{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:11:24Z","timestamp":1790795484549,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-94735-2","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T09:04:32Z","timestamp":1742720672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Contribution of 18\u00a0F-fluorocholine PET-CT to the preoperative localisation of parathyroid adenoma for the treatment of primary hyperparathyroidism"],"prefix":"10.1038","volume":"15","author":[{"given":"Suzanne","family":"Garnier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mentine","family":"Mah\u00e9o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gael","family":"Potard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-B\u00e9atrice","family":"Cavarec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Roudaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Thuillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Marianowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Abgral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Leclere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"key":"94735_CR1","unstructured":"Bilezikian, J. P. and al., International workshop on primary hyperparathyroidism, evaluation and management of primary hyperparathyroidism: summary statement and guidelines from the fifth international workshop. J. Bone Miner. Res. 37 (11), 2293\u20132314. (2022)."},{"issue":"4","key":"94735_CR2","doi-asserted-by":"publisher","first-page":"577","DOI":"10.2967\/jnumed.119.229914","volume":"61","author":"A Cuderman","year":"2020","unstructured":"Cuderman, A. 18F-Fluorocholine PET\/CT in primary hyperparathyroidism: superior diagnostic performance to conventional scintigraphic imaging for localization of hyperfunctioning parathyroid glands. J. Nucl. Med. 61 (4), 577\u2013583 (2020).","journal-title":"J. Nucl. Med."},{"issue":"1","key":"94735_CR3","first-page":"58","volume":"32","author":"T Madkhali","year":"2016","unstructured":"Madkhali, T., Alhefdhi, A., Chen, H. & Elfenbein, D. Primary hyperparathyroidism. Ulus Cerrahi Derg. 32 (1), 58\u201366 (2016).","journal-title":"Ulus Cerrahi Derg"},{"key":"94735_CR4","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s12020-020-02487-y","volume":"71","author":"L Giovanella","year":"2021","unstructured":"Giovanella, L. Will 18F-fluorocholine PET\/CT replace other methods of preoperative parathyroid imaging ? Endocrine 71, 285\u2013297 (2021).","journal-title":"Endocrine"},{"issue":"4","key":"94735_CR5","doi-asserted-by":"publisher","first-page":"104315","DOI":"10.1016\/j.amjoto.2024.104315","volume":"45","author":"SB Ferrari","year":"2024","unstructured":"Ferrari, S. B. Clinical predictors of negative\/equivocal SPECT imaging outcomes in primary hyperparathyroidism: factors calling for 18F-choline-PET. Am. J. Otolaryngol. 45 (4), 104315 (2024).","journal-title":"Am. J. Otolaryngol."},{"issue":"12","key":"94735_CR6","doi-asserted-by":"publisher","first-page":"4531","DOI":"10.1210\/jc.2014-2821","volume":"99","author":"L Michaud","year":"2014","unstructured":"Michaud, L. Is 18F-fluorocholine-positron emission tomography\/computerized tomography a new imaging tool for detecting hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism ? J. Clin. Endocrinol. Metab. 99 (12), 4531\u20134536 (2014).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"94735_CR7","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1001\/jamaoto.2021.0915","volume":"147","author":"SW Lee","year":"2021","unstructured":"Lee, S. W., Shim, S. R., Jeong, S. Y. & Kim, S. J. Direct comparison of preoperative imaging modalities for localization of primary hyperparathyroidism: a systematic review and network meta-analysis. JAMA Otolaryngol. Head Neck Surg. 147, 692\u2013706 (2021).","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"issue":"1","key":"94735_CR8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1530\/EJE-21-0038","volume":"185","author":"F Bioletto","year":"2021","unstructured":"Bioletto, F. Comparison of the diagnostic accuracy of 18F-Fluorocholine PET and 11\u00a0C-Methionine PET for parathyroid localization in primary hyperparathyroidism: a systematic review and meta-analysis. Eur. J. Endocrinol. 185 (1), 109\u2013120 (2021).","journal-title":"Eur. J. Endocrinol."},{"key":"94735_CR9","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1007\/s00259-018-4018-z","volume":"45","author":"S Grimaldi","year":"2018","unstructured":"Grimaldi, S. Challenging pre-surgical localization of hyperfunctioning parathyroid glands in primary hyperparathyroidism: the added value of 18F-fluorocholine PET\/CT. Eur. J. Nucl. Med. Mol. Imaging  45, 1772\u20131780 (2018).","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"3","key":"94735_CR10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3390\/biomedicines9030231","volume":"9","author":"C Ferrari","year":"2021","unstructured":"Ferrari, C. Diagnostic value of choline PET in the preoperative localization of hyperfunctioning parathyroid gland(s): a comprehensive overview. Biomedicines 9 (3), 231 (2021).","journal-title":"Biomedicines"},{"issue":"12","key":"94735_CR11","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.21037\/gs-23-317","volume":"12","author":"HW Wolf","year":"2023","unstructured":"Wolf, H. W. & Nebiker, C. A. Preoperative identification of small parathyroid adenomas-better done by fluorocholine positron emission tomography\/computed tomography. Gland Surg. 12 (12), 1686\u20131695 (2023).","journal-title":"Gland Surg."},{"issue":"2","key":"94735_CR12","doi-asserted-by":"publisher","first-page":"96","DOI":"10.23736\/S1824-4785.23.03513-6","volume":"67","author":"JN Talbot","year":"2023","unstructured":"Talbot, J. N. 18F-fluorocholine PET\/CT detects parathyroid gland hyperplasia as well as adenoma: 401 PET\/CTs in one center. Q. J. Nucl. Med. Mol. Imaging  67 (2), 96\u2013113 (2023).","journal-title":"Q. J. Nucl. Med. Mol. Imaging"},{"key":"94735_CR13","doi-asserted-by":"crossref","unstructured":"Quak, E. and al., F18-Choline PET\/CT or Mibi SPECT\/CT in the surgical management of primary hyperparathyroidism: a diagnostic randomized clinical trial. JAMA Otolaryngol. Head Neck Surg. e241421. (2024).","DOI":"10.1001\/jamaoto.2024.1421"},{"issue":"4","key":"94735_CR14","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1055\/a-2262-9249","volume":"132","author":"A Mandic","year":"2024","unstructured":"Mandic, A. Diagnostic performance of 99mTc-Sestamibi SPECT\/CT and 18F-Choline PET\/CT in locating hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism. Exp. Clin. Endocrinol. Diabetes  132 (4), 216\u2013220 (2024).","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"2","key":"94735_CR15","doi-asserted-by":"publisher","first-page":"130","DOI":"10.23736\/S1824-4785.23.03514-8","volume":"67","author":"F Fiz","year":"2023","unstructured":"Fiz, F. [18F]F-Choline PET\/CT and 4D-CT in the evaluation of primary hyperparathyroidism: rivals or allies ? Q. J. Nucl. Med. Mol. Imaging 67 (2), 130\u2013137 (2023).","journal-title":"Q. J. Nucl. Med. Mol. Imaging"},{"key":"94735_CR16","doi-asserted-by":"crossref","unstructured":"Aphale, R. and al., Impact of fluoro-choline PET\/CT in reduction in failed parathyroid localization in primary hyperparathyroidism. World J. Surg. (2023).","DOI":"10.1007\/s00268-022-06866-6"},{"issue":"3","key":"94735_CR17","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/cen.14875","volume":"99","author":"DD Patel","year":"2023","unstructured":"Patel, D. D. Comparison of 4D computed tomography and F-18 fluorocholine PET for localisation of parathyroid lesions in primary hyperparathyroidism: a systematic review and meta-analysis. Clin. Endocrinol. (Oxford)  99 (3), 262\u2013271 (2023).","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"5","key":"94735_CR18","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1007\/s00259-023-06573-x","volume":"51","author":"G Treglia","year":"2024","unstructured":"Treglia, G., Rizzo, A. & Piccardo, A. Expanding the clinical indications of [18F]fluorocholine PET\/CT in primary hyperparathyroidism: the evidence cannot be evaded. Eur. J. Nucl. Med. Mol. Imaging  51 (5), 1345\u20131348 (2024).","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"issue":"8","key":"94735_CR19","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1210\/clinem\/dgad073","volume":"108","author":"E Koumakis","year":"2023","unstructured":"Koumakis, E. FCH-PET\/CT in primary hyperparathyroidism with discordant\/negative Mibi scintigraphy and ultrasonography. J. Clin. Endocrinol. Metab. 108 (8), 1958\u20131967 (2023).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"94735_CR20","first-page":"43","volume":"73","author":"A Mazurek","year":"2022","unstructured":"Mazurek, A. The utility of 18F-fluorocholine PET\/CT in the imaging of parathyroid adenomas. Endokrynol. Pol. 73 (1), 43\u201348 (2022).","journal-title":"Endokrynol Pol."},{"key":"94735_CR21","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3389\/fendo.2017.00380","volume":"8","author":"S Fischli","year":"2018","unstructured":"Fischli, S. The significance of 18F-Fluorocholine-PET\/CT as localizing imaging technique in patients with primary hyperparathyroidism and negative conventional imaging. Front. Endocrinol. (Lausanne)  8, 380 (2018).","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1\u20132","key":"94735_CR22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10354-018-0660-0","volume":"169","author":"G Schweighofer-Zwink","year":"2019","unstructured":"Schweighofer-Zwink, G. Darstellung und lokalisation von nebenschilddr\u00fcsenadenomen Mit F\u201318 Cholin PET\/CT [imaging of parathyroid adenomas with F\u201318 choline PET-CT]. Wien Med. Wochenschr.  169 (1\u20132), 15\u201324 (2019).","journal-title":"Wien Med. Wochenschr"},{"issue":"3","key":"94735_CR23","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s00259-018-4123-z","volume":"46","author":"G Treglia","year":"2019","unstructured":"Treglia, G. Diagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysis. Eur. J. Nucl. Med. Mol. Imaging 46 (3), 751\u2013765 (2019).","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"94735_CR24","doi-asserted-by":"publisher","first-page":"1148287","DOI":"10.3389\/fmed.2023.1148287","volume":"10","author":"A Imperiale","year":"2023","unstructured":"Imperiale, A. Does 18F-Fluorocholine PET\/CT add value to positive parathyroid scintigraphy in the presurgical assessment of primary hyperparathyroidism? Front. Med. (Lausanne) 10, 1148287 (2023).","journal-title":"Front. Med. (Lausanne)"},{"issue":"1","key":"94735_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1530\/EJE-12-0742","volume":"168","author":"F Boi","year":"2012","unstructured":"Boi, F. Thyroid diseases cause mismatch between MIBI scan and neck ultrasound in the diagnosis of hyperfunctioning parathyroids: usefulness of FNA-PTH assay. Eur. J. Endocrinol. 168 (1), 49\u201358 (2012).","journal-title":"Eur. J. Endocrinol."},{"issue":"5","key":"94735_CR26","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1007\/s00268-019-04910-6","volume":"43","author":"C Amadou","year":"2019","unstructured":"Amadou, C. 18F-Fluorocholine PET\/CT and parathyroid 4D computed tomography for primary hyperparathyroidism : the challenge of reoperative patients. World J. Surg. 43 (5), 1232\u20131242 (2019).","journal-title":"World J. Surg."},{"issue":"7","key":"94735_CR27","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1308\/rcsann.2019.0059","volume":"101","author":"I Christakis","year":"2019","unstructured":"Christakis, I. 18Fluorocholine PET\/CT scanning with arterial phase-enhanced CT is useful for persistent\/recurrent primary hyperparathyroidism: first UK case series results. Ann. R Coll. Surg. Engl. 101 (7), 501\u2013507 (2019).","journal-title":"Ann. R Coll. Surg. Engl."},{"key":"94735_CR28","unstructured":"Gauth\u00e9, M. Optimisation m\u00e9dico-\u00e9conomique des strat\u00e9gies d\u2019utilisation des examens TEP\/TDM en imagerie oncologique. M\u00e9decine Hum.  Pathol.  (2020)."},{"key":"94735_CR29","doi-asserted-by":"crossref","unstructured":"Van Mossel, S. and al., Cost-effectiveness of one-stop-shop [18F] Fluorocholine PET\/CT to localise parathyroid adenomas in patients suffering from primary hyperparathyroidism. Eur. J. Nucl. Med. Mol. Imaging (2024).","DOI":"10.1007\/s00259-024-06771-1"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94735-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94735-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94735-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T20:45:27Z","timestamp":1742762727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-94735-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,23]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["94735"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-94735-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,23]]},"assertion":[{"value":"18 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10018"}}