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Early diagnosis is crucial for intervention and improved prognosis. Dentists can help identify these signs through oral masses, gingival bleeding, and oral ulceration, with radiographical features like bone osteolysis, moth-eating appearance, and abnormal tooth chronology. This study aimed to achieve early diagnosis of leukemic child patients (LCP) by the dentist based on their clinical, age estimation, and radiographical oral signs. Twenty-three children suffer from leukemia, selected after an initial diagnosis based on their clinical signs with an abnormal CBC or abnormal WBCs. These patients were accessed clinically for oral signs and radiographically using panoramic radiographs and cone beam computed tomography (CBCT) to evaluate chronology and bone density. LCP were compared with systematically free control child cases (SFC) who went for a panoramic image and CBCT scan needed for their orthodontic problems. Clinical results for LCP revealed (100%) of cases showed gingival bleeding, (87%) of cases showed gingival masses, (83%) of cases revealed aphthous-like ulceration, and (100%) of cases had different grades of mobility related to the lower first permanent molar used as markers for tooth affection. Radiographical results revealed a statistically significant decrease (P value\u2009\u2264\u20090.05) in LCP age revealed by panoramic and CBCT images in comparison with their actual age. Also, there was a statistically significant decrease in bone density shown by LCP regarding selected regions. LCP could be early diagnosed by the dentist through clinical and radiographical indicators. Diagnosing acute lymphoblastic leukemia (ALL) in its early stages remains a significant challenge due to the nonspecific and often subtle nature of initial symptoms. Dental practitioners can bridge the gap between routine dental care and early systemic disease detection, potentially expediting medical intervention and improving outcomes for children with acute lymphoblastic leukemia.<\/jats:p>","DOI":"10.1038\/s41598-025-95014-w","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T02:22:06Z","timestamp":1744338126000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early diagnosis of acute lymphoblastic leukemia utilizing clinical, radiographic, and dental age indicators"],"prefix":"10.1038","volume":"15","author":[{"given":"Rehab F","family":"Ghouraba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa S.","family":"EL-Desouky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed R.","family":"El-Shanshory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A.","family":"Kabbash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Metwally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"95014_CR1","doi-asserted-by":"crossref","unstructured":"Mitchell, C., Hall, G. & Clarke, R. 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