{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:16:52Z","timestamp":1792736212416,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-94698-4","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T13:56:49Z","timestamp":1742651809000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel antiluminal breast cancer and immunological activities of Sidr and SidrZamZam honeys and their biogenic AgNPs"],"prefix":"10.1038","volume":"15","author":[{"given":"Hamed A.","family":"Ghramh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essam H.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr Ahmed","family":"El-Arabey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"94698_CR1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.aoas.2015.10.015","volume":"60","author":"SA El Sohaimy","year":"2015","unstructured":"El Sohaimy, S. A., Masry, S. H. D. & Shehata, M. G. Physicochemical characteristics of honey from different origins. Ann. Agric. Sci. 60, 279\u2013287 (2015).","journal-title":"Ann. Agric. Sci."},{"key":"94698_CR2","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1080\/00218839.2020.1746036","volume":"60","author":"EKA Taha","year":"2021","unstructured":"Taha, E. K. A., Al-Kahtani, S. & Taha, R. Comparison of the physicochemical characteristics of sidr (Ziziphus spp.) honey produced by Apis florea F. and Apis mellifera L. J. Apic. Res. 60, 470\u2013477 (2021).","journal-title":"J. Apic. Res."},{"key":"94698_CR3","first-page":"1923","volume":"24","author":"G Al-Ghamdi","year":"2020","unstructured":"Al-Ghamdi, G., Hussein, R. H. & Al-azragi, R. The antioxidant impact of Saudi sidr honey against acetyl salicylic acid- induced gastric ulcer. Med. Sci. 24, 1923\u20131929 (2020).","journal-title":"Med. Sci."},{"key":"94698_CR4","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.4236\/ajps.2018.913192","volume":"9","author":"RA Almalki","year":"2018","unstructured":"Almalki, R. A., Alzahrani, D. A., Almalki, R. A. & Alzahrani, D. A. Morphological Investigation of Genus Ziziphus Mill. (Rhamnaceae) in Saudi Arabia. Am. J. Plant Sci. 9, 2644\u20132658 (2018).","journal-title":"Am. J. Plant Sci."},{"key":"94698_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2020.101329","volume":"33","author":"AA Al-Ghamdi","year":"2021","unstructured":"Al-Ghamdi, A. A. & Ansari, M. J. Biological and therapeutic roles of Saudi Arabian honey: A comparative review. J. King Saud Univ. - Sci. 33, 101329 (2021).","journal-title":"J. King Saud Univ. - Sci."},{"key":"94698_CR6","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1080\/00218839.2017.1399663","volume":"57","author":"S Zerrouk","year":"2018","unstructured":"Zerrouk, S., Seijo, M. C., Escuredo, O. & Rodr\u00edguez-Flores, M. S. Characterization of Ziziphus lotus (jujube) honey produced in Algeria. J. Apic. Res. 57, 166\u2013174 (2018).","journal-title":"J. Apic. Res."},{"key":"94698_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.702487","author":"LA Sampaio","year":"2021","unstructured":"Sampaio, L. A., Pina, L. T. S., Serafini, M. R., Tavares, D. D. S. & Guimar\u00e3es, A. G. Antitumor effects of carvacrol and thymol: A systematic review. Front. Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2021.702487 (2021).","journal-title":"Front. Pharmacol."},{"key":"94698_CR8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.32823","author":"TS Alkhalifah","year":"2022","unstructured":"Alkhalifah, T. S., Almuhaish, L. A. & Syed Mahin, P. M. Remineralization effect of zamzam water on initial artificial carious lesion of permanent teeth. Cureus https:\/\/doi.org\/10.7759\/cureus.32823 (2022).","journal-title":"Cureus"},{"key":"94698_CR9","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/sj.bjp.0707130","volume":"150","author":"C Medina","year":"2007","unstructured":"Medina, C., Santos-Martinez, M. J., Radomski, A., Corrigan, O. I. & Radomski, M. W. Nanoparticles: pharmacological and toxicological significance. Br. J. Pharmacol. 150, 552\u2013558 (2007).","journal-title":"Br. J. Pharmacol."},{"key":"94698_CR10","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3390\/nano8090681","volume":"8","author":"AC Burdu\u0219el","year":"2018","unstructured":"Burdu\u0219el, A. C. et al. Biomedical applications of silver nanoparticles: An up-to-date overview. Nanomaterials 8, 681 (2018).","journal-title":"Nanomaterials"},{"key":"94698_CR11","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.3390\/nano12152560","volume":"12","author":"N Bahari","year":"2022","unstructured":"Bahari, N., Hashim, N., Md Akim, A. & Maringgal, B. Recent advances in honey-based nanoparticles for wound dressing: A review. Nanomaterials 12, 2560 (2022).","journal-title":"Nanomaterials"},{"key":"94698_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5455\/njppp.2022.11.07239202120072021","volume":"12","author":"NR Guruvu","year":"2021","unstructured":"Guruvu, N. R. et al. Synergistic antimicrobial activity of honey combined with silver nanoparticles topically applied in experimentally infected wounds in Wistar albino rats. Natl. J. Physiol. Pharm. Pharmacol. 12, 1\u20131 (2021).","journal-title":"Natl. J. Physiol. Pharm. Pharmacol."},{"key":"94698_CR13","doi-asserted-by":"publisher","first-page":"506","DOI":"10.15537\/smj.2016.5.15000","volume":"37","author":"NA Alnegheimish","year":"2016","unstructured":"Alnegheimish, N. A. et al. Molecular subtypes of breast carcinoma in Saudi Arabia. A retrospective study. Saudi Med. J. 37, 506\u2013512 (2016).","journal-title":"Saudi Med. J."},{"key":"94698_CR14","first-page":"913","volume":"15","author":"B AlRajhi","year":"2023","unstructured":"AlRajhi, B. et al. Breast cancer awareness among women in Saudi Arabia: A systematic review. Breast Cancer. 15, 913\u2013924 (2023).","journal-title":"Breast Cancer."},{"key":"94698_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106758","volume":"86","author":"AA El-Arabey","year":"2020","unstructured":"El-Arabey, A. A., Abdalla, M. & Abd-Allah, A. R. SnapShot: TP53 status and macrophages infiltration in TCGA-analyzed tumors. Int. Immunopharmacol. 86, 106758 (2020).","journal-title":"Int. Immunopharmacol."},{"key":"94698_CR16","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1016\/j.clnu.2018.12.019","volume":"38","author":"M Waheed","year":"2019","unstructured":"Waheed, M. et al. Honey and cancer: A mechanistic review. Clin. Nutr. 38, 2499\u20132503 (2019).","journal-title":"Clin. Nutr."},{"key":"94698_CR17","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1166\/jbt.2021.2551","volume":"11","author":"EH Ibrahim","year":"2021","unstructured":"Ibrahim, E. H. et al. Lepidium sativum and its biogenic silver nanoparticles activate immune cells and induce apoptosis and cell cycle arrest in HT-29 colon cancer cells. Biomater. Tissue Eng. 11, 195\u2013209 (2021).","journal-title":"Biomater. Tissue Eng."},{"key":"94698_CR18","first-page":"109","volume":"9","author":"A Verma","year":"2016","unstructured":"Verma, A. & Mehata, M. S. Controllable synthesis of silver nanoparticles using Neem leaves and their antimicrobial activity. J. Radiat. Res. Appl. Sci. 9, 109\u2013115 (2016).","journal-title":"J. Radiat. Res. Appl. Sci."},{"key":"94698_CR19","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s12010-022-04156-4","volume":"195","author":"P Chirumamilla","year":"2023","unstructured":"Chirumamilla, P., Dharavath, S. B. & Taduri, S. Eco-friendly green synthesis of silver nanoparticles from leaf extract of Solanum khasianum: optical properties and biological applications. Appl. Biochem. Biotechnol. 195, 353\u2013368 (2023).","journal-title":"Appl. Biochem. Biotechnol."},{"key":"94698_CR20","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1016\/j.sjbs.2020.10.017","volume":"28","author":"S Almasaudi","year":"2021","unstructured":"Almasaudi, S. The antibacterial activities of honey. Saudi J. Biol. Sci. 28, 2188 (2021).","journal-title":"Saudi J. Biol. Sci."},{"key":"94698_CR21","doi-asserted-by":"publisher","first-page":"5777","DOI":"10.3390\/ijms24065777","volume":"24","author":"A Baran","year":"2023","unstructured":"Baran, A., Kwiatkowska, A. & Potocki, L. Antibiotics and bacterial resistance-A short story of an endless arms race. Int. J. Mol. Sci. 24, 5777 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"94698_CR22","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.3390\/microorganisms10122325","volume":"10","author":"D Rom\u00e1rio-Silva","year":"2022","unstructured":"Rom\u00e1rio-Silva, D. et al. Antimicrobial activity of honey against oral microorganisms: Current reality, methodological challenges and solutions. Microorganisms 10, 2325 (2022).","journal-title":"Microorganisms"},{"key":"94698_CR23","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3390\/antibiotics11070975","volume":"11","author":"ML Hossain","year":"2022","unstructured":"Hossain, M. L., Lim, L. Y., Hammer, K., Hettiarachchi, D. & Locher, C. A review of commonly used methodologies for assessing the antibacterial activity of honey and honey products. Antibiot. 11, 975 (2022).","journal-title":"Antibiot."},{"key":"94698_CR24","doi-asserted-by":"publisher","first-page":"7715","DOI":"10.3390\/ijms22147715","volume":"22","author":"G Czernel","year":"2021","unstructured":"Czernel, G. et al. Biodirected synthesis of silver nanoparticles using aqueous honey solutions and evaluation of their antifungal activity against Pathogenic Candida Spp. Int. J. Mol. Sci 22, 7715 (2021).","journal-title":"Int. J. Mol. Sci"},{"key":"94698_CR25","doi-asserted-by":"publisher","DOI":"10.1088\/2043-6254\/aa8b44","volume":"8","author":"AMS Hosny","year":"2017","unstructured":"Hosny, A. M. S., Kashef, M. T., Rasmy, S. A., Aboul-Magd, D. S. & El-Bazza, Z. E. Antimicrobial activity of silver nanoparticles synthesized using honey and gamma radiation against silver-resistant bacteria from wounds and burns. Adv. Nat. Sci. Nanosci. Nanotechnol. 8, 045009 (2017).","journal-title":"Adv. Nat. Sci. Nanosci. Nanotechnol."},{"key":"94698_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/109636","volume":"2012","author":"SZ Hussein","year":"2012","unstructured":"Hussein, S. Z., Mohd Yusoff, K., Makpol, S. & Mohd Yusof, Y. A. Gelam honey inhibits the production of proinflammatory, mediators NO, PGE 2, TNF-\u03b1, and IL-6 in carrageenan-induced acute paw edema in rats. Evid. Based Complement. Altern. Med. 2012, 1\u201313 (2012).","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"94698_CR27","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s12951-022-01476-9","volume":"20","author":"GSR Raju","year":"2022","unstructured":"Raju, G. S. R. et al. Nanoparticles mediated tumor microenvironment modulation: Current advances and applications. J. Nanobiotechnol. 20, 274 (2022).","journal-title":"J. Nanobiotechnol."},{"key":"94698_CR28","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/s10311-020-01033-6","volume":"18","author":"AB Sengul","year":"2020","unstructured":"Sengul, A. B. & Asmatulu, E. Toxicity of metal and metal oxide nanoparticles: A review. Environ. Chem. Lett. 18, 1659\u20131683 (2020).","journal-title":"Environ. Chem. Lett."},{"issue":"4","key":"94698_CR29","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.3390\/nu13041269","volume":"13","author":"RJ Masad","year":"2021","unstructured":"Masad, R. J. et al. The immunomodulatory effects of honey and associated flavonoids in cancer. Nutrients 13(4), 1269 (2021).","journal-title":"Nutrients"},{"key":"94698_CR30","doi-asserted-by":"publisher","first-page":"4536","DOI":"10.21037\/jtd.2020.03.119","volume":"12","author":"KM Quinn","year":"2020","unstructured":"Quinn, K. M. Innovative approaches to immunotherapy in breast cancer. J. Thorac. Dis. 12, 4536\u20134540 (2020).","journal-title":"J. Thorac. Dis."},{"key":"94698_CR31","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s10549-019-05135-w","volume":"175","author":"L Guo","year":"2019","unstructured":"Guo, L. et al. A high-risk luminal A dominant breast cancer subtype with increased mobility. Breast Cancer Res. Treat. 175, 459\u2013472 (2019).","journal-title":"Breast Cancer Res. Treat."},{"key":"94698_CR32","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s10311-016-0583-1","volume":"14","author":"N Dasgupta","year":"2016","unstructured":"Dasgupta, N. & Ramalingam, C. Silver nanoparticle antimicrobial activity explained by membrane rupture and reactive oxygen generation. Environ. Chem. Lett. 14, 477\u2013485 (2016).","journal-title":"Environ. Chem. Lett."},{"key":"94698_CR33","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s10311-018-0800-1","volume":"17","author":"Z Guo","year":"2018","unstructured":"Guo, Z., Zeng, G., Cui, K. & Chen, A. Toxicity of environmental nanosilver: mechanism and assessment. Environ. Chem. Lett. 17, 319\u2013333 (2018).","journal-title":"Environ. Chem. Lett."},{"key":"94698_CR34","doi-asserted-by":"publisher","first-page":"djv073","DOI":"10.1093\/jnci\/djv073","volume":"107","author":"AV Lee","year":"2015","unstructured":"Lee, A. V., Oesterreich, S. & Davidson, N. E. MCF-7 cells\u2013changing the course of breast cancer research and care for 45 years. J. Natl. Cancer Inst. 107, djv073 (2015).","journal-title":"J. Natl. Cancer Inst."},{"key":"94698_CR35","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1177\/09731296221145076","volume":"19","author":"WS Hamadou","year":"2023","unstructured":"Hamadou, W. S. et al. Acacia honey-derived bioactive compounds exhibit induction of p53-dependent apoptosis in the MCF-7 human breast cancer cell line. Pharmacogn. Mag. 19, 144\u2013155. https:\/\/doi.org\/10.1177\/09731296221145076 (2023).","journal-title":"Pharmacogn. Mag."},{"key":"94698_CR36","doi-asserted-by":"publisher","first-page":"208","DOI":"10.5306\/wjco.v15.i2.208","volume":"15","author":"H-L Zhang","year":"2024","unstructured":"Zhang, H.-L. et al. Elucidating the molecular basis of ATP-induced cell death in breast cancer: Construction of a robust prognostic model. World J. Clin. Oncol. 15, 208\u2013242 (2024).","journal-title":"World J. Clin. Oncol."},{"key":"94698_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00167","author":"P Aryappalli","year":"2017","unstructured":"Aryappalli, P. et al. The IL-6\/STAT3 signaling pathway is an early target of manuka honey-induced suppression of human breast cancer cells. Front. Oncol. https:\/\/doi.org\/10.3389\/fonc.2017.00167 (2017).","journal-title":"Front. Oncol."},{"key":"94698_CR38","doi-asserted-by":"publisher","unstructured":"Portokalakis, I., Mohd Yusof, H. I., Ghanotakis, D. F., Singh Nigam, P. & Owusu-Apenten, R. K. Manuka honeyinduced cytotoxicity against MCF7 breast cancer cells is correlated to total phenol content and antioxidant power. J. adv. biol. biotechnol., 8(2), 1\u201310. https:\/\/doi.org\/10.9734\/JABB\/2016\/27899 (2016).","DOI":"10.9734\/JABB\/2016\/27899"},{"key":"94698_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2022.101878","volume":"34","author":"EH Ibrahim","year":"2022","unstructured":"Ibrahim, E. H. et al. Origanum majorana harvested from Al-Soda, Saudi Arabia promotes mitotic arrest and apoptosis in colon cancer cells. J. King Saud Univ. Sci. 34, 101878 (2022).","journal-title":"J. King Saud Univ. Sci."},{"key":"94698_CR40","first-page":"297","volume":"37","author":"HA Gramah","year":"2024","unstructured":"Gramah, H. A., Ahmad, Z. & Ibrahim, E. H. Facile synthesis of silver and gold nanoparticles using mangrove (Avicennia marina) leaves extract and its cytotoxicity and larvicidal activity\u2014PubMed. Pak. J. Pharm. Sci. 37, 297\u2013305 (2024).","journal-title":"Pak. J. Pharm. Sci."},{"key":"94698_CR41","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.aspen.2017.12.001","volume":"21","author":"HA Ghramh","year":"2018","unstructured":"Ghramh, H. A., Al-Ghamdi, K. M., Mahyoub, J. A. & Ibrahim, E. H. Chrysanthemum extract and extract prepared silver nanoparticles as biocides to control Aedes aegypti (L.), the vector of dengue fever. J. Asia. Pac. Entomol. 21, 205\u2013210 (2018).","journal-title":"J. Asia. Pac. Entomol."},{"key":"94698_CR42","doi-asserted-by":"publisher","unstructured":"Arora, S. et al. Synergistic effect of plant extracts on endodontic pathogens isolated from teeth with root canal treatment failure: An in vitro study. Antibiotics 10, 552. https:\/\/doi.org\/10.3390\/antibiotics10050552 (2021).","DOI":"10.3390\/antibiotics10050552"},{"key":"94698_CR43","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1016\/j.sjbs.2018.08.019","volume":"26","author":"EH Ibrahim","year":"2019","unstructured":"Ibrahim, E. H., Taha, R., Ghramh, H. A. & Kilany, M. Development of rift valley fever (RVF) vaccine by genetic joining of the RVF-glycoprotein Gn with the strong adjuvant subunit B of cholera toxin (CTB) and expression in bacterial system. Saudi J. Biol. Sci. 26, 1676\u20131681 (2019).","journal-title":"Saudi J. Biol. Sci."},{"key":"94698_CR44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059140","volume":"8","author":"M Oves","year":"2013","unstructured":"Oves, M. et al. Antibacterial and cytotoxic efficacy of extracellular silver nanoparticles biofabricated from chromium reducing novel OS4 strain of Stenotrophomonas maltophilia. PLoS One 8, e59140 (2013).","journal-title":"PLoS One"},{"key":"94698_CR45","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.3390\/nu13041269","volume":"13","author":"RJ Masad","year":"2021","unstructured":"Masad, R. J. et al. The immunomodulatory effects of honey and associated flavonoids in cancer. Nutrients 13, 1269 (2021).","journal-title":"Nutrients"},{"key":"94698_CR46","doi-asserted-by":"publisher","first-page":"970","DOI":"10.2174\/1871520620666200213104224","volume":"20","author":"HA Ghramh","year":"2020","unstructured":"Ghramh, H. A., Ibrahim, E. H. & Kilnay, M. Majra honey abrogated the normal and cancer cells proliferation inhibition by Juniperus procera extract and extract\/honey generated AgNPs. Anticancer. Agents Med. Chem. 20, 970\u2013981 (2020).","journal-title":"Anticancer. Agents Med. Chem."},{"key":"94698_CR47","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1054","volume":"3","author":"A Santos","year":"2015","unstructured":"Santos, A. et al. Comprehensive comparison of large-scale tissue expression datasets. PeerJ 3, e1054 (2015).","journal-title":"PeerJ"},{"key":"94698_CR48","first-page":"bae100","volume":"2016","author":"AD Rouillard","year":"2016","unstructured":"Rouillard, A. D. et al. The harmonizome: A collection of processed datasets gathered to serve and mine knowledge about genes and proteins. Database J. Biol. Databases Curation 2016, bae100 (2016).","journal-title":"Database J. Biol. Databases Curation"},{"key":"94698_CR49","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","volume":"77","author":"T Li","year":"2017","unstructured":"Li, T. et al. TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 77, e108\u2013e110 (2017).","journal-title":"Cancer Res."},{"key":"94698_CR50","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s12032-023-02140-4","volume":"40","author":"AA El-Arabey","year":"2023","unstructured":"El-Arabey, A. A. et al. Metformin as a promising target for DPP4 expression: Computational modeling and experimental validation. Med. Oncol. 40, 277 (2023).","journal-title":"Med. Oncol."},{"key":"94698_CR51","doi-asserted-by":"publisher","unstructured":"Li, W., Shih, A., Freudenberg-Hua, Y., Fury, W. & Yang Y. Beyond standard pipeline and p < 0.05 in pathway enrichment analyses. Comput. Biol. Chem. 92, 107455. https:\/\/doi.org\/10.1016\/j.compbiolchem.2021.107455 (2021).","DOI":"10.1016\/j.compbiolchem.2021.107455"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94698-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94698-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94698-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T03:00:46Z","timestamp":1742958046000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94698-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,22]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["94698"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-94698-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,22]]},"assertion":[{"value":"15 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9973"}}