{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:28:03Z","timestamp":1790803683357,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Science and Technology Program of Traditional Chinese Medicine in Zhejiang Province","award":["2024ZL718"],"award-info":[{"award-number":["2024ZL718"]}]},{"name":"Japan Science and Technology Agency (JST) Support for Pioneering Research Initiated by the Next Generation","award":["JPMJSP2145"],"award-info":[{"award-number":["JPMJSP2145"]}]},{"name":"Tongji University Support for Outstanding Ph.D Student Short-Term Overseas Research Funding","award":["2023020043"],"award-info":[{"award-number":["2023020043"]}]},{"name":"Zhejiang Provincial Medical and Health Technology Project","award":["WKJZJ-2315"],"award-info":[{"award-number":["WKJZJ-2315"]}]},{"name":"Science and Technology Development Project of Hangzhou","award":["202204A10"],"award-info":[{"award-number":["202204A10"]}]},{"name":"Medical and Health Technology Project of Hangzhou","award":["Z20240021"],"award-info":[{"award-number":["Z20240021"]}]},{"name":"Medical Key Disciplines of Hangzhou","award":["OO20200485"],"award-info":[{"award-number":["OO20200485"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-94734-3","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T04:03:30Z","timestamp":1742961810000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["AI-powered model for predicting mortality risk in VA-ECMO patients: a multicenter cohort study"],"prefix":"10.1038","volume":"15","author":[{"given":"Shuai","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichen","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifeng","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"94734_CR1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00134-022-06947-z","volume":"49","author":"LC Pladet","year":"2023","unstructured":"Pladet, L. C. et al. Prognostic models for mortality risk in patients requiring ecmo. Intensive Care Med. 49, 131\u2013141 (2023).","journal-title":"Intensive Care Med."},{"key":"94734_CR2","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1093\/eurheartj\/ehv051","volume":"36","author":"H Thiele","year":"2015","unstructured":"Thiele, H., Ohman, E. M., Desch, S., Eitel, I. & De Waha, S. Management of cardiogenic shock. Eur. Heart J. 36, 1223\u20131230 (2015).","journal-title":"Eur. Heart J."},{"key":"94734_CR3","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/j.jacc.2014.03.046","volume":"63","author":"D Abrams","year":"2014","unstructured":"Abrams, D., Combes, A. & Brodie, D. Extracorporeal membrane oxygenation in cardiopulmonary disease in adults. J. Am. Coll. Cardiol. 63, 2769\u20132778 (2014).","journal-title":"J. Am. Coll. Cardiol."},{"key":"94734_CR4","first-page":"172","volume":"15","author":"A Zangrillo","year":"2013","unstructured":"Zangrillo, A. et al. A meta- analysis of complications and mortality of extracorporeal membrane oxygenation. Crit. Care Resusc. 15, 172\u2013178 (2013).","journal-title":"Crit. Care Resusc."},{"key":"94734_CR5","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s00134-016-4273-z","volume":"42","author":"C Karagiannidis","year":"2016","unstructured":"Karagiannidis, C. et al. Extracorporeal membrane oxygenation: evolving epidemiology and mortality. Intensive Care Med. 42, 889\u2013896 (2016).","journal-title":"Intensive Care Med."},{"key":"94734_CR6","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.athoracsur.2013.09.008","volume":"97","author":"R Cheng","year":"2014","unstructured":"Cheng, R. et al. Complications of extracorporeal membrane oxygenation for treatment of cardiogenic shock and cardiac arrest: A meta-analysis of 1,866 adult patients. Ann. Thorac. Surg. 97, 610\u2013616 (2014).","journal-title":"Ann. Thorac. Surg."},{"key":"94734_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/cc11811","volume":"16","author":"CL Hodgson","year":"2012","unstructured":"Hodgson, C. L. et al. Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia. Crit. Care 16, 1\u201310 (2012).","journal-title":"Crit. Care"},{"key":"94734_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0003-4975(03)01329-8","volume":"77","author":"N Doll","year":"2004","unstructured":"Doll, N. et al. Five-year results of 219 consecutive patients treated with extracorporeal membrane oxygenation for refractory postoperative cardiogenic shock. Ann. Thorac. Surg. 77, 151\u2013157 (2004).","journal-title":"Ann. Thorac. Surg."},{"key":"94734_CR9","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.resuscitation.2012.01.037","volume":"83","author":"H Kim","year":"2012","unstructured":"Kim, H. et al. Efficacy of veno-arterial extracorporeal membrane oxygenation in acute myocardial infarction with cardiogenic shock. Resuscitation 83, 971\u2013975 (2012).","journal-title":"Resuscitation"},{"key":"94734_CR10","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1097\/CCM.0b013e3181e8acf7","volume":"38","author":"J-J Sheu","year":"2010","unstructured":"Sheu, J.-J. et al. Early extracorporeal membrane oxygenator-assisted primary percutaneous coronary intervention improved 30-day clinical outcomes in patients with st-segment elevation myocardial infarction complicated with profound cardiogenic shock. Crit. Care Med. 38, 1810\u20131817 (2010).","journal-title":"Crit. Care Med."},{"key":"94734_CR11","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1093\/eurheartj\/ehv194","volume":"36","author":"M Schmidt","year":"2015","unstructured":"Schmidt, M. et al. Predicting survival after ECMO for refractory cardiogenic shock: The survival after veno-arterial-ECMO (save)-score. Eur. Heart J. 36, 2246\u20132256 (2015).","journal-title":"Eur. Heart J."},{"key":"94734_CR12","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s11897-014-0206-8","volume":"11","author":"S Laribi","year":"2014","unstructured":"Laribi, S. & Mebazaa, A. Cardiohepatic syndrome: Liver injury in decompensated heart failure. Curr. Heart Fail. Rep. 11, 236\u2013240 (2014).","journal-title":"Curr. Heart Fail. Rep."},{"key":"94734_CR13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1055\/s-0031-1284434","volume":"8","author":"AM Alvarez","year":"2011","unstructured":"Alvarez, A. M. & Mukherjee, D. Liver abnormalities in cardiac diseases and heart failure. Int. J. Angiol. 8, 135\u2013142 (2011).","journal-title":"Int. J. Angiol."},{"key":"94734_CR14","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1365-2362.2011.02573.x","volume":"42","author":"G Poelzl","year":"2012","unstructured":"Poelzl, G. et al. Liver dysfunction in chronic heart failure: Prevalence, characteristics and prognostic significance. Eur. J. Clin. Investig. 42, 153\u2013163 (2012).","journal-title":"Eur. J. Clin. Investig."},{"key":"94734_CR15","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1002\/hep.21178","volume":"43","author":"RK Sterling","year":"2006","unstructured":"Sterling, R. K. et al. Development of a simple noninvasive index to predict significant fibrosis in patients with hiv\/hcv coinfection. Hepatology 43, 1317\u20131325 (2006).","journal-title":"Hepatology"},{"key":"94734_CR16","doi-asserted-by":"publisher","first-page":"e000598","DOI":"10.1136\/openhrt-2017-000598","volume":"4","author":"Y Sato","year":"2017","unstructured":"Sato, Y. et al. Liver stiffness assessed by fibrosis-4 index predicts mortality in patients with heart failure. Open Heart 4, e000598 (2017).","journal-title":"Open Heart"},{"key":"94734_CR17","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/s00380-019-01505-y","volume":"35","author":"D Maeda","year":"2020","unstructured":"Maeda, D. et al. Fibrosis-4 index reflects right-sided filling pressure in patients with heart failure. Heart Vessels 35, 376\u2013383 (2020).","journal-title":"Heart Vessels"},{"key":"94734_CR18","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1002\/ehf2.13317","volume":"8","author":"M Nakashima","year":"2021","unstructured":"Nakashima, M. et al. Fibrosis-4 index reflects right ventricular function and prognosis in heart failure with preserved ejection fraction. ESC Heart Fail. 8, 2240\u20132247 (2021).","journal-title":"ESC Heart Fail."},{"key":"94734_CR19","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ijcard.2020.09.056","volume":"324","author":"N Shibata","year":"2021","unstructured":"Shibata, N. et al. Impact of predictive value of fibrosis-4 index in patients hospitalized for acute heart failure. Int. J. Cardiol. 324, 90\u201395 (2021).","journal-title":"Int. J. Cardiol."},{"key":"94734_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.hepres.2005.12.004","volume":"34","author":"AM Attallah","year":"2006","unstructured":"Attallah, A. M., Shiha, G. E., Omran, M. M. & Zalata, K. R. A discriminant score based on four routine laboratory blood tests for accurate diagnosis of severe fibrosis and\/or liver cirrhosis in Egyptian patients with chronic hepatitis C. Hepatol. Res. 34, 163\u2013169 (2006).","journal-title":"Hepatol. Res."},{"key":"94734_CR21","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1002\/ehf2.13829","volume":"9","author":"D Maeda","year":"2022","unstructured":"Maeda, D. et al. Prognostic value of the liver fibrosis marker fibrosis-5 index in patients with acute heart failure. ESC Heart Fail. 9, 1380\u20131387 (2022).","journal-title":"ESC Heart Fail."},{"key":"94734_CR22","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1161\/CIR.0000000000000525","volume":"136","author":"S Van Diepen","year":"2017","unstructured":"Van Diepen, S. et al. Contemporary management of cardiogenic shock: A scientific statement from the American Heart Association. Circulation 136, e232\u2013e268 (2017).","journal-title":"Circulation"},{"key":"94734_CR23","first-page":"385","volume":"8","author":"GS Collins","year":"2024","unstructured":"Collins, G. S. et al. Tripod+ ai statement: Updated guidance for reporting clinical prediction models that use regression or machine learning methods. BMJ 8, 385 (2024).","journal-title":"BMJ"},{"key":"94734_CR24","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1007\/s00134-011-2358-2","volume":"37","author":"N Aissaoui","year":"2011","unstructured":"Aissaoui, N. et al. Predictors of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory cardiogenic shock. Intensive Care Med. 37, 1738\u20131745 (2011).","journal-title":"Intensive Care Med."},{"key":"94734_CR25","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1161\/CIRCRESAHA.115.306883","volume":"118","author":"FB Ortega","year":"2016","unstructured":"Ortega, F. B., Lavie, C. J. & Blair, S. N. Obesity and cardiovascular disease. Circul. Res. 118, 1752\u20131770 (2016).","journal-title":"Circul. Res."},{"key":"94734_CR26","first-page":"970","volume":"383","author":"Y Lu","year":"2013","unstructured":"Lu, Y. et al. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: A pooled analysis of 97 prospective cohorts with 1\u00b7 8 million participants. Lancet (London, England) 383, 970\u2013983 (2013).","journal-title":"Lancet (London, England)"},{"key":"94734_CR27","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1586\/14779072.2014.952283","volume":"12","author":"B Plourde","year":"2014","unstructured":"Plourde, B., Sarrazin, J.-F., Nault, I. & Poirier, P. Sudden cardiac death and obesity. Expert Rev. Cardiovasc. Ther. 12, 1099\u20131110 (2014).","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"94734_CR28","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1177\/2047487317751291","volume":"25","author":"G Finocchiaro","year":"2018","unstructured":"Finocchiaro, G. et al. Obesity and sudden cardiac death in the young: Clinical and pathological insights from a large national registry. Eur. J. Prevent. Cardiol. 25, 395\u2013401 (2018).","journal-title":"Eur. J. Prevent. Cardiol."},{"key":"94734_CR29","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.ijcard.2017.05.004","volume":"240","author":"MA Ohlsson","year":"2017","unstructured":"Ohlsson, M. A., Kennedy, L. M. A., Juhlin, T. & Melander, O. Midlife risk factor exposure and incidence of cardiac arrest depending on cardiac or non-cardiac origin. Int. J. Cardiol. 240, 398\u2013402 (2017).","journal-title":"Int. J. Cardiol."},{"key":"94734_CR30","doi-asserted-by":"publisher","first-page":"18638","DOI":"10.1038\/s41598-020-75752-9","volume":"10","author":"C-W Sung","year":"2020","unstructured":"Sung, C.-W. et al. Obese cardiogenic arrest survivors with significant coronary artery disease had worse in-hospital mortality and neurological outcomes. Sci. Rep. 10, 18638 (2020).","journal-title":"Sci. Rep."},{"key":"94734_CR31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.resuscitation.2016.09.011","volume":"109","author":"G Geri","year":"2016","unstructured":"Geri, G. et al. Influence of body mass index on the prognosis of patients successfully resuscitated from out-of-hospital cardiac arrest treated by therapeutic hypothermia. Resuscitation 109, 49\u201355 (2016).","journal-title":"Resuscitation"},{"key":"94734_CR32","doi-asserted-by":"publisher","first-page":"154025","DOI":"10.1016\/j.jcrc.2022.154025","volume":"69","author":"MP Chavda","year":"2022","unstructured":"Chavda, M. P., Bihari, S., Woodman, R. J., Secombe, P. & Pilcher, D. The impact of obesity on outcomes of patients admitted to intensive care after cardiac arrest. J. Crit. Care 69, 154025 (2022).","journal-title":"J. Crit. Care"},{"key":"94734_CR33","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.5005\/jp-journals-10071-23665","volume":"24","author":"MP Chavda","year":"2020","unstructured":"Chavda, M. P., Pakavakis, A. & Ernest, D. Does obesity influence the outcome of the patients following a cardiac arrest?. Indian J. Crit. Care Med. Peer-Rev. 24, 1077 (2020).","journal-title":"Indian J. Crit. Care Med. Peer-Rev."},{"key":"94734_CR34","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1016\/j.chest.2021.08.001","volume":"160","author":"MR Anderson","year":"2021","unstructured":"Anderson, M. R. & Shashaty, M. G. Impact of obesity in critical illness. Chest 160, 2135\u20132145 (2021).","journal-title":"Chest"},{"key":"94734_CR35","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1097\/CCM.0000000000001310","volume":"43","author":"Y Sakr","year":"2015","unstructured":"Sakr, Y. et al. Being overweight is associated with greater survival in ICU patients: Results from the intensive care over nations audit. Crit. Care Med. 43, 2623\u20132632 (2015).","journal-title":"Crit. Care Med."},{"key":"94734_CR36","doi-asserted-by":"publisher","first-page":"e294","DOI":"10.1097\/CCM.0000000000002954","volume":"46","author":"A De Jong","year":"2018","unstructured":"De Jong, A. et al. Medical versus surgical icu obese patient outcome: A propensity-matched analysis to resolve clinical trial controversies. Crit. Care Med. 46, e294\u2013e301 (2018).","journal-title":"Crit. Care Med."},{"key":"94734_CR37","first-page":"0391","volume":"8","author":"WWS Ng","year":"2025","unstructured":"Ng, W. W. S. et al. Impact of obesity on outcomes in patients receiving extracorporeal membrane oxygenation: A systematic review and meta-analysis. Int. J. Artif. Organs 8, 0391 (2025).","journal-title":"Int. J. Artif. Organs"},{"key":"94734_CR38","doi-asserted-by":"publisher","first-page":"108928","DOI":"10.1016\/j.surg.2024.10.019","volume":"178","author":"C-H Pai","year":"2025","unstructured":"Pai, C.-H. et al. Does obesity matter in patients receiving venoarterial extracorporeal membrane oxygenation? The u-shaped relationship between body mass index and mortality after extracorporeal cardiopulmonary resuscitation. Surgery 178, 108928 (2025).","journal-title":"Surgery"},{"key":"94734_CR39","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s13679-023-00497-1","volume":"12","author":"S Simati","year":"2023","unstructured":"Simati, S., Kokkinos, A., Dalamaga, M. & Argyrakopoulou, G. Obesity paradox: Fact or fiction?. Curr. Obes. Rep. 12, 75\u201385 (2023).","journal-title":"Curr. Obes. Rep."},{"key":"94734_CR40","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1038\/s41366-021-00872-9","volume":"45","author":"R Dana","year":"2021","unstructured":"Dana, R. et al. Obesity and mortality in critically ill covid-19 patients with respiratory failure. Int. J. Obes. 45, 2028\u20132037 (2021).","journal-title":"Int. J. Obes."},{"key":"94734_CR41","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1164\/rccm.202212-2293OC","volume":"208","author":"D Rudym","year":"2023","unstructured":"Rudym, D. et al. Mortality in patients with obesity and acute respiratory distress syndrome receiving extracorporeal membrane oxygenation: The Multicenter Ecmobesity Study. Am. J. Respir. Crit. Care Med. 208, 685\u2013694 (2023).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"94734_CR42","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12890-024-02971-5","volume":"24","author":"X Huang","year":"2024","unstructured":"Huang, X. & Lin, X. Impact of obesity on outcomes of extracorporeal membrane oxygenation support: A systematic review and meta-analysis. BMC Pulm. Med. 24, 157 (2024).","journal-title":"BMC Pulm. Med."},{"key":"94734_CR43","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00134-022-06926-4","volume":"49","author":"M Peetermans","year":"2023","unstructured":"Peetermans, M. et al. Impact of bmi on outcomes in respiratory ecmo: An elso registry study. Intensive Care Med. 49, 37\u201349 (2023).","journal-title":"Intensive Care Med."},{"key":"94734_CR44","first-page":"10","volume":"8","author":"CG McCloskey","year":"2024","unstructured":"McCloskey, C. G., Hatton, K. W., Furfaro, D. & Engoren, M. Obesity is associated with increased mortality in patients undergoing venoarterial extracorporeal membrane oxygenation. Crit. Care Med. 8, 10\u20131097 (2024).","journal-title":"Crit. Care Med."},{"key":"94734_CR45","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13054-022-04074-1","volume":"26","author":"D Zhou","year":"2022","unstructured":"Zhou, D., Wang, C., Lin, Q. & Li, T. The obesity paradox for survivors of critically ill patients. Crit. Care 26, 198 (2022).","journal-title":"Crit. Care"},{"key":"94734_CR46","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00134-019-05594-1","volume":"45","author":"M Schetz","year":"2019","unstructured":"Schetz, M. et al. Obesity in the critically ill: A narrative review. Intensive Care Med. 45, 757\u2013769 (2019).","journal-title":"Intensive Care Med."},{"key":"94734_CR47","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.pcad.2018.06.004","volume":"61","author":"M-E Piche","year":"2018","unstructured":"Piche, M.-E., Poirier, P., Lemieux, I. & Despres, J.-P. Overview of epidemiology and contribution of obesity and body fat distribution to cardiovascular disease: An update. Progress Cardiovasc. Dis. 61, 103\u2013113 (2018).","journal-title":"Progress Cardiovasc. Dis."},{"key":"94734_CR48","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.jcrc.2015.01.015","volume":"30","author":"A Tejedor","year":"2015","unstructured":"Tejedor, A. et al. Accuracy of vigileo\/flotrac monitoring system in morbidly obese patients. J. Crit. Care 30, 562\u2013566 (2015).","journal-title":"J. Crit. Care"},{"key":"94734_CR49","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1053\/j.ajkd.2008.03.020","volume":"52","author":"F Tentori","year":"2008","unstructured":"Tentori, F. et al. Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and pth: The dialysis outcomes and practice patterns study (dopps). Am. J. Kidney Dis. 52, 519\u2013530 (2008).","journal-title":"Am. J. Kidney Dis."},{"key":"94734_CR50","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/sj.ki.5001514","volume":"70","author":"K Kalantar-Zadeh","year":"2006","unstructured":"Kalantar-Zadeh, K. et al. Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients. Kidney Int. 70, 771\u2013780 (2006).","journal-title":"Kidney Int."},{"key":"94734_CR51","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1053\/j.ajkd.2013.08.011","volume":"63","author":"M Fukagawa","year":"2014","unstructured":"Fukagawa, M. et al. Abnormal mineral metabolism and mortality in hemodialysis patients with secondary hyperparathyroidism: Evidence from marginal structural models used to adjust for time-dependent confounding. Am. J. Kidney Dis. 63, 979\u2013987 (2014).","journal-title":"Am. J. Kidney Dis."},{"key":"94734_CR52","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1093\/ndt\/gfv099","volume":"30","author":"JL Fernandez-Mart\u0131n","year":"2015","unstructured":"Fernandez-Mart\u0131n, J. L. et al. Improvement of mineral and bone metabolism markers is associated with better survival in haemodialysis patients: The cosmos study. Nephrol. Dial. Transpl. 30, 1542\u20131551 (2015).","journal-title":"Nephrol. Dial. Transpl."},{"key":"94734_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000478972","volume":"45","author":"J-G Zhu","year":"2018","unstructured":"Zhu, J.-G. et al. Association between extreme values of markers of chronic kidney disease: Mineral and bone disorder and 5-year mortality among prevalent hemodialysis patients. Blood Purif. 45, 1\u20137 (2018).","journal-title":"Blood Purif."},{"key":"94734_CR54","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1001\/jama.2011.308","volume":"305","author":"SC Palmer","year":"2011","unstructured":"Palmer, S. C. et al. Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: A systematic review and meta-analysis. JAMA 305, 1119\u20131127 (2011).","journal-title":"JAMA"},{"key":"94734_CR55","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1097\/MAT.0000000000000895","volume":"65","author":"L Masha","year":"2019","unstructured":"Masha, L. et al. Yellow means caution: Correlations between liver injury and mortality with the use of va-ecmo. ASAIO J. 65, 812\u2013818 (2019).","journal-title":"ASAIO J."},{"key":"94734_CR56","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1177\/2048872615610865","volume":"5","author":"H Sern Lim","year":"2016","unstructured":"Sern Lim, H. Baseline meld-xi score and outcome from veno-arterial extracorporeal membrane oxygenation support for acute decompensated heart failure. Eur. Heart J. Acute Cardiovasc. Care 5, 82\u201388 (2016).","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"94734_CR57","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/MAT.0000000000000171","volume":"61","author":"YH Cho","year":"2015","unstructured":"Cho, Y. H. et al. Extracorporeal life support as a bridge to heart transplantation: Importance of organ failure in recipient selection. ASAIO J. 61, 139\u2013143 (2015).","journal-title":"ASAIO J."},{"key":"94734_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13054-016-1242-4","volume":"20","author":"C Roth","year":"2016","unstructured":"Roth, C. et al. Liver function predicts survival in patients undergoing extracorporeal membrane oxygenation following cardiovascular surgery. Crit. Care 20, 1\u20137 (2016).","journal-title":"Crit. Care"},{"key":"94734_CR59","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1111\/aor.12386","volume":"38","author":"B Maxhera","year":"2014","unstructured":"Maxhera, B. et al. Survival predictors in ventricular assist device patients with prior extracorporeal life support: Selecting appropriate candidates. Artif. Organs 38, 727\u2013732 (2014).","journal-title":"Artif. Organs"},{"key":"94734_CR60","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1177\/039139880602901205","volume":"29","author":"A Rastan","year":"2006","unstructured":"Rastan, A. et al. Autopsy findings in patients on postcardiotomy extracorporeal membrane oxygenation (ECMO). Int. J. Artif. Organs 29, 1121\u20131131 (2006).","journal-title":"Int. J. Artif. Organs"},{"key":"94734_CR61","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41598-021-04519-7","volume":"12","author":"S Roth","year":"2022","unstructured":"Roth, S. et al. Neutrophil-lymphoycyte-ratio, platelet-lymphocyte-ratio and procalcitonin for early assessment of prognosis in patients undergoing va-ecmo. Sci. Rep. 12, 542 (2022).","journal-title":"Sci. Rep."},{"key":"94734_CR62","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1007\/s12265-020-10078-5","volume":"14","author":"NA Diakos","year":"2021","unstructured":"Diakos, N. A. et al. Systemic inflammatory burden correlates with severity and predicts outcomes in patients with cardiogenic shock supported by a percutaneous mechanical assist device. J. Cardiovasc. Transl. Res. 14, 476\u2013483 (2021).","journal-title":"J. Cardiovasc. Transl. Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94734-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94734-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94734-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T09:03:40Z","timestamp":1746003820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94734-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["94734"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-94734-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]},"assertion":[{"value":"27 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this Article was revised: The Funding section in the original version of this Article was omitted. The Funding section now reads: \u201cThis research was partially supported by Science and Technology Program of Traditional Chinese Medicine in Zhejiang Province (Grant: 2024ZL718), Zhejiang Provincial Medical and Health Technology Project (Grant: WKJZJ-2315), Science and Technology Development Project of Hangzhou (Grant: 202204A10), Medical and Health Technology Project of Hangzhou (Grant: Z20240021), Construction Fund of Medical Key Disciplines of Hangzhou (Grant: OO20200485), the Japan Science and Technology Agency (JST) Support for Pioneering Research Initiated by the Next Generation (SPRING) (Grant Number: JPMJSP2145), and the Tongji University Support for Outstanding Ph.D Student Short-Term Overseas Research Funding (Grant Number: 2023020043).\u201d The original article has been corrected.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the local institutional review boards. The patients\/participants provided their written informed consent to participate in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"10362"}}