{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:37:11Z","timestamp":1793979431353,"version":"4.8.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-025-95005-x","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T03:43:43Z","timestamp":1742787823000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of oral nutritional supplementation combined with probiotics on the liver function and intestinal microflora in lung cancer chemotherapy patients through the gut-liver axis"],"prefix":"10.1038","volume":"15","author":[{"given":"Xuelong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fubo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"95005_CR1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","volume":"72","author":"RL Siegel","year":"2022","unstructured":"Siegel, R. L., Miller, K. D., Fuchs, H. E. & Jemal, A. Cancer statistics, 2022. CA Cancer J. Clin. 72, 7\u201333 (2022).","journal-title":"CA Cancer J. Clin."},{"key":"95005_CR2","doi-asserted-by":"crossref","first-page":"102361","DOI":"10.1016\/j.anaerobe.2021.102361","volume":"68","author":"N Chattipakorn","year":"2021","unstructured":"Chattipakorn, N. & Chattipakorn, S. C.The alterations of microbiota and pathological conditions in the gut of patients with colorectal cancer undergoing chemotherapy. Anaerobe 68, 102361 (2021).","journal-title":"Anaerobe"},{"issue":"1","key":"95005_CR3","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1080\/10942912.2023.2215967","volume":"26","author":"X Li","year":"2023","unstructured":"Li, X., Cui, C., Gong, W.,  Li, G. & Huang, P. Oral nutrition supplement improves nutrition and inflammation of cancer patients by regulating iron metabolism. Int. J. Food Prop. 26 (1), 1304\u20131310 (2023).","journal-title":"Int. J. Food Prop."},{"key":"95005_CR4","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1016\/j.clnu.2019.11.008","volume":"39","author":"A Darbandi","year":"2020","unstructured":"Darbandi, A. et al. The effects of probiotics on reducing the colorectal cancer surgery complications: A periodic review during 2007\u20132017. Clin. Nutr. 39, 2358\u20132367 (2020). [CrossRef].","journal-title":"Clin. Nutr."},{"key":"95005_CR5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/01635581.2020.1865420","volume":"74","author":"G Tang","year":"2022","unstructured":"Tang, G. & Zhang, L. Update on strategies of probiotics for the prevention and treatment of colorectal cancer. Nutr. Cancer. 74, 27\u201338 (2022).","journal-title":"Nutr. Cancer"},{"issue":"5","key":"95005_CR6","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1016\/j.clnu.2021.02.005","volume":"40","author":"M Muscaritoli","year":"2021","unstructured":"Muscaritoli, M. et al. ESPEN practical guideline: clinical nutrition in cancer. Clin. Nutr. (Edinburgh Scotland). 40 (5), 2898\u20132913 (2021).","journal-title":"Clin. Nutr. (Edinburgh Scotland)"},{"key":"95005_CR7","doi-asserted-by":"crossref","first-page":"102361","DOI":"10.1016\/j.anaerobe.2021.102361","volume":"68","author":"Y Yixia","year":"2021","unstructured":"Yixia, Y., Sripetchwandee, I., Chattipakorn, N. & Chattipakorn, S. C. The alterations of microbiota and pathological conditions in the gut of patients with colorectal cancer undergoing chemotherapy. Anaerobe 68, 102361 (2021).","journal-title":"Anaerobe"},{"key":"95005_CR8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ygyno.2023.06.015","volume":"175","author":"M Morton","year":"2023","unstructured":"Morton, M. et al. Malnutrition, sarcopenia, and cancer cachexia in gynecologic cancer. Gynecol. Oncol. 175, 142\u2013155 (2023).","journal-title":"Gynecol. Oncol."},{"issue":"14","key":"95005_CR9","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.3390\/nu14142958","volume":"14","author":"S Salas","year":"2022","unstructured":"Salas, S. et al. Nutritional factors during and after cancer: impacts on survival and quality of life. Nutrients 14 (14), 2958 (2022).","journal-title":"Nutrients"},{"issue":"1","key":"95005_CR10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clnu.2016.07.015","volume":"36","author":"J Arends","year":"2017","unstructured":"Arends, J. et al. ESPEN guidelines on nutrition in cancer patients. Clin. Nutr. (Edinburgh Scotland). 36 (1), 11\u201348 (2017).","journal-title":"Clin. Nutr. (Edinburgh Scotland)"},{"issue":"1","key":"95005_CR11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.clnu.2020.04.043","volume":"40","author":"Q Meng","year":"2021","unstructured":"Meng, Q. et al. Post-discharge oral nutritional supplements with dietary advice in patients at nutritional risk after surgery for gastric cancer: A randomized clinical trial. Clin. Nutr. 40 (1), 40\u201346 (2021).","journal-title":"Clin. Nutr."},{"issue":"1","key":"95005_CR12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.clnu.2020.05.038","volume":"40","author":"S Tan","year":"2021","unstructured":"Tan, S. et al. Impact of oral nutritional supplements in post-discharge patients at nutritional risk following colorectal cancer surgery: A randomised clinical trial. Clin. Nutr. 40 (1), 47\u201353 (2021).","journal-title":"Clin. Nutr."},{"issue":"1","key":"95005_CR13","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s00384-023-04504-8","volume":"38","author":"K Xiong","year":"2023","unstructured":"Xiong, K. et al. Effects of glutamine on plasma protein and inflammation in postoperative patients with colorectal cancer: a meta-analysis of randomized controlled trials. Int. J. Colorectal Dis. 38 (1), 212 (2023).","journal-title":"Int. J. Colorectal Dis."},{"issue":"1","key":"95005_CR14","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s40168-022-01289-w","volume":"10","author":"W Zhong","year":"2022","unstructured":"Zhong, W. et al. Gut dysbiosis promotes prostate cancer progression and docetaxel resistance via activating NF-\u03baB-IL6-STAT3 axis. Microbiome 10 (1), 94 (2022).","journal-title":"Microbiome"},{"issue":"9","key":"95005_CR15","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.2337\/dc21-0099","volume":"44","author":"J Gao","year":"2021","unstructured":"Gao, J. et al. The association of fried meat consumption with the gut microbiota and fecal metabolites and its impact on glucose homoeostasis, intestinal endotoxin levels, and systemic inflammation: A randomized Controlled-Feeding trial. Diabetes Care. 44 (9), 1970\u20131979 (2021).","journal-title":"Diabetes Care"},{"issue":"2","key":"95005_CR16","doi-asserted-by":"crossref","first-page":"2240031","DOI":"10.1080\/19490976.2023.2240031","volume":"15","author":"J Rajapakse","year":"2023","unstructured":"Rajapakse, J. et al. Unveiling the complex relationship between gut microbiota and liver cancer: opportunities for novel therapeutic interventions. Gut Microbes. 15 (2), 2240031 (2023).","journal-title":"Gut Microbes"},{"issue":"5","key":"95005_CR17","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","volume":"71","author":"WM de Vos","year":"2022","unstructured":"de Vos, W. M., Tilg, H., Van Hul, M. & Cani, P. D. Gut Microbiome and health: mechanistic insights. Gut 71 (5), 1020\u20131032 (2022).","journal-title":"Gut"},{"key":"95005_CR18","doi-asserted-by":"crossref","unstructured":"Pushpanathan, P., Mathew, G. S., Selvarajan, S., Seshadri, K. G. & Srikanth, P. Gut microbiota and its mysteries. Indian J. Med. Microbiol. ;37 (2), 268\u2013277 (2019).","DOI":"10.4103\/ijmm.IJMM_19_373"},{"key":"95005_CR19","doi-asserted-by":"crossref","first-page":"997018","DOI":"10.3389\/fcimb.2022.997018","volume":"12","author":"J Fang","year":"2022","unstructured":"Fang, J. et al. Gut dysbiosis in nonalcoholic fatty liver disease: pathogenesis, diagnosis, and therapeutic implications. Front. Cell. Infect. Microbiol. 12, 997018 (2022).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"95005_CR20","doi-asserted-by":"crossref","unstructured":"Assimakopoulos, S. F. et al. Intestinal barrier biomarker ZO1 and endotoxin are increased in blood of patients with COVID-19-associated pneumonia. In Vivo 35 (4), 2483\u20132488 (2021).","DOI":"10.21873\/invivo.12528"},{"issue":"7","key":"95005_CR21","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s00520-013-1741-7","volume":"21","author":"AM Stringer","year":"2013","unstructured":"Stringer, A. M. et al. Biomarkers of chemotherapy-induced diarrhoea: a clinical study of intestinal Microbiome alterations, inflammation and Circulating matrix metalloproteinases. Support Care Cancer. 21 (7), 1843\u20131852 (2013).","journal-title":"Support Care Cancer"},{"issue":"1","key":"95005_CR22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.clnu.2015.11.008","volume":"36","author":"M Motoori","year":"2017","unstructured":"Motoori, M. et al. Randomized study of the effect of synbiotics during neoadjuvant chemotherapy on adverse events in esophageal cancer patients. Clin. Nutr. 36 (1), 93\u201399 (2017).","journal-title":"Clin. Nutr."},{"key":"95005_CR23","doi-asserted-by":"crossref","first-page":"104952","DOI":"10.1016\/j.ebiom.2023.104952","volume":"100","author":"HC Lau","year":"2024","unstructured":"Lau, H. C. et al. Lactobacillus acidophilus suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma through producing valeric acid. EBioMedicine 100, 104952 (2024).","journal-title":"EBioMedicine"},{"issue":"8","key":"95005_CR24","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/s41430-020-00852-8","volume":"75","author":"X Li","year":"2021","unstructured":"Li, X. et al. Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury. Eur. J. Clin. Nutr. 75 (8), 1227\u20131236 (2021).","journal-title":"Eur. J. Clin. Nutr."},{"issue":"2","key":"95005_CR25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/nu15020356","volume":"15","author":"F Huang","year":"2023","unstructured":"Huang, F. et al. Postoperative probiotics administration attenuates Gastrointestinal complications and gut microbiota dysbiosis caused by chemotherapy in colorectal cancer patients. Nutrients 15 (2), 356 (2023).","journal-title":"Nutrients"},{"key":"95005_CR26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejca.2021.11.006","volume":"161","author":"Z Juan","year":"2022","unstructured":"Juan, Z. et al. Probiotic supplement attenuates chemotherapy-related cognitive impairment in patients with breast cancer: a randomised, double-blind, and placebo-controlled trial. Eur. J. Cancer. 161, 10\u201322 (2022).","journal-title":"Eur. J. Cancer"},{"key":"95005_CR27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.clnesp.2024.03.035","volume":"61","author":"A Ostadrahimi","year":"2024","unstructured":"Ostadrahimi, A. et al. Effect of combination of beta glucan and Lactobacillus rhamnosus herizi on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: A randomized double-blind placebo-controlled clinical trial. Clin. Nutr. ESPEN. 61, 281\u2013287 (2024).","journal-title":"Clin. Nutr. ESPEN"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95005-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95005-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95005-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T03:44:19Z","timestamp":1742787859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-025-95005-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["95005"],"URL":"https:\/\/doi.org\/10.1038\/s41598-025-95005-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,24]]},"assertion":[{"value":"25 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the Ethics Committee of the Yuhuangding Hospital (No. 2022\u2009\u2212\u2009237). All procedures involving human participants have been conducted according to the tenets of the Declaration of Helsinki. Written informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"10063"}}