{"key":"94472_CR53","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1002\/alz.12412","volume":"18","author":"GT Gomez","year":"2022","unstructured":"Gomez, G. T. et al. The association of motoric cognitive risk with incident dementia and neuroimaging characteristics: The atherosclerosis risk in communities study. Alzheimers Dement 18, 434\u2013444. https:\/\/doi.org\/10.1002\/alz.12412 (2022).","journal-title":"Alzheimers Dement"},{"key":"94472_CR54","doi-asserted-by":"publisher","first-page":"925","DOI":"10.3233\/JAD-220712","volume":"91","author":"H Zhao","year":"2023","unstructured":"Zhao, H., Wei, W., Xie, H. & Huang, Y. Motoric cognitive risk syndrome among Chinese older adults with white matter lesions: A cross-sectional observational study. J Alzheimers Dis 91, 925\u2013931. https:\/\/doi.org\/10.3233\/JAD-220712 (2023).","journal-title":"J Alzheimers Dis"},{"key":"94472_CR55","doi-asserted-by":"publisher","first-page":"308","DOI":"10.5014\/ajot.43.5.308","volume":"43","author":"D Larkin","year":"1989","unstructured":"Larkin, D. Movement laterality and its relationship to hemispheric specialization. Am J Occup Ther 43, 308\u2013312. https:\/\/doi.org\/10.5014\/ajot.43.5.308 (1989).","journal-title":"Am J Occup Ther"},{"key":"94472_CR56","first-page":"188","volume":"63","author":"N Geschwind","year":"1975","unstructured":"Geschwind, N. The apraxias: Neural mechanisms of disorders of learned movement. Am Sci 63, 188\u2013195 (1975).","journal-title":"Am Sci"},{"key":"94472_CR57","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1046\/j.1468-1331.2001.00242.x","volume":"8","author":"A Solodkin","year":"2001","unstructured":"Solodkin, A., Hlustik, P., Noll, D. C. & Small, S. L. Lateralization of motor circuits and handedness during finger movements. Eur J Neurol 8, 425\u2013434. https:\/\/doi.org\/10.1046\/j.1468-1331.2001.00242.x (2001).","journal-title":"Eur J Neurol"},{"key":"94472_CR58","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/j.neuroimage.2006.05.043","volume":"32","author":"E Kapreli","year":"2006","unstructured":"Kapreli, E. et al. Lateralization of brain activity during lower limb joints movement. An fMRI study. Neuroimage 32, 1709\u20131721. https:\/\/doi.org\/10.1016\/j.neuroimage.2006.05.043 (2006).","journal-title":"Neuroimage"},{"key":"94472_CR59","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1002\/hbm.22743","volume":"36","author":"T Wu","year":"2015","unstructured":"Wu, T., Hou, Y., Hallett, M., Zhang, J. & Chan, P. Lateralization of brain activity pattern during unilateral movement in Parkinson\u2019s disease. Hum Brain Mapp 36, 1878\u20131891. https:\/\/doi.org\/10.1002\/hbm.22743 (2015).","journal-title":"Hum Brain Mapp"},{"key":"94472_CR60","doi-asserted-by":"publisher","first-page":"119736","DOI":"10.1016\/j.neuroimage.2022.119736","volume":"264","author":"JP Hennessee","year":"2022","unstructured":"Hennessee, J. P. et al. Relationship of prefrontal brain lateralization to optimal cognitive function differs with age. Neuroimage 264, 119736. https:\/\/doi.org\/10.1016\/j.neuroimage.2022.119736 (2022).","journal-title":"Neuroimage"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94472-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94472-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94472-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T13:14:38Z","timestamp":1745673278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94472-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,26]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["94472"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-94472-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,26]]},"assertion":[{"value":"6 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study have been approved by the Ethics Committee of the Nanjing Drum Tower Hospital (Ethics number: 2022-472-02) and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Written informed consent has been obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"14679"}}